Overview
Availability
- Dr Christopher Howard is:
- Available for supervision
Qualifications
- Doctor of Philosophy, Queensland University of Technology
Research interests
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Protein engineering, Programmable Bionanomaterials, Molecular Discovery, Bio Nano Technologies
Works
Search Professor Christopher Howard’s works on UQ eSpace
Featured
2023
Journal Article
A universal reagent for detection of emerging diseases using bioengineered multifunctional yeast nanofragments
Li, Junrong, Howard, Christopher B., Dey, Shuvashis, Lowry, Kym, Whiley, David M., Puttick, Simon, Rose, Stephen, Lobb, Richard J., Wuethrich, Alain, Edwardraja, Selvakumar and Trau, Matt (2023). A universal reagent for detection of emerging diseases using bioengineered multifunctional yeast nanofragments. Nature Nanotechnology, 18 (10), 1222-1229. doi: 10.1038/s41565-023-01415-1
Featured
2023
Journal Article
Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia
Moles, Ernest, Howard, Christopher B., Huda, Pie, Karsa, Mawar, McCalmont, Hannah, Kimpton, Kathleen, Duly, Alastair, Chen, Yongjuan, Huang, Yizhou, Tursky, Melinda L., Ma, David, Bustamante, Sonia, Pickford, Russell, Connerty, Patrick, Omari, Sofia, Jolly, Christopher J., Joshi, Swapna, Shen, Sylvie, Pimanda, John E., Dolnikov, Alla, Cheung, Laurence C., Kotecha, Rishi S., Norris, Murray D., Haber, Michelle, de Bock, Charles E., Somers, Klaartje, Lock, Richard B., Thurecht, Kristofer J. and Kavallaris, Maria (2023). Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia. Science Translational Medicine, 15 (696) abm1262, 1-17. doi: 10.1126/scitranslmed.abm1262
Featured
2023
Journal Article
A multiplexed SERS microassay for accurate detection of SARS-CoV-2 and variants of concern
Vedelago, Courtney, Li, Junrong, Lowry, Kym, Howard, Christopher, Wuethrich, Alain and Trau, Matt (2023). A multiplexed SERS microassay for accurate detection of SARS-CoV-2 and variants of concern. ACS Sensors, 8 (4), 1648-1657. doi: 10.1021/acssensors.2c02782
2026
Journal Article
A digital SERS platform powered by bispecific antibody fragments for SARS-CoV-2 diagnostics
Wang, Jing, Zhou, Quan, Lowry, Kym, Howard, Christopher B. and Trau, Matt (2026). A digital SERS platform powered by bispecific antibody fragments for SARS-CoV-2 diagnostics. Biosensors and Bioelectronics, 294 118252, 1-6. doi: 10.1016/j.bios.2025.118252
2026
Journal Article
Engineered protein corona by bispecific antibody endows liposome with enhanced tumor targeting ability and mitigated accelerated blood clearance effect
Wei, Xiaoli, Ding, Tianhao, Xi, Meili, Thurecht, Kristofer J., Howard, Christopher B., Cui, Jiwei, Zhan, Changyou and Zhang, Zui (2026). Engineered protein corona by bispecific antibody endows liposome with enhanced tumor targeting ability and mitigated accelerated blood clearance effect. Nano Today, 66 102923, 102923. doi: 10.1016/j.nantod.2025.102923
2025
Journal Article
Pretargeted polymeric systems for conducting chemo-radiotherapy on glioblastoma: an evaluation of the impact of nanomedicine structure on bioorthogonal chemistry in vivo
Chu, Weijing, Ediriweera, Gayathri R., Prior, Amber, Huda, Pie, Lum, Benedict, Howard, Christopher B., Fletcher, Nicholas L., Bernhardt, Paul V. and Thurecht, Kristofer J. (2025). Pretargeted polymeric systems for conducting chemo-radiotherapy on glioblastoma: an evaluation of the impact of nanomedicine structure on bioorthogonal chemistry in vivo. Biomacromolecules acs.biomac.5c01157. doi: 10.1021/acs.biomac.5c01157
2025
Journal Article
Programmable dual‐targeting nano bioconjugates: a universal bioconjugation strategy to enhance single molecule proteomic assays
Farokhinejad, Fahimeh, Anderson, Will, Niu, Xueming, Wuethrich, Alain, Howard, Christopher B. and Trau, Matt (2025). Programmable dual‐targeting nano bioconjugates: a universal bioconjugation strategy to enhance single molecule proteomic assays. Small Methods e01235, e01235. doi: 10.1002/smtd.202501235
2025
Journal Article
Evaluating mRNA Delivery Using Nuclear Medicine
Humphries, James, Witjaksono, Andrea, Poudel, Abishek, Mardon, Karine, Migotto, Mary-anne, Cheetham, Seth, Howard, Christopher and Thurecht, Kristofer (2025). Evaluating mRNA Delivery Using Nuclear Medicine. Nuclear Medicine and Biology, 150-151 109117, 109117. doi: 10.1016/j.nucmedbio.2025.109117
2025
Journal Article
Physicochemical Tuning of Bispecific Antibody Fragment Immobilization for Robust Digital SERS Biosensing
Wang, Jing, Zhou, Quan, Howard, Christopher B. and Trau, Matt (2025). Physicochemical Tuning of Bispecific Antibody Fragment Immobilization for Robust Digital SERS Biosensing. Analytical Chemistry, 97 (43) acs.analchem.5c03980, 23994-24002. doi: 10.1021/acs.analchem.5c03980
2025
Journal Article
Exploiting the geranylgeranyl-pyrophosphate-sensing N-terminal domain of HMG-CoA reductase 2 to regulate farnesyl pyrophosphate synthase (Erg20p) for improved monoterpene production in Saccharomyces cerevisiae
Lu, Zeyu, Evans, Samuel, McDonnell, Liam, Bandari, Naga Chandra, Weng, Yilun, Jin, Wanli, Speight, Robert, Schenk, Gerhard, Howard, Christopher B., Vickers, Claudia E. and Peng, Bingyin (2025). Exploiting the geranylgeranyl-pyrophosphate-sensing N-terminal domain of HMG-CoA reductase 2 to regulate farnesyl pyrophosphate synthase (Erg20p) for improved monoterpene production in Saccharomyces cerevisiae. Yeast, 42 (8-10), 169-180. doi: 10.1002/yea.4005
2025
Journal Article
Targeted mRNA delivery with bispecific antibodies that tether LNPs to cell-surface markers
Dietmair, Bettina, Humphries, James, Mercer, Timothy R., Thurecht, Kristofer J., Howard, Christopher B. and Cheetham, Seth W. (2025). Targeted mRNA delivery with bispecific antibodies that tether LNPs to cell-surface markers. Molecular Therapy Nucleic Acids, 36 (2) 102520, 1-7. doi: 10.1016/j.omtn.2025.102520
2025
Journal Article
Immune-modulating nanomedicines for enhanced drug delivery to non-small-cell lung cancer
Liu, Feifei, Howard, Christopher B., Huda, Pie, Fletcher, Nicholas L., Bell, Craig A., Blakey, Idriss, Agrez, Michael and Thurecht, Kristofer J. (2025). Immune-modulating nanomedicines for enhanced drug delivery to non-small-cell lung cancer. Biomaterials, 317 123089, 1-14. doi: 10.1016/j.biomaterials.2025.123089
2025
Journal Article
Development and application of multivalent nanobody-functionalized plasmonic probes in SERS sensing platforms
Wang, Jing, Zhou, Quan, Lowry, Kym, Howard, Christopher B. and Trau, Matt (2025). Development and application of multivalent nanobody-functionalized plasmonic probes in SERS sensing platforms. Biosensors and Bioelectronics, 278 117292, 117292. doi: 10.1016/j.bios.2025.117292
2025
Journal Article
Multiplexing label-free polymeric nanocarriers via antipolymer antibodies
Humphries, James, Hobson-Peters, Jody, Ghosh, Saikat, Howard, Christopher B., Huda, Pie, Bell, Craig A., Fletcher, Nicholas L., Kempe, Kristian and Thurecht, Kristofer J. (2025). Multiplexing label-free polymeric nanocarriers via antipolymer antibodies. ACS Sensors, 10 (2), 1280-1288. doi: 10.1021/acssensors.4c03184
2025
Journal Article
Application of chimeric antigens to paper-based diagnostics for detection of West Nile virus infections of Crocodylus porosus – A novel animal test case
Johnston, Ryan A., Habarugira, Gervais, Harrison, Jessica J., Isberg, Sally R., Moran, Jasmin, Morgan, Mahali S., Davis, Steven S., Melville, Lorna, Howard, Christopher B., Henry, Charles S., Macdonald, Joanne, Bielefeldt-Ohmann, Helle, Hall, Roy A. and Hobson-Peters, Jody (2025). Application of chimeric antigens to paper-based diagnostics for detection of West Nile virus infections of Crocodylus porosus – A novel animal test case. Sensors and Actuators B: Chemical, 422 136611, 1-11. doi: 10.1016/j.snb.2024.136611
2024
Journal Article
A novel immunomodulating peptide with potential to complement oligodeoxynucleotide-mediated adjuvanticity in vaccination strategies
Agrez, Michael, Chandler, Christopher, Thurecht, Kristofer J., Fletcher, Nicholas L., Liu, Feifei, Subramaniam, Gayathri, Howard, Christopher B., Parker, Stephen, Turner, Darryl, Rzepecka, Justyna, Knox, Gavin, Nika, Anastasia, Hall, Andrew M., Gooding, Hayley and Gallagher, Laura (2024). A novel immunomodulating peptide with potential to complement oligodeoxynucleotide-mediated adjuvanticity in vaccination strategies. Scientific Reports, 14 (1) 26737, 1-17. doi: 10.1038/s41598-024-78150-7
2024
Conference Publication
Evaluating the efficacy of targeted vs non-targeted dox nanoparticles in treating triple negative breast cancer bone metastases in a humanized mouse model
Mcgovern, J. A., Landgraf, M., Frankenbach, T., Fletcher, N., Howard, C., Ravichandran, A., Shafiee, A., Thurecht, K. and Hutmacher, D. W. (2024). Evaluating the efficacy of targeted vs non-targeted dox nanoparticles in treating triple negative breast cancer bone metastases in a humanized mouse model. 7th Termis World Congress, Seattle, WA USA, 25-28 June 2024. New Rochelle, NY USA: Mary Ann Liebert, Inc. Publishers.
2024
Journal Article
mRNA display pipeline for protein biosensor construction
Cui, Zhenling, Ayva, Cagla Ergun, Liew, Yi Jin, Guo, Zhong, Mutschler, Roxane, Dreier, Birgit, Fiorito, Maria M., Walden, Patricia, Howard, Christopher B., Ely, Fernanda, Plückthun, Andreas, Pretorius, Carel, Ungerer, Jacobus P.J., Buckle, Ashley M. and Alexandrov, Kirill (2024). mRNA display pipeline for protein biosensor construction. ACS Sensors, 9 (6), 2846-2857. doi: 10.1021/acssensors.3c02471
2024
Journal Article
LowTempGAL: a highly responsive low temperature-inducible GAL system in Saccharomyces cerevisiae
Lu, Zeyu, Shen, Qianyi, Bandari, Naga Chandra, Evans, Samuel, Mcdonnell, Liam, Liu, Lian, Jin, Wanli, Luna-Flores, Carlos Horacio, Collier, Thomas, Talbo, Gert, Mccubbin, Tim, Esquirol, Lygie, Myers, Chris, Trau, Matt, Dumsday, Geoff, Speight, Robert, Howard, Christopher B., Vickers, Claudia E. and Peng, Bingyin (2024). LowTempGAL: a highly responsive low temperature-inducible GAL system in Saccharomyces cerevisiae. Nucleic Acids Research, 52 (12) gkae460, 7367-7383. doi: 10.1093/nar/gkae460
2024
Journal Article
EGFR targeting of liposomal doxorubicin improves recognition and suppression of non-small cell lung cancer
Moles, Ernest, Chang, David, Mansfeld, Friederike, Duly, Alastair, Kimpton, Kathleen, Logan, Amy, Howard, Christopher, Thurecht, Kristofer and Kavallaris, Maria (2024). EGFR targeting of liposomal doxorubicin improves recognition and suppression of non-small cell lung cancer. International Journal of Nanomedicine, 2024 (19), 3623-3639. doi: 10.2147/ijn.s450534
Funding
Current funding
Supervision
Availability
- Dr Christopher Howard is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Available projects
-
Molecular Discovery and bioengineering of innovative biologics to detect pandemic threat pathogens, new virus variants and emerging viruses
Explore the molecular discovery and bioengineering of innovative biologics for the detection of pandemic threat pathogens, such as Sars Cov2, SCV2 variants and influenza.
Supervision history
Current supervision
-
Doctor Philosophy
Molecular Discovery and bioengineering of innovative biologics to detect pandemic threat pathogens, new virus variants and emerging viruses
Principal Advisor
Other advisors: Professor David Owen, Dr Kym Lowry, Dr Pie Huda
-
Doctor Philosophy
mRNA cancer therapies
Associate Advisor
Other advisors: Professor Timothy Mercer, Associate Professor Seth Cheetham
-
Doctor Philosophy
Investigating therapeutic potentials of brain-derived exosomes
Associate Advisor
Other advisors: Professor Matt Trau, Dr Richard Lobb
-
Doctor Philosophy
An integrated nano-bioengineered chip for enhanced molecular evolution
Associate Advisor
Other advisors: Professor Matt Trau, Dr Selvakumar Edwardraja, Dr Fiach Antaw
-
Doctor Philosophy
Engineering Novel Theranostics for High Grade Glioma Through Site-Specific EphA2 Antibody Modification
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler, Dr Martina Jones
Completed supervision
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2025
Doctor Philosophy
Development of next-generation molecular tools for diagnostics
Principal Advisor
Other advisors: Professor Matt Trau, Dr Selvakumar Edwardraja
-
2024
Doctor Philosophy
Engineering synthetic regulatory circuits for precise metabolic control in Saccharomyces cerevisiae
Principal Advisor
Other advisors: Professor Gary Schenk
-
2023
Doctor Philosophy
Discovery and Development of a Novel Human Glypican-1 Monoclonal Antibody for Targeting Solid Cancers
Principal Advisor
Other advisors: Emeritus Professor Stephen Mahler, Dr Martina Jones
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2021
Doctor Philosophy
Evaluation of the impact of the upstream bioprocess parameters on the proteomic profile of recombinant factor IX
Principal Advisor
Other advisors: Professor Benjamin Schulz
-
2020
Doctor Philosophy
Development of novel bioconjugation strategies for creating cancer-targeting nanomaterials
Principal Advisor
Other advisors: Emeritus Professor Stephen Mahler, Dr Martina Jones
-
2025
Doctor Philosophy
Integration of innovative diagnostic technologies for the detection of flaviviral infections
Associate Advisor
Other advisors: Associate Professor Jody Peters
-
2025
Doctor Philosophy
Towards n-plex quantitation of molecular interactions for evolution-free biopanning
Associate Advisor
Other advisors: Professor Matt Trau
-
2024
Doctor Philosophy
Development of Antibody Delivery Systems Against Intracellular Targets
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler
-
2023
Doctor Philosophy
Novel antibody theranostics for oncology
Associate Advisor
Other advisors: Dr Pie Huda, Professor Kristofer Thurecht
-
2023
Doctor Philosophy
Bioengineering yeast nanofragment affinity probes for dengue diagnostics
Associate Advisor
Other advisors: Associate Professor Alain Wuethrich, Professor Matt Trau
-
2022
Doctor Philosophy
Engineering and production of recombinant proteins with appropriate glycostructures for early in vivo studies
Associate Advisor
Other advisors: Dr Lucia Zacchi, Professor Benjamin Schulz
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2019
Master Philosophy
Radiosensitization of Prostate Cancer by Nanoparticle Mediated RNA Interference
Associate Advisor
Other advisors: Honorary Professor Kum Kum Khanna, Dr Nick Fletcher, Professor Kristofer Thurecht
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2019
Doctor Philosophy
Isolation and characterisation of antibodies against human and canine EphA2_ targets for comparative studies in brain cancer
Associate Advisor
Other advisors: Dr Martina Jones, Professor Andrew Whittaker, Emeritus Professor Stephen Mahler
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2018
Doctor Philosophy
Isolation and development of antibodies for active targeting of nanocells for cancer therapy
Associate Advisor
Other advisors: Dr Martina Jones, Emeritus Professor Stephen Mahler
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2018
Doctor Philosophy
Engineering lipid-coated calcium phosphate nanoparticles with multiple ligands to amplify in vivo tumor target delivery
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler
-
2017
Doctor Philosophy
Development and Application of Novel Biosensor Technologies
Associate Advisor
Other advisors: Dr Martina Jones, Emeritus Professor Stephen Mahler
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2017
Master Philosophy
Development of anti-PEG bispecific antibodies for targeting PEGylated nanoparticles to tumour cells
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler
Media
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