Overview
Availability
- Professor Esteban Marcellin is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Chemical Engineering, Universidad Iberoamericana
- Doctor of Philosophy, The University of Queensland
Research interests
-
Systems and Synthetic Biology
Systems and synthetic biology are powerful tools to guide the improvement of biological systems for producing fuels, chemicals, foods and biopharmaceuticals. Systems and synthetic approaches can be used to identify metabolic engineering targets and develop new production strains. Using data-driven approaches that take advantage of the tremendous growth in high throughput ‘-omics (genomics, transcriptomics, proteomics and metabolomics) coupled with mathematical models we can better understand cells. The data gathered can be used to suggest potential metabolic engineering strategies (e.g. bottlenecks that can be targeted for knockout/up-regulation) to improve yields and productivity. Biological systems are refined and improved using biological data, leading to further iterative rounds of metabolic engineering to enhance production. Using gas fermentation, we are consuming greenhouse gases (CO and CO2) as feedstock for fermentation and converting those greenhouse gases into valuable fuels, chemicals and fuels. This allows us to decrease our dependence on finite fossil fuel resources and improves sustainability for Australia. Our projects aim at producing efficient cell lines to increase the yields and productivity of biological systems. In collaboration with leaders in the industry, such as Lanzatech, Amyris, Zoetis, Dow, CSL and Thermo-Fisher, we are applying systems metabolic engineering to enhance yields and increase the production scope of the advanced biomanufacturing sector.
Works
Search Professor Esteban Marcellin’s works on UQ eSpace
2023
Journal Article
Cyclic-di-AMP signalling in lactic acid bacteria
Turner, Mark S., Xiang, Yuwei, Liang, Zhao-Xun, Marcellin, Esteban and Pham, Huong Thi (2023). Cyclic-di-AMP signalling in lactic acid bacteria. FEMS Microbiology Reviews, 47 (3) fuad025, 1-16. doi: 10.1093/femsre/fuad025
2023
Journal Article
Multi-omic profiling reveals an RNA processing rheostat that predisposes to prostate cancer
Stentenbach, Maike, Ermer, Judith A, Rudler, Danielle L, Perks, Kara L, Raven, Samuel A, Lee, Richard G, McCubbin, Tim, Marcellin, Esteban, Siira, Stefan J, Rackham, Oliver and Filipovska, Aleksandra (2023). Multi-omic profiling reveals an RNA processing rheostat that predisposes to prostate cancer. EMBO Molecular Medicine, 15 (6) e17463, 1-22. doi: 10.15252/emmm.202317463
2023
Journal Article
Copy number variation in tRNA isodecoder genes impairs mammalian development and balanced translation
Hughes, Laetitia A., Rudler, Danielle L., Siira, Stefan J., McCubbin, Tim, Raven, Samuel A., Browne, Jasmin M., Ermer, Judith A., Rientjes, Jeanette, Rodger, Jennifer, Marcellin, Esteban, Rackham, Oliver and Filipovska, Aleksandra (2023). Copy number variation in tRNA isodecoder genes impairs mammalian development and balanced translation. Nature Communications, 14 (1) 2210, 1-19. doi: 10.1038/s41467-023-37843-9
2023
Journal Article
Molecular understanding of Eubacterium limosum chemostat methanol metabolism
Wood, Jamin C., Gonzalez-Garcia, R. Axayacatl, Daygon, Dara, Talbo, Gert, Plan, Manuel R., Marcellin, Esteban and Virdis, Bernardino (2023). Molecular understanding of Eubacterium limosum chemostat methanol metabolism. Sustainable Energy and Fuels, 7 (10), 2397-2412. doi: 10.1039/d2se01551j
2023
Journal Article
Microbial conversion of waste gases into single-cell protein
Jain, Surbhi, Heffernan, James, Joshi, Jitendra, Watts, Thomas, Marcellin, Esteban and Greening, Chris (2023). Microbial conversion of waste gases into single-cell protein. Microbiology Australia, 44 (1), 27-30. doi: 10.1071/ma23007
2023
Journal Article
Gas fermentation for microbial sustainable aviation fuel production
Rodriguez, Karen, Pedroso, Marcelo, Harris, Audrey, Garg, Shivani, Hine, Damian, Köpke, Michael, Schenk, Gerhard and Marcellin, Esteban (2023). Gas fermentation for microbial sustainable aviation fuel production. Microbiology Australia, 44 (1), 31-35. doi: 10.1071/ma23008
2023
Journal Article
Structural and functional insight into the mechanism of the Fe‐S cluster‐dependent dehydratase from Paralcaligenes ureilyticus
Bayaraa, Tenuun, Lonhienne, Thierry, Sutiono, Samuel, Melse, Okke, Brück, Thomas B., Marcellin, Esteban, Bernhardt, Paul V., Boden, Mikael, Harmer, Jeffrey R., Sieber, Volker, Guddat, Luke W. and Schenk, Gerhard (2023). Structural and functional insight into the mechanism of the Fe‐S cluster‐dependent dehydratase from Paralcaligenes ureilyticus. Chemistry: A European Journal, 29 (9) e202203140, 1-13. doi: 10.1002/chem.202203140
2023
Journal Article
Biogas upgrading using Clostridium autoethanogenum for value-added products
Heffernan, James K., Lai, Chun-Yu, Gonzalez-Garcia, R. Axayacatl, Nielsen, Lars Keld, Guo, Jianhua and Marcellin, Esteban (2023). Biogas upgrading using Clostridium autoethanogenum for value-added products. Chemical Engineering Journal, 452 (Part 1) 138950, 1-7. doi: 10.1016/j.cej.2022.138950
2022
Journal Article
Deleterious variants in CRLS1 lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease
Lee, Richard G., Balasubramaniam, Shanti, Stentenbach, Maike, Kralj, Tom, McCubbin, Tim, Padman, Benjamin, Smith, Janine, Riley, Lisa G., Priyadarshi, Archana, Peng, Liuyu, Nuske, Madison R., Webster, Richard, Peacock, Ken, Roberts, Philip, Stark, Zornitza, Lemire, Gabrielle, Ito, Yoko A., Boycott, Kym M., Geraghty, Michael T., Klinken, Jan Bert, Ferdinandusse, Sacha, Zhou, Ying, Walsh, Rebecca, Marcellin, Esteban, Thorburn, David R., Rosciolli, Tony, Fletcher, Janice, Rackham, Oliver, Vaz, Frédéric M. ... Care4Rare Canada Consortium (2022). Deleterious variants in CRLS1 lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease. Human Molecular Genetics, 31 (21), 3597-3612. doi: 10.1093/hmg/ddac040
2022
Journal Article
Library adaptors with integrated reference controls improve the accuracy and reliability of nanopore sequencing
Gunter, Helen M., Youlten, Scott E., Madala, Bindu Swapna, Reis, Andre L. M., Stevanovski, Igor, Wong, Ted, Kummerfield, Sarah K., Deveson, Ira W., Santini, Nadia S., Marcellin, Esteban and Mercer, Tim R. (2022). Library adaptors with integrated reference controls improve the accuracy and reliability of nanopore sequencing. Nature Communications, 13 (1) 6437, 1-11. doi: 10.1038/s41467-022-34028-8
2022
Journal Article
RNA-seq sample preparation kits strongly affect transcriptome profiles of a gas-fermenting bacterium
de Lima, Lorena Azevedo, Reinmets, Kristina, Nielsen, Lars Keld, Marcellin, Esteban, Harris, Audrey, Köpke, Michael and Valgepea, Kaspar (2022). RNA-seq sample preparation kits strongly affect transcriptome profiles of a gas-fermenting bacterium. Microbiology Spectrum, 10 (4), 1-7. doi: 10.1128/spectrum.02303-22
2022
Journal Article
Knockout of Dicer-2 in the Sf9 cell line enhances the replication of Spodoptera frugiperda rhabdovirus and conditionally increases baculovirus replication
de Malmanche, Henry, Hussain, Mazhar, Marcellin, Esteban, Reid, Steve and Asgari, Sassan (2022). Knockout of Dicer-2 in the Sf9 cell line enhances the replication of Spodoptera frugiperda rhabdovirus and conditionally increases baculovirus replication. Journal of General Virology, 103 (8) 001779, 1-18. doi: 10.1099/jgv.0.001779
2022
Journal Article
Role of the substrate on Ni inhibition in biological sulfate reduction
Liu, Yun, Vaughan, James, Southam, Gordon, Serrano, Antonio, Gao, Han, Palfreyman, Robin, Marcellin, Esteban and Villa-Gomez, Denys K. (2022). Role of the substrate on Ni inhibition in biological sulfate reduction. Journal of Environmental Management, 316 115216, 115216. doi: 10.1016/j.jenvman.2022.115216
2022
Journal Article
Recycling carbon for sustainable protein production using gas fermentation
Marcellin, Esteban, Angenent, Largus T., Nielsen, Lars K. and Molitor, Bastian (2022). Recycling carbon for sustainable protein production using gas fermentation. Current Opinion in Biotechnology, 76 102723, 102723. doi: 10.1016/j.copbio.2022.102723
2022
Conference Publication
Adaptive laboratory evolution of Clostridium autoethanogenum to enhance CO2 valorization
Heffernan, James, Gonzalez Garcia, Ricardo A., McCubbin, Timothy, Daygon, Dara, Plan, Manuel, Talbo, Gert, Liu, Lian, Palfreyman, Robin, Köpke, Michael, Nielsen, Lars K. and Marcellin, Esteban (2022). Adaptive laboratory evolution of Clostridium autoethanogenum to enhance CO2 valorization. Biochemical and Molecular Engineering XXII, Cancun, Mexico, 26-30 June 2022.
2022
Journal Article
Engineering death resistance in CHO cells for improved perfusion culture
MacDonald, Michael A., Nöbel, Matthias, Martínez, Verónica S., Baker, Kym, Shave, Evan, Gray, Peter P., Mahler, Stephen, Munro, Trent, Nielsen, Lars K. and Marcellin, Esteban (2022). Engineering death resistance in CHO cells for improved perfusion culture. mAbs, 14 (1) e2083465, 1-13. doi: 10.1080/19420862.2022.2083465
2022
Journal Article
Analytical tools for unravelling the metabolism of gas-fermenting Clostridia
Heffernan, James K., Mahamkali, Vishnu, Valgepea, Kaspar, Marcellin, Esteban and Nielsen, Lars K. (2022). Analytical tools for unravelling the metabolism of gas-fermenting Clostridia. Current Opinion in Biotechnology, 75 102700, 102700. doi: 10.1016/j.copbio.2022.102700
2022
Journal Article
Response of the anaerobic methanotrophic archaeon candidatus “methanoperedens nitroreducens” to the long-term ferrihydrite amendment
Cai, Chen, Ni, Gaofeng, Xia, Jun, Zhang, Xueqin, Zheng, Yue, He, Bingqing, Marcellin, Esteban, Li, Weiwei, Pu, Jiaoyang, Yuan, Zhiguo and Hu, Shihu (2022). Response of the anaerobic methanotrophic archaeon candidatus “methanoperedens nitroreducens” to the long-term ferrihydrite amendment. Frontiers in Microbiology, 13 799859, 799859. doi: 10.3389/fmicb.2022.799859
2022
Journal Article
Recent advances in the production of recombinant factor IX: bioprocessing and cell engineering
Beauglehole, Aiden C, Roche Recinos, Dinora, Pegg, Cassandra L, Lee, Yih Yean, Turnbull, Victor, Herrmann, Susann, Marcellin, Esteban, Howard, Christopher B and Schulz, Benjamin L (2022). Recent advances in the production of recombinant factor IX: bioprocessing and cell engineering. Critical Reviews in Biotechnology, 43 (3), 1-19. doi: 10.1080/07388551.2022.2036691
2022
Journal Article
Faster growth enhances low carbon fuel and chemical production through gas fermentation
de Lima, Lorena Azevedo, Ingelman, Henri, Brahmbhatt, Kush, Reinmets, Kristina, Barry, Craig, Harris, Audrey, Marcellin, Esteban, Köpke, Michael and Valgepea, Kaspar (2022). Faster growth enhances low carbon fuel and chemical production through gas fermentation. Frontiers in Bioengineering and Biotechnology, 10 879578. doi: 10.3389/fbioe.2022.879578
Funding
Current funding
Supervision
Availability
- Professor Esteban Marcellin is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Harnessing Microbal Power: Turning Carbon into valuable Produscts through gas fermentation
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
Modelling cyanobacterial metabolism for the production of high-value products
Principal Advisor
-
Doctor Philosophy
Biorecycyling carbon using acetogens
Principal Advisor
Other advisors: Professor Lars Nielsen, Professor Gary Schenk, Dr Axa Gonzalez, Dr James Heffernan
-
Doctor Philosophy
Greenhouse Gas Fermentation and Computational Fluid Dynamics (CFD)
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
Engineering Eubacterium limosum for Enhanced CO2 Fixation via rational genome-scale
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
Harnessing Microbal Power: Turning Carbon into valuable Produscts through gas fermentation
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
Engineering cyanobacteria for high-value flavours and fragrances production
Principal Advisor
-
Doctor Philosophy
Optimizing Mixed Gas Fermentation for Enhanced Biofuel Production
Principal Advisor
Other advisors: Dr James Heffernan, Dr Yosephine Gumulya
-
Doctor Philosophy
Biorecycyling carbon using acetogens
Principal Advisor
Other advisors: Professor Lars Nielsen, Professor Gary Schenk, Dr Axa Gonzalez, Dr James Heffernan
-
Doctor Philosophy
Optimizing Gas Fermentation for the Valorization of Mixed Gases into High-Value Bio-Products
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
Modelling cyanobacterial metabolism for the production of high-value products
Principal Advisor
-
Doctor Philosophy
Profitable Upcycling of GM Biomass from Precision Fermentation
Principal Advisor
Other advisors: Dr Denys Villa Gomez
-
Doctor Philosophy
Engineering cyanobacteria for high-value flavours and fragrances production
Principal Advisor
-
Doctor Philosophy
Production of the Mannopeptimycin Antibiotic and other unknown Biosynthetic Gene Clusters from Streptomyces hygroscopicus
Principal Advisor
Other advisors: Dr Zeinab Khalil
-
Doctor Philosophy
Pathway engineering and systems biology for optimised isobutanol production in gas-fermenting acetogens: From strain isolation to metabolic limitations identification
Principal Advisor
Other advisors: Professor Lars Nielsen, Professor Gary Schenk, Dr Axa Gonzalez, Dr James Heffernan
-
Doctor Philosophy
Accelerating the design of cell lines for biologic production
Principal Advisor
Other advisors: Dr Marianne Gillard, Professor Timothy Mercer
-
Doctor Philosophy
Biological CO2 and H2 utilization for sustainable animal feed production
Principal Advisor
Other advisors: Professor Lars Nielsen, Dr James Heffernan
-
Master Philosophy
Harnessing Microbial Power: Turning Carbon into Valuable Products through Gas Fermentation
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
EnzOnomy - an enzyme-based production pipeline for the bioeconomy
Associate Advisor
Other advisors: Professor Damian Hine, Professor Gary Schenk
-
Doctor Philosophy
Co-assimilation of C1 compounds (methanol, formate, formaldehyde) and components from lignocellulosic feedstock
Associate Advisor
Other advisors: Dr Birgitta Ebert
-
Doctor Philosophy
Microbial fatty acid derivative production from CO2-derived C2 intermediates
Associate Advisor
Other advisors: Dr Birgitta Ebert
-
Doctor Philosophy
Accelerating the extraction of critical metals such as rare earth elements and gallium from red mud tailings.
Associate Advisor
Other advisors: Dr Denys Villa Gomez
-
Doctor Philosophy
Using synthetic biology to accelerate critical metals recovery from mine waste
Associate Advisor
Other advisors: Dr Denys Villa Gomez
-
Doctor Philosophy
Advancing biofertiliser for sustainable agriculture
Associate Advisor
Other advisors: Professor Susanne Schmidt, Dr Axa Gonzalez
-
Doctor Philosophy
Leveraging Biomass Waste: Exploiting Proteins from Precision Fermentation Bioprocesses
Associate Advisor
Other advisors: Dr Huadong Peng
-
Doctor Philosophy
Mechanisms of osmoresistance in industrial Lactococcus cemoris
Associate Advisor
Other advisors: Professor Mark Turner
-
Doctor Philosophy
Systems biology-guided cell line engineering for production of therapeutic proteins with complex post-translational modifications
Associate Advisor
Other advisors: Professor Benjamin Schulz
-
Doctor Philosophy
Engineering biology of yeast for sustainable fragrance production through precision fermentation
Associate Advisor
Other advisors: Dr Axa Gonzalez, Dr Huadong Peng
-
Doctor Philosophy
Influence of structurally different polysaccharides and their interactions with saliva and tannins on mouthfeel in wine
Associate Advisor
Other advisors: Dr Marlize Bekker, Dr Huadong Peng, Professor Heather Smyth
-
Doctor Philosophy
Advancing biofertiliser for sustainable agriculture
Associate Advisor
Other advisors: Professor Susanne Schmidt, Dr Axa Gonzalez
-
Doctor Philosophy
Systems biology-guided cell line engineering for production of therapeutic proteins with complex post-translational modifications
Associate Advisor
Other advisors: Professor Benjamin Schulz
Completed supervision
-
2024
Doctor Philosophy
Production of the Mannopeptimycin Antibiotic and Other Unknown Biosynthetic Gene Clusters from Streptomyces hygroscopicus
Principal Advisor
Other advisors: Dr Zeinab Khalil
-
2023
Doctor Philosophy
Systems metabolic engineering for one-carbon (C1) utilization metabolism
Principal Advisor
Other advisors: Honorary Professor Zhiguo Yuan
-
2023
Doctor Philosophy
Sustainable fuel and chemical production via Gas Fermentation: exploring CO2 metabolism by Clostridium autoethanogenum
Principal Advisor
Other advisors: Professor Lars Nielsen, Dr Axa Gonzalez
-
2023
Doctor Philosophy
Modelling and characterising life and death of mammalian suspension cultures
Principal Advisor
Other advisors: Professor Lars Nielsen, Dr Veronica Martinez Salazar, Dr Gert Talbo
-
2022
Doctor Philosophy
Cell Line Development for High Density Culture of CHO Cells in Perfusion: Applications of Apoptosis Resistance
Principal Advisor
Other advisors: Professor Peter Gray, Dr Veronica Martinez Salazar
-
2021
Doctor Philosophy
Insight into acetogens metabolism through the use of thermodynamic metabolic flux analysis
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2020
Doctor Philosophy
Understanding toxin production in Clostridium tetani: a systems approach
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2019
Doctor Philosophy
From waste to chemicals: On the metabolism of Clostridium autoethanogenum and PHB production from gas fermentation
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2018
Doctor Philosophy
Exploring the metabolism of propionibacteria using genome-scale modelling
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2018
Doctor Philosophy
Metabolic Engineering of propionibacteria's Wood Werkman cycle in Escherichia coli and Saccharomyces cerevisiae
Principal Advisor
Other advisors: Professor Lars Nielsen, Professor Mark Turner
-
2017
Doctor Philosophy
Understanding high propionic acid production in Propionibacterium
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2025
Doctor Philosophy
Systems biology-guided cell line engineering for production of therapeutic proteins with complex post-translational modifications
Associate Advisor
Other advisors: Dr Lucia Zacchi, Professor Benjamin Schulz
-
2024
Doctor Philosophy
Mechanisms of osmoresistance in industrial Lactococcus cemoris
Associate Advisor
Other advisors: Dr Huong Thi Pham, Professor Mark Turner
-
2023
Doctor Philosophy
Exploring Metabolic Demands of High Cell Density Chinese Hamster Ovary Cell Culture - Studying Apoptosis Resistance in Perfusion Culture
Associate Advisor
Other advisors: Dr Gert Talbo, Dr Veronica Martinez Salazar
-
2023
Doctor Philosophy
Production of liquid chemicals from C1 feedstocks using Eubacterium limosum
Associate Advisor
Other advisors: Dr Bernardino Virdis
-
2022
Doctor Philosophy
Sf9 cell line engineering to improve baculovirus expression
Associate Advisor
-
2016
Doctor Philosophy
Understanding CHO cells biology for enhanced biopharmaceutical production: a comparative transcriptomic and proteomic approach
Associate Advisor
Other advisors: Professor Peter Gray, Professor Lars Nielsen
-
2015
Doctor Philosophy
Quantitative bacterial phosphoproteomics
Associate Advisor
Other advisors: Professor Lars Nielsen
-
2014
Doctor Philosophy
Characterisation of the Saccharopolyspora erythraea metabolic switch: a systems approach
Associate Advisor
Other advisors: Professor Lars Nielsen
Media
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