Dr Richard Lobb
Dr

Richard Lobb

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Background

I lead the extracellular vesicle (EV) diagnostic and therapeutic research theme within the Centre for Personalised Nanomedicine at the Australian Institute for Bioengineering and Nanotechnology (AIBN). My expertise spans EV biology, hypoxia research, cancer metastasis, and cancer immunology. At the AIBN, my research program focuses on developing innovative approaches to engineer therapeutic EVs and develop cutting-edge technologies to profile circulating EVs in the bloodstream. I have made significant conceptual contributions in the field through new analytical techniques and optimal isolation methodologies for EVs. This has been fundamental to the field and has contributed to overcoming the limitations of existing purification protocols that have hindered the potential translational applications of EVs in cancer.

Availability

Dr Richard Lobb is:
Available for supervision

Qualifications

  • Doctor of Philosophy, The University of Queensland

Research interests

  • Extracellular Vesicles

    Clinical interest in extracellular vesicles (EVs) has heightened as accumulating evidence underscores their significance in intercellular communication. Small EVs, or exosomes, are constitutively secreted lipid bilayer vesicles across cell lineages, ranging from 30 to 150 nm in size. These vesicles contain a diverse molecular cargo comprising proteins, lipids, various RNA species (mRNA, miRNA, lncRNA), and DNA molecules (dsDNA, ssDNA, mtDNA). Consequently, EVs have emerged as potential biomarkers, offering prospects for monitoring cancer progression and serving as targets for therapeutic interventions. Notably, cancer-derived small EVs (sEVs) are detectable in a range of bodily fluids, including blood, urine, mucus, and bronchial fluids, thereby rendering them exploitable in liquid biopsy approaches.

  • Therapeutics

    The ability of small EVs to transfer biomolecules between cells highlights their potential in modulating intercellular communication for therapeutic purposes. Small EVs possess natural traits that facilitate effective drug delivery, including their ability to traverse biological barriers and be administered via various routes, offering flexibility in treatment strategies. These inherent advantages can be exploited with precise bioengineering of EV membrane proteins for targeted distribution to specific organs and cell types, improving therapeutic outcomes while minimizing unintended effects. As a result, EVs as an advanced bionanoparticle therapeutic may represent next-generation drug delivery resulting in safer and more effective therapies

Search Professor Richard Lobb’s works on UQ eSpace

32 works between 2014 and 2024
All (32) Journal Article (29) Book Chapter (1) Conference Publication (1) Other Outputs (1)

21 - 32 of 32 works

2018

Other Outputs

Exosomes in the disease progression of non-small cell lung cancer (NSCLC) patients. Exosomes as biomarkers in NSCLC

Lobb, Richard John (2018). Exosomes in the disease progression of non-small cell lung cancer (NSCLC) patients. Exosomes as biomarkers in NSCLC. PhD Thesis, School of Medicine, The University of Queensland. doi: 10.14264/uql.2018.236

Exosomes in the disease progression of non-small cell lung cancer (NSCLC) patients. Exosomes as biomarkers in NSCLC

2017

Journal Article

Oncogenic transformation of lung cells results in distinct exosome protein profile similar to the cell of origin

Lobb, Richard J., Hastie, Marcus L., Norris, Emma L., van Amerongen, Rosa, Gorman, Jeffrey J. and Möller, Andreas (2017). Oncogenic transformation of lung cells results in distinct exosome protein profile similar to the cell of origin. Proteomics, 17 (23-24) 1600432, 1-10. doi: 10.1002/pmic.201600432

Oncogenic transformation of lung cells results in distinct exosome protein profile similar to the cell of origin

2017

Journal Article

Exosomes derived from mesenchymal non-small cell lung cancer cells promote chemoresistance

Lobb, Richard J., van Amerongen, Rosa, Wiegmans, Adrian, Ham, Sunyoung, Larsen, Jill E. and Moller, Andreas (2017). Exosomes derived from mesenchymal non-small cell lung cancer cells promote chemoresistance. International Journal of Cancer, 141 (3), 614-620. doi: 10.1002/ijc.30752

Exosomes derived from mesenchymal non-small cell lung cancer cells promote chemoresistance

2017

Journal Article

An electrochemical method for the detection of disease-apecific exosomes

Yadav, Sharda, Boriachek, Kseniia, Islam, Md Nazmul, Lobb, Richard, Moller, Andreas, Hill, Michelle M., Hossain, Md Shahriar Al, Nguyen, Nam-Trung and Shiddiky, Muhammad J. A. (2017). An electrochemical method for the detection of disease-apecific exosomes. ChemElectroChem, 4 (4), 967-971. doi: 10.1002/celc.201600391

An electrochemical method for the detection of disease-apecific exosomes

2017

Journal Article

Unique molecular profile of exosomes derived from primary human proximal tubular epithelial cells under diseased conditions

Wang, Xiangju, Wilkinson, Ray, Kildey, Katrina, Potriquet, Jeremy, Mulvenna, Jason, Lobb, Richard J., Moller, Andreas, Cloonan, Nicole, Mukhopadhyay, Pamela, Kassianos, Andrew J. and Healy, Helen (2017). Unique molecular profile of exosomes derived from primary human proximal tubular epithelial cells under diseased conditions. Journal of Extracellular Vesicles, 6 (1) 1314073, 1314073-1314073. doi: 10.1080/20013078.2017.1314073

Unique molecular profile of exosomes derived from primary human proximal tubular epithelial cells under diseased conditions

2017

Journal Article

Exosomes: key mediators of metastasis and pre-metastatic niche formation

Lobb, Richard J., Lima, Luize G. and Moller, Andreas (2017). Exosomes: key mediators of metastasis and pre-metastatic niche formation. Seminars in Cell and Developmental Biology, 67, 3-10. doi: 10.1016/j.semcdb.2017.01.004

Exosomes: key mediators of metastasis and pre-metastatic niche formation

2017

Book Chapter

Size exclusion chromatography: a simple and reliable method for exosome purification

Lobb, Richard and Moller, Andreas (2017). Size exclusion chromatography: a simple and reliable method for exosome purification. In Winston Patrick Kuo and Shidong Jia (Ed.), Extracellular vesicles: methods and protocols (pp. 105-110) New York, NY, United States: Humana Press. doi:10.1007/978-1-4939-7253-1_9

Size exclusion chromatography: a simple and reliable method for exosome purification

2016

Journal Article

The biodistribution and immune suppressive effects of breast cancer-derived exosomes

Wen, Shu Wen, Sceneay, Jaclyn, Lima, Luize Goncalves, Wong, Christina S. F., Becker, Melanie, Krumeich, Sophie, Lobb, Richard J., Castillo, Vanessa, Wong, Ke Ni, Ellis, Sarah, Parker, Belinda S. and Moller, Andreas (2016). The biodistribution and immune suppressive effects of breast cancer-derived exosomes. Cancer Research, 76 (23), 6816-6827. doi: 10.1158/0008-5472.CAN-16-0868

The biodistribution and immune suppressive effects of breast cancer-derived exosomes

2016

Journal Article

Radiotherapy for non-small cell lung cancer induces DNA damage response in both irradiated and out-of-field normal tissues

Siva, Shankar, Lobachevsky, Pavel, MacManus, Michael P., Kron, Tomas, Möller, Andreas, Lobb, Richard J., Ventura, Jessica, Best, Nickala, Smith, Jai, Ball, David and Martin, Olga A. (2016). Radiotherapy for non-small cell lung cancer induces DNA damage response in both irradiated and out-of-field normal tissues. Clinical Cancer Research, 22 (19), 4817-4826. doi: 10.1158/1078-0432.CCR-16-0138

Radiotherapy for non-small cell lung cancer induces DNA damage response in both irradiated and out-of-field normal tissues

2015

Conference Publication

Purification and Analysis of Exosomes Derived From Primary Human Proximal Epithelial Cells (Ptec)

Wang, X., Kassianos, A. J., Potriquet, J., Lobb, R., Wilkinson, R. and Healy, H. (2015). Purification and Analysis of Exosomes Derived From Primary Human Proximal Epithelial Cells (Ptec). 51st Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Canberra, Australia, 7-9 September 2015. HOBOKEN: WILEY-BLACKWELL.

Purification and Analysis of Exosomes Derived From Primary Human Proximal Epithelial Cells (Ptec)

2015

Journal Article

Optimized exosome isolation protocol for cell culture supernatant and human plasma

Lobb, Richard J., Becker, Melanie, Wen, Shu Wen, Wong, Christina S. F., Wiegmans, Adrian P., Leimgruber, Antione and Moller, Andreas (2015). Optimized exosome isolation protocol for cell culture supernatant and human plasma. Journal of Extracellular Vesicles, 4 (1) 27031, 27031. doi: 10.3402/jev.v4.27031

Optimized exosome isolation protocol for cell culture supernatant and human plasma

2014

Journal Article

Exosomes in cancer metastasis: Novel targets for diagnosis and therapy?

Wen, Shu Wen, Lobb, Richard and Moller, Andreas (2014). Exosomes in cancer metastasis: Novel targets for diagnosis and therapy?. Cancer Forum, 38 (2), 116-120.

Exosomes in cancer metastasis: Novel targets for diagnosis and therapy?

Current funding

  • 2025 - 2029
    Across the blood-brain barrier: digital profiling of circulating brain-derived extracellular vesicles to monitor primary brain cancer and brain metastases
    NHMRC Investigator Grants
    Open grant

Past funding

  • 2024
    Liquid Biopsy array platform to monitor GBM Progression (The Mark Hughes Foundation grant administered by The University of Newcastle)
    University of Newcastle
    Open grant
  • 2022 - 2025
    nanoIMPAC: Monitoring immune toxicities and tumour immune evasion in lung cancer
    Cancer Australia
    Open grant
  • 2021 - 2024
    Can the brain's immune cell be used to track treatment response in high-grade glioma? (University of Newcastle led Mark Huges Foundation Brain Cancer Innovation Project Grant)
    University of Newcastle
    Open grant
  • 2019 - 2022
    Engineering therapeutic cells for pan-cancer diagnosis and eradication
    CSIRO Synthetic Biology Fellowship
    Open grant

Availability

Dr Richard Lobb is:
Available for supervision

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Available projects

Supervision history

Current supervision

Enquiries

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