
Overview
Availability
- Professor Esteban Marcellin is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Chemical Engineering, Universidad Iberoamericana
- Doctor of Philosophy, The University of Queensland
Research interests
-
Systems and Synthetic Biology
Systems and synthetic biology are powerful tools to guide the improvement of biological systems for producing fuels, chemicals, foods and biopharmaceuticals. Systems and synthetic approaches can be used to identify metabolic engineering targets and develop new production strains. Using data-driven approaches that take advantage of the tremendous growth in high throughput ‘-omics (genomics, transcriptomics, proteomics and metabolomics) coupled with mathematical models we can better understand cells. The data gathered can be used to suggest potential metabolic engineering strategies (e.g. bottlenecks that can be targeted for knockout/up-regulation) to improve yields and productivity. Biological systems are refined and improved using biological data, leading to further iterative rounds of metabolic engineering to enhance production. Using gas fermentation, we are consuming greenhouse gases (CO and CO2) as feedstock for fermentation and converting those greenhouse gases into valuable fuels, chemicals and fuels. This allows us to decrease our dependence on finite fossil fuel resources and improves sustainability for Australia. Our projects aim at producing efficient cell lines to increase the yields and productivity of biological systems. In collaboration with leaders in the industry, such as Lanzatech, Amyris, Zoetis, Dow, CSL and Thermo-Fisher, we are applying systems metabolic engineering to enhance yields and increase the production scope of the advanced biomanufacturing sector.
Works
Search Professor Esteban Marcellin’s works on UQ eSpace
2018
Journal Article
Talaropeptides A-D: Structure and Biosynthesis of Extensively N-methylated Linear Peptides From an Australian Marine Tunicate-Derived Talaromyces sp
Dewapriya, Pradeep, Khalil, Zeinab G., Prasad, Pritesh, Salim, Angela A., Cruz-Morales, Pablo, Marcellin, Esteban and Capon, Robert J. (2018). Talaropeptides A-D: Structure and Biosynthesis of Extensively N-methylated Linear Peptides From an Australian Marine Tunicate-Derived Talaromyces sp. Frontiers in Chemistry, 6 394, 394. doi: 10.3389/fchem.2018.00394
2018
Journal Article
Inter-Kingdom beach warfare: Microbial chemical communication activates natural chemical defences
Khalil, Zeinab G., Cruz-Morales, Pablo, Licona-Cassani, Cuauhtemoc, Marcellin, Esteban and Capon, Robert J. (2018). Inter-Kingdom beach warfare: Microbial chemical communication activates natural chemical defences. The ISME journal, 13 (1), 147-158. doi: 10.1038/s41396-018-0265-z
2018
Journal Article
Linking genotype and phenotype in an economically viable propionic acid biosynthesis process
Luna-Flores, Carlos H., Stowers, Chris C., Cox, Brad M., Nielsen, Lars K. and Marcellin, Esteban (2018). Linking genotype and phenotype in an economically viable propionic acid biosynthesis process. Biotechnology for Biofuels, 11 (1) 224, 224. doi: 10.1186/s13068-018-1222-9
2018
Journal Article
Synthetic microbe communities provide internal reference standards for metagenome sequencing and analysis
Hardwick, Simon A., Chen, Wendy Y., Wong, Ted, Kanakamedala, Bindu S., Deveson, Ira W., Ongley, Sarah E., Santini, Nadia S., Marcellin, Esteban, Smith, Martin A., Nielsen, Lars K., Lovelock, Catherine E., Neilan, Brett A. and Mercer, Tim R. (2018). Synthetic microbe communities provide internal reference standards for metagenome sequencing and analysis. Nature Communications, 9 (1) 3096, 3096. doi: 10.1038/s41467-018-05555-0
2018
Journal Article
Enhanced uptake of potassium or glycine betaine or export of cyclic-di-AMP restores osmoresistance in a high cyclic-di-AMP Lactococcus lactis mutant
Pham, Huong Thi, Nhiep, Nguyen Thi Hanh, Vu, Thu Ngoc Minh, Huynh, TuAnh Ngoc, Zhu, Yan, Huynh, Anh Le Diep, Chakrabortti, Alolika, Marcellin, Esteban, Lo, Raquel, Howard, Christopher B., Bansal, Nidhi, Woodward, Joshua J., Liang, Zhao-Xun and Turner, Mark S. (2018). Enhanced uptake of potassium or glycine betaine or export of cyclic-di-AMP restores osmoresistance in a high cyclic-di-AMP Lactococcus lactis mutant. PLOS Genetics, 14 (8) e1007574, e1007574. doi: 10.1371/journal.pgen.1007574
2018
Journal Article
RNA-seq highlights high clonal variation in monoclonal antibody producing CHO cells
Orellana, Camila A., Marcellin, Esteban, Palfreyman, Robin W., Munro, Trent P., Gray, Peter P. and Nielsen, Lars K. (2018). RNA-seq highlights high clonal variation in monoclonal antibody producing CHO cells. Biotechnology Journal, 13 (3) 1700231, e1700231. doi: 10.1002/biot.201700231
2018
Journal Article
H2 drives metabolic rearrangements in gas-fermenting Clostridium autoethanogenum
Valgepea, Kaspar, de Souza Pinto Lemgruber, Renato, Abdalla, Tanus, Binos, Steve, Takemori, Nobuaki, Takemori, Ayako, Tanaka, Yuki, Tappel, Ryan, Köpke, Michael, Simpson, Séan Dennis, Nielsen, Lars Keld and Marcellin, Esteban (2018). H2 drives metabolic rearrangements in gas-fermenting Clostridium autoethanogenum. Biotechnology for Biofuels, 11 (1) 55, 55. doi: 10.1186/s13068-018-1052-9
2018
Journal Article
Quantitative analysis of tetrahydrofolate metabolites from clostridium autoethanogenum
Lemgruber, Renato de Souza Pinto, Valgepea, Kaspar, Hodson, Mark P., Tappel, Ryan, Simpson, Sean D., Kopke, Michael, Nielsen, Lars K. and Marcellin, Esteban (2018). Quantitative analysis of tetrahydrofolate metabolites from clostridium autoethanogenum. Metabolomics, 14 (3) 35, 35. doi: 10.1007/s11306-018-1331-2
2018
Journal Article
Advances in analytical tools for high throughput strain engineering
Marcellin, Esteban and Nielsen, Lars Keld (2018). Advances in analytical tools for high throughput strain engineering. Current Opinion in Biotechnology, 54, 33-40. doi: 10.1016/j.copbio.2018.01.027
2018
Conference Publication
Talaropeptides A–D: Structure and biosynthesis of extensively N-methylated linear peptides from an Australian marine tunicate-derived Talaromyces sp.
Dewapriya, Pradeep, Khalil, Zeinab G., Prasad, Pritesh, Salim, Angela A., Morales, Pablo C., Marcellin, Esteban and Capon, Robert J. (2018). Talaropeptides A–D: Structure and biosynthesis of extensively N-methylated linear peptides from an Australian marine tunicate-derived Talaromyces sp.. American Society of Pharmacognosy Annual Meeting ASP 2018, Lexington, KY United States, 21-25 July 2018.
2017
Journal Article
Genome-scale model guided design of Propionibacterium for enhanced propionic acid production
Navone, Laura, McCubbin, Tim, Gonzalez-Garcia, Ricardo A., Nielsen, Lars K. and Marcellin, Esteban (2017). Genome-scale model guided design of Propionibacterium for enhanced propionic acid production. Metabolic Engineering Communications, 6, 1-12. doi: 10.1016/j.meteno.2017.11.001
2017
Journal Article
Diverse cone-snail species harbor closely related streptomyces species with conserved chemical and genetic profiles, including polycyclic tetramic acid macrolactams
Quezada, Michelle, Licona-Cassani, Cuauhtemoc, Cruz-Morales, Pablo, Salim, Angela A., Marcellin, Esteban, Capon, Robert J. and Barona-Gomez, Francisco (2017). Diverse cone-snail species harbor closely related streptomyces species with conserved chemical and genetic profiles, including polycyclic tetramic acid macrolactams. Frontiers in Microbiology, 8 (NOV) 2305, 2305. doi: 10.3389/fmicb.2017.02305
2017
Journal Article
Overcoming the energetic limitations of syngas fermentation
Molitor, Bastian, Marcellin, Esteban and Angenent, Largus T (2017). Overcoming the energetic limitations of syngas fermentation. Current Opinion in Chemical Biology, 41, 84-92. doi: 10.1016/j.cbpa.2017.10.003
2017
Journal Article
Overexpression of the regulatory subunit of glutamate-cysteine ligase enhances monoclonal antibody production in CHO cells
Orellana, Camila A., Marcellin, Esteban, Gray, Peter P. and Nielsen, Lars K. (2017). Overexpression of the regulatory subunit of glutamate-cysteine ligase enhances monoclonal antibody production in CHO cells. Biotechnology and Bioengineering, 114 (8), 1825-1836. doi: 10.1002/bit.26316
2017
Journal Article
Awakening sleeping beauty: production of propionic acid in Escherichia coli through the sbm operon requires the activity of a methylmalonyl-CoA epimerase
Gonzalez-Garcia, Ricardo Axayacatl, McCubbin, Tim, Wille, Annalena, Plan, Manuel, Nielsen, Lars Keld and Marcellin, Esteban (2017). Awakening sleeping beauty: production of propionic acid in Escherichia coli through the sbm operon requires the activity of a methylmalonyl-CoA epimerase. Microbial Cell Factories, 16 (1) 121, 121. doi: 10.1186/s12934-017-0735-4
2017
Journal Article
Maintenance of ATP homeostasis triggers metabolic shifts in gas-fermenting acetogens
Valgepea, Kaspar, Lemgruber, Renato de Souza Pinto, Meaghan, Kieran, Palfreyman, Robin William, Abdalla, Tanus, Heijstra, Bjom Daniel, Behrendorff, James Bruce, Tappel, Ryan, Kopke, Michael, Simpson, Sean Dennis, Nielsen, Lars Keld and Marcellin, Esteban (2017). Maintenance of ATP homeostasis triggers metabolic shifts in gas-fermenting acetogens. Cell Systems, 4 (5), 505-515.e5. doi: 10.1016/j.cels.2017.04.008
2017
Journal Article
Microbial Propionic Acid Production
Gonzalez Garcia, Ricardo Axayacatl, McCubbin, Timothy, Navone, Laura, Stowers, Chris, Nielsen, Lars K. and Marcellin Saldana, Esteban Stefane (2017). Microbial Propionic Acid Production. Fermentation, 3 (2) 3020021, 1-20. doi: 10.3390/fermentation3020021
2017
Journal Article
Arginine deiminase pathway provides ATP and boosts growth of the gas-fermenting acetogen Clostridium autoethanogenum
Valgepea, Kaspar, Loi, Kim Q., Behrendorff, James B., Lemgruber, Renato de S. P., Plan, Manuel, Hodson, Mark P., Koepke, Michael, Nielsen, Lars K. and Marcellin, Esteban (2017). Arginine deiminase pathway provides ATP and boosts growth of the gas-fermenting acetogen Clostridium autoethanogenum. Metabolic Engineering, 41, 202-211. doi: 10.1016/j.ymben.2017.04.007
2017
Journal Article
Genome sequence of Propionibacterium acidipropionici ATCC 55737
Luna-Flores, Carlos H., Nielsen, Lars K. and Marcellin, Estaban (2017). Genome sequence of Propionibacterium acidipropionici ATCC 55737. Genome Announcements, 4 (3) e00248-16. doi: 10.1128/genomeA.00248-16
2017
Journal Article
Improved production of propionic acid using genome shuffling
Luna-Flores, Carlos H., Palfreyman, Robin W., Kromer, Jens O., Nielsen, Lars K. and Marcellin, Esteban (2017). Improved production of propionic acid using genome shuffling. Biotechnology Journal, 12 (2) 1600120, 1600120. doi: 10.1002/biot.201600120
Funding
Current funding
Supervision
Availability
- Professor Esteban Marcellin is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Biological CO2 and H2 utilization for sustainable animal feed production
Principal Advisor
Other advisors: Professor Lars Nielsen, Dr James Heffernan
-
Doctor Philosophy
Production of the Mannopeptimycin Antibiotic and other unknown Biosynthetic Gene Clusters from Streptomyces hygroscopicus
Principal Advisor
Other advisors: Dr Zeinab Khalil
-
Doctor Philosophy
Optimizing Gas Fermentation for the Valorization of Mixed Gases into High-Value Bio-Products
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
Biorecycyling carbon using acetogens
Principal Advisor
Other advisors: Professor Lars Nielsen, Professor Gary Schenk, Dr Axa Gonzalez, Dr James Heffernan
-
Doctor Philosophy
Modelling cyanobacterial metabolism for the production of high-value products
Principal Advisor
-
Doctor Philosophy
Modelling cyanobacterial metabolism for the production of high-value products
Principal Advisor
-
Doctor Philosophy
Profitable Upcycling of GM Biomass from Precision Fermentation
Principal Advisor
Other advisors: Dr Denys Villa Gomez
-
Master Philosophy
Harnessing Microbial Power: Turning Carbon into Valuable Products through Gas Fermentation
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
Harnessing Microbal Power: Turning Carbon into valuable Produscts through gas fermentation
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
Pathway engineering and systems biology for optimised isobutanol production in gas-fermenting acetogens: From strain isolation to metabolic limitations identification
Principal Advisor
Other advisors: Professor Lars Nielsen, Professor Gary Schenk, Dr Axa Gonzalez, Dr James Heffernan
-
Doctor Philosophy
Engineering cyanobacteria for high-value flavours and fragrances production
Principal Advisor
-
Doctor Philosophy
Optimizing Mixed Gas Fermentation for Enhanced Biofuel Production
Principal Advisor
Other advisors: Dr James Heffernan, Dr Yosephine Gumulya
-
Doctor Philosophy
Engineering Eubacterium limosum for Enhanced CO2 Fixation via rational genome-scale
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
Greenhouse Gas Fermentation and Computational Fluid Dynamics (CFD)
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
Accelerating the design of cell lines for biologic production
Principal Advisor
Other advisors: Dr Marianne Gillard, Professor Timothy Mercer
-
Doctor Philosophy
Biorecycyling carbon using acetogens
Principal Advisor
Other advisors: Professor Lars Nielsen, Professor Gary Schenk, Dr Axa Gonzalez, Dr James Heffernan
-
Doctor Philosophy
Engineering cyanobacteria for high-value flavours and fragrances production
Principal Advisor
-
Doctor Philosophy
Harnessing Microbal Power: Turning Carbon into valuable Produscts through gas fermentation
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
EnzOnomy - an enzyme-based production pipeline for the bioeconomy
Associate Advisor
Other advisors: Professor Damian Hine, Professor Gary Schenk
-
Doctor Philosophy
Systems biology-guided cell line engineering for production of therapeutic proteins with complex post-translational modifications
Associate Advisor
Other advisors: Professor Benjamin Schulz
-
Doctor Philosophy
Engineering biology of yeast for sustainable fragrance production through precision fermentation
Associate Advisor
Other advisors: Dr Axa Gonzalez, Dr Huadong Peng
-
Doctor Philosophy
Influence of structurally different polysaccharides and their interactions with saliva and tannins on mouthfeel in wine
Associate Advisor
Other advisors: Dr Marlize Bekker, Dr Huadong Peng, Professor Heather Smyth
-
Doctor Philosophy
Advancing biofertiliser for sustainable agriculture
Associate Advisor
Other advisors: Professor Susanne Schmidt, Dr Axa Gonzalez
-
Doctor Philosophy
Mechanisms of osmoresistance in industrial Lactococcus cemoris
Associate Advisor
Other advisors: Professor Mark Turner
-
Doctor Philosophy
Leveraging Biomass Waste: Exploiting Proteins from Precision Fermentation Bioprocesses
Associate Advisor
Other advisors: Dr Huadong Peng
-
Doctor Philosophy
Co-assimilation of C1 compounds (methanol, formate, formaldehyde) and components from lignocellulosic feedstock
Associate Advisor
Other advisors: Dr Birgitta Ebert
-
Doctor Philosophy
Microbial fatty acid derivative production from CO2-derived C2 intermediates
Associate Advisor
Other advisors: Dr Birgitta Ebert
-
Doctor Philosophy
Systems biology-guided cell line engineering for production of therapeutic proteins with complex post-translational modifications
Associate Advisor
Other advisors: Professor Benjamin Schulz
-
Doctor Philosophy
Accelerating the extraction of critical metals such as rare earth elements and gallium from red mud tailings.
Associate Advisor
Other advisors: Dr Denys Villa Gomez
-
Doctor Philosophy
Advancing biofertiliser for sustainable agriculture
Associate Advisor
Other advisors: Professor Susanne Schmidt, Dr Axa Gonzalez
-
Doctor Philosophy
Using synthetic biology to accelerate critical metals recovery from mine waste
Associate Advisor
Other advisors: Dr Denys Villa Gomez
Completed supervision
-
2024
Doctor Philosophy
Production of the Mannopeptimycin Antibiotic and Other Unknown Biosynthetic Gene Clusters from Streptomyces hygroscopicus
Principal Advisor
Other advisors: Dr Zeinab Khalil
-
2023
Doctor Philosophy
Systems metabolic engineering for one-carbon (C1) utilization metabolism
Principal Advisor
Other advisors: Honorary Professor Zhiguo Yuan
-
2023
Doctor Philosophy
Sustainable fuel and chemical production via Gas Fermentation: exploring CO2 metabolism by Clostridium autoethanogenum
Principal Advisor
Other advisors: Professor Lars Nielsen, Dr Axa Gonzalez
-
2023
Doctor Philosophy
Modelling and characterising life and death of mammalian suspension cultures
Principal Advisor
Other advisors: Professor Lars Nielsen, Dr Veronica Martinez Salazar, Dr Gert Talbo
-
2022
Doctor Philosophy
Cell Line Development for High Density Culture of CHO Cells in Perfusion: Applications of Apoptosis Resistance
Principal Advisor
Other advisors: Professor Peter Gray, Dr Veronica Martinez Salazar
-
2021
Doctor Philosophy
Insight into acetogens metabolism through the use of thermodynamic metabolic flux analysis
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2020
Doctor Philosophy
Understanding toxin production in Clostridium tetani: a systems approach
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2019
Doctor Philosophy
From waste to chemicals: On the metabolism of Clostridium autoethanogenum and PHB production from gas fermentation
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2018
Doctor Philosophy
Exploring the metabolism of propionibacteria using genome-scale modelling
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2018
Doctor Philosophy
Metabolic Engineering of propionibacteria's Wood Werkman cycle in Escherichia coli and Saccharomyces cerevisiae
Principal Advisor
Other advisors: Professor Lars Nielsen, Professor Mark Turner
-
2017
Doctor Philosophy
Understanding high propionic acid production in Propionibacterium
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2025
Doctor Philosophy
Systems biology-guided cell line engineering for production of therapeutic proteins with complex post-translational modifications
Associate Advisor
Other advisors: Dr Lucia Zacchi, Professor Benjamin Schulz
-
2024
Doctor Philosophy
Mechanisms of osmoresistance in industrial Lactococcus cemoris
Associate Advisor
Other advisors: Dr Huong Thi Pham, Professor Mark Turner
-
2023
Doctor Philosophy
Exploring Metabolic Demands of High Cell Density Chinese Hamster Ovary Cell Culture - Studying Apoptosis Resistance in Perfusion Culture
Associate Advisor
Other advisors: Dr Gert Talbo, Dr Veronica Martinez Salazar
-
2023
Doctor Philosophy
Production of liquid chemicals from C1 feedstocks using Eubacterium limosum
Associate Advisor
Other advisors: Dr Bernardino Virdis
-
2022
Doctor Philosophy
Sf9 cell line engineering to improve baculovirus expression
Associate Advisor
-
2016
Doctor Philosophy
Understanding CHO cells biology for enhanced biopharmaceutical production: a comparative transcriptomic and proteomic approach
Associate Advisor
Other advisors: Professor Peter Gray, Professor Lars Nielsen
-
2015
Doctor Philosophy
Quantitative bacterial phosphoproteomics
Associate Advisor
Other advisors: Professor Lars Nielsen
-
2014
Doctor Philosophy
Characterisation of the Saccharopolyspora erythraea metabolic switch: a systems approach
Associate Advisor
Other advisors: Professor Lars Nielsen
Media
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