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2024 Journal Article Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivationNöbel, Matthias, Barry, Craig, MacDonald, Michael A., Baker, Kym, Shave, Evan, Mahler, Stephen, Munro, Trent, Martínez, Verónica S., Nielsen, Lars K. and Marcellin, Esteban (2024). Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation. Biotechnology and Bioengineering, 121 (4), 1371-1383. doi: 10.1002/bit.28613 |
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2024 Journal Article Amino acid degradation pathway inhibitory by‐products trigger apoptosis in CHO cellsMartínez, Verónica S., Rodriguez, Karen, McCubbin, Timothy, Tong, Junjie, Mahler, Stephen, Shave, Evan, Baker, Kym, Munro, Trent P. and Marcellin, Esteban (2024). Amino acid degradation pathway inhibitory by‐products trigger apoptosis in CHO cells. Biotechnology Journal, 19 (2) ARTN e2300338, e2300338. doi: 10.1002/biot.202300338 |
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2023 Conference Publication Does Acute Psychedelic "Therapy" Persistently Reverse Reward-Related Anhedonia Induced by Early Life Adversity?Lawson, Kate, Ruiz, Christina, Martinez, Maricela, Coates, Darrien, Weems, Nya, Scofield, Michael and Mahler, Stephen (2023). Does Acute Psychedelic "Therapy" Persistently Reverse Reward-Related Anhedonia Induced by Early Life Adversity?. 62nd Annual Meeting of the American-College-of-Neuropsychopharmacology (ACNP), Tampa Fl, Dec 03-06, 2023. LONDON: SPRINGERNATURE. |
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2023 Journal Article Design of polarity-dependent immunosensors based on the structural analysis of engineered antibodiesIslam, Jiaul, Conroy, Paul, Fercher, Christian, Kim, Mijin, Yaari, Zvi, Jones, Martina, Bell, Toby D. M., Caradoc-Davies, Tom, Law, Ruby, Whisstock, James, Heller, Daniel, Mahler, Stephen and Corrie, Simon (2023). Design of polarity-dependent immunosensors based on the structural analysis of engineered antibodies. ACS Chemical Biology, 18 (8), 1863-1871. doi: 10.1021/acschembio.3c00303 |
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2022 Journal Article Evaluation of phage display biopanning strategies for the selection of anti-cell surface receptor antibodiesPanagides, Nadya, Zacchi, Lucia F., Souza, Mitchell J. De, Morales, Rodrigo A. V., Karnowski, Alexander, Liddament, Mark T., Owczarek, Catherine M., Mahler, Stephen M., Panousis, Con, Jones, Martina L. and Fercher, Christian (2022). Evaluation of phage display biopanning strategies for the selection of anti-cell surface receptor antibodies. International Journal of Molecular Sciences, 23 (15) 8470, 8470. doi: 10.3390/ijms23158470 |
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2022 Journal Article Engineering death resistance in CHO cells for improved perfusion cultureMacDonald, Michael A., Nöbel, Matthias, Martínez, Verónica S., Baker, Kym, Shave, Evan, Gray, Peter P., Mahler, Stephen, Munro, Trent, Nielsen, Lars K. and Marcellin, Esteban (2022). Engineering death resistance in CHO cells for improved perfusion culture. mAbs, 14 (1) e2083465, 1-13. doi: 10.1080/19420862.2022.2083465 |
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2022 Journal Article Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruptionJanowicz, Phillip W., Houston, Zachary H., Bunt, Jens, Fletcher, Nicholas L., Bell, Craig A., Cowin, Gary, Howard, Christopher B., Taslima, Dewan, Westra van Holthe, Nicholas, Prior, Amber, Soh, Vanessa, Ghosh, Saikat, Humphries, James, Huda, Pie, Mahler, Stephen M., Richards, Linda J. and Thurecht, Kristofer J. (2022). Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruption. Biomaterials, 283 121416, 121416. doi: 10.1016/j.biomaterials.2022.121416 |
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2022 Journal Article Modelling apoptosis resistance in CHO cells with CRISPR‐mediated knock‐outs of Bak1, Bax, and BokMacDonald, Michael A., Barry, Craig, Groves, Teddy, Martínez, Verónica S., Gray, Peter P., Baker, Kym, Shave, Evan, Mahler, Stephen, Munro, Trent, Marcellin, Esteban and Nielsen, Lars K. (2022). Modelling apoptosis resistance in CHO cells with CRISPR‐mediated knock‐outs of Bak1, Bax, and Bok. Biotechnology and Bioengineering, 119 (6), 1380-1391. doi: 10.1002/bit.28062 |
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2021 Journal Article Disulfide bond engineering of AppA phytase for increased thermostability requires co-expression of protein disulfide isomerase in Pichia pastorisNavone, Laura, Vogl, Thomas, Luangthongkam, Pawarisa, Blinco, Jo-Anne, Luna-Flores, Carlos H., Chen, Xiaojing, von Hellens, Juhani, Mahler, Stephen and Speight, Robert (2021). Disulfide bond engineering of AppA phytase for increased thermostability requires co-expression of protein disulfide isomerase in Pichia pastoris. Biotechnology for Biofuels, 14 (1) 80, 80. doi: 10.1186/s13068-021-01936-8 |
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2021 Journal Article In silico molecular dynamics of human glycophorin A (GPA) extracellular structureEkman, Serena, Flower, Robert, Mahler, Stephen, Gould, Alison, Barnard, Ross T., Hyland, Catherine, Jones, Martina, Malde, Alpeshkumar K. and Bui, Xuan T. (2021). In silico molecular dynamics of human glycophorin A (GPA) extracellular structure. Annals of Blood, 6 (June) 11. doi: 10.21037/aob-20-51 |
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2021 Journal Article Coagulation factor IX analysis in bioreactor cell culture supernatant predicts quality of the purified productZacchi, Lucia F., Roche-Recinos, Dinora, Pegg, Cassandra L., Phung, Toan K., Napoli, Mark, Aitken, Campbell, Sandford, Vanessa, Mahler, Stephen M., Lee, Yih Yean, Schulz, Benjamin L. and Howard, Christopher B. (2021). Coagulation factor IX analysis in bioreactor cell culture supernatant predicts quality of the purified product. Communications Biology, 4 (1) 390, 390. doi: 10.1038/s42003-021-01903-x |
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2021 Journal Article Recombinant antibody engineering enables reversible binding for continuous protein biosensingFercher, Christian, Jones, Martina L., Mahler, Stephen M. and Corrie, Simon R (2021). Recombinant antibody engineering enables reversible binding for continuous protein biosensing. ACS Sensors, 6 (3) acssensors.0c01510, 764-776. doi: 10.1021/acssensors.0c01510 |
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2021 Journal Article Incorporation of unnatural amino acid into antibody fragment for creating a stable antibody-drug conjugateWardiana, Andri, Jones, Martina L., Mahler, Stephen M. and Howard, Christopher B. (2021). Incorporation of unnatural amino acid into antibody fragment for creating a stable antibody-drug conjugate. Indonesian Journal of Pharmacy, 32 (1), 96-105. doi: 10.22146/ijp.1101 |
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2021 Journal Article Perfusion culture of Chinese Hamster Ovary cells for bioprocessing applicationsMacDonald, Michael A., Nöbel, Matthias, Roche Recinos, Dinora, Martínez, Verónica S., Schulz, Benjamin L., Howard, Christopher B., Baker, Kym, Shave, Evan, Lee, Yih Yean, Marcellin, Esteban, Mahler, Stephen, Nielsen, Lars Keld and Munro, Trent (2021). Perfusion culture of Chinese Hamster Ovary cells for bioprocessing applications. Critical Reviews in Biotechnology, 42 (7), 1-17. doi: 10.1080/07388551.2021.1998821 |
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2020 Journal Article A bispecific T cell engager targeting Glypican-1 redirects T cell cytolytic activity to kill prostate cancer cellsLund, Maria E., Howard, Christopher B., Thurecht, Kristofer J., Campbell, Douglas H., Mahler, Stephen M. and Walsh, Bradley J. (2020). A bispecific T cell engager targeting Glypican-1 redirects T cell cytolytic activity to kill prostate cancer cells. BMC Cancer, 20 (1) 1214, 1214. doi: 10.1186/s12885-020-07562-1 |
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2020 Journal Article Aggregates in blood filter chambers used from the plasma donations of anti-D donors: evaluation for monoclonal antibody discovery using phage displayMcGowan, Eunike C., Flower, Robert L., Jones, Martina L., Irving, David O., Barnard, Ross T., Hyland, Catherine A., Mahler, Stephen M. and Bui, Xuan T. (2020). Aggregates in blood filter chambers used from the plasma donations of anti-D donors: evaluation for monoclonal antibody discovery using phage display. Blood Transfusion , 19 (1), 64-72. doi: 10.2450/2020.0093-20 |
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2020 Journal Article Controlling the biological fate of micellar nanoparticles: balancing stealth and targetingSivaram, Amal J., Wardiana, Andri, Alcantara, Sheilajen, Sonderegger, Stefan E., Fletcher, Nicholas L., Houston, Zachary H., Howard, Christopher B., Mahler, Stephen M., Alexander, Cameron, Kent, Stephen J., Bell, Craig A. and Thurecht, Kristofer J. (2020). Controlling the biological fate of micellar nanoparticles: balancing stealth and targeting. ACS Nano, 14 (10) acsnano.0c06033, 13739-13753. doi: 10.1021/acsnano.0c06033 |
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2020 Journal Article ‘Omics driven discoveries of gene targets for apoptosis attenuation in CHO cellsOrellana, Camila A., Martínez, Verónica S., MacDonald, Michael A., Henry, Matthew N., Gillard, Marianne, Gray, Peter P., Nielsen, Lars K., Mahler, Stephen and Marcellin, Esteban (2020). ‘Omics driven discoveries of gene targets for apoptosis attenuation in CHO cells. Biotechnology and Bioengineering, 118 (1) bit.27548, 481-490. doi: 10.1002/bit.27548 |
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2020 Journal Article Phage display derived monoclonal antibodies: from bench to bedsideAlfaleh, Mohamed A., Alsaab, Hashem O., Mahmoud, Ahmad Bakur, Alkayyal, Almohanad A., Jones, Martina L., Mahler, Stephen M. and Hashem, Anwar M. (2020). Phage display derived monoclonal antibodies: from bench to bedside. Frontiers in Immunology, 11 1986, 1986. doi: 10.3389/fimmu.2020.01986 |
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2020 Journal Article Targeting the undruggable: emerging technologies in antibody delivery against intracellular targetsNiamsuphap, Suchada, Fercher, Christian, Kumble, Sumukh, Huda, Pie, Mahler, Stephen M. and Howard, Christopher B. (2020). Targeting the undruggable: emerging technologies in antibody delivery against intracellular targets. Expert Opinion on Drug Delivery, 17 (9), 1189-1211. doi: 10.1080/17425247.2020.1781088 |
