Overview
Availability
- Professor Esteban Marcellin is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Chemical Engineering, Universidad Iberoamericana
- Doctor of Philosophy, The University of Queensland
Research interests
-
Systems and Synthetic Biology
Systems and synthetic biology are powerful tools to guide the improvement of biological systems for producing fuels, chemicals, foods and biopharmaceuticals. Systems and synthetic approaches can be used to identify metabolic engineering targets and develop new production strains. Using data-driven approaches that take advantage of the tremendous growth in high throughput ‘-omics (genomics, transcriptomics, proteomics and metabolomics) coupled with mathematical models we can better understand cells. The data gathered can be used to suggest potential metabolic engineering strategies (e.g. bottlenecks that can be targeted for knockout/up-regulation) to improve yields and productivity. Biological systems are refined and improved using biological data, leading to further iterative rounds of metabolic engineering to enhance production. Using gas fermentation, we are consuming greenhouse gases (CO and CO2) as feedstock for fermentation and converting those greenhouse gases into valuable fuels, chemicals and fuels. This allows us to decrease our dependence on finite fossil fuel resources and improves sustainability for Australia. Our projects aim at producing efficient cell lines to increase the yields and productivity of biological systems. In collaboration with leaders in the industry, such as Lanzatech, Amyris, Zoetis, Dow, CSL and Thermo-Fisher, we are applying systems metabolic engineering to enhance yields and increase the production scope of the advanced biomanufacturing sector.
Works
Search Professor Esteban Marcellin’s works on UQ eSpace
2009
Journal Article
Proteome analysis of the hyaluronic acid-producing bacterium, Streptococcus zooepidemicus
Marcellin, Esteban, Gruber, Christian W., Archer, Colin, Craik, David J. and Nielsen, Lars K. (2009). Proteome analysis of the hyaluronic acid-producing bacterium, Streptococcus zooepidemicus. Proteome Science, 7 (13) 13, 1-13. doi: 10.1186/1477-5956-7-13
2009
Journal Article
Quantitative analysis of intracellular sugar phosphates and sugar nucleotides in encapsulated streptococci using HPAEC-PAD
Marcellin, Esteban, Nielsen, Lars K., Abeydeera, Peter and Kromer, Jens O. (2009). Quantitative analysis of intracellular sugar phosphates and sugar nucleotides in encapsulated streptococci using HPAEC-PAD. Biotechnology Journal, 4 (1), 58-63. doi: 10.1002/biot.200800197
2009
Book Chapter
Microbial hyaluronic acid biosynthesis
Marcellin, Esteban, Chen, Wendy and Nielsen, Lars Keld (2009). Microbial hyaluronic acid biosynthesis. Microbial Production of Biopolymers and Polymer Precursors: Applications and Perspectives. (pp. 163-180) edited by B.H.A. Rehm. Norfolk, UK: Caister Academic Press.
2009
Conference Publication
Metabolic engineering of hyaluronic acid production in streptococci
Nielsen, Lars K., Marcellin, Esteban and Chen, Wendy (2009). Metabolic engineering of hyaluronic acid production in streptococci. SIM Annual Meeting and Exhibition 2009, Toronto, Canada, 26-30 July 2009. Fairfax, VA, United States: Society for Industrial Microbiology (SIM).
2008
Conference Publication
Proteome analysis of hyaluronic acid producing bacteria for strain optimisation
Marcellin, E., Chen, W. Y. and Nielsen, L. K. (2008). Proteome analysis of hyaluronic acid producing bacteria for strain optimisation. Metabolic engineering VII, Puerto Vallarta, Mexico, 14-18 September.
2008
Conference Publication
Streptococcus zooepidemicus engineered to overexpress Pgi and GlmU produces high molecular weight hyaluronic acid.
Chen WY, Marcellin E, Hung J and Nielsen LK (2008). Streptococcus zooepidemicus engineered to overexpress Pgi and GlmU produces high molecular weight hyaluronic acid.. Cooperative Research Centre for Sugar Industry Innovation through Biotechnology (CRC SIIB) Symposium, Brisbane, Australia, 3-4th December.
2008
Conference Publication
Understanding molecular weight control in bacterial fermentation: a systems biotechnology approach
Marcellin E, Chen WY, Archer C and Nielsen LK (2008). Understanding molecular weight control in bacterial fermentation: a systems biotechnology approach. GIW2008, Gold Coast , QLD, Australia, 1-3 December.
2008
Conference Publication
Streptococcus zooepidemicus engineered to overexpress Pgi produces high molecular weight hyaluronic acid
Chen WY, Marcellin E, Hung J and Nielsen LK (2008). Streptococcus zooepidemicus engineered to overexpress Pgi produces high molecular weight hyaluronic acid. Metabolic engineering VII, Puerto Vallarta, Mexico, 14-18 September.
2007
Conference Publication
Genome scale model of Streptococcus zooepidemicus: understanding hyaluronic acid production
Marcellin E, Archer C and Nielsen LK (2007). Genome scale model of Streptococcus zooepidemicus: understanding hyaluronic acid production. Bioinformatics Australia, Brisbane / Brisbane Convention Centre, 23-24 October.
Funding
Current funding
Supervision
Availability
- Professor Esteban Marcellin is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Biological CO2 and H2 utilization for sustainable animal feed production
Principal Advisor
Other advisors: Professor Lars Nielsen, Dr James Heffernan
-
Doctor Philosophy
Production of the Mannopeptimycin Antibiotic and other unknown Biosynthetic Gene Clusters from Streptomyces hygroscopicus
Principal Advisor
Other advisors: Dr Zeinab Khalil
-
Doctor Philosophy
Optimizing Gas Fermentation for the Valorization of Mixed Gases into High-Value Bio-Products
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
Biorecycyling carbon using acetogens
Principal Advisor
Other advisors: Professor Lars Nielsen, Professor Gary Schenk, Dr Axa Gonzalez, Dr James Heffernan
-
Doctor Philosophy
Modelling cyanobacterial metabolism for the production of high-value products
Principal Advisor
-
Doctor Philosophy
Modelling cyanobacterial metabolism for the production of high-value products
Principal Advisor
-
Doctor Philosophy
Profitable Upcycling of GM Biomass from Precision Fermentation
Principal Advisor
Other advisors: Dr Denys Villa Gomez
-
Master Philosophy
Harnessing Microbial Power: Turning Carbon into Valuable Products through Gas Fermentation
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
Harnessing Microbal Power: Turning Carbon into valuable Produscts through gas fermentation
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
Pathway engineering and systems biology for optimised isobutanol production in gas-fermenting acetogens: From strain isolation to metabolic limitations identification
Principal Advisor
Other advisors: Professor Lars Nielsen, Professor Gary Schenk, Dr Axa Gonzalez, Dr James Heffernan
-
Doctor Philosophy
Engineering cyanobacteria for high-value flavours and fragrances production
Principal Advisor
-
Doctor Philosophy
Optimizing Mixed Gas Fermentation for Enhanced Biofuel Production
Principal Advisor
Other advisors: Dr James Heffernan, Dr Yosephine Gumulya
-
Doctor Philosophy
Engineering Eubacterium limosum for Enhanced CO2 Fixation via rational genome-scale
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
Greenhouse Gas Fermentation and Computational Fluid Dynamics (CFD)
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
Accelerating the design of cell lines for biologic production
Principal Advisor
Other advisors: Dr Marianne Gillard, Professor Timothy Mercer
-
Doctor Philosophy
Biorecycyling carbon using acetogens
Principal Advisor
Other advisors: Professor Lars Nielsen, Professor Gary Schenk, Dr Axa Gonzalez, Dr James Heffernan
-
Doctor Philosophy
Engineering cyanobacteria for high-value flavours and fragrances production
Principal Advisor
-
Doctor Philosophy
Harnessing Microbal Power: Turning Carbon into valuable Produscts through gas fermentation
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
EnzOnomy - an enzyme-based production pipeline for the bioeconomy
Associate Advisor
Other advisors: Professor Damian Hine, Professor Gary Schenk
-
Doctor Philosophy
Systems biology-guided cell line engineering for production of therapeutic proteins with complex post-translational modifications
Associate Advisor
Other advisors: Professor Benjamin Schulz
-
Doctor Philosophy
Engineering biology of yeast for sustainable fragrance production through precision fermentation
Associate Advisor
Other advisors: Dr Axa Gonzalez, Dr Huadong Peng
-
Doctor Philosophy
Influence of structurally different polysaccharides and their interactions with saliva and tannins on mouthfeel in wine
Associate Advisor
Other advisors: Dr Marlize Bekker, Dr Huadong Peng, Professor Heather Smyth
-
Doctor Philosophy
Advancing biofertiliser for sustainable agriculture
Associate Advisor
Other advisors: Professor Susanne Schmidt, Dr Axa Gonzalez
-
Doctor Philosophy
Mechanisms of osmoresistance in industrial Lactococcus cemoris
Associate Advisor
Other advisors: Professor Mark Turner
-
Doctor Philosophy
Leveraging Biomass Waste: Exploiting Proteins from Precision Fermentation Bioprocesses
Associate Advisor
Other advisors: Dr Huadong Peng
-
Doctor Philosophy
Co-assimilation of C1 compounds (methanol, formate, formaldehyde) and components from lignocellulosic feedstock
Associate Advisor
Other advisors: Dr Birgitta Ebert
-
Doctor Philosophy
Microbial fatty acid derivative production from CO2-derived C2 intermediates
Associate Advisor
Other advisors: Dr Birgitta Ebert
-
Doctor Philosophy
Systems biology-guided cell line engineering for production of therapeutic proteins with complex post-translational modifications
Associate Advisor
Other advisors: Professor Benjamin Schulz
-
Doctor Philosophy
Accelerating the extraction of critical metals such as rare earth elements and gallium from red mud tailings.
Associate Advisor
Other advisors: Dr Denys Villa Gomez
-
Doctor Philosophy
Advancing biofertiliser for sustainable agriculture
Associate Advisor
Other advisors: Professor Susanne Schmidt, Dr Axa Gonzalez
-
Doctor Philosophy
Using synthetic biology to accelerate critical metals recovery from mine waste
Associate Advisor
Other advisors: Dr Denys Villa Gomez
Completed supervision
-
2024
Doctor Philosophy
Production of the Mannopeptimycin Antibiotic and Other Unknown Biosynthetic Gene Clusters from Streptomyces hygroscopicus
Principal Advisor
Other advisors: Dr Zeinab Khalil
-
2023
Doctor Philosophy
Systems metabolic engineering for one-carbon (C1) utilization metabolism
Principal Advisor
Other advisors: Honorary Professor Zhiguo Yuan
-
2023
Doctor Philosophy
Sustainable fuel and chemical production via Gas Fermentation: exploring CO2 metabolism by Clostridium autoethanogenum
Principal Advisor
Other advisors: Professor Lars Nielsen, Dr Axa Gonzalez
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2023
Doctor Philosophy
Modelling and characterising life and death of mammalian suspension cultures
Principal Advisor
Other advisors: Professor Lars Nielsen, Dr Veronica Martinez Salazar, Dr Gert Talbo
-
2022
Doctor Philosophy
Cell Line Development for High Density Culture of CHO Cells in Perfusion: Applications of Apoptosis Resistance
Principal Advisor
Other advisors: Professor Peter Gray, Dr Veronica Martinez Salazar
-
2021
Doctor Philosophy
Insight into acetogens metabolism through the use of thermodynamic metabolic flux analysis
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2020
Doctor Philosophy
Understanding toxin production in Clostridium tetani: a systems approach
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2019
Doctor Philosophy
From waste to chemicals: On the metabolism of Clostridium autoethanogenum and PHB production from gas fermentation
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2018
Doctor Philosophy
Exploring the metabolism of propionibacteria using genome-scale modelling
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2018
Doctor Philosophy
Metabolic Engineering of propionibacteria's Wood Werkman cycle in Escherichia coli and Saccharomyces cerevisiae
Principal Advisor
Other advisors: Professor Lars Nielsen, Professor Mark Turner
-
2017
Doctor Philosophy
Understanding high propionic acid production in Propionibacterium
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2025
Doctor Philosophy
Systems biology-guided cell line engineering for production of therapeutic proteins with complex post-translational modifications
Associate Advisor
Other advisors: Dr Lucia Zacchi, Professor Benjamin Schulz
-
2024
Doctor Philosophy
Mechanisms of osmoresistance in industrial Lactococcus cemoris
Associate Advisor
Other advisors: Dr Huong Thi Pham, Professor Mark Turner
-
2023
Doctor Philosophy
Exploring Metabolic Demands of High Cell Density Chinese Hamster Ovary Cell Culture - Studying Apoptosis Resistance in Perfusion Culture
Associate Advisor
Other advisors: Dr Gert Talbo, Dr Veronica Martinez Salazar
-
2023
Doctor Philosophy
Production of liquid chemicals from C1 feedstocks using Eubacterium limosum
Associate Advisor
Other advisors: Dr Bernardino Virdis
-
2022
Doctor Philosophy
Sf9 cell line engineering to improve baculovirus expression
Associate Advisor
-
2016
Doctor Philosophy
Understanding CHO cells biology for enhanced biopharmaceutical production: a comparative transcriptomic and proteomic approach
Associate Advisor
Other advisors: Professor Peter Gray, Professor Lars Nielsen
-
2015
Doctor Philosophy
Quantitative bacterial phosphoproteomics
Associate Advisor
Other advisors: Professor Lars Nielsen
-
2014
Doctor Philosophy
Characterisation of the Saccharopolyspora erythraea metabolic switch: a systems approach
Associate Advisor
Other advisors: Professor Lars Nielsen
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