Overview
Availability
- Professor Esteban Marcellin is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Chemical Engineering, unknown
- Doctor of Philosophy, The University of Queensland
Research interests
-
Systems and Synthetic Biology
Systems and synthetic biology are powerful tools to guide the improvement of biological systems for producing fuels, chemicals, foods and biopharmaceuticals. Systems and synthetic approaches can be used to identify metabolic engineering targets and develop new production strains. Using data-driven approaches that take advantage of the tremendous growth in high throughput ‘-omics (genomics, transcriptomics, proteomics and metabolomics) coupled with mathematical models we can better understand cells. The data gathered can be used to suggest potential metabolic engineering strategies (e.g. bottlenecks that can be targeted for knockout/up-regulation) to improve yields and productivity. Biological systems are refined and improved using biological data, leading to further iterative rounds of metabolic engineering to enhance production. Using gas fermentation, we are consuming greenhouse gases (CO and CO2) as feedstock for fermentation and converting those greenhouse gases into valuable fuels, chemicals and fuels. This allows us to decrease our dependence on finite fossil fuel resources and improves sustainability for Australia. Our projects aim at producing efficient cell lines to increase the yields and productivity of biological systems. In collaboration with leaders in the industry, such as Lanzatech, Amyris, Zoetis, Dow, CSL and Thermo-Fisher, we are applying systems metabolic engineering to enhance yields and increase the production scope of the advanced biomanufacturing sector.
Works
Search Professor Esteban Marcellin’s works on UQ eSpace
2022
Journal Article
RNA-seq sample preparation kits strongly affect transcriptome profiles of a gas-fermenting bacterium
de Lima, Lorena Azevedo, Reinmets, Kristina, Nielsen, Lars Keld, Marcellin, Esteban, Harris, Audrey, Köpke, Michael and Valgepea, Kaspar (2022). RNA-seq sample preparation kits strongly affect transcriptome profiles of a gas-fermenting bacterium. Microbiology Spectrum, 10 (4), 1-7. doi: 10.1128/spectrum.02303-22
2022
Journal Article
Knockout of Dicer-2 in the Sf9 cell line enhances the replication of Spodoptera frugiperda rhabdovirus and conditionally increases baculovirus replication
de Malmanche, Henry, Hussain, Mazhar, Marcellin, Esteban, Reid, Steve and Asgari, Sassan (2022). Knockout of Dicer-2 in the Sf9 cell line enhances the replication of Spodoptera frugiperda rhabdovirus and conditionally increases baculovirus replication. Journal of General Virology, 103 (8) 001779, 1-18. doi: 10.1099/jgv.0.001779
2022
Journal Article
Role of the substrate on Ni inhibition in biological sulfate reduction
Liu, Yun, Vaughan, James, Southam, Gordon, Serrano, Antonio, Gao, Han, Palfreyman, Robin, Marcellin, Esteban and Villa-Gomez, Denys K. (2022). Role of the substrate on Ni inhibition in biological sulfate reduction. Journal of Environmental Management, 316 115216, 115216. doi: 10.1016/j.jenvman.2022.115216
2022
Journal Article
Recycling carbon for sustainable protein production using gas fermentation
Marcellin, Esteban, Angenent, Largus T., Nielsen, Lars K. and Molitor, Bastian (2022). Recycling carbon for sustainable protein production using gas fermentation. Current Opinion in Biotechnology, 76 102723, 102723. doi: 10.1016/j.copbio.2022.102723
2022
Journal Article
Engineering death resistance in CHO cells for improved perfusion culture
MacDonald, Michael A., Nöbel, Matthias, Martínez, Verónica S., Baker, Kym, Shave, Evan, Gray, Peter P., Mahler, Stephen, Munro, Trent, Nielsen, Lars K. and Marcellin, Esteban (2022). Engineering death resistance in CHO cells for improved perfusion culture. mAbs, 14 (1) e2083465, 1-13. doi: 10.1080/19420862.2022.2083465
2022
Journal Article
Analytical tools for unravelling the metabolism of gas-fermenting Clostridia
Heffernan, James K., Mahamkali, Vishnu, Valgepea, Kaspar, Marcellin, Esteban and Nielsen, Lars K. (2022). Analytical tools for unravelling the metabolism of gas-fermenting Clostridia. Current Opinion in Biotechnology, 75 102700, 102700. doi: 10.1016/j.copbio.2022.102700
2022
Journal Article
Response of the anaerobic methanotrophic archaeon candidatus “methanoperedens nitroreducens” to the long-term ferrihydrite amendment
Cai, Chen, Ni, Gaofeng, Xia, Jun, Zhang, Xueqin, Zheng, Yue, He, Bingqing, Marcellin, Esteban, Li, Weiwei, Pu, Jiaoyang, Yuan, Zhiguo and Hu, Shihu (2022). Response of the anaerobic methanotrophic archaeon candidatus “methanoperedens nitroreducens” to the long-term ferrihydrite amendment. Frontiers in Microbiology, 13 799859, 799859. doi: 10.3389/fmicb.2022.799859
2022
Journal Article
Recent advances in the production of recombinant factor IX: bioprocessing and cell engineering
Beauglehole, Aiden C, Roche Recinos, Dinora, Pegg, Cassandra L, Lee, Yih Yean, Turnbull, Victor, Herrmann, Susann, Marcellin, Esteban, Howard, Christopher B and Schulz, Benjamin L (2022). Recent advances in the production of recombinant factor IX: bioprocessing and cell engineering. Critical Reviews in Biotechnology, 43 (3), 1-19. doi: 10.1080/07388551.2022.2036691
2022
Journal Article
Faster growth enhances low carbon fuel and chemical production through gas fermentation
de Lima, Lorena Azevedo, Ingelman, Henri, Brahmbhatt, Kush, Reinmets, Kristina, Barry, Craig, Harris, Audrey, Marcellin, Esteban, Köpke, Michael and Valgepea, Kaspar (2022). Faster growth enhances low carbon fuel and chemical production through gas fermentation. Frontiers in Bioengineering and Biotechnology, 10 879578. doi: 10.3389/fbioe.2022.879578
2022
Journal Article
Knockout of Sf‐Caspase‐1 generates apoptosis‐resistant Sf9 cell lines: implications for baculovirus expression
Malmanche, Henry, Marcellin, Esteban and Reid, Steven (2022). Knockout of Sf‐Caspase‐1 generates apoptosis‐resistant Sf9 cell lines: implications for baculovirus expression. Biotechnology Journal, 17 (7) 2100532, 2100532. doi: 10.1002/biot.202100532
2022
Journal Article
Absolute proteome quantification in the gas-fermenting acetogen Clostridium autoethanogenum
Valgepea, Kaspar, Talbo, Gert, Takemori, Nobuaki, Takemori, Ayako, Ludwig, Christina, Mahamkali, Vishnuvardhan, Mueller, Alexander P., Tappel, Ryan, Köpke, Michael, Simpson, Séan Dennis, Nielsen, Lars Keld and Marcellin, Esteban (2022). Absolute proteome quantification in the gas-fermenting acetogen Clostridium autoethanogenum. mSystems, 7 (2), 1. doi: 10.1128/msystems.00026-22
2022
Journal Article
A genome-scale metabolic model of Methanoperedens nitroreducens: assessing bioenergetics and thermodynamic feasibility
He, Bingqing, Cai, Chen, McCubbin, Tim, Muriel, Jorge Carrasco, Sonnenschein, Nikolaus, Hu, Shihu, Yuan, Zhiguo and Marcellin, Esteban (2022). A genome-scale metabolic model of Methanoperedens nitroreducens: assessing bioenergetics and thermodynamic feasibility. Metabolites, 12 (4) 314, 314. doi: 10.3390/metabo12040314
2022
Journal Article
Modelling apoptosis resistance in CHO cells with CRISPR‐mediated knock‐outs of Bak1, Bax, and Bok
MacDonald, Michael A., Barry, Craig, Groves, Teddy, Martínez, Verónica S., Gray, Peter P., Baker, Kym, Shave, Evan, Mahler, Stephen, Munro, Trent, Marcellin, Esteban and Nielsen, Lars K. (2022). Modelling apoptosis resistance in CHO cells with CRISPR‐mediated knock‐outs of Bak1, Bax, and Bok. Biotechnology and Bioengineering, 119 (6), 1380-1391. doi: 10.1002/bit.28062
2022
Journal Article
Multi-omic characterisation of Streptomyces hygroscopicus NRRL 30439: detailed assessment of its secondary metabolic potential
Barry, Craig P., Gillane, Rosemary, Talbo, Gert H., Plan, Manual, Palfreyman, Robin, Haber-Stuk, Andrea K., Power, John, Nielsen, Lars K. and Marcellin, Esteban (2022). Multi-omic characterisation of Streptomyces hygroscopicus NRRL 30439: detailed assessment of its secondary metabolic potential. Molecular Omics, 18 (3), 226-236. doi: 10.1039/d1mo00150g
2022
Journal Article
Advances in systems metabolic engineering of autotrophic carbon oxide-fixing biocatalysts towards a circular economy
Pavan, Marilene, Reinmets, Kristina, Garg, Shivani, Mueller, Alexander P., Marcellin, Esteban, Köpke, Michael and Valgepea, Kaspar (2022). Advances in systems metabolic engineering of autotrophic carbon oxide-fixing biocatalysts towards a circular economy. Metabolic Engineering, 71, 117-141. doi: 10.1016/j.ymben.2022.01.015
2021
Journal Article
High methanol‐to‐formate ratios induce butanol production in Eubacterium limosum
Wood, Jamin C., Marcellin, Esteban, Plan, Manuel R. and Virdis, Bernardino (2021). High methanol‐to‐formate ratios induce butanol production in Eubacterium limosum. Microbial Biotechnology, 15 (5), 1542-1549. doi: 10.1111/1751-7915.13963
2021
Journal Article
Strategies to improve viability of a circular carbon bioeconomy – A techno-economic review of microbial electrosynthesis and gas fermentation
Wood, Jamin C., Grové, Johannes, Marcellin, Esteban, Heffernan, James K., Hu, Shihu, Yuan, Zhiguo and Virdis, Bernardino (2021). Strategies to improve viability of a circular carbon bioeconomy – A techno-economic review of microbial electrosynthesis and gas fermentation. Water Research, 201 117306, 1-14. doi: 10.1016/j.watres.2021.117306
2021
Journal Article
Roles and opportunities for microbial anaerobic oxidation of methane in natural and engineered systems
Cai, Chen, Zhang, Xueqin, Wu, Mengxiong, Liu, Tao, Lai, Chun-Yu, Frank, Joshua, He, Bingqing, Marcellin, Esteban, Guo, Jianhua, Hu, Shihu and Yuan, Zhiguo (2021). Roles and opportunities for microbial anaerobic oxidation of methane in natural and engineered systems. Energy and Environmental Science, 14 (9), 4803-4830. doi: 10.1039/d1ee00708d
2021
Journal Article
Comparative Economic Analysis Between Endogenous and Recombinant Production of Hyaluronic Acid
Torres-Acosta, Mario A., Castaneda-Aponte, Héctor M., Mora-Galvez, Liliana M., Gil-Garzon, Monica R., Banda-Magaña, Martin P., Marcellin, Esteban, Mayolo-Deloisa, Karla and Licona-Cassani, Cuauhtemoc (2021). Comparative Economic Analysis Between Endogenous and Recombinant Production of Hyaluronic Acid. Frontiers in Bioengineering and Biotechnology, 9 680278, 680278. doi: 10.3389/fbioe.2021.680278
2021
Journal Article
Network analyses predict small RNAs that might modulate gene expression in the testis and epididymis of Bos indicus bulls
de Lima, Andressa O., Afonso, Juliana, Edson, Janette, Marcellin, Esteban, Palfreyman, Robin, Porto-Neto, Laercio R., Reverter, Antonio and Fortes, Marina R. S. (2021). Network analyses predict small RNAs that might modulate gene expression in the testis and epididymis of Bos indicus bulls. Frontiers in Genetics, 12 610116, 610116. doi: 10.3389/fgene.2021.610116
Funding
Current funding
Supervision
Availability
- Professor Esteban Marcellin is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Biorecycyling carbon using acetogens
Principal Advisor
Other advisors: Professor Lars Nielsen, Professor Gary Schenk, Dr Axa Gonzalez, Dr James Heffernan
-
Doctor Philosophy
Accelerating the design of cell lines for biologic production
Principal Advisor
Other advisors: Dr Marianne Gillard, Professor Timothy Mercer
-
Doctor Philosophy
Production of the Mannopeptimycin Antibiotic and other unknown Biosynthetic Gene Clusters from Streptomyces hygroscopicus
Principal Advisor
Other advisors: Dr Zeinab Khalil
-
Doctor Philosophy
Biological CO2 and H2 utilization for sustainable animal feed production
Principal Advisor
Other advisors: Professor Lars Nielsen, Dr James Heffernan
-
Master Philosophy
Harnessing Microbial Power: Turning Carbon into Valuable Products through Gas Fermentation
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
Modelling cyanobacterial metabolism for the production of high-value products
Principal Advisor
-
Doctor Philosophy
Engineering cyanobacteria for high-value flavours and fragrances production
Principal Advisor
-
Doctor Philosophy
EnzOnomy - an enzyme-based production pipeline for the bioeconomy
Associate Advisor
Other advisors: Professor Damian Hine, Professor Gary Schenk
-
Doctor Philosophy
Influence of structurally different polysaccharides and their interactions with saliva and tannins on mouthfeel in wine
Associate Advisor
Other advisors: Dr Raisa Rudge, Dr Marlize Bekker, Professor Heather Smyth
-
Doctor Philosophy
Advancing biofertiliser for sustainable agriculture
Associate Advisor
Other advisors: Professor Susanne Schmidt, Dr Axa Gonzalez
-
Doctor Philosophy
Co-assimilation of C1 compounds (methanol, formate, formaldehyde) and components from lignocellulosic feedstock
Associate Advisor
Other advisors: Dr Birgitta Ebert
-
Doctor Philosophy
Mechanisms of osmoresistance in industrial Lactococcus cemoris
Associate Advisor
Other advisors: Professor Mark Turner
-
Doctor Philosophy
Systems biology-guided cell line engineering for production of therapeutic proteins with complex post-translational modifications
Associate Advisor
Other advisors: Dr Lucia Zacchi, Professor Benjamin Schulz
-
Doctor Philosophy
Accelerating the extraction of critical metals such as rare earth elements and gallium from red mud tailings.
Associate Advisor
Other advisors: Dr Denys Villa Gomez
-
Doctor Philosophy
Using synthetic biology to accelerate critical metals recovery from mine waste
Associate Advisor
Other advisors: Dr Denys Villa Gomez
Completed supervision
-
2023
Doctor Philosophy
Systems metabolic engineering for one-carbon (C1) utilization metabolism
Principal Advisor
Other advisors: Honorary Professor Zhiguo Yuan
-
2023
Doctor Philosophy
Modelling and characterising life and death of mammalian suspension cultures
Principal Advisor
Other advisors: Professor Lars Nielsen, Dr Verónica Martinez Salazar, Dr Gert Talbo
-
2023
Doctor Philosophy
Sustainable fuel and chemical production via Gas Fermentation: exploring CO2 metabolism by Clostridium autoethanogenum
Principal Advisor
Other advisors: Professor Lars Nielsen, Dr Axa Gonzalez
-
2022
Doctor Philosophy
Cell Line Development for High Density Culture of CHO Cells in Perfusion: Applications of Apoptosis Resistance
Principal Advisor
Other advisors: Professor Peter Gray, Dr Verónica Martinez Salazar
-
2021
Doctor Philosophy
Insight into acetogens metabolism through the use of thermodynamic metabolic flux analysis
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2020
Doctor Philosophy
Understanding toxin production in Clostridium tetani: a systems approach
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2019
Doctor Philosophy
From waste to chemicals: On the metabolism of Clostridium autoethanogenum and PHB production from gas fermentation
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2018
Doctor Philosophy
Exploring the metabolism of propionibacteria using genome-scale modelling
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2018
Doctor Philosophy
Metabolic Engineering of propionibacteria's Wood Werkman cycle in Escherichia coli and Saccharomyces cerevisiae
Principal Advisor
Other advisors: Professor Lars Nielsen, Professor Mark Turner
-
2017
Doctor Philosophy
Understanding high propionic acid production in Propionibacterium
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2023
Doctor Philosophy
Exploring Metabolic Demands of High Cell Density Chinese Hamster Ovary Cell Culture - Studying Apoptosis Resistance in Perfusion Culture
Associate Advisor
Other advisors: Dr Gert Talbo, Dr Verónica Martinez Salazar
-
2023
Doctor Philosophy
Production of liquid chemicals from C1 feedstocks using Eubacterium limosum
Associate Advisor
Other advisors: Dr Bernardino Virdis
-
2022
Doctor Philosophy
Sf9 cell line engineering to improve baculovirus expression
Associate Advisor
-
2016
Doctor Philosophy
Understanding CHO cells biology for enhanced biopharmaceutical production: a comparative transcriptomic and proteomic approach
Associate Advisor
Other advisors: Professor Peter Gray, Professor Lars Nielsen
-
2015
Doctor Philosophy
Quantitative bacterial phosphoproteomics
Associate Advisor
Other advisors: Professor Lars Nielsen
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2014
Doctor Philosophy
Characterisation of the Saccharopolyspora erythraea metabolic switch: a systems approach
Associate Advisor
Other advisors: Professor Lars Nielsen
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