Overview
Background
I lead the extracellular vesicle (EV) diagnostic and therapeutic research theme within the Centre for Personalised Nanomedicine at the Australian Institute for Bioengineering and Nanotechnology (AIBN). My expertise spans EV biology, hypoxia research, cancer metastasis, and cancer immunology. At the AIBN, my research program focuses on developing innovative approaches to engineer therapeutic EVs and develop cutting-edge technologies to profile circulating EVs in the bloodstream. I have made significant conceptual contributions in the field through new analytical techniques and optimal isolation methodologies for EVs. This has been fundamental to the field and has contributed to overcoming the limitations of existing purification protocols that have hindered the potential translational applications of EVs in cancer.
Availability
- Dr Richard Lobb is:
- Available for supervision
Qualifications
- Doctor of Philosophy, The University of Queensland
Research interests
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Extracellular Vesicles
Clinical interest in extracellular vesicles (EVs) has heightened as accumulating evidence underscores their significance in intercellular communication. Small EVs, or exosomes, are constitutively secreted lipid bilayer vesicles across cell lineages, ranging from 30 to 150 nm in size. These vesicles contain a diverse molecular cargo comprising proteins, lipids, various RNA species (mRNA, miRNA, lncRNA), and DNA molecules (dsDNA, ssDNA, mtDNA). Consequently, EVs have emerged as potential biomarkers, offering prospects for monitoring cancer progression and serving as targets for therapeutic interventions. Notably, cancer-derived small EVs (sEVs) are detectable in a range of bodily fluids, including blood, urine, mucus, and bronchial fluids, thereby rendering them exploitable in liquid biopsy approaches.
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Therapeutics
The ability of small EVs to transfer biomolecules between cells highlights their potential in modulating intercellular communication for therapeutic purposes. Small EVs possess natural traits that facilitate effective drug delivery, including their ability to traverse biological barriers and be administered via various routes, offering flexibility in treatment strategies. These inherent advantages can be exploited with precise bioengineering of EV membrane proteins for targeted distribution to specific organs and cell types, improving therapeutic outcomes while minimizing unintended effects. As a result, EVs as an advanced bionanoparticle therapeutic may represent next-generation drug delivery resulting in safer and more effective therapies
Works
Search Professor Richard Lobb’s works on UQ eSpace
2024
Journal Article
Analysis of secreted small extracellular vesicles from activated human microglial cell lines reveals distinct pro‐ and anti‐inflammatory proteomic profiles
Niu, Xueming, Zhang, Zhen, Zhou, Quan, Wuethrich, Alain, Lobb, Richard and Trau, Matt (2024). Analysis of secreted small extracellular vesicles from activated human microglial cell lines reveals distinct pro‐ and anti‐inflammatory proteomic profiles. Proteomics, 24 (11) 2300094, e2300094. doi: 10.1002/pmic.202300094
2024
Journal Article
A mesoporous gold biosensor to investigate immune checkpoint protein heterogeneity in single lung cancer cells
Ahmed, Emtiaz, Masud, Mostafa Kamal, Komatineni, Prathyusha, Dey, Shuvashis, Lobb, Richard, Hossain, Md Shahriar A., Möller, Andreas, Yamauchi, Yusuke, Sina, Abu Ali Ibn and Trau, Matt (2024). A mesoporous gold biosensor to investigate immune checkpoint protein heterogeneity in single lung cancer cells. Biosensors and Bioelectronics, 249 115984, 1-9. doi: 10.1016/j.bios.2023.115984
2024
Journal Article
Tracking the EMT-like phenotype switching during targeted therapy in melanoma by analyzing extracellular vesicle phenotypes
Zhou, Quan, Wang, Jing, Zhang, Zhen, Wuethrich, Alain, Lobb, Richard J. and Trau, Matt (2024). Tracking the EMT-like phenotype switching during targeted therapy in melanoma by analyzing extracellular vesicle phenotypes. Biosensors and Bioelectronics, 244 115819, 1-10. doi: 10.1016/j.bios.2023.115819
2024
Journal Article
Glycan profiling in small extracellular vesicles with a SERS microfluidic biosensor identifies early malignant development in lung cancer
Zhou, Quan, Niu, Xueming, Zhang, Zhen, O'Byrne, Kenneth, Kulasinghe, Arutha, Fielding, David, Möller, Andreas, Wuethrich, Alain, Lobb, Richard J. and Trau, Matt (2024). Glycan profiling in small extracellular vesicles with a SERS microfluidic biosensor identifies early malignant development in lung cancer. Advanced Science, 11 (33) 2401818, e2401818. doi: 10.1002/advs.202401818
2023
Journal Article
A microfluidic liquid biopsy platform to monitor protein biomarker heterogeneity in single circulating therapy‐resistance cancer cell
Ahmed, Emtiaz, Shanmugasundaram, Karthik Balaji, Li, Junrong, Behren, Andreas, Lobb, Richard, Möller, Andreas, Wuethrich, Alain, Dey, Shuvashis, Sina, Abu Ali Ibn and Trau, Matt (2023). A microfluidic liquid biopsy platform to monitor protein biomarker heterogeneity in single circulating therapy‐resistance cancer cell. Advanced Sensor Research, 2 (12) ARTN 2300059. doi: 10.1002/adsr.202300059
2023
Journal Article
A universal reagent for detection of emerging diseases using bioengineered multifunctional yeast nanofragments
Li, Junrong, Howard, Christopher B., Dey, Shuvashis, Lowry, Kym, Whiley, David M., Puttick, Simon, Rose, Stephen, Lobb, Richard J., Wuethrich, Alain, Edwardraja, Selvakumar and Trau, Matt (2023). A universal reagent for detection of emerging diseases using bioengineered multifunctional yeast nanofragments. Nature Nanotechnology, 18 (10), 1222-1229. doi: 10.1038/s41565-023-01415-1
2023
Journal Article
An epithelial-to-mesenchymal transition induced extracellular vesicle prognostic signature in non-small cell lung cancer
Lobb, Richard J., Visan, Kekoolani S., Wu, Li-Ying, Norris, Emma L., Hastie, Marcus L., Everitt, Sarah, Yang, Ian A., Bowman, Rayleen V., Siva, Shankar, Larsen, Jill E., Gorman, Jeffrey J., MacManus, Michael, Leimgruber, Antoine, Fong, Kwun M. and Möller, Andreas (2023). An epithelial-to-mesenchymal transition induced extracellular vesicle prognostic signature in non-small cell lung cancer. Communications biology, 6 (1) 68, 68. doi: 10.1038/s42003-022-04350-4
2023
Journal Article
Digital decoding of single extracellular vesicle phenotype differentiates early malignant and benign lung lesions
Li, Junrong, Sina, Abu A. I., Antaw, Fiach, Fielding, David, Möller, Andreas, Lobb, Richard, Wuethrich, Alain and Trau, Matt (2023). Digital decoding of single extracellular vesicle phenotype differentiates early malignant and benign lung lesions. Advanced Science, 10 (1) 2204207, e2204207. doi: 10.1002/advs.202204207
2022
Journal Article
Comparative analysis of tangential flow filtration and ultracentrifugation, both combined with subsequent size exclusion chromatography, for the isolation of small extracellular vesicles
Visan, Kekoolani S., Lobb, Richard J., Ham, Sunyoung, Lima, Luize G., Palma, Carlos, Edna, Chai Pei Zhi, Wu, Li-Ying, Gowda, Harsha, Datta, Keshava K., Hartel, Gunter, Salomon, Carlos and Möller, Andreas (2022). Comparative analysis of tangential flow filtration and ultracentrifugation, both combined with subsequent size exclusion chromatography, for the isolation of small extracellular vesicles. Journal of Extracellular Vesicles, 11 (9) 12266, 12266. doi: 10.1002/jev2.12266
2022
Journal Article
Blood-derived extracellular vesicle-associated miR-3182 detects non-small cell lung cancer patients
Visan, Kekoolani S., Lobb, Richard J., Wen, Shu Wen, Bedo, Justin, Lima, Luize G., Krumeich, Sophie, Palma, Carlos, Ferguson, Kaltin, Green, Ben, Niland, Colleen, Cloonan, Nicole, Simpson, Peter T., McCart Reed, Amy E., Everitt, Sarah J., MacManus, Michael P., Hartel, Gunter, Salomon, Carlos, Lakhani, Sunil R., Fielding, David and Möller, Andreas (2022). Blood-derived extracellular vesicle-associated miR-3182 detects non-small cell lung cancer patients. Cancers, 14 (1) 257, 257. doi: 10.3390/cancers14010257
2021
Journal Article
Generation of nanoyeast single-chain variable fragments as high-avidity biomaterials for dengue virus detection
Farokhinejad, Fahimeh, Lane, Rebecca E., Lobb, Richard J., Edwardraja, Selvakumar, Wuethrich, Alain, Howard, Christopher B. and Trau, Matt (2021). Generation of nanoyeast single-chain variable fragments as high-avidity biomaterials for dengue virus detection. ACS Biomaterials Science and Engineering, 7 (12) acsbiomaterials.1c01001, 5850-5860. doi: 10.1021/acsbiomaterials.1c01001
2021
Journal Article
Characterizing the heterogeneity of small extracellular vesicle populations in multiple cancer types via an ultrasensitive chip
Wang, Jing, Wuethrich, Alain, Lobb, Richard J., Antaw, Fiach, Sina, Abu Ali Ibn, Lane, Rebecca E., Zhou, Quan, Zieschank, Chloe, Bell, Caroline, Bonazzi, Vanessa F., Aoude, Lauren G., Everitt, Sarah, Yeo, Belinda, Barbour, Andrew P., Möller, Andreas and Trau, Matt (2021). Characterizing the heterogeneity of small extracellular vesicle populations in multiple cancer types via an ultrasensitive chip. ACS Sensors, 6 (9) acssensors.1c00358, 3182-3194. doi: 10.1021/acssensors.1c00358
2021
Journal Article
Amplification-free SARS-CoV-2 detection using nanoyeast-scFv and ultrasensitive plasmonic nanobox-integrated nanomixing microassay
Li, Junrong, Wuethrich, Alain, Edwardraja, Selvakumar, Lobb, Richard J., Puttick, Simon, Rose, Stephen, Howard, Christopher B. and Trau, Matt (2021). Amplification-free SARS-CoV-2 detection using nanoyeast-scFv and ultrasensitive plasmonic nanobox-integrated nanomixing microassay. Analytical Chemistry, 93 (29) acs.analchem.1c01657, 10251-10260. doi: 10.1021/acs.analchem.1c01657
2021
Journal Article
Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
Lima, Luize G., Ham, Sunyoung, Shin, Hyunku, Chai, Edna P. Z., Lek, Erica S. H., Lobb, Richard J., Müller, Alexandra F., Mathivanan, Suresh, Yeo, Belinda, Choi, Yeonho, Parker, Belinda S. and Möller, Andreas (2021). Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution. Nature Communications, 12 (1) 3543, 1-12. doi: 10.1038/s41467-021-23946-8
2020
Journal Article
The evolving translational potential of small extracellular vesicles in cancer
Möller, Andreas and Lobb, Richard J. (2020). The evolving translational potential of small extracellular vesicles in cancer. Nature Reviews Cancer, 20 (12), 697-709. doi: 10.1038/s41568-020-00299-w
2020
Journal Article
The role of exosomes in the promotion of epithelial-to-mesenchymal transition and metastasis
Visan, Kekoolani S., Lobb, Richard J. and Moller, Andreas (2020). The role of exosomes in the promotion of epithelial-to-mesenchymal transition and metastasis. Frontiers in Bioscience - Landmark, 25 (6) 4846, 1022-1057. doi: 10.2741/4846
2019
Journal Article
Breast cancer-derived exosomes reflect the cell-of-origin phenotype
Wen, Shu Wen, Lima, Luize G., Lobb, Richard J., Norris, Emma L., Hastie, Marcus L., Krumeich, Sophie and Möller, Andreas (2019). Breast cancer-derived exosomes reflect the cell-of-origin phenotype. Proteomics, 19 (8) 1800180, 1800180. doi: 10.1002/pmic.201800180
2019
Journal Article
Secreted cellular prion protein binds doxorubicin and correlates with anthracycline resistance in breast cancer
Wiegmans, Adrian P., Saunus, Jodi M., Ham, Sunyoung, Lobb, Richard J., Kutasovic, Jamie R., Dalley, Andrew J., Miranda, Mariska, Atkinson, Caroline, Foliaki, Simote T., Ferguson, Kaltin, Niland, Colleen, Johnstone, Cameron N., Lewis, Victoria, Collins, Steven, Lakhani, Sunil R., Al-Ejeh, Fares and Möller, Andreas (2019). Secreted cellular prion protein binds doxorubicin and correlates with anthracycline resistance in breast cancer. JCI Insight, 5 (6) ARTN e124092. doi: 10.1172/jci.insight.124092
2018
Journal Article
The interaction of selenium with chemotherapy and radiation on normal and malignant human mononuclear blood cells
Lobb, Richard J., Jacobson, Gregory M., Cursons, Ray T. and Jameson, Michael B. (2018). The interaction of selenium with chemotherapy and radiation on normal and malignant human mononuclear blood cells. International Journal of Molecular Sciences, 19 (10) 3167, 3167. doi: 10.3390/ijms19103167
2018
Journal Article
Breast cancer-derived exosomes alter macrophage polarization via gp130/STAT3 signaling
Ham, Sunyoung, Lima, Luize G., Chai, Edna Pei Zhi, Muller, Alexandra, Lobb, Richard J., Krumeich, Sophie, Wen, Shu Wen, Wiegmans, Adrian P. and Moeller, Andreas (2018). Breast cancer-derived exosomes alter macrophage polarization via gp130/STAT3 signaling. Frontiers in Immunology, 9 (MAY) 871, 871. doi: 10.3389/fimmu.2018.00871
Supervision
Availability
- Dr Richard Lobb is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Projects in therapeutic approaches and monitoring of patients with brain cancer
- Developing novel translational nanotechnology for monitring extracellular vesicles realsed from the brain
- Deveoping extracellular vesicle therapeutics for brain cancer
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Multiplexed nanotechnology platform to monitor glioblastoma and metastatic brain lesion risk
Develop a diagnostic and prognostic liquid biopsy nanotechnology platform for monitoring brain cancer progression and risk of brain metastases by mapping the phenotype of extracellular vesicles in the blood.
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Projects in therapeutic approaches and monitoring of patients with brain cancer
- Developing novel translational nanotechnology for monitring extracellular vesicles realsed from the brain
- Deveoping extracellular vesicle therapeutics for brain cancer
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Multiplexed nanotechnology platform to monitor glioblastoma and metastatic brain lesion risk
Develop a diagnostic and prognostic liquid biopsy nanotechnology platform for monitoring brain cancer progression and risk of brain metastases by mapping the phenotype of extracellular vesicles in the blood.
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Multiplexed nanotechnology platform to monitor glioblastoma and metastatic brain lesion risk
Develop a diagnostic and prognostic liquid biopsy nanotechnology platform for monitoring brain cancer progression and risk of brain metastases by mapping the phenotype of extracellular vesicles in the blood.
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Multiplexed nanotechnology platform to monitor glioblastoma and metastatic brain lesion risk
Develop a diagnostic and prognostic liquid biopsy nanotechnology platform for monitoring brain cancer progression and risk of brain metastases by mapping the phenotype of extracellular vesicles in the blood.
Supervision history
Current supervision
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Doctor Philosophy
Investigating therapeutic potentials of brain-derived exosomes
Principal Advisor
Other advisors: Professor Matt Trau, Dr Christopher Howard
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Doctor Philosophy
The investigation of microglial activation in brain cancer and brain metastasis by an integrated nano-sensor
Principal Advisor
Other advisors: Professor Matt Trau, Dr Alain Wuethrich
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Doctor Philosophy
Single Molecule Readout of Immune Disfunction
Associate Advisor
Other advisors: Dr Alain Wuethrich, Professor Matt Trau
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Doctor Philosophy
Utilising extracellular vesicles for the diagnosis of lung cancer.
Associate Advisor
Other advisors: Dr Alain Wuethrich, Professor Matt Trau
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Doctor Philosophy
Digital Nanotechnologies to track molecular aberrations in cancer
Associate Advisor
Other advisors: Dr Alain Wuethrich, Professor Matt Trau
Media
Enquiries
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