Dr Selvakumar Edwardraja
Dr

Selvakumar Edwardraja

Email: 
Phone: 
+61 7 334 64265

Availability

Dr Selvakumar Edwardraja is:
Available for supervision

Fields of research

Biological Sciences Medical biotechnology Medical biotechnology diagnostics (incl. biosensors)

Qualifications

  • Doctor of Philosophy, Pusan National University

Research interests

  • Protein Based Biosensor Development

Search Professor Selvakumar Edwardraja’s works on UQ eSpace

32 works between 2008 and 2023
All (32) Journal Article (31) Conference Publication (1)

1 - 20 of 32 works

2023

Journal Article

A universal reagent for detection of emerging diseases using bioengineered multifunctional yeast nanofragments

Li, Junrong, Howard, Christopher B., Dey, Shuvashis, Lowry, Kym, Whiley, David M., Puttick, Simon, Rose, Stephen, Lobb, Richard J., Wuethrich, Alain, Edwardraja, Selvakumar and Trau, Matt (2023). A universal reagent for detection of emerging diseases using bioengineered multifunctional yeast nanofragments. Nature Nanotechnology, 18 (10), 1222-1229. doi: 10.1038/s41565-023-01415-1

A universal reagent for detection of emerging diseases using bioengineered multifunctional yeast nanofragments

2022

Journal Article

Exploring performance parameters of artificial allosteric protein switches

Ergun Ayva, Cagla, Fiorito, Maria M., Guo, Zhong, Edwardraja, Selvakumar, Kaczmarski, Joe A., Gagoski, Dejan, Walden, Patricia, Johnston, Wayne A., Jackson, Colin J., Nebl, Tom and Alexandrov, Kirill (2022). Exploring performance parameters of artificial allosteric protein switches. Journal of Molecular Biology, 434 (17) 167678, 1-14. doi: 10.1016/j.jmb.2022.167678

Exploring performance parameters of artificial allosteric protein switches

2022

Journal Article

Engineering and exploiting synthetic allostery of NanoLuc luciferase

Guo, Zhong, Parakra, Rinky D., Xiong, Ying, Johnston, Wayne A., Walden, Patricia, Edwardraja, Selvakumar, Moradi, Shayli Varasteh, Ungerer, Jacobus P. J., Ai, Hui-wang, Phillips, Jonathan J. and Alexandrov, Kirill (2022). Engineering and exploiting synthetic allostery of NanoLuc luciferase. Nature Communications, 13 (1) 789, 789. doi: 10.1038/s41467-022-28425-2

Engineering and exploiting synthetic allostery of NanoLuc luciferase

2021

Journal Article

Generation of nanoyeast single-chain variable fragments as high-avidity biomaterials for dengue virus detection

Farokhinejad, Fahimeh, Lane, Rebecca E., Lobb, Richard J., Edwardraja, Selvakumar, Wuethrich, Alain, Howard, Christopher B. and Trau, Matt (2021). Generation of nanoyeast single-chain variable fragments as high-avidity biomaterials for dengue virus detection. ACS Biomaterials Science and Engineering, 7 (12) acsbiomaterials.1c01001, 5850-5860. doi: 10.1021/acsbiomaterials.1c01001

Generation of nanoyeast single-chain variable fragments as high-avidity biomaterials for dengue virus detection

2021

Journal Article

Connecting artificial proteolytic and electrochemical signaling systems with caged messenger peptides

Bollella, Paolo, Edwardraja, Selvakumar, Guo, Zhong, Vickers, Claudia E., Whitfield, Jason, Walden, Patricia, Melman, Artem, Alexandrov, Kirill and Katz, Evgeny (2021). Connecting artificial proteolytic and electrochemical signaling systems with caged messenger peptides. ACS Sensors, 6 (10), 3596-3603. doi: 10.1021/acssensors.1c00845

Connecting artificial proteolytic and electrochemical signaling systems with caged messenger peptides

2021

Journal Article

Amplification-free SARS-CoV-2 detection using nanoyeast-scFv and ultrasensitive plasmonic nanobox-integrated nanomixing microassay

Li, Junrong, Wuethrich, Alain, Edwardraja, Selvakumar, Lobb, Richard J., Puttick, Simon, Rose, Stephen, Howard, Christopher B. and Trau, Matt (2021). Amplification-free SARS-CoV-2 detection using nanoyeast-scFv and ultrasensitive plasmonic nanobox-integrated nanomixing microassay. Analytical Chemistry, 93 (29) acs.analchem.1c01657, 10251-10260. doi: 10.1021/acs.analchem.1c01657

Amplification-free SARS-CoV-2 detection using nanoyeast-scFv and ultrasensitive plasmonic nanobox-integrated nanomixing microassay

2021

Journal Article

Self-powered molecule release systems activated with chemical signals processed through reconfigurable Implication or Inhibition Boolean logic gates

Bollella, Paolo, Guo, Zhong, Edwardraja, Selvakumar, Krishna Kadambar, Vasantha, Alexandrov, Kirill, Melman, Artem and Katz, Evgeny (2021). Self-powered molecule release systems activated with chemical signals processed through reconfigurable Implication or Inhibition Boolean logic gates. Bioelectrochemistry, 138 107735, 107735. doi: 10.1016/j.bioelechem.2020.107735

Self-powered molecule release systems activated with chemical signals processed through reconfigurable Implication or Inhibition Boolean logic gates

2020

Journal Article

Control of allosteric electrochemical protein switch using magnetic signals

Bollella, Paolo, Edwardraja, Selvakumar, Guo, Zhong, Alexandrov, Kirill and Katz, Evgeny (2020). Control of allosteric electrochemical protein switch using magnetic signals. Chemical Communications, 56 (64), 9206-9209. doi: 10.1039/d0cc04284f

Control of allosteric electrochemical protein switch using magnetic signals

2020

Journal Article

Control of Allosteric Protein Electrochemical Switches with Biomolecular and Electronic Signals

Bollella, Paolo, Edwardraja, Selvakumar, Guo, Zhong, Alexandrov, Kirill and Katz, Evgeny (2020). Control of Allosteric Protein Electrochemical Switches with Biomolecular and Electronic Signals. The journal of physical chemistry letters, 11 (14), 5549-5554. doi: 10.1021/acs.jpclett.0c01223

Control of Allosteric Protein Electrochemical Switches with Biomolecular and Electronic Signals

2020

Journal Article

Caged activators of artificial allosteric protein biosensors

Edwardraja, Selvakumar, Guo, Zhong, Whitfield, Jason, Lantadilla, Ignacio Retamal, Johnston, Wayne A., Walden, Patricia, Vickers, Claudia E. and Alexandrov, Kirill (2020). Caged activators of artificial allosteric protein biosensors. ACS Synthetic Biology, 9 (6) acssynbio.9b00500, 1306-1314. doi: 10.1021/acssynbio.9b00500

Caged activators of artificial allosteric protein biosensors

2019

Journal Article

Generalizable protein biosensors based on synthetic switch modules

Guo, Zhong, Johnston, Wayne A., Whitfield, Jason, Walden, Patricia, Cui, Zhenling, Wijker, Elvira, Edwardraja, Selvakumar, Retamal Lantadilla, Ignacio, Ely, Fernanda, Vickers, Claudia, Ungerer, Jacobus P. J. and Alexandrov, Kirill (2019). Generalizable protein biosensors based on synthetic switch modules. Journal of the American Chemical Society, 141 (20) jacs.8b12298, 8128-8135. doi: 10.1021/jacs.8b12298

Generalizable protein biosensors based on synthetic switch modules

2018

Journal Article

Computational screening of potential non-immunoglobulin scaffolds using overlapped conserved residues (OCR)-based fingerprints

Munussami, Ganapathiraman, Sokalingam, Sriram, Edwardraja, Selvakumar, Kim, Jung Rae, Chung, Sungwook and Lee, Sun-Gu (2018). Computational screening of potential non-immunoglobulin scaffolds using overlapped conserved residues (OCR)-based fingerprints. Korean Journal of Chemical Engineering, 35 (3), 717-724. doi: 10.1007/s11814-017-0350-4

Computational screening of potential non-immunoglobulin scaffolds using overlapped conserved residues (OCR)-based fingerprints

2018

Conference Publication

Connecting biochemistry and elelctronics with artifical allosteric protein biosensors

Guo, Zhong, Whitfield, Jason, Edwardraja, Selvakumar and Alexandrov, Kirill (2018). Connecting biochemistry and elelctronics with artifical allosteric protein biosensors. 2018 International Conference Laser Optics, ICLO 2018, St. Petersburg, Russia, 4-8 June 2018. Piscataway, NJ, United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/LO.2018.8435862

Connecting biochemistry and elelctronics with artifical allosteric protein biosensors

2017

Journal Article

Biochemical and spectroscopic characterization of dinuclear Mn-sites in artificial four-helix bundle proteins

Olson, Tien L., Espiritu, Eduardo, Edwardraja, Selvakumar, Canarie, Elizabeth, Flores, Marco, Williams, JoAnn C., Ghirlanda, Giovanna and Allen, James P. (2017). Biochemical and spectroscopic characterization of dinuclear Mn-sites in artificial four-helix bundle proteins. Biochimica et Biophysica Acta - Bioenergetics, 1858 (12), 945-954. doi: 10.1016/j.bbabio.2017.08.013

Biochemical and spectroscopic characterization of dinuclear Mn-sites in artificial four-helix bundle proteins

2017

Journal Article

Rational design of an anticalin-type sugar-binding protein using a genetically encoded boronate side chain

Edwardraja, Selvakumar, Eichinger, Andreas, Theobald, Ina, Sommer, Carina Andrea, Reichert, Andreas J and Skerra, Arne (2017). Rational design of an anticalin-type sugar-binding protein using a genetically encoded boronate side chain. ACS Synthetic Biology, 6 (12), 2241-2247. doi: 10.1021/acssynbio.7b00199

Rational design of an anticalin-type sugar-binding protein using a genetically encoded boronate side chain

2016

Journal Article

Generation of efficient fingerprint for GFP-like fold and computational identification of potential GFP-like homologs

Edwardraja, Selvakumar, Munussami, Ganapathiraman, Goyal, Amit and Lee, Sun-Gu (2016). Generation of efficient fingerprint for GFP-like fold and computational identification of potential GFP-like homologs. Biotechnology and Bioprocess Engineering, 21 (6), 712-719. doi: 10.1007/s12257-016-0362-7

Generation of efficient fingerprint for GFP-like fold and computational identification of potential GFP-like homologs

2016

Journal Article

Design of dinuclear manganese cofactors for bacterial reaction centers

Olson, Tien L., Espiritu, Eduardo, Edwardraja, Selvakumar, Simmons, Chad R., Williams, JoAnn C., Ghirlanda, Giovanna and Allen, James P. (2016). Design of dinuclear manganese cofactors for bacterial reaction centers. Biochimica et Biophysica Acta - Bioenergetics, 1857 (5), 539-547. doi: 10.1016/j.bbabio.2015.09.003

Design of dinuclear manganese cofactors for bacterial reaction centers

2015

Journal Article

Copper environment in artificial metalloproteins probed by electron paramagnetic resonance spectroscopy

Flores, Marco, Olson, Tien L., Wang, Dong, Edwardraja, Selvakumar, Shinde, Sandip, Williams, JoAnn C., Ghirlanda, Giovanna and Allen, James P. (2015). Copper environment in artificial metalloproteins probed by electron paramagnetic resonance spectroscopy. Journal of Physical Chemistry B, 119 (43), 13825-13833. doi: 10.1021/acs.jpcb.5b04172

Copper environment in artificial metalloproteins probed by electron paramagnetic resonance spectroscopy

2014

Journal Article

Targeted delivery of ubiquitin-conjugated BH3 peptide-based Mcl-1 inhibitors into cancer cells

Muppidi, Avinash, Doi, Kenichiro, Edwardraja, Selvakumar, Pulayarti, Surya V. S. R. K., Szyperski, Thomas, Wang, Hong-Gang and Lin, Qing (2014). Targeted delivery of ubiquitin-conjugated BH3 peptide-based Mcl-1 inhibitors into cancer cells. Bioconjugate Chemistry, 25 (2), 424-432. doi: 10.1021/bc4005574

Targeted delivery of ubiquitin-conjugated BH3 peptide-based Mcl-1 inhibitors into cancer cells

2014

Journal Article

3-Hydroxyisobutyrate dehydrogenase-I from Pseudomonas denitrificans ATCC 13867 degrades 3-hydroxypropionic acid

Lee, Philah, Raj, Subramanian Mohan, Zhou, Shengfang, Ashok, Somasundar, Edwardraja, Selvakumar and Park, Sunghoon (2014). 3-Hydroxyisobutyrate dehydrogenase-I from Pseudomonas denitrificans ATCC 13867 degrades 3-hydroxypropionic acid. Biotechnology and Bioprocess Engineering, 19 (1), 1-7. doi: 10.1007/s12257-013-0487-x

3-Hydroxyisobutyrate dehydrogenase-I from Pseudomonas denitrificans ATCC 13867 degrades 3-hydroxypropionic acid

Current funding

  • 2022 - 2025
    An integrated nano-bioengineered chip for enhanced molecular evolution
    ARC Discovery Projects
    Open grant

Availability

Dr Selvakumar Edwardraja is:
Available for supervision

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Available projects

  • An integrated nano-bioengineered chip for enhanced molecular evolution (2022–2024)

    This project aims to develop a novel molecular evolution platform technology for the rapid selection of high value target binding molecules from diverse molecular libraries using an electrically activated nanofluidic chip coated with target. Significant outcomes from the project is the controlled selection of target binding molecules that is not possible with current methods and improved understanding of nanoforce driven molecular collisions on nano-bioengineered surfaces. This provides significant benefits, creating new knowledge in nanomaterials and advanced manufacturing of nanofabricated devices, creating commercial interest and positioning Australia at the forefront of molecular discovery technology, a highly valuable global market.

Supervision history

Current supervision

Enquiries

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