Overview
Availability
- Professor Esteban Marcellin is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Chemical Engineering, unknown
- Doctor of Philosophy, The University of Queensland
Research interests
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Systems and Synthetic Biology
Systems and synthetic biology are powerful tools to guide the improvement of biological systems for producing fuels, chemicals, foods and biopharmaceuticals. Systems and synthetic approaches can be used to identify metabolic engineering targets and develop new production strains. Using data-driven approaches that take advantage of the tremendous growth in high throughput ‘-omics (genomics, transcriptomics, proteomics and metabolomics) coupled with mathematical models we can better understand cells. The data gathered can be used to suggest potential metabolic engineering strategies (e.g. bottlenecks that can be targeted for knockout/up-regulation) to improve yields and productivity. Biological systems are refined and improved using biological data, leading to further iterative rounds of metabolic engineering to enhance production. Using gas fermentation, we are consuming greenhouse gases (CO and CO2) as feedstock for fermentation and converting those greenhouse gases into valuable fuels, chemicals and fuels. This allows us to decrease our dependence on finite fossil fuel resources and improves sustainability for Australia. Our projects aim at producing efficient cell lines to increase the yields and productivity of biological systems. In collaboration with leaders in the industry, such as Lanzatech, Amyris, Zoetis, Dow, CSL and Thermo-Fisher, we are applying systems metabolic engineering to enhance yields and increase the production scope of the advanced biomanufacturing sector.
Works
Search Professor Esteban Marcellin’s works on UQ eSpace
2024
Journal Article
Autotrophic adaptive laboratory evolution of the acetogen Clostridium autoethanogenum delivers the gas-fermenting strain LAbrini with superior growth, products, and robustness
Ingelman, Henri, Heffernan, James K., Harris, Audrey, Brown, Steven D., Shaikh, Kurshedaktar Majibullah, Saqib, Asfand Yar, Pinheiro, Marina J., de Lima, Lorena Azevedo, Rodriguez Martinez, Karen, Gonzalez-Garcia, Ricardo A., Hawkins, Grant, Daleiden, Jim, Tran, Loan, Zeleznik, Hunter, Jensen, Rasmus O., Reynoso, Vinicio, Schindel, Heidi, Jänes, Jürgen, Simpson, Séan D., Köpke, Michael, Marcellin, Esteban and Valgepea, Kaspar (2024). Autotrophic adaptive laboratory evolution of the acetogen Clostridium autoethanogenum delivers the gas-fermenting strain LAbrini with superior growth, products, and robustness. New Biotechnology, 83, 1-15. doi: 10.1016/j.nbt.2024.06.002
2024
Journal Article
Adaptive laboratory evolution of Clostridium autoethanogenum to metabolize CO2 and H2 enhances growth rates in chemostat and unravels proteome and metabolome alterations
Heffernan, James, Garcia Gonzalez, R. Axayactl, Mahamkali, Vishnu, McCubbin, Tim, Daygon, Dara, Liu, Lian, Palfreyman, Robin, Harris, Audrey, Koepke, Michael, Valgepea, Kaspar, Nielsen, Lars Keld and Marcellin, Esteban (2024). Adaptive laboratory evolution of Clostridium autoethanogenum to metabolize CO2 and H2 enhances growth rates in chemostat and unravels proteome and metabolome alterations. Microbial Biotechnology, 17 (4) e14452, e14452. doi: 10.1111/1751-7915.14452
2024
Journal Article
Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation
Nöbel, Matthias, Barry, Craig, MacDonald, Michael A., Baker, Kym, Shave, Evan, Mahler, Stephen, Munro, Trent, Martínez, Verónica S., Nielsen, Lars K. and Marcellin, Esteban (2024). Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation. Biotechnology and Bioengineering, 121 (4), 1371-1383. doi: 10.1002/bit.28613
2024
Journal Article
A universal molecular control for DNA, mRNA and protein expression
Gunter, Helen M., Youlten, Scott E., Reis, Andre L. M., McCubbin, Tim, Madala, Bindu Swapna, Wong, Ted, Stevanovski, Igor, Cipponi, Arcadi, Deveson, Ira W., Santini, Nadia S., Kummerfeld, Sarah, Croucher, Peter I., Marcellin, Esteban and Mercer, Tim R. (2024). A universal molecular control for DNA, mRNA and protein expression. Nature Communications, 15 (1) 2480, 1-13. doi: 10.1038/s41467-024-46456-9
2024
Conference Publication
Protein identification for binding of critical elements in bauxite residue
Webster, Luke, Marcellin, Esteban and Villa-Gomez, Denys (2024). Protein identification for binding of critical elements in bauxite residue. Australian Mine Waste Symposium Abstracts, Brisbane, QLD Australia, 6-7 February 2024. Brisbane, QLD Australia: Sustainable Minerals Institute.
2024
Journal Article
Quantitative subcellular reconstruction reveals a lipid mediated inter-organelle biogenesis network
Lee, Richard G., Rudler, Danielle L., Raven, Samuel A., Peng, Liuyu, Chopin, Anaelle, Moh, Edward S. X., McCubbin, Tim, Siira, Stefan J., Fagan, Samuel V., Debono, Nicholas J., Stentenbach, Maike, Browne, Jasmin, Rackham, Filip F., Li, Ji, Simpson, Kaylene J., Marcellin, Esteban, Packer, Nicolle H., Reid, Gavin E., Padman, Benjamin S., Rackham, Oliver and Filipovska, Aleksandra (2024). Quantitative subcellular reconstruction reveals a lipid mediated inter-organelle biogenesis network. Nature Cell Biology, 26 (1), 57-71+. doi: 10.1038/s41556-023-01297-4
2023
Journal Article
An integrated systems biology approach reveals differences in formate metabolism in the genus Methanothermobacter
Casini, Isabella, McCubbin, Tim, Esquivel-Elizondo, Sofia, Luque, Guillermo G., Evseeva, Daria, Fink, Christian, Beblawy, Sebastian, Youngblut, Nicholas D., Aristilde, Ludmilla, Huson, Daniel H., Dräger, Andreas, Ley, Ruth E., Marcellin, Esteban, Angenent, Largus T. and Molitor, Bastian (2023). An integrated systems biology approach reveals differences in formate metabolism in the genus Methanothermobacter. iScience, 26 (10) 108016, 1-26. doi: 10.1016/j.isci.2023.108016
2023
Journal Article
mRNA vaccine quality analysis using RNA sequencing
Gunter, Helen M., Idrisoglu, Senel, Singh, Swati, Han, Dae Jong, Ariens, Emily, Peters, Jonathan R., Wong, Ted, Cheetham, Seth W., Xu, Jun, Rai, Subash Kumar, Feldman, Robert, Herbert, Andy, Marcellin, Esteban, Tropee, Romain, Munro, Trent and Mercer, Tim R. (2023). mRNA vaccine quality analysis using RNA sequencing. Nature Communications, 14 (1) 5663, 1-12. doi: 10.1038/s41467-023-41354-y
2023
Journal Article
Salinity effect on an anaerobic methane- and ammonium-oxidising consortium: shifts in activity, morphology, osmoregulation and syntrophic relationship
Frank, Joshua, Zhang, Xueqin, Marcellin, Esteban, Yuan, Zhiguo and Hu, Shihu (2023). Salinity effect on an anaerobic methane- and ammonium-oxidising consortium: shifts in activity, morphology, osmoregulation and syntrophic relationship. Water Research, 242 120090, 120090. doi: 10.1016/j.watres.2023.120090
2023
Journal Article
Tuning flow-through cu-based hollow fiber gas-diffusion electrode for high-efficiency carbon monoxide (CO) electroreduction to C2+products
Rabiee, Hesamoddin, Heffernan, James K., Ge, Lei, Zhang, Xueqin, Yan, Penghui, Marcellin, Esteban, Hu, Shihu, Zhu, Zhonghua, Wang, Hao and Yuan, Zhiguo (2023). Tuning flow-through cu-based hollow fiber gas-diffusion electrode for high-efficiency carbon monoxide (CO) electroreduction to C2+products. Applied Catalysis B: Environmental, 330 122589, 122589. doi: 10.1016/j.apcatb.2023.122589
2023
Journal Article
Characterisation of acetogen formatotrophic potential using Eubacterium limosum
Wood, Jamin C., Gonzalez-Garcia, R. Axayacatl, Daygon, Dara, Talbo, Gert, Plan, Manuel R., Marcellin, Esteban and Virdis, Bernardino (2023). Characterisation of acetogen formatotrophic potential using Eubacterium limosum. Applied Microbiology and Biotechnology, 107 (14), 4507-4518. doi: 10.1007/s00253-023-12600-6
2023
Journal Article
Cyclic-di-AMP signalling in lactic acid bacteria
Turner, Mark S., Xiang, Yuwei, Liang, Zhao-Xun, Marcellin, Esteban and Pham, Huong Thi (2023). Cyclic-di-AMP signalling in lactic acid bacteria. FEMS Microbiology Reviews, 47 (3) fuad025, 1-16. doi: 10.1093/femsre/fuad025
2023
Journal Article
Copy number variation in tRNA isodecoder genes impairs mammalian development and balanced translation
Hughes, Laetitia A., Rudler, Danielle L., Siira, Stefan J., McCubbin, Tim, Raven, Samuel A., Browne, Jasmin M., Ermer, Judith A., Rientjes, Jeanette, Rodger, Jennifer, Marcellin, Esteban, Rackham, Oliver and Filipovska, Aleksandra (2023). Copy number variation in tRNA isodecoder genes impairs mammalian development and balanced translation. Nature Communications, 14 (1) 2210, 1-19. doi: 10.1038/s41467-023-37843-9
2023
Journal Article
Molecular understanding of Eubacterium limosum chemostat methanol metabolism
Wood, Jamin C., Gonzalez-Garcia, R. Axayacatl, Daygon, Dara, Talbo, Gert, Plan, Manuel R., Marcellin, Esteban and Virdis, Bernardino (2023). Molecular understanding of Eubacterium limosum chemostat methanol metabolism. Sustainable Energy and Fuels, 7 (10), 2397-2412. doi: 10.1039/d2se01551j
2023
Journal Article
Microbial conversion of waste gases into single-cell protein
Jain, Surbhi, Heffernan, James, Joshi, Jitendra, Watts, Thomas, Marcellin, Esteban and Greening, Chris (2023). Microbial conversion of waste gases into single-cell protein. Microbiology Australia, 44 (1), 27-30. doi: 10.1071/ma23007
2023
Journal Article
Gas fermentation for microbial sustainable aviation fuel production
Rodriguez, Karen, Pedroso, Marcelo, Harris, Audrey, Garg, Shivani, Hine, Damian, Köpke, Michael, Schenk, Gerhard and Marcellin, Esteban (2023). Gas fermentation for microbial sustainable aviation fuel production. Microbiology Australia, 44 (1), 31-35. doi: 10.1071/ma23008
2023
Journal Article
Structural and functional insight into the mechanism of the Fe‐S cluster‐dependent dehydratase from Paralcaligenes ureilyticus
Bayaraa, Tenuun, Lonhienne, Thierry, Sutiono, Samuel, Melse, Okke, Brück, Thomas B., Marcellin, Esteban, Bernhardt, Paul V., Boden, Mikael, Harmer, Jeffrey R., Sieber, Volker, Guddat, Luke W. and Schenk, Gerhard (2023). Structural and functional insight into the mechanism of the Fe‐S cluster‐dependent dehydratase from Paralcaligenes ureilyticus. Chemistry: A European Journal, 29 (9) e202203140, 1-13. doi: 10.1002/chem.202203140
2023
Journal Article
Biogas upgrading using Clostridium autoethanogenum for value-added products
Heffernan, James K., Lai, Chun-Yu, Gonzalez-Garcia, R. Axayacatl, Nielsen, Lars Keld, Guo, Jianhua and Marcellin, Esteban (2023). Biogas upgrading using Clostridium autoethanogenum for value-added products. Chemical Engineering Journal, 452 (Part 1) 138950, 1-7. doi: 10.1016/j.cej.2022.138950
2022
Journal Article
Deleterious variants in CRLS1 lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease
Lee, Richard G., Balasubramaniam, Shanti, Stentenbach, Maike, Kralj, Tom, McCubbin, Tim, Padman, Benjamin, Smith, Janine, Riley, Lisa G., Priyadarshi, Archana, Peng, Liuyu, Nuske, Madison R., Webster, Richard, Peacock, Ken, Roberts, Philip, Stark, Zornitza, Lemire, Gabrielle, Ito, Yoko A., Boycott, Kym M., Geraghty, Michael T., Klinken, Jan Bert, Ferdinandusse, Sacha, Zhou, Ying, Walsh, Rebecca, Marcellin, Esteban, Thorburn, David R., Rosciolli, Tony, Fletcher, Janice, Rackham, Oliver, Vaz, Frédéric M. ... Care4Rare Canada Consortium (2022). Deleterious variants in CRLS1 lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease. Human Molecular Genetics, 31 (21), 3597-3612. doi: 10.1093/hmg/ddac040
2022
Journal Article
Library adaptors with integrated reference controls improve the accuracy and reliability of nanopore sequencing
Gunter, Helen M., Youlten, Scott E., Madala, Bindu Swapna, Reis, Andre L. M., Stevanovski, Igor, Wong, Ted, Kummerfield, Sarah K., Deveson, Ira W., Santini, Nadia S., Marcellin, Esteban and Mercer, Tim R. (2022). Library adaptors with integrated reference controls improve the accuracy and reliability of nanopore sequencing. Nature Communications, 13 (1) 6437, 1-11. doi: 10.1038/s41467-022-34028-8
Funding
Current funding
Supervision
Availability
- Professor Esteban Marcellin is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Biorecycyling carbon using acetogens
Principal Advisor
Other advisors: Professor Lars Nielsen, Professor Gary Schenk, Dr Axa Gonzalez, Dr James Heffernan
-
Doctor Philosophy
Accelerating the design of cell lines for biologic production
Principal Advisor
Other advisors: Dr Marianne Gillard, Professor Timothy Mercer
-
Doctor Philosophy
Production of the Mannopeptimycin Antibiotic and other unknown Biosynthetic Gene Clusters from Streptomyces hygroscopicus
Principal Advisor
Other advisors: Dr Zeinab Khalil
-
Doctor Philosophy
Biological CO2 and H2 utilization for sustainable animal feed production
Principal Advisor
Other advisors: Professor Lars Nielsen, Dr James Heffernan
-
Master Philosophy
Harnessing Microbial Power: Turning Carbon into Valuable Products through Gas Fermentation
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
Modelling cyanobacterial metabolism for the production of high-value products
Principal Advisor
-
Doctor Philosophy
Engineering cyanobacteria for high-value flavours and fragrances production
Principal Advisor
-
Doctor Philosophy
EnzOnomy - an enzyme-based production pipeline for the bioeconomy
Associate Advisor
Other advisors: Professor Damian Hine, Professor Gary Schenk
-
Doctor Philosophy
Influence of structurally different polysaccharides and their interactions with saliva and tannins on mouthfeel in wine
Associate Advisor
Other advisors: Dr Raisa Rudge, Dr Marlize Bekker, Professor Heather Smyth
-
Doctor Philosophy
Advancing biofertiliser for sustainable agriculture
Associate Advisor
Other advisors: Professor Susanne Schmidt, Dr Axa Gonzalez
-
Doctor Philosophy
Co-assimilation of C1 compounds (methanol, formate, formaldehyde) and components from lignocellulosic feedstock
Associate Advisor
Other advisors: Dr Birgitta Ebert
-
Doctor Philosophy
Mechanisms of osmoresistance in industrial Lactococcus cemoris
Associate Advisor
Other advisors: Professor Mark Turner
-
Doctor Philosophy
Systems biology-guided cell line engineering for production of therapeutic proteins with complex post-translational modifications
Associate Advisor
Other advisors: Dr Lucia Zacchi, Professor Benjamin Schulz
-
Doctor Philosophy
Accelerating the extraction of critical metals such as rare earth elements and gallium from red mud tailings.
Associate Advisor
Other advisors: Dr Denys Villa Gomez
-
Doctor Philosophy
Using synthetic biology to accelerate critical metals recovery from mine waste
Associate Advisor
Other advisors: Dr Denys Villa Gomez
Completed supervision
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2023
Doctor Philosophy
Systems metabolic engineering for one-carbon (C1) utilization metabolism
Principal Advisor
Other advisors: Honorary Professor Zhiguo Yuan
-
2023
Doctor Philosophy
Sustainable fuel and chemical production via Gas Fermentation: exploring CO2 metabolism by Clostridium autoethanogenum
Principal Advisor
Other advisors: Professor Lars Nielsen, Dr Axa Gonzalez
-
2023
Doctor Philosophy
Modelling and characterising life and death of mammalian suspension cultures
Principal Advisor
Other advisors: Professor Lars Nielsen, Dr Verónica Martinez Salazar, Dr Gert Talbo
-
2022
Doctor Philosophy
Cell Line Development for High Density Culture of CHO Cells in Perfusion: Applications of Apoptosis Resistance
Principal Advisor
Other advisors: Professor Peter Gray, Dr Verónica Martinez Salazar
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2021
Doctor Philosophy
Insight into acetogens metabolism through the use of thermodynamic metabolic flux analysis
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2020
Doctor Philosophy
Understanding toxin production in Clostridium tetani: a systems approach
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2019
Doctor Philosophy
From waste to chemicals: On the metabolism of Clostridium autoethanogenum and PHB production from gas fermentation
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2018
Doctor Philosophy
Exploring the metabolism of propionibacteria using genome-scale modelling
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2018
Doctor Philosophy
Metabolic Engineering of propionibacteria's Wood Werkman cycle in Escherichia coli and Saccharomyces cerevisiae
Principal Advisor
Other advisors: Professor Lars Nielsen, Professor Mark Turner
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2017
Doctor Philosophy
Understanding high propionic acid production in Propionibacterium
Principal Advisor
Other advisors: Professor Lars Nielsen
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2023
Doctor Philosophy
Exploring Metabolic Demands of High Cell Density Chinese Hamster Ovary Cell Culture - Studying Apoptosis Resistance in Perfusion Culture
Associate Advisor
Other advisors: Dr Gert Talbo, Dr Verónica Martinez Salazar
-
2023
Doctor Philosophy
Production of liquid chemicals from C1 feedstocks using Eubacterium limosum
Associate Advisor
Other advisors: Dr Bernardino Virdis
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2022
Doctor Philosophy
Sf9 cell line engineering to improve baculovirus expression
Associate Advisor
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2016
Doctor Philosophy
Understanding CHO cells biology for enhanced biopharmaceutical production: a comparative transcriptomic and proteomic approach
Associate Advisor
Other advisors: Professor Peter Gray, Professor Lars Nielsen
-
2015
Doctor Philosophy
Quantitative bacterial phosphoproteomics
Associate Advisor
Other advisors: Professor Lars Nielsen
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2014
Doctor Philosophy
Characterisation of the Saccharopolyspora erythraea metabolic switch: a systems approach
Associate Advisor
Other advisors: Professor Lars Nielsen
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