Professor

Timothy Mercer

Email: 
Phone: 
+61 7 334 64300

Availability

Professor Timothy Mercer is:
Available for supervision

Qualifications

  • Doctor of Philosophy, The University of Queensland

Search Professor Timothy Mercer’s works on UQ eSpace

95 works between 2007 and 2024
All (95) Journal Article (89) Conference Publication (5) Other Outputs (1)

1 - 20 of 95 works

2024

Journal Article

Targeted DNA-seq and RNA-seq of reference samples with short-read and long-read sequencing

Gong, Binsheng, Li, Dan, Labaj, Pawel P., Pan, Bohu, Novoradovskaya, Natalia, Thierry-Mieg, Danielle, Thierry-Mieg, Jean, Chen, Guangchun, Bergstrom Lucas, Anne, Lococo, Jennifer S., Richmond, Todd A., Tseng, Elizabeth, Kusko, Rebecca, Happe, Scott, Mercer, Timothy R., Pabon-Pena, Carlos, Salmans, Michael, Tilgner, Hagen U., Xiao, Wenzhong, Johann, Donald J., Jones, Wendell, Tong, Weida, Mason, Christopher E., Kreil, David P. and Xu, Joshua (2024). Targeted DNA-seq and RNA-seq of reference samples with short-read and long-read sequencing. Scientific Data, 11 (1) 892. doi: 10.1038/s41597-024-03741-y

Targeted DNA-seq and RNA-seq of reference samples with short-read and long-read sequencing

2024

Journal Article

Ageing-Related Changes to H3K4me3, H3K27ac, and H3K27me3 in Purified Mouse Neurons

Signal, Brandon, Phipps, Andrew J., Giles, Katherine A., Huskins, Shannon N., Mercer, Timothy R., Robinson, Mark D., Woodhouse, Adele and Taberlay, Phillippa C. (2024). Ageing-Related Changes to H3K4me3, H3K27ac, and H3K27me3 in Purified Mouse Neurons. Cells, 13 (16) 1393, 1393. doi: 10.3390/cells13161393

Ageing-Related Changes to H3K4me3, H3K27ac, and H3K27me3 in Purified Mouse Neurons

2024

Journal Article

A universal molecular control for DNA, mRNA and protein expression

Gunter, Helen M., Youlten, Scott E., Reis, Andre L. M., McCubbin, Tim, Madala, Bindu Swapna, Wong, Ted, Stevanovski, Igor, Cipponi, Arcadi, Deveson, Ira W., Santini, Nadia S., Kummerfeld, Sarah, Croucher, Peter I., Marcellin, Esteban and Mercer, Tim R. (2024). A universal molecular control for DNA, mRNA and protein expression. Nature Communications, 15 (1) 2480, 1-13. doi: 10.1038/s41467-024-46456-9

A universal molecular control for DNA, mRNA and protein expression

2023

Journal Article

Parallel laboratory evolution and rational debugging reveal genomic plasticity to S. cerevisiae synthetic chromosome XIV defects

Williams, Thomas C., Kroukamp, Heinrich, Xu, Xin, Wightman, Elizabeth L. I., Llorente, Briardo, Borneman, Anthony R., Carpenter, Alexander C., Van Wyk, Niel, Meier, Felix, Collier, Thomas R. V., Espinosa, Monica I., Daniel, Elizabeth L., Walker, Roy S. K., Cai, Yizhi, Nevalainen, Helena K. M., Curach, Natalie C., Deveson, Ira W., Mercer, Timothy R., Johnson, Daniel L., Mitchell, Leslie A., Bader, Joel S., Stracquadanio, Giovanni, Boeke, Jef D., Goold, Hugh D., Pretorius, Isak S. and Paulsen, Ian T. (2023). Parallel laboratory evolution and rational debugging reveal genomic plasticity to S. cerevisiae synthetic chromosome XIV defects. Cell Genomics, 3 (11) 100379, 1-23. doi: 10.1016/j.xgen.2023.100379

Parallel laboratory evolution and rational debugging reveal genomic plasticity to S. cerevisiae synthetic chromosome XIV defects

2023

Journal Article

mRNA vaccine quality analysis using RNA sequencing

Gunter, Helen M., Idrisoglu, Senel, Singh, Swati, Han, Dae Jong, Ariens, Emily, Peters, Jonathan R., Wong, Ted, Cheetham, Seth W., Xu, Jun, Rai, Subash Kumar, Feldman, Robert, Herbert, Andy, Marcellin, Esteban, Tropee, Romain, Munro, Trent and Mercer, Tim R. (2023). mRNA vaccine quality analysis using RNA sequencing. Nature Communications, 14 (1) 5663, 1-12. doi: 10.1038/s41467-023-41354-y

mRNA vaccine quality analysis using RNA sequencing

2023

Journal Article

Erratum: The splicing effect of variants at branchpoint elements in cancer genes (Genetics in Medicine (2022) 24(2) (398–409), (S109836002105348X), (10.1016/j.gim.2021.09.020))

Canson, Daffodil M., Dumenil, Troy, Parsons, Michael T., O'Mara, Tracy A., Davidson, Aimee L., Okano, Satomi, Signal, Bethany, Mercer, Tim R., Glubb, Dylan M. and Spurdle, Amanda B. (2023). Erratum: The splicing effect of variants at branchpoint elements in cancer genes (Genetics in Medicine (2022) 24(2) (398–409), (S109836002105348X), (10.1016/j.gim.2021.09.020)). Genetics in Medicine, 25 (1), 166-166. doi: 10.1016/j.gim.2022.11.015

Erratum: The splicing effect of variants at branchpoint elements in cancer genes (Genetics in Medicine (2022) 24(2) (398–409), (S109836002105348X), (10.1016/j.gim.2021.09.020))

2023

Journal Article

Long non-coding RNAs: definitions, functions, challenges and recommendations

Mattick, John S., Amaral, Paulo P., Carninci, Piero, Carpenter, Susan, Chang, Howard Y., Chen, Ling-Ling, Chen, Runsheng, Dean, Caroline, Dinger, Marcel E., Fitzgerald, Katherine A., Gingeras, Thomas R., Guttman, Mitchell, Hirose, Tetsuro, Huarte, Maite, Johnson, Rory, Kanduri, Chandrasekhar, Kapranov, Philipp, Lawrence, Jeanne B., Lee, Jeannie T., Mendell, Joshua T., Mercer, Timothy R., Moore, Kathryn J., Nakagawa, Shinichi, Rinn, John L., Spector, David L., Ulitsky, Igor, Wan, Yue, Wilusz, Jeremy E. and Wu, Mian (2023). Long non-coding RNAs: definitions, functions, challenges and recommendations. Nature Reviews Molecular Cell Biology, 24 (6), 430-447. doi: 10.1038/s41580-022-00566-8

Long non-coding RNAs: definitions, functions, challenges and recommendations

2022

Journal Article

Bioengineered textiles with peptide binders that capture SARS-CoV-2 viral particles

Navone, Laura, Moffitt, Kaylee, Johnston, Wayne A., Mercer, Tim, Cooper, Crystal, Spann, Kirsten and Speight, Robert E. (2022). Bioengineered textiles with peptide binders that capture SARS-CoV-2 viral particles. Communications Materials, 3 (1) 54, 1-9. doi: 10.1038/s43246-022-00278-8

Bioengineered textiles with peptide binders that capture SARS-CoV-2 viral particles

2022

Journal Article

The Coronavirus Standards Working Group’s roadmap for improved population testing

Mercer, Tim, Almond, Neil, Crone, Michael A., Chain, Patrick S. G., Deshpande, Alina, Eveleigh, Deepa, Freemont, Paul, Fuchs, Sebastien, Garlick, Russell, Huggett, Jim, Kammel, Martin, Li, Po-E, Milavec, Mojca, Marlowe, Elizabeth M., O’Sullivan, Denise M., Page, Mark, Pestano, Gary A., Suliman, Sara, Simen, Birgitte, Sninsky, John J., Sopchak, Lynne, Tato, Cristina M., Vallone, Peter M., Vandesompele, Jo, White, Thomas J., Zeichhardt, Heinz and Salit, Marc (2022). The Coronavirus Standards Working Group’s roadmap for improved population testing. Nature Biotechnology, 40 (11), 1563-1568. doi: 10.1038/s41587-022-01538-1

The Coronavirus Standards Working Group’s roadmap for improved population testing

2022

Journal Article

Library adaptors with integrated reference controls improve the accuracy and reliability of nanopore sequencing

Gunter, Helen M., Youlten, Scott E., Madala, Bindu Swapna, Reis, Andre L. M., Stevanovski, Igor, Wong, Ted, Kummerfield, Sarah K., Deveson, Ira W., Santini, Nadia S., Marcellin, Esteban and Mercer, Tim R. (2022). Library adaptors with integrated reference controls improve the accuracy and reliability of nanopore sequencing. Nature Communications, 13 (1) 6437, 1-11. doi: 10.1038/s41467-022-34028-8

Library adaptors with integrated reference controls improve the accuracy and reliability of nanopore sequencing

2022

Journal Article

The potential of long noncoding RNA therapies

Mercer, Tim R., Munro, Trent and Mattick, John S. (2022). The potential of long noncoding RNA therapies. Trends in Pharmacological Sciences, 43 (4), 269-280. doi: 10.1016/j.tips.2022.01.008

The potential of long noncoding RNA therapies

2022

Journal Article

ADRAM is an experience-dependent long noncoding RNA that drives fear extinction through a direct interaction with the chaperone protein 14-3-3

Wei, Wei, Zhao, Qiongyi, Wang, Ziqi, Liau, Wei-Siang, Basic, Dean, Ren, Haobin, Marshall, Paul R., Zajaczkowski, Esmi L., Leighton, Laura J., Madugalle, Sachithrani U., Musgrove, Mason, Periyakaruppiah, Ambika, Shi, Jichun, Zhang, Jianjian, Mattick, John S., Mercer, Timothy R., Spitale, Robert C., Li, Xiang and Bredy, Timothy W. (2022). ADRAM is an experience-dependent long noncoding RNA that drives fear extinction through a direct interaction with the chaperone protein 14-3-3. Cell Reports, 38 (12) 110546, 110546. doi: 10.1016/j.celrep.2022.110546

ADRAM is an experience-dependent long noncoding RNA that drives fear extinction through a direct interaction with the chaperone protein 14-3-3

2022

Journal Article

Towards accurate and reliable resolution of structural variants for clinical diagnosis

Liu, Zhichao, Roberts, Ruth, Mercer, Timothy R., Xu, Joshua, Sedlazeck, Fritz J. and Tong, Weida (2022). Towards accurate and reliable resolution of structural variants for clinical diagnosis. Genome Biology, 23 (1) 68, 68. doi: 10.1186/s13059-022-02636-8

Towards accurate and reliable resolution of structural variants for clinical diagnosis

2022

Journal Article

The splicing effect of variants at branchpoint elements in cancer genes

Canson, Daffodil M., Dumenil, Troy, Parsons, Michael T., O'Mara, Tracy A., Davidson, Aimee L., Okano, Satomi, Signal, Bethany, Mercer, Tim R., Glubb, Dylan M. and Spurdle, Amanda B. (2022). The splicing effect of variants at branchpoint elements in cancer genes. Genetics in Medicine, 24 (2), 398-409. doi: 10.1016/j.gim.2021.09.020

The splicing effect of variants at branchpoint elements in cancer genes

2022

Journal Article

Using synthetic chromosome controls to evaluate the sequencing of difficult regions within the human genome

Reis, Andre L. M., Deveson, Ira W., Madala, Bindu Swapna, Wong, Ted, Barker, Chris, Xu, Joshua, Lennon, Niall, Tong, Weida, Mercer, Tim R. and on behalf of the SEQC2 Consortium (2022). Using synthetic chromosome controls to evaluate the sequencing of difficult regions within the human genome. Genome Biology, 23 (1) 19, 19. doi: 10.1186/s13059-021-02579-6

Using synthetic chromosome controls to evaluate the sequencing of difficult regions within the human genome

2022

Journal Article

Emerging technologies and their impact on regulatory science

Anklam, Elke, Bahl, Martin Iain, Ball, Robert, Beger, Richard D, Cohen, Jonathan, Fitzpatrick, Suzanne, Girard, Philippe, Halamoda-Kenzaoui, Blanka, Hinton, Denise, Hirose, Akihiko, Hoeveler, Arnd, Honma, Masamitsu, Hugas, Marta, Ishida, Seichi, Kass, George EN, Kojima, Hajime, Krefting, Ira, Liachenko, Serguei, Liu, Yan, Masters, Shane, Marx, Uwe, McCarthy, Timothy, Mercer, Tim, Patri, Anil, Pelaez, Carmen, Pirmohamed, Munir, Platz, Stefan, Ribeiro, Alexandre JS, Rodricks, Joseph V ... Slikker Jr., William (2022). Emerging technologies and their impact on regulatory science. Experimental Biology and Medicine, 247 (1), 1-75. doi: 10.1177/15353702211052280

Emerging technologies and their impact on regulatory science

2021

Journal Article

A clinical laboratory-developed LSC17 stemness score assay for rapid risk assessment of acute myeloid leukemia patients

Ng, Stanley W. K., Murphy, Tracy, King, Ian, Zhang, Tong, Mah, Michelle, Lu, Zhibin, Stickle, Natalie, Ibrahimova, Narmin, Arruda, Andrea, Mitchell, Amanda, Mai, Ming, He, Rong, Madala, Bindu Swapna, Viswanatha, David S., Dick, John E., Chan, Steven M. C., Virtanen, Carl, Minden, Mark D., Mercer, Timothy R., Stockley, Tracy L. and Wang, Jean C. Y. (2021). A clinical laboratory-developed LSC17 stemness score assay for rapid risk assessment of acute myeloid leukemia patients. Blood Advances, 6 (3), 1064-1073. doi: 10.1182/bloodadvances.2021005741

A clinical laboratory-developed LSC17 stemness score assay for rapid risk assessment of acute myeloid leukemia patients

2021

Journal Article

The Sequencing Quality Control 2 study: establishing community standards for sequencing in precision medicine

Mercer, Tim R., Xu, Joshua, Mason, Christopher E. and Tong, Weida (2021). The Sequencing Quality Control 2 study: establishing community standards for sequencing in precision medicine. Genome Biology, 22 (1) 306, 306. doi: 10.1186/s13059-021-02528-3

The Sequencing Quality Control 2 study: establishing community standards for sequencing in precision medicine

2021

Journal Article

Reporting guidelines for human microbiome research: the STORMS checklist

Mirzayi, Chloe, Renson, Audrey, Furlanello, Cesare, Sansone, Susanna-Assunta, Zohra, Fatima, Elsafoury, Shaimaa, Geistlinger, Ludwig, Kasselman, Lora J., Eckenrode, Kelly, van de Wijgert, Janneke, Loughman, Amy, Marques, Francine Z., MacIntyre, David A., Arumugam, Manimozhiyan, Azhar, Rimsha, Beghini, Francesco, Bergstrom, Kirk, Bhatt, Ami, Bisanz, Jordan E., Braun, Jonathan, Bravo, Hector Corrada, Buck, Gregory A., Bushman, Frederic, Casero, David, Clarke, Gerard, Collado, Maria Carmen, Cotter, Paul D., Cryan, John F., Demmer, Ryan T. ... Massive Analysis and Quality Control Society (2021). Reporting guidelines for human microbiome research: the STORMS checklist. Nature Medicine, 27 (11), 1885-1892. doi: 10.1038/s41591-021-01552-x

Reporting guidelines for human microbiome research: the STORMS checklist

2021

Journal Article

Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing

Fang, Li Tai, Zhu, Bin, Zhao, Yongmei, Chen, Wanqiu, Yang, Zhaowei, Kerrigan, Liz, Langenbach, Kurt, de Mars, Maryellen, Lu, Charles, Idler, Kenneth, Jacob, Howard, Zheng, Yuanting, Ren, Luyao, Yu, Ying, Jaeger, Erich, Schroth, Gary P., Abaan, Ogan D., Talsania, Keyur, Lack, Justin, Shen, Tsai-Wei, Chen, Zhong, Stanbouly, Seta, Tran, Bao, Shetty, Jyoti, Kriga, Yuliya, Meerzaman, Daoud, Nguyen, Cu, Petitjean, Virginie, Sultan, Marc ... Zheng, Yuanting (2021). Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing. Nature Biotechnology, 39 (9), 1151-1160. doi: 10.1038/s41587-021-00993-6

Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing

Current funding

  • 2024 - 2029
    Building mRNA Cancer Vaccines for Australia.
    MRFF - National Critical Infrastructure Initiative
    Open grant
  • 2023 - 2028
    Translational ecosystem for clinical development of mRNA modalities (externally led by Southern RNA)
    Southern RNA PTY LTD
    Open grant
  • 2023 - 2025
    Base - NCRIS 2022 (administered by the Therapeutic Innovation Australia (TIA))
    Therapeutic Innovation Australia Limited
    Open grant
  • 2023 - 2028
    Building the next mRNA vaccines and therapies
    MRFF - National Critical Infrastructure Initiative
    Open grant
  • 2023 - 2027
    Building RNA therapies to re-program gene expression.
    NHMRC Investigator Grants
    Open grant
  • 2022 - 2024
    Building Synthetic DNA Controls for Oxford Nanopore Sequencing
    NHMRC Development Grant
    Open grant

Past funding

  • 2024
    Conjugation of targeting protein moieties to non-viral vectors such as lipid nanoparticles (LNPs) (University College London administered UKRI BBSRC grant)
    University College London
    Open grant
  • 2023 - 2024
    Optimisation of mRNA production and purification using the AMBR15 and AMBRCF
    Innovation Connections
    Open grant
  • 2011 - 2012
    Receptor-specific targeting of extracellular RNA to recipient cells
    UQ Early Career Researcher
    Open grant

Availability

Professor Timothy Mercer is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Building the next-generation of mRNA drugs

    Principal Advisor

    Other advisors: Dr Seth Cheetham

  • Doctor Philosophy

    mRNA cancer therapies

    Associate Advisor

    Other advisors: Dr Seth Cheetham

  • Doctor Philosophy

    Accelerating the design of cell lines for biologic production

    Associate Advisor

    Other advisors: Dr Marianne Gillard, Professor Esteban Marcellin

  • Doctor Philosophy

    Drugging the undruggable with mRNA technologies

    Associate Advisor

    Other advisors: Dr Seth Cheetham

  • Doctor Philosophy

    Inhibition of transcription factors using mRNA technology

    Associate Advisor

    Other advisors: Dr Seth Cheetham

Completed supervision

Enquiries

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