Professor Esteban Marcellin
Professor

Esteban Marcellin

Email: 
Phone: 
+61 7 334 64298

Availability

Professor Esteban Marcellin is:
Available for supervision

Fields of research

Biochemistry and cell biology Biological Sciences Biomedical engineering Engineering Industrial biotechnology Microbiology Synthetic biology Systems biology

Qualifications

  • Bachelor (Honours) of Chemical Engineering, unknown
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Systems and Synthetic Biology

    Systems and synthetic biology are powerful tools to guide the improvement of biological systems for producing fuels, chemicals, foods and biopharmaceuticals. Systems and synthetic approaches can be used to identify metabolic engineering targets and develop new production strains. Using data-driven approaches that take advantage of the tremendous growth in high throughput ‘-omics (genomics, transcriptomics, proteomics and metabolomics) coupled with mathematical models we can better understand cells. The data gathered can be used to suggest potential metabolic engineering strategies (e.g. bottlenecks that can be targeted for knockout/up-regulation) to improve yields and productivity. Biological systems are refined and improved using biological data, leading to further iterative rounds of metabolic engineering to enhance production. Using gas fermentation, we are consuming greenhouse gases (CO and CO2) as feedstock for fermentation and converting those greenhouse gases into valuable fuels, chemicals and fuels. This allows us to decrease our dependence on finite fossil fuel resources and improves sustainability for Australia. Our projects aim at producing efficient cell lines to increase the yields and productivity of biological systems. In collaboration with leaders in the industry, such as Lanzatech, Amyris, Zoetis, Dow, CSL and Thermo-Fisher, we are applying systems metabolic engineering to enhance yields and increase the production scope of the advanced biomanufacturing sector.

Search Professor Esteban Marcellin’s works on UQ eSpace

134 works between 2007 and 2024
All (134) Journal Article (106) Book Chapter (4) Conference Publication (23) Other Outputs (1)

101 - 120 of 134 works

2015

Conference Publication

A pan-genomic guided metabolic reconstruction and omics integration to understand Propionibacterium metabolism

McCubbins, Tim, Nielsen, Lars. K. and Marcellin, Esteban (2015). A pan-genomic guided metabolic reconstruction and omics integration to understand Propionibacterium metabolism. 4th Conference on Constraint-Based Reconstruction and Analysis (COBRA 2015), Heidelberg, Germany, 16 - 18 September 2015.

A pan-genomic guided metabolic reconstruction and omics integration to understand Propionibacterium metabolism

2014

Journal Article

Escherichia coli W shows fast, highly oxidative sucrose metabolism and low acetate formation

Arifin, Yalun, Archer, Colin, Lim, SooA, Quek, Lake-Ee, Sugiarto, Haryadi, Marcellin, Esteban, Vickers, Claudia E., Kromer, Jens O. and Nielsen, Lars K. (2014). Escherichia coli W shows fast, highly oxidative sucrose metabolism and low acetate formation. Applied Microbiology and Biotechnology, 98 (21), 9033-9044. doi: 10.1007/s00253-014-5956-4

Escherichia coli W shows fast, highly oxidative sucrose metabolism and low acetate formation

2014

Journal Article

Control of chitin and N-acetylglucosamine utilization in Saccharopolyspora erythraea

Liao, Chengheng, Rigali, Sebastien, Cassani, Cuauhtemoc Licona, Marcellin, Esteban, Nielsen, Lars Keld and Ye, Bang-Ce (2014). Control of chitin and N-acetylglucosamine utilization in Saccharopolyspora erythraea. Microbiology (United Kingdom), 160 (9), 1914-1928. doi: 10.1099/mic.0.078261-0

Control of chitin and N-acetylglucosamine utilization in Saccharopolyspora erythraea

2014

Journal Article

Insight into hyaluronic acid molecular weight control

Marcellin, Esteban, Steen, Jennifer A. and Nielsen, Lars K. (2014). Insight into hyaluronic acid molecular weight control. Applied Microbiology and Biotechnology, 98 (16), 6947-6956. doi: 10.1007/s00253-014-5853-x

Insight into hyaluronic acid molecular weight control

2014

Journal Article

Temporal dynamics of the Saccharopolyspora erythraea phosphoproteome

Licona-Cassani, Cuauhtemoc, Lim, SooA, Marcellin, Esteban and Nielsen, Lars K. (2014). Temporal dynamics of the Saccharopolyspora erythraea phosphoproteome. Molecular and Cellular Proteomics, 13 (5), 1219-1230. doi: 10.1074/mcp.M113.033951

Temporal dynamics of the Saccharopolyspora erythraea phosphoproteome

2014

Conference Publication

Developing an integrated systems and synthetic biology platform for gas fermentation

Marcellin, Esteban, Segovia, Simon, De Tissera, Sashini, Mitchell, Wayne, Kopke, Michael and Nielsen, Lars K. (2014). Developing an integrated systems and synthetic biology platform for gas fermentation. Metabolic Engineering X, Vancouver, BC, Canada, 15-19 June 2014.

Developing an integrated systems and synthetic biology platform for gas fermentation

2014

Journal Article

Allantoin catabolism influences the production of antibiotics in Streptomyces coelicolor

Navone, Laura, Casati, Paula, Licona-Cassani, Cuauhtémoc, Marcellin, Esteban, Nielsen, Lars K., Rodriguez, Eduardo and Gramajo, Hugo (2014). Allantoin catabolism influences the production of antibiotics in Streptomyces coelicolor. Applied Microbiology and Biotechnology., 98 (1), 351-360. doi: 10.1007/s00253-013-5372-1

Allantoin catabolism influences the production of antibiotics in Streptomyces coelicolor

2013

Journal Article

Re-annotation of the Saccharopolyspora erythraea genome using a systems biology approach

Marcellin, Esteban, Licona-Cassani, Cuauhtemoc, Mercer, Tim R., Palfreyman, Robin W. and Nielsen, Lars K. (2013). Re-annotation of the Saccharopolyspora erythraea genome using a systems biology approach. BMC Genomics, 14: Provisional (699) 699, 1-18. doi: 10.1186/1471-2164-14-699

Re-annotation of the Saccharopolyspora erythraea genome using a systems biology approach

2013

Journal Article

The role of hyaluronic acid precursor concentrations in molecular weight control in Streptococcus zooepidemicus

Chen, Wendy Yiting, Marcellin, Esteban, Steen, Jennifer A. and Nielsen, Lars Keld (2013). The role of hyaluronic acid precursor concentrations in molecular weight control in Streptococcus zooepidemicus. Molecular Biotechnology, 56 (2), 147-156. doi: 10.1007/s12033-013-9690-4

The role of hyaluronic acid precursor concentrations in molecular weight control in Streptococcus zooepidemicus

2013

Journal Article

Saccharopolyspora erythraea's genome is organised in high-order transcriptional regions mediated by targeted degradation at the metabolic switch

Marcellin, Esteban, Mercer, Tim R., Licona-Cassani, Cuauhtemoc, Palfreyman, Robin W., Dinger, Marcel E., Steen, Jennifer A., Mattick, John S. and Nielsen, Lars K. (2013). Saccharopolyspora erythraea's genome is organised in high-order transcriptional regions mediated by targeted degradation at the metabolic switch. BMC Genomics, 14 (1) 15, 15.1-15.9. doi: 10.1186/1471-2164-14-15

Saccharopolyspora erythraea's genome is organised in high-order transcriptional regions mediated by targeted degradation at the metabolic switch

2012

Journal Article

Reconstruction of the Saccharopolyspora erythraea genome-scale model and its use for enhancing erythromycin production

Licona-Cassani, Cuauhtemoc, Marcellin, Esteban, Quek, Lake-Ee, Jacob, Shana and Nielsen, Lars K. (2012). Reconstruction of the Saccharopolyspora erythraea genome-scale model and its use for enhancing erythromycin production. Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology, 102 (3), 493-502. doi: 10.1007/s10482-012-9783-2

Reconstruction of the Saccharopolyspora erythraea genome-scale model and its use for enhancing erythromycin production

2012

Journal Article

Engineering and adaptive evolution of Escherichia coli for D-lactate fermentation reveals GatC as a xylose transporter

Utrilla, Jose, Licona-Cassani, Cuauhtemoc, Marcellin, Esteban, Gosset, Guillermo, Nielsen, Lars K. and Martinez, Alfredo (2012). Engineering and adaptive evolution of Escherichia coli for D-lactate fermentation reveals GatC as a xylose transporter. Metabolic Engineering, 14 (5), 469-476. doi: 10.1016/j.ymben.2012.07.007

Engineering and adaptive evolution of Escherichia coli for D-lactate fermentation reveals GatC as a xylose transporter

2012

Journal Article

METABOLIC PATHWAY ENGINEERING FOR HYALURONIC ACID PRODUCTION

Marcellin, Esteban, Chen, Wendy Y. and Nielsen, Lars K. (2012). METABOLIC PATHWAY ENGINEERING FOR HYALURONIC ACID PRODUCTION. Carbohydrate-Modifying Biocatalysts, 571-584.

METABOLIC PATHWAY ENGINEERING FOR HYALURONIC ACID PRODUCTION

2012

Conference Publication

Dynamic analysis of Saccharopolyspora erythraea life cycle in bioreactors; a systems approach

Licona Cassani, Cuauthemoc, Marcellin Saldana, Esteban Stefane and Nielsen, Lars K. (2012). Dynamic analysis of Saccharopolyspora erythraea life cycle in bioreactors; a systems approach. Actinobacteria within soil, Munster, Germany, 25-28 October 2012.

Dynamic analysis of Saccharopolyspora erythraea life cycle in bioreactors; a systems approach

2012

Book Chapter

Metabolic pathway engineering for hyaluronic acid production

Marcellin, Esteban, Chen, Wendy Y. and Nielsen, Lars K. (2012). Metabolic pathway engineering for hyaluronic acid production. Carbohydrate modifying biocatalysts. (pp. 571-584) edited by Peter Grundwald. Singapore: Pan Stanford Publishing. doi: 10.4032/9789814303484

Metabolic pathway engineering for hyaluronic acid production

2011

Conference Publication

Systems biology for industrial microorganisms

Marcellin, E., Mercer, T. R., Licona, C. and Nielsen, L. K. (2011). Systems biology for industrial microorganisms. XIV Congreso Nacional de Biotecnología y Bioingeniería, Queretaro, Mexico, 19-24 June 2011.

Systems biology for industrial microorganisms

2011

Conference Publication

Dynamic System-level study for protein expression in Saccharopolyspora erythraea

Licona Cassani, Cuauthemoc, Marcellin Saldana, Esteban Stefane and Nielsen, Lars K. (2011). Dynamic System-level study for protein expression in Saccharopolyspora erythraea. 16th International Symposium on the Biology of Actinomycetes, Puerto Vallarta, Mexico, 11-15 December 2011.

Dynamic System-level study for protein expression in Saccharopolyspora erythraea

2011

Conference Publication

Building Systems biology platforms for Actinobacteria

Marcellin Saldana, Esteban Stefane, Mercer, Timothy, Licona Cassani, Cuauthemoc and Nielsen, Lars K. (2011). Building Systems biology platforms for Actinobacteria. ISBA XVI, Puerto Vallarta, Mexico, 11-15 December 2011.

Building Systems biology platforms for Actinobacteria

2010

Other Outputs

Production of hyaluronic acid

Nielsen, Lars Keld, Chen, Wendy and Saldana Marcellin, Esteban Stefane (2010). Production of hyaluronic acid. EP 2195348 A1.

Production of hyaluronic acid

2010

Conference Publication

Reconstruction of the Saccharopolyspora erythraea GEM

Licona Cassani, Cuauthemoc, Marcellin Saldana, Esteban Stefane, Quek, Lake-ee, Palfreyman, Robin William and Nielsen, Lars K. (2010). Reconstruction of the Saccharopolyspora erythraea GEM. 11th International Symposium on the Genetics of Industrial Microorganisms, Melbourne, VIC, Australia, 10-15 July 2010.

Reconstruction of the Saccharopolyspora erythraea GEM

Current funding

  • 2024 - 2027
    Harnessing the gut microbiome to improve stem cell transplant outcome (NHMRC Ideas 2023 Administered by The Council of the Queensland Institute of Medical Research)
    Queensland Institute of Medical Research
    Open grant
  • 2023 - 2026
    Understanding and resolving the biological bottlenecks of recombinant dairy protein production in host microorganisms
    Trailblazer Universities Program
    Open grant
  • 2023 - 2028
    Biosustainability Hub: Paving the way to net zero using biological strategies
    Woodside Energy Technologies Pty Ltd
    Open grant
  • 2023 - 2029
    ARC Research Hub for Carbon Utilisation and Recycling (ARC ITRP administered by Monash University)
    Monash University
    Open grant
  • 2023 - 2025
    Assessing the potential of engineered microbial communities to reduce nitrous oxide (N2O) emissions from agricultural soils
    Grains Research & Development Corporation
    Open grant
  • 2023 - 2028
    Bioplatforms Australia (BPA) NCRIS 2022 administered by Bioplatforms Australia Ltd
    Bioplatforms Australia Ltd
    Open grant
  • 2023 - 2024
    Towards decarbonized aerobic fermentation: metabolic understanding of hydrogenase activity and its utilization for bioproduction
    Universities Australia - Germany Joint Research Co-operation Scheme
    Open grant
  • 2022 - 2027
    The University of Queensland Accelerating Growth in Australia's Food and Beverage Manufacturing [F&B Accelerate; FaBA]
    Trailblazer Universities Program
    Open grant
  • 2022 - 2024
    Production of valuable chemicals from gaseous waste
    ARC Linkage Projects
    Open grant
  • 2020 - 2024
    Engineering cyanobacteria for high-value flavours and fragrances production
    ARC Linkage Projects
    Open grant
  • 2020 - 2027
    ARC Centre of Excellence in Synthetic Biology (ARC Centre of Excellence administered by Macquarie University)
    Macquarie University
    Open grant
  • 2019 - 2024
    BioPlatforms Australia (BPA) Queensland Co-Investment (RICF)
    Bioplatforms Australia Ltd
    Open grant
  • 2013 - 2024
    Bioplatforms Australia Project - Metabolomics (Commonwealth NCRIS 2013 (2013-2023) grant administered by Macquarie University via Bioplatforms Australia Ltd)
    Bioplatforms Australia Ltd
    Open grant

Past funding

  • 2022 - 2024
    Microbial conversion of greenhouse gases into high-value animal feeds (Monash University led Woodside Energy Technologies grant)
    Monash University
    Open grant
  • 2022 - 2024
    Synthetic Biology for Synthesis of Novel Polymers Used in Energy Storage
    Commonwealth Defence Science and Technology Group
    Open grant
  • 2021 - 2022
    Production of biopolymers from plastic waste
    Innovation Connections
    Open grant
  • 2019 - 2023
    Unravelling a novel stress-signalling system in bacteria
    ARC Discovery Projects
    Open grant
  • 2017 - 2020
    BiG Chem: Biological Gas-to-Chemicals
    UQ Development Fellowships
    Open grant
  • 2017 - 2023
    ARC Training Centre for Biopharmaceutical Innovation
    ARC Industrial Transformation Training Centres
    Open grant
  • 2016 - 2019
    Improving clostridial toxoid production through molecular fermentation maps
    ARC Linkage Projects
    Open grant
  • 2016
    Instrumentation for the analysis of cellular and metabolic phenotypes
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2018
    Developing an integrated systems and synthetic biology platform to expand the product spectrum of acetogens
    ARC Linkage Projects
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    Building a Gas Fermentation Facility for the Production of Fuels and Chemicals
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2017
    From waste to biofuels: a systems biology approach
    Queensland Government Accelerate Fellowships
    Open grant
  • 2012 - 2014
    Transforming greenhouse gases into fuels and chemicals: A systems approach
    UQ Collaboration and Industry Engagement Fund
    Open grant
  • 2012
    Reconstruction of a Genome Scale Model
    LanzaTech New Zealand Limited
    Open grant
  • 2012 - 2014
    Transforming industrial greenhouse gas emissions into useful chemicals: a systems biology approach
    UQ FirstLink Scheme
    Open grant
  • 2012 - 2016
    Clostridial Systems Biology
    Zoetis Australia Research and Manufacturing Pty Ltd
    Open grant
  • 2011 - 2012
    Elucidating the transcriptome of Saccharopolyspora erythraea using RNA-seq
    UQ Early Career Researcher
    Open grant
  • 2010 - 2011
    Sponsored Research Agreement (Microbes)
    Dow Chemical Australia Limited
    Open grant
  • 2009 - 2010
    Building a Systems Biology Platform for the Production of a Vaccine to Prevent Enterotoxaemia
    UQ FirstLink Scheme
    Open grant

Availability

Professor Esteban Marcellin is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Biorecycyling carbon using acetogens

    Principal Advisor

    Other advisors: Professor Lars Nielsen, Professor Gary Schenk, Dr Axa Gonzalez, Dr James Heffernan

  • Doctor Philosophy

    Engineering cyanobacteria for high-value flavours and fragrances production

    Principal Advisor

  • Doctor Philosophy

    Accelerating the design of cell lines for biologic production

    Principal Advisor

    Other advisors: Dr Marianne Gillard, Professor Timothy Mercer

  • Doctor Philosophy

    Production of the Mannopeptimycin Antibiotic and other unknown Biosynthetic Gene Clusters from Streptomyces hygroscopicus

    Principal Advisor

    Other advisors: Dr Zeinab Khalil

  • Doctor Philosophy

    Biological CO2 and H2 utilization for sustainable animal feed production

    Principal Advisor

    Other advisors: Professor Lars Nielsen, Dr James Heffernan

  • Master Philosophy

    Harnessing Microbial Power: Turning Carbon into Valuable Products through Gas Fermentation

    Principal Advisor

    Other advisors: Dr James Heffernan

  • Doctor Philosophy

    Modelling cyanobacterial metabolism for the production of high-value products

    Principal Advisor

  • Doctor Philosophy

    Co-assimilation of C1 compounds (methanol, formate, formaldehyde) and components from lignocellulosic feedstock

    Associate Advisor

    Other advisors: Dr Birgitta Ebert

  • Doctor Philosophy

    Mechanisms of osmoresistance in industrial Lactococcus cemoris

    Associate Advisor

    Other advisors: Professor Mark Turner

  • Doctor Philosophy

    Systems biology-guided cell line engineering for production of therapeutic proteins with complex post-translational modifications

    Associate Advisor

    Other advisors: Dr Lucia Zacchi, Professor Benjamin Schulz

  • Doctor Philosophy

    Accelerating the extraction of critical metals such as rare earth elements and gallium from red mud tailings.

    Associate Advisor

    Other advisors: Dr Denys Villa Gomez

  • Doctor Philosophy

    Using synthetic biology to accelerate critical metals recovery from mine waste

    Associate Advisor

    Other advisors: Dr Denys Villa Gomez

  • Doctor Philosophy

    EnzOnomy - an enzyme-based production pipeline for the bioeconomy

    Associate Advisor

    Other advisors: Professor Damian Hine, Professor Gary Schenk

  • Doctor Philosophy

    Influence of structurally different polysaccharides and their interactions with saliva and tannins on mouthfeel in wine

    Associate Advisor

    Other advisors: Dr Raisa Rudge, Dr Marlize Bekker, Professor Heather Smyth

  • Doctor Philosophy

    Advancing biofertiliser for sustainable agriculture

    Associate Advisor

    Other advisors: Professor Susanne Schmidt, Dr Axa Gonzalez

Completed supervision

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