Overview
Background
Professor Stephen Mahler is a Senior Group Leader at the Australian Institute for Bioengineering and Nanotechnology and Director of the Australian Research Council Training Centre for Biopharmaceutical Innovation (CBI), University of Queensland. Professor Mahler is a biotechnologist with a focus on R&D of recombinant-DNA derived protein biopharmaceuticals, drug delivery systems and nanomedicines. Professor Mahler has a record of translational research success and engages extensively with industry associated with the biomedical sciences both nationally and internationally.
Research within CBI covers three thematic research areas; discovery of new biopharmaceuticals, engineering cells for production of protein-based biopharmaceuticals and advanced manufacturing for industrial production. A current research interest is at the interface of the life sciences and materials science, using a synthetic biology approach for creating novel therapeutic entities as well as new systems for drug delivery.
Professor Mahler has a strong interest in education and training and was formerly Head of the Chemical and Biological Engineering Plan at the University of Queensland (2010-2016). Other educational initiatives include development of Masters Programs and a Continuing Professional Development program in the area of biopharmaceuticals. The CPD program is available to stakeholders in the industry, both in Australia and internationally.
Availability
- Emeritus Professor Stephen Mahler is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Research impacts
Professor Mahler has a strong engagement with industry both nationally and internationally, that through collaborative research has led to some significant translational outcomes including clinical trial of biopharmaceutical drug candidates through to approval. The Australian Research Council Training Centre for Biopharmaceutical Innovation is a consortium of partners including government, the University of Queensland and several industry partners, with a goal of contributing to the transformation of the biopharmaceutical industry. Through the Centre and the CPD Program in Biopharmaceuticals, Professor Mahler continues to work with stakeholders to ensure a vibrant future for the biopharmaceutical industry in Australia.
Works
Search Professor Stephen Mahler’s works on UQ eSpace
2024
Journal Article
Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation
Nöbel, Matthias, Barry, Craig, MacDonald, Michael A., Baker, Kym, Shave, Evan, Mahler, Stephen, Munro, Trent, Martínez, Verónica S., Nielsen, Lars K. and Marcellin, Esteban (2024). Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation. Biotechnology and Bioengineering, 121 (4), 1371-1383. doi: 10.1002/bit.28613
2024
Journal Article
Amino acid degradation pathway inhibitory by‐products trigger apoptosis in CHO cells
Martínez, Verónica S., Rodriguez, Karen, McCubbin, Timothy, Tong, Junjie, Mahler, Stephen, Shave, Evan, Baker, Kym, Munro, Trent P. and Marcellin, Esteban (2024). Amino acid degradation pathway inhibitory by‐products trigger apoptosis in CHO cells. Biotechnology Journal, 19 (2) ARTN e2300338, e2300338. doi: 10.1002/biot.202300338
2023
Conference Publication
Does Acute Psychedelic "Therapy" Persistently Reverse Reward-Related Anhedonia Induced by Early Life Adversity?
Lawson, Kate, Ruiz, Christina, Martinez, Maricela, Coates, Darrien, Weems, Nya, Scofield, Michael and Mahler, Stephen (2023). Does Acute Psychedelic "Therapy" Persistently Reverse Reward-Related Anhedonia Induced by Early Life Adversity?. 62nd Annual Meeting of the American-College-of-Neuropsychopharmacology (ACNP), Tampa Fl, Dec 03-06, 2023. LONDON: SPRINGERNATURE.
2023
Journal Article
Design of polarity-dependent immunosensors based on the structural analysis of engineered antibodies
Islam, Jiaul, Conroy, Paul, Fercher, Christian, Kim, Mijin, Yaari, Zvi, Jones, Martina, Bell, Toby D. M., Caradoc-Davies, Tom, Law, Ruby, Whisstock, James, Heller, Daniel, Mahler, Stephen and Corrie, Simon (2023). Design of polarity-dependent immunosensors based on the structural analysis of engineered antibodies. ACS Chemical Biology, 18 (8), 1863-1871. doi: 10.1021/acschembio.3c00303
2022
Journal Article
Evaluation of phage display biopanning strategies for the selection of anti-cell surface receptor antibodies
Panagides, Nadya, Zacchi, Lucia F., Souza, Mitchell J. De, Morales, Rodrigo A. V., Karnowski, Alexander, Liddament, Mark T., Owczarek, Catherine M., Mahler, Stephen M., Panousis, Con, Jones, Martina L. and Fercher, Christian (2022). Evaluation of phage display biopanning strategies for the selection of anti-cell surface receptor antibodies. International Journal of Molecular Sciences, 23 (15) 8470, 8470. doi: 10.3390/ijms23158470
2022
Journal Article
Engineering death resistance in CHO cells for improved perfusion culture
MacDonald, Michael A., Nöbel, Matthias, Martínez, Verónica S., Baker, Kym, Shave, Evan, Gray, Peter P., Mahler, Stephen, Munro, Trent, Nielsen, Lars K. and Marcellin, Esteban (2022). Engineering death resistance in CHO cells for improved perfusion culture. mAbs, 14 (1) e2083465, 1-13. doi: 10.1080/19420862.2022.2083465
2022
Journal Article
Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruption
Janowicz, Phillip W., Houston, Zachary H., Bunt, Jens, Fletcher, Nicholas L., Bell, Craig A., Cowin, Gary, Howard, Christopher B., Taslima, Dewan, Westra van Holthe, Nicholas, Prior, Amber, Soh, Vanessa, Ghosh, Saikat, Humphries, James, Huda, Pie, Mahler, Stephen M., Richards, Linda J. and Thurecht, Kristofer J. (2022). Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruption. Biomaterials, 283 121416, 121416. doi: 10.1016/j.biomaterials.2022.121416
2022
Journal Article
Modelling apoptosis resistance in CHO cells with CRISPR‐mediated knock‐outs of Bak1, Bax, and Bok
MacDonald, Michael A., Barry, Craig, Groves, Teddy, Martínez, Verónica S., Gray, Peter P., Baker, Kym, Shave, Evan, Mahler, Stephen, Munro, Trent, Marcellin, Esteban and Nielsen, Lars K. (2022). Modelling apoptosis resistance in CHO cells with CRISPR‐mediated knock‐outs of Bak1, Bax, and Bok. Biotechnology and Bioengineering, 119 (6), 1380-1391. doi: 10.1002/bit.28062
2021
Journal Article
Disulfide bond engineering of AppA phytase for increased thermostability requires co-expression of protein disulfide isomerase in Pichia pastoris
Navone, Laura, Vogl, Thomas, Luangthongkam, Pawarisa, Blinco, Jo-Anne, Luna-Flores, Carlos H., Chen, Xiaojing, von Hellens, Juhani, Mahler, Stephen and Speight, Robert (2021). Disulfide bond engineering of AppA phytase for increased thermostability requires co-expression of protein disulfide isomerase in Pichia pastoris. Biotechnology for Biofuels, 14 (1) 80, 80. doi: 10.1186/s13068-021-01936-8
2021
Journal Article
In silico molecular dynamics of human glycophorin A (GPA) extracellular structure
Ekman, Serena, Flower, Robert, Mahler, Stephen, Gould, Alison, Barnard, Ross T., Hyland, Catherine, Jones, Martina, Malde, Alpeshkumar K. and Bui, Xuan T. (2021). In silico molecular dynamics of human glycophorin A (GPA) extracellular structure. Annals of Blood, 6 (June) 11. doi: 10.21037/aob-20-51
2021
Journal Article
Coagulation factor IX analysis in bioreactor cell culture supernatant predicts quality of the purified product
Zacchi, Lucia F., Roche-Recinos, Dinora, Pegg, Cassandra L., Phung, Toan K., Napoli, Mark, Aitken, Campbell, Sandford, Vanessa, Mahler, Stephen M., Lee, Yih Yean, Schulz, Benjamin L. and Howard, Christopher B. (2021). Coagulation factor IX analysis in bioreactor cell culture supernatant predicts quality of the purified product. Communications Biology, 4 (1) 390, 390. doi: 10.1038/s42003-021-01903-x
2021
Journal Article
Recombinant antibody engineering enables reversible binding for continuous protein biosensing
Fercher, Christian, Jones, Martina L., Mahler, Stephen M. and Corrie, Simon R (2021). Recombinant antibody engineering enables reversible binding for continuous protein biosensing. ACS Sensors, 6 (3) acssensors.0c01510, 764-776. doi: 10.1021/acssensors.0c01510
2021
Journal Article
Incorporation of unnatural amino acid into antibody fragment for creating a stable antibody-drug conjugate
Wardiana, Andri, Jones, Martina L., Mahler, Stephen M. and Howard, Christopher B. (2021). Incorporation of unnatural amino acid into antibody fragment for creating a stable antibody-drug conjugate. Indonesian Journal of Pharmacy, 32 (1), 96-105. doi: 10.22146/ijp.1101
2021
Journal Article
Perfusion culture of Chinese Hamster Ovary cells for bioprocessing applications
MacDonald, Michael A., Nöbel, Matthias, Roche Recinos, Dinora, Martínez, Verónica S., Schulz, Benjamin L., Howard, Christopher B., Baker, Kym, Shave, Evan, Lee, Yih Yean, Marcellin, Esteban, Mahler, Stephen, Nielsen, Lars Keld and Munro, Trent (2021). Perfusion culture of Chinese Hamster Ovary cells for bioprocessing applications. Critical Reviews in Biotechnology, 42 (7), 1-17. doi: 10.1080/07388551.2021.1998821
2020
Journal Article
A bispecific T cell engager targeting Glypican-1 redirects T cell cytolytic activity to kill prostate cancer cells
Lund, Maria E., Howard, Christopher B., Thurecht, Kristofer J., Campbell, Douglas H., Mahler, Stephen M. and Walsh, Bradley J. (2020). A bispecific T cell engager targeting Glypican-1 redirects T cell cytolytic activity to kill prostate cancer cells. BMC Cancer, 20 (1) 1214, 1214. doi: 10.1186/s12885-020-07562-1
2020
Journal Article
Aggregates in blood filter chambers used from the plasma donations of anti-D donors: evaluation for monoclonal antibody discovery using phage display
McGowan, Eunike C., Flower, Robert L., Jones, Martina L., Irving, David O., Barnard, Ross T., Hyland, Catherine A., Mahler, Stephen M. and Bui, Xuan T. (2020). Aggregates in blood filter chambers used from the plasma donations of anti-D donors: evaluation for monoclonal antibody discovery using phage display. Blood Transfusion , 19 (1), 64-72. doi: 10.2450/2020.0093-20
2020
Journal Article
Controlling the biological fate of micellar nanoparticles: balancing stealth and targeting
Sivaram, Amal J., Wardiana, Andri, Alcantara, Sheilajen, Sonderegger, Stefan E., Fletcher, Nicholas L., Houston, Zachary H., Howard, Christopher B., Mahler, Stephen M., Alexander, Cameron, Kent, Stephen J., Bell, Craig A. and Thurecht, Kristofer J. (2020). Controlling the biological fate of micellar nanoparticles: balancing stealth and targeting. ACS Nano, 14 (10) acsnano.0c06033, 13739-13753. doi: 10.1021/acsnano.0c06033
2020
Journal Article
‘Omics driven discoveries of gene targets for apoptosis attenuation in CHO cells
Orellana, Camila A., Martínez, Verónica S., MacDonald, Michael A., Henry, Matthew N., Gillard, Marianne, Gray, Peter P., Nielsen, Lars K., Mahler, Stephen and Marcellin, Esteban (2020). ‘Omics driven discoveries of gene targets for apoptosis attenuation in CHO cells. Biotechnology and Bioengineering, 118 (1) bit.27548, 481-490. doi: 10.1002/bit.27548
2020
Journal Article
Phage display derived monoclonal antibodies: from bench to bedside
Alfaleh, Mohamed A., Alsaab, Hashem O., Mahmoud, Ahmad Bakur, Alkayyal, Almohanad A., Jones, Martina L., Mahler, Stephen M. and Hashem, Anwar M. (2020). Phage display derived monoclonal antibodies: from bench to bedside. Frontiers in Immunology, 11 1986, 1986. doi: 10.3389/fimmu.2020.01986
2020
Journal Article
Targeting the undruggable: emerging technologies in antibody delivery against intracellular targets
Niamsuphap, Suchada, Fercher, Christian, Kumble, Sumukh, Huda, Pie, Mahler, Stephen M. and Howard, Christopher B. (2020). Targeting the undruggable: emerging technologies in antibody delivery against intracellular targets. Expert Opinion on Drug Delivery, 17 (9), 1189-1211. doi: 10.1080/17425247.2020.1781088
Funding
Past funding
Supervision
Availability
- Emeritus Professor Stephen Mahler is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Biosimilar litigation and market entry
Associate Advisor
Other advisors: Professor Avril Robertson, Dr Lisette Pregelj
-
Doctor Philosophy
From Target Discovery to Therapeutic Antibodies
Associate Advisor
Other advisors: Associate Professor Jessica Mar, Dr Lucia Zacchi
-
Doctor Philosophy
Engineering Novel Theranostics for High Grade Glioma Through Site-Specific EphA2 Antibody Modification
Associate Advisor
Other advisors: Dr Christopher Howard, Dr Martina Jones
Completed supervision
-
2021
Doctor Philosophy
Characterising murine red blood cell phenotypes: the impact of genetic variants in Klf1 and Casd1
Principal Advisor
Other advisors: Professor Benjamin Schulz
-
2020
Doctor Philosophy
Engineering Chinese Hamster Ovary Cells for Improved Monoclonal Antibody Productivity by Modulating Feedback Regulation of the Secretory Pathway
Principal Advisor
Other advisors: Dr Marianne Gillard, Professor Peter Gray
-
2019
Doctor Philosophy
Isolation and characterisation of antibodies against human and canine EphA2_ targets for comparative studies in brain cancer
Principal Advisor
Other advisors: Dr Martina Jones, Professor Andrew Whittaker, Dr Christopher Howard
-
2018
Doctor Philosophy
Isolation and development of antibodies for active targeting of nanocells for cancer therapy
Principal Advisor
Other advisors: Dr Martina Jones, Dr Christopher Howard
-
2017
Master Philosophy
Development of anti-PEG bispecific antibodies for targeting PEGylated nanoparticles to tumour cells
Principal Advisor
Other advisors: Dr Christopher Howard
-
2017
Doctor Philosophy
Development and Application of Novel Biosensor Technologies
Principal Advisor
Other advisors: Dr Martina Jones, Dr Christopher Howard
-
2015
Doctor Philosophy
Beyond antibodies: development of a novel molecular scaffold based on human Chaperonin 10
Principal Advisor
-
2015
Doctor Philosophy
Design, Assembly and Characterisation of a Multifunctional, Self-Assembled Nanoparticle incorporating Antibody Fragments
Principal Advisor
Other advisors: Dr Martina Jones, Professor Kristofer Thurecht
-
2015
Doctor Philosophy
Engineering bispecific antibodies for targeted delivery of cytotoxin-loaded nanoparticles to tumour cells
Principal Advisor
Other advisors: Dr Martina Jones
-
2015
Doctor Philosophy
Antibody Discovery for Development of a Serotyping Dengue Virus NS1 Capture Assay
Principal Advisor
Other advisors: Dr Martina Jones
-
2024
Doctor Philosophy
Development of Antibody Delivery Systems Against Intracellular Targets
Associate Advisor
Other advisors: Dr Christopher Howard
-
2023
Doctor Philosophy
Discovery and Development of a Novel Human Glypican-1 Monoclonal Antibody for Targeting Solid Cancers
Associate Advisor
Other advisors: Dr Martina Jones, Dr Christopher Howard
-
2022
Doctor Philosophy
Dielectric spectroscopy and significance of blood analytes in the microwave and millimetre-wave bands
Associate Advisor
Other advisors: Professor Amin Abbosh
-
2022
Doctor Philosophy
Investigating monoclonal antibody targets on P. falciparum and red blood cell antigens using experimental mouse model and phage display technology
Associate Advisor
Other advisors: Dr Martina Jones
-
2022
Doctor Philosophy
Development of monoclonal antibodies against human neutrophil antigen 3 (HNA-3)
Associate Advisor
Other advisors: Dr Martina Jones
-
2021
Doctor Philosophy
An investigation of human antibodies to blood group antigens for the management of haemolytic disease of the fetus and newborn
Associate Advisor
Other advisors: Dr Martina Jones
-
2021
Doctor Philosophy
The Isolation and Characterisation of Novel Antibodies Against the Murine Beta Common Receptor Using Two Methods of Phage Display Biopanning
Associate Advisor
Other advisors: Dr Martina Jones
-
2021
Doctor Philosophy
Structural Studies of MNS Glycophorins to Guide the Discovery of Monoclonal Antibodies
Associate Advisor
Other advisors: Dr Martina Jones
-
2020
Doctor Philosophy
Development of novel bioconjugation strategies for creating cancer-targeting nanomaterials
Associate Advisor
Other advisors: Dr Martina Jones, Dr Christopher Howard
-
2018
Doctor Philosophy
Engineering lipid-coated calcium phosphate nanoparticles with multiple ligands to amplify in vivo tumor target delivery
Associate Advisor
Other advisors: Dr Christopher Howard
-
2015
Doctor Philosophy
Development of monoclonal antibodies as tools for analysis of PTPRJ function.
Associate Advisor
Other advisors: Dr Martina Jones
-
2014
Doctor Philosophy
Surface interactions and biochemical responses to bacterial attachment in bioleaching of minerals
Associate Advisor
Other advisors: Professor Anh Nguyen
Media
Enquiries
Contact Emeritus Professor Stephen Mahler directly for media enquiries about:
- Antibodies
- Biologic medicines
- Pharmaceuticals
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