
Overview
Availability
- Professor Esteban Marcellin is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Chemical Engineering, Universidad Iberoamericana
- Doctor of Philosophy, The University of Queensland
Research interests
-
Systems and Synthetic Biology
Systems and synthetic biology are powerful tools to guide the improvement of biological systems for producing fuels, chemicals, foods and biopharmaceuticals. Systems and synthetic approaches can be used to identify metabolic engineering targets and develop new production strains. Using data-driven approaches that take advantage of the tremendous growth in high throughput ‘-omics (genomics, transcriptomics, proteomics and metabolomics) coupled with mathematical models we can better understand cells. The data gathered can be used to suggest potential metabolic engineering strategies (e.g. bottlenecks that can be targeted for knockout/up-regulation) to improve yields and productivity. Biological systems are refined and improved using biological data, leading to further iterative rounds of metabolic engineering to enhance production. Using gas fermentation, we are consuming greenhouse gases (CO and CO2) as feedstock for fermentation and converting those greenhouse gases into valuable fuels, chemicals and fuels. This allows us to decrease our dependence on finite fossil fuel resources and improves sustainability for Australia. Our projects aim at producing efficient cell lines to increase the yields and productivity of biological systems. In collaboration with leaders in the industry, such as Lanzatech, Amyris, Zoetis, Dow, CSL and Thermo-Fisher, we are applying systems metabolic engineering to enhance yields and increase the production scope of the advanced biomanufacturing sector.
Works
Search Professor Esteban Marcellin’s works on UQ eSpace
2020
Conference Publication
Revamping the model CO-fermenting acetogen, Clostridium autoethanogenum, as a CO2-valorisation platform
Heffernan, James, Valgepea, Kaspar, de Souza Pinto Lemgruber, Renato, Casini, Isabella, Plan, Manuel, Tappel, Ryan, Simpson, Sean D., Köpke, Michael, Gonzalez-Garcia, Ricardo A., Nielsen, Lars K. and Marcellin, Esteban (2020). Revamping the model CO-fermenting acetogen, Clostridium autoethanogenum, as a CO2-valorisation platform. International Chain Elongation Conference 2020, Virtual, 26-27 October 2020. Wageningen, Germany: Wageningen University and Research. doi: 10.18174/icec2020.18019
2020
Journal Article
A pan-genome guided metabolic network reconstruction of five Propionibacterium species reveals extensive metabolic diversity
McCubbin, Tim, Gonzalez-Garcia, R. Axayacatl, Palfreyman, Robin W., Stowers, Chris, Nielsen, Lars K. and Marcellin, Esteban (2020). A pan-genome guided metabolic network reconstruction of five Propionibacterium species reveals extensive metabolic diversity. Genes, 11 (10) 1115, 1-26. doi: 10.3390/genes11101115
2020
Journal Article
‘Omics driven discoveries of gene targets for apoptosis attenuation in CHO cells
Orellana, Camila A., Martínez, Verónica S., MacDonald, Michael A., Henry, Matthew N., Gillard, Marianne, Gray, Peter P., Nielsen, Lars K., Mahler, Stephen and Marcellin, Esteban (2020). ‘Omics driven discoveries of gene targets for apoptosis attenuation in CHO cells. Biotechnology and Bioengineering, 118 (1) bit.27548, 481-490. doi: 10.1002/bit.27548
2020
Journal Article
A universal and independent synthetic DNA ladder for the quantitative measurement of genomic features
Reis, Andre L. M., Deveson, Ira W., Wong, Ted, Madala, Bindu Swapna, Barker, Chris, Blackburn, James, Marcellin, Esteban and Mercer, Tim R. (2020). A universal and independent synthetic DNA ladder for the quantitative measurement of genomic features. Nature Communications, 11 (1) 3609, 3609. doi: 10.1038/s41467-020-17445-5
2020
Journal Article
Nickel complexation as an innovative approach for nickel-cobalt selective recovery using sulfate-reducing bacteria
Liu, Yun, Serrano, Antonio, Wyman, Valentina, Marcellin, Esteban, Southam, Gordon, Vaughan, James and Villa-Gomez, Denys (2020). Nickel complexation as an innovative approach for nickel-cobalt selective recovery using sulfate-reducing bacteria. Journal of Hazardous Materials, 402 123506, 123506. doi: 10.1016/j.jhazmat.2020.123506
2020
Journal Article
Redox controls metabolic robustness in the gas-fermenting acetogen Clostridium autoethanogenum
Mahamkali, Vishnuvardhan, Valgepea, Kaspar, de Souza Pinto Lemgruber, Renato, Plan, Manuel, Tappel, Ryan, Köpke, Michael, Simpson, Séan Dennis, Nielsen, Lars Keld and Marcellin, Esteban (2020). Redox controls metabolic robustness in the gas-fermenting acetogen Clostridium autoethanogenum. Proceedings of the National Academy of Sciences of the United States of America, 117 (23), 13168-13175. doi: 10.1073/pnas.1919531117
2020
Journal Article
Heterologous production of 6-deoxyerythronolide B in Escherichia coli through the wood werkman cycle
Gonzalez-Garcia, R. Axayacatl, Nielsen, Lars K. and Marcellin, Esteban (2020). Heterologous production of 6-deoxyerythronolide B in Escherichia coli through the wood werkman cycle. Metabolites, 10 (6) 228, 228. doi: 10.3390/metabo10060228
2020
Journal Article
Correction to: Deletion of the hypothetical protein SCO2127 of Streptomyces coelicolor allowed identification of a new regulator of actinorhodin production (Applied Microbiology and Biotechnology, (2016), 100, 21, (9229-9237), 10.1007/s00253-016-7811-2)
Tierrafría, Víctor H., Licona-Cassani, Cuauhtemoc, Maldonado-Carmona, Nidia, Romero-Rodríguez, Alba, Centeno-Leija, Sara, Marcellin, Esteban, Rodríguez-Sanoja, Romina, Ruiz-Villafán, Beatriz, Nielsen, Lars K. and Sánchez, Sergio (2020). Correction to: Deletion of the hypothetical protein SCO2127 of Streptomyces coelicolor allowed identification of a new regulator of actinorhodin production (Applied Microbiology and Biotechnology, (2016), 100, 21, (9229-9237), 10.1007/s00253-016-7811-2). Applied Microbiology and Biotechnology, 104 (8), 3687-3687. doi: 10.1007/s00253-020-10499-x
2020
Journal Article
Enhancing CO2-valorization using Clostridium autoethanogenum for sustainable fuel and chemicals production
Heffernan, James K., Valgepea, Kaspar, Lemgruber, Renato de Souza Pinto, Casini, Isabella, Plan, Manuel, Tappel, Ryan, Simpson, Sean D., Kopke, Michael, Nielsen, Lars K. and Marcellin, Esteban (2020). Enhancing CO2-valorization using Clostridium autoethanogenum for sustainable fuel and chemicals production. Frontiers in Bioengineering and Biotechnology, 8, 1-10. doi: 10.3389/fbioe.2020.00204
2020
Other Outputs
Enhancing CO2-valorization using Clostridium autoethanogenum for sustainable fuel and chemicals production
Heffernan, James K., Valgepea, Kaspar, de Souza Pinto Lemgruber, Renato, Casini, Isabella, Plan, Manuel, Tappel, Ryan, Simpson, Sean D., Köpke, Michael, Nielsen, Lars K. and Marcellin, Esteban (2020). Enhancing CO2-valorization using Clostridium autoethanogenum for sustainable fuel and chemicals production. doi: 10.1101/2020.01.23.917666
2020
Journal Article
Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production
Henry, Matthew N., MacDonald, Michael A., Orellana, Camila A., Gray, Peter P., Gillard, Marianne, Baker, Kym, Nielsen, Lars K., Marcellin, Esteban, Mahler, Stephen and Martinez, Veronica S. (2020). Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production. Biotechnology and Bioengineering, 117 (4) bit.27269, 1187-1203. doi: 10.1002/bit.27269
2020
Journal Article
Engineering Escherichia coli for propionic acid production through the Wood‐Werkman cycle
Gonzalez‐Garcia, R. A., McCubbin, T., Turner, M. S., Nielsen, L. K. and Marcellin, E. (2020). Engineering Escherichia coli for propionic acid production through the Wood‐Werkman cycle. Biotechnology and Bioengineering, 117 (1), 167-183. doi: 10.1002/bit.27182
2020
Book Chapter
Osmoregulation via cyclic di-AMP signaling
Turner, Mark S., Vu, Thu Ngoc Minh, Marcellin, Esteban, Liang, Zhao-Xun and Pham, Huong Thi (2020). Osmoregulation via cyclic di-AMP signaling. Microbial cyclic di-nucleotide signaling. (pp. 177-189) edited by Shan-Ho Chou, Nicolas Guiliani, Vincent T. Lee and Ute Römling. Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-030-33308-9_11
2019
Journal Article
A TetR-family protein (CAETHG_0459) activates transcription from a new promoter motif associated with essential genes for autotrophic growth in acetogens
Lemgruber, Renato de Souza Pinto, Valgepea, Kaspar, Garcia, Ricardo Axayacatl Gonzalez, de Bakker, Christopher, Palfreyman, Robin William, Tappel, Ryan, Kopke, Michael, Simpson, Sean Dennis, Nielsen, Lars Keld and Marcellin, Esteban (2019). A TetR-family protein (CAETHG_0459) activates transcription from a new promoter motif associated with essential genes for autotrophic growth in acetogens. Frontiers in Microbiology, 10 2549, 2549. doi: 10.3389/fmicb.2019.02549
2019
Journal Article
Vaccine production to protect animals against pathogenic clostridia
Zaragoza, Nicolas, E., Orellana, Camila A., Moonen, Glenn A., Moutafis, George and Marcellin, Esteban (2019). Vaccine production to protect animals against pathogenic clostridia. Toxins, 11 (9) 525, 525. doi: 10.3390/toxins11090525
2019
Other Outputs
Engineering and Evolution of Methanol Assimilation in Saccharomyces cerevisiae
Espinosa, Monica I., Gonzalez-Garcia, Ricardo A., Valgepea, Kaspar, Plan, Manuel, Scott, Colin, Pretorius, Isak S., Marcellin, Esteban, Paulsen, Ian T. and Williams, Thomas C. (2019). Engineering and Evolution of Methanol Assimilation in Saccharomyces cerevisiae. doi: 10.1101/717942
2019
Journal Article
Revisiting the Evolution and Taxonomy of Clostridia, a Phylogenomic Update
Cruz-Morales, Pablo, Orellana, Camila A., Moutafis, George, Moonen, Glenn, Rincon, Gonzalo, Nielsen, Lars K. and Marcellin, Esteban (2019). Revisiting the Evolution and Taxonomy of Clostridia, a Phylogenomic Update. Genome Biology and Evolution, 11 (7), 2035-2044. doi: 10.1093/gbe/evz096
2019
Journal Article
Systems-level engineering and characterization of Clostridium autoethanogenum through heterologous production of poly-3-hydroxybutyrate (PHB)
de Souza Pinto Lemgruber, Renato, Valgepea, Kaspar, Tappel, Ryan, Behrendorff, James B., Palfreyman, Robin William, Plan, Manuel, Hodson, Mark P., Simpson, Séan Dennis, Nielsen, Lars K., Köpke, Michael and Marcellin, Esteban (2019). Systems-level engineering and characterization of Clostridium autoethanogenum through heterologous production of poly-3-hydroxybutyrate (PHB). Metabolic Engineering, 53, 14-23. doi: 10.1016/j.ymben.2019.01.003
2019
Journal Article
A novel multidomain acyl-CoA carboxylase in Saccharopolyspora erythraea provides malonyl-CoA for de novo fatty acid biosynthesis
Livieri, Andrea L., Navone, Laura, Marcellin, Esteban, Gramajo, Hugo and Rodriguez, Eduardo (2019). A novel multidomain acyl-CoA carboxylase in Saccharopolyspora erythraea provides malonyl-CoA for de novo fatty acid biosynthesis. Scientific Reports, 9 (1) 6725, 6725. doi: 10.1038/s41598-019-43223-5
2018
Conference Publication
Microbial-mediated Ni and Co recovery from mine tailings
Villa Gomez, Denys , Liu, Yun, Vaughan, James, Marcellin, Esteban, Wyman, Valentina, Serrano, Antonio and Southam, Gordon (2018). Microbial-mediated Ni and Co recovery from mine tailings. 11th ICARD | IMWA | WISA MWD 2018 Conference – Risk to Opportunity, Pretoria, South Africa, 10-14 September 2018. Pretoria, South Africa: International Mine Water Association/WISA Mine Water Division.
Funding
Current funding
Supervision
Availability
- Professor Esteban Marcellin is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Optimizing Gas Fermentation for the Valorization of Mixed Gases into High-Value Bio-Products
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
Accelerating the design of cell lines for biologic production
Principal Advisor
Other advisors: Dr Marianne Gillard, Professor Timothy Mercer
-
Doctor Philosophy
Biorecycyling carbon using acetogens
Principal Advisor
Other advisors: Professor Lars Nielsen, Professor Gary Schenk, Dr Axa Gonzalez, Dr James Heffernan
-
Doctor Philosophy
Modelling cyanobacterial metabolism for the production of high-value products
Principal Advisor
-
Doctor Philosophy
Modelling cyanobacterial metabolism for the production of high-value products
Principal Advisor
-
Doctor Philosophy
Profitable Upcycling of GM Biomass from Precision Fermentation
Principal Advisor
Other advisors: Dr Denys Villa Gomez
-
Master Philosophy
Harnessing Microbial Power: Turning Carbon into Valuable Products through Gas Fermentation
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
Biological CO2 and H2 utilization for sustainable animal feed production
Principal Advisor
Other advisors: Professor Lars Nielsen, Dr James Heffernan
-
Doctor Philosophy
Pathway engineering and systems biology for optimised isobutanol production in gas-fermenting acetogens: From strain isolation to metabolic limitations identification
Principal Advisor
Other advisors: Professor Lars Nielsen, Professor Gary Schenk, Dr Axa Gonzalez, Dr James Heffernan
-
Doctor Philosophy
Production of the Mannopeptimycin Antibiotic and other unknown Biosynthetic Gene Clusters from Streptomyces hygroscopicus
Principal Advisor
Other advisors: Dr Zeinab Khalil
-
Doctor Philosophy
Engineering cyanobacteria for high-value flavours and fragrances production
Principal Advisor
-
Doctor Philosophy
Optimizing Mixed Gas Fermentation for Enhanced Biofuel Production
Principal Advisor
Other advisors: Dr James Heffernan, Dr Yosephine Gumulya
-
Doctor Philosophy
Harnessing Microbal Power: Turning Carbon into valuable Produscts through gas fermentation
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
Biorecycyling carbon using acetogens
Principal Advisor
Other advisors: Professor Lars Nielsen, Professor Gary Schenk, Dr Axa Gonzalez, Dr James Heffernan
-
Doctor Philosophy
Engineering Eubacterium limosum for Enhanced CO2 Fixation via rational genome-scale
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
Greenhouse Gas Fermentation and Computational Fluid Dynamics (CFD)
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
Harnessing Microbal Power: Turning Carbon into valuable Produscts through gas fermentation
Principal Advisor
Other advisors: Dr James Heffernan
-
Doctor Philosophy
Engineering cyanobacteria for high-value flavours and fragrances production
Principal Advisor
-
Doctor Philosophy
Co-assimilation of C1 compounds (methanol, formate, formaldehyde) and components from lignocellulosic feedstock
Associate Advisor
Other advisors: Dr Birgitta Ebert
-
Doctor Philosophy
Systems biology-guided cell line engineering for production of therapeutic proteins with complex post-translational modifications
Associate Advisor
Other advisors: Professor Benjamin Schulz
-
Doctor Philosophy
EnzOnomy - an enzyme-based production pipeline for the bioeconomy
Associate Advisor
Other advisors: Professor Damian Hine, Professor Gary Schenk
-
Doctor Philosophy
Advancing biofertiliser for sustainable agriculture
Associate Advisor
Other advisors: Professor Susanne Schmidt, Dr Axa Gonzalez
-
Doctor Philosophy
Leveraging Biomass Waste: Exploiting Proteins from Precision Fermentation Bioprocesses
Associate Advisor
Other advisors: Dr Huadong Peng
-
Doctor Philosophy
Accelerating the extraction of critical metals such as rare earth elements and gallium from red mud tailings.
Associate Advisor
Other advisors: Dr Denys Villa Gomez
-
Doctor Philosophy
Microbial fatty acid derivative production from CO2-derived C2 intermediates
Associate Advisor
Other advisors: Dr Birgitta Ebert
-
Doctor Philosophy
Mechanisms of osmoresistance in industrial Lactococcus cemoris
Associate Advisor
Other advisors: Professor Mark Turner
-
Doctor Philosophy
Systems biology-guided cell line engineering for production of therapeutic proteins with complex post-translational modifications
Associate Advisor
Other advisors: Professor Benjamin Schulz
-
Doctor Philosophy
Influence of structurally different polysaccharides and their interactions with saliva and tannins on mouthfeel in wine
Associate Advisor
Other advisors: Dr Marlize Bekker, Dr Huadong Peng, Professor Heather Smyth
-
Doctor Philosophy
Engineering biology of yeast for sustainable fragrance production through precision fermentation
Associate Advisor
Other advisors: Dr Axa Gonzalez, Dr Huadong Peng
-
Doctor Philosophy
Advancing biofertiliser for sustainable agriculture
Associate Advisor
Other advisors: Professor Susanne Schmidt, Dr Axa Gonzalez
-
Doctor Philosophy
Using synthetic biology to accelerate critical metals recovery from mine waste
Associate Advisor
Other advisors: Dr Denys Villa Gomez
Completed supervision
-
2024
Doctor Philosophy
Production of the Mannopeptimycin Antibiotic and Other Unknown Biosynthetic Gene Clusters from Streptomyces hygroscopicus
Principal Advisor
Other advisors: Dr Zeinab Khalil
-
2023
Doctor Philosophy
Systems metabolic engineering for one-carbon (C1) utilization metabolism
Principal Advisor
Other advisors: Honorary Professor Zhiguo Yuan
-
2023
Doctor Philosophy
Modelling and characterising life and death of mammalian suspension cultures
Principal Advisor
Other advisors: Professor Lars Nielsen, Dr Veronica Martinez Salazar, Dr Gert Talbo
-
2023
Doctor Philosophy
Sustainable fuel and chemical production via Gas Fermentation: exploring CO2 metabolism by Clostridium autoethanogenum
Principal Advisor
Other advisors: Professor Lars Nielsen, Dr Axa Gonzalez
-
2022
Doctor Philosophy
Cell Line Development for High Density Culture of CHO Cells in Perfusion: Applications of Apoptosis Resistance
Principal Advisor
Other advisors: Professor Peter Gray, Dr Veronica Martinez Salazar
-
2021
Doctor Philosophy
Insight into acetogens metabolism through the use of thermodynamic metabolic flux analysis
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2020
Doctor Philosophy
Understanding toxin production in Clostridium tetani: a systems approach
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2019
Doctor Philosophy
From waste to chemicals: On the metabolism of Clostridium autoethanogenum and PHB production from gas fermentation
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2018
Doctor Philosophy
Exploring the metabolism of propionibacteria using genome-scale modelling
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2018
Doctor Philosophy
Metabolic Engineering of propionibacteria's Wood Werkman cycle in Escherichia coli and Saccharomyces cerevisiae
Principal Advisor
Other advisors: Professor Lars Nielsen, Professor Mark Turner
-
2017
Doctor Philosophy
Understanding high propionic acid production in Propionibacterium
Principal Advisor
Other advisors: Professor Lars Nielsen
-
2025
Doctor Philosophy
Systems biology-guided cell line engineering for production of therapeutic proteins with complex post-translational modifications
Associate Advisor
Other advisors: Dr Lucia Zacchi, Professor Benjamin Schulz
-
2024
Doctor Philosophy
Mechanisms of osmoresistance in industrial Lactococcus cemoris
Associate Advisor
Other advisors: Dr Huong Thi Pham, Professor Mark Turner
-
2023
Doctor Philosophy
Exploring Metabolic Demands of High Cell Density Chinese Hamster Ovary Cell Culture - Studying Apoptosis Resistance in Perfusion Culture
Associate Advisor
Other advisors: Dr Gert Talbo, Dr Veronica Martinez Salazar
-
2023
Doctor Philosophy
Production of liquid chemicals from C1 feedstocks using Eubacterium limosum
Associate Advisor
Other advisors: Dr Bernardino Virdis
-
2022
Doctor Philosophy
Sf9 cell line engineering to improve baculovirus expression
Associate Advisor
-
2016
Doctor Philosophy
Understanding CHO cells biology for enhanced biopharmaceutical production: a comparative transcriptomic and proteomic approach
Associate Advisor
Other advisors: Professor Peter Gray, Professor Lars Nielsen
-
2015
Doctor Philosophy
Quantitative bacterial phosphoproteomics
Associate Advisor
Other advisors: Professor Lars Nielsen
-
2014
Doctor Philosophy
Characterisation of the Saccharopolyspora erythraea metabolic switch: a systems approach
Associate Advisor
Other advisors: Professor Lars Nielsen
Media
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