Overview
Background
Professor Stephen Mahler is a Senior Group Leader at the Australian Institute for Bioengineering and Nanotechnology and Director of the Australian Research Council Training Centre for Biopharmaceutical Innovation (CBI), University of Queensland. Professor Mahler is a biotechnologist with a focus on R&D of recombinant-DNA derived protein biopharmaceuticals, drug delivery systems and nanomedicines. Professor Mahler has a record of translational research success and engages extensively with industry associated with the biomedical sciences both nationally and internationally.
Research within CBI covers three thematic research areas; discovery of new biopharmaceuticals, engineering cells for production of protein-based biopharmaceuticals and advanced manufacturing for industrial production. A current research interest is at the interface of the life sciences and materials science, using a synthetic biology approach for creating novel therapeutic entities as well as new systems for drug delivery.
Professor Mahler has a strong interest in education and training and was formerly Head of the Chemical and Biological Engineering Plan at the University of Queensland (2010-2016). Other educational initiatives include development of Masters Programs and a Continuing Professional Development program in the area of biopharmaceuticals. The CPD program is available to stakeholders in the industry, both in Australia and internationally.
Availability
- Emeritus Professor Stephen Mahler is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Research impacts
Professor Mahler has a strong engagement with industry both nationally and internationally, that through collaborative research has led to some significant translational outcomes including clinical trial of biopharmaceutical drug candidates through to approval. The Australian Research Council Training Centre for Biopharmaceutical Innovation is a consortium of partners including government, the University of Queensland and several industry partners, with a goal of contributing to the transformation of the biopharmaceutical industry. Through the Centre and the CPD Program in Biopharmaceuticals, Professor Mahler continues to work with stakeholders to ensure a vibrant future for the biopharmaceutical industry in Australia.
Works
Search Professor Stephen Mahler’s works on UQ eSpace
2018
Journal Article
Recent advances in the generation of antibody-nanomaterial conjugates
Sivaram, Amal J, Wardiana, Andri, Howard, Christopher B, Mahler, Stephen M and Thurecht, Kristofer J (2018). Recent advances in the generation of antibody-nanomaterial conjugates. Advanced Healthcare Materials, 7 (1) 1700607. doi: 10.1002/adhm.201700607
2017
Journal Article
Targeting mesothelin receptors with drug-loaded bacterial nanocells suppresses human mesothelioma tumour growth in mouse xenograft models
Alfaleh, Mohamed A., Howard, Christopher B., Sedliarou, Ilya, Jones, Martina L., Gudhka, Reema, Vanegas, Natasha, Weiss, Jocelyn, Suurbach, Julia H., de Bakker, Christopher J., Milne, Michael R., Rumballe, Bree A., MacDiarmid, Jennifer A., Brahmbhatt, Himanshu and Mahler, Stephen M. (2017). Targeting mesothelin receptors with drug-loaded bacterial nanocells suppresses human mesothelioma tumour growth in mouse xenograft models. Plos One, 12 (10) e0186137, e0186137. doi: 10.1371/journal.pone.0186137
2017
Journal Article
Insights into the interfacial structure-function of poly(ethylene glycol)-decorated peptide-stabilised nanoscale emulsions
Tayeb, Hossam H, Piantavigna, Stefania, Howard, Christopher B, Nouwens, Amanda, Mahler, Stephen M, Middelberg, Anton P J, He, Lizhong, Holt, Stephen A and Sainsbury, Frank (2017). Insights into the interfacial structure-function of poly(ethylene glycol)-decorated peptide-stabilised nanoscale emulsions. Soft matter, 13 (43), 7953-7961. doi: 10.1039/c7sm01614j
2017
Journal Article
Cell-free pipeline for discovery of thermotolerant xylanases and endo-1,4-β-glucanases
Gagoski, Dejan, Shi, Zhenyu, Nielsen, Lars Keld, Vickers, Claudia E., Mahler, Stephen, Speight, Robert, Johnston, Wayne A. and Alexandrov, Kirill (2017). Cell-free pipeline for discovery of thermotolerant xylanases and endo-1,4-β-glucanases. Journal of Biotechnology, 259, 191-198. doi: 10.1016/j.jbiotec.2017.07.014
2017
Journal Article
Strategies for Selecting Membrane Protein-Specific Antibodies using Phage Display with Cell-Based Panning
Alfaleh, Mohamed A., Jones, Martina L., Howard, Christopher B. and Mahler, Stephen M. (2017). Strategies for Selecting Membrane Protein-Specific Antibodies using Phage Display with Cell-Based Panning. Antibodies, 6 (3) 10, 1-19. doi: 10.3390/antib6030010
2017
Journal Article
Safety of biologics therapy: monoclonal antibodies, cytokines, fusion proteins, hormones, enzymes, coagulation proteins, vaccines, botulinum toxins
Mahler, Stephen (2017). Safety of biologics therapy: monoclonal antibodies, cytokines, fusion proteins, hormones, enzymes, coagulation proteins, vaccines, botulinum toxins. mAbs, 9 (6), 885-888. doi: 10.1080/19420862.2017.1343709
2017
Journal Article
Isolation of serotype-specific antibodies against dengue virus non-structural protein 1 using phage display and application in a multiplexed serotyping assay
Lebani, Kebaneilwe, Jones, Martina L., Watterson, Daniel, Ranzoni, Andrea, Traves, Renee J., Young, Paul R. and Mahler, Stephen M. (2017). Isolation of serotype-specific antibodies against dengue virus non-structural protein 1 using phage display and application in a multiplexed serotyping assay. PLoS One, 12 (7) e0180669, e0180669. doi: 10.1371/journal.pone.0180669
2017
Journal Article
Computational identification of antibody epitopes on the dengue virus NS1 protein
Jones, Martina L., Legge, Fiona S., Lebani, Kebaneilwe, Mahler, Stephen M., Young, Paul R., Watterson, Daniel, Treutlein, Herbert R. and Zeng, Jun (2017). Computational identification of antibody epitopes on the dengue virus NS1 protein. Molecules, 22 (4) 607, 607. doi: 10.3390/molecules22040607
2016
Journal Article
Beyond antibodies: development of a novel protein scaffold based on human chaperonin 10
Alsultan, Abdulkarim M., Chin, David Y., Howard, Christopher B., de Bakker, Christopher J., Jones, Martina L. and Mahler, Stephen M. (2016). Beyond antibodies: development of a novel protein scaffold based on human chaperonin 10. Scientific Reports, 5 (37348) 37348, 37348. doi: 10.1038/srep37348
2016
Journal Article
Nanoyeast and other cell envelope compositions for protein studies and biosensor applications
Grewal, Yadveer S., Shiddiky, Muhammad J. A., Mahler, Stephen M., Cangelosi, Gerard A. and Trau, Matt (2016). Nanoyeast and other cell envelope compositions for protein studies and biosensor applications. ACS Applied Materials and Interfaces, 8 (45), 30649-30664. doi: 10.1021/acsami.6b09263
2016
Journal Article
Biosimilars approved for treatment of inflammatory rheumatological diseases
Mahler, Stephen M., Wardiana, Andri, Jones, Martina L., De Bakker, Christopher J., Graham, Garry G. and Howard, Christopher B. (2016). Biosimilars approved for treatment of inflammatory rheumatological diseases. International Journal of Rheumatic Diseases, 19 (11), 1043-1048. doi: 10.1111/1756-185X.13037
2016
Journal Article
Targeted nanomaterials: overcoming instability of antibody-nanomaterial conjugates: next generation targeted nanomedicines using bispecific antibodies (Adv. Healthcare Mater. 16/2016)
Howard, Christopher B., Fletcher, Nicholas, Houston, Zachary H., Fuchs, Adrian V., Boase, Nathan R. B., Simpson, Joshua D., Raftery, Lyndon J., Ruder, Tim, Jones, Martina L., de Bakker, Christopher J., Mahler, Stephen M. and Thurecht, Kristofer J. (2016). Targeted nanomaterials: overcoming instability of antibody-nanomaterial conjugates: next generation targeted nanomedicines using bispecific antibodies (Adv. Healthcare Mater. 16/2016). Advanced Healthcare Materials, 5 (16), 1994-1994. doi: 10.1002/adhm.201670084
2016
Journal Article
Overcoming Instability of Antibody-Nanomaterial Conjugates: Next Generation Targeted Nanomedicines Using Bispecific Antibodies
Howard, Christopher B., Fletcher, Nicholas, Houston, Zachary H., Fuchs, Adrian V., Boase, Nathan R. B., Simpson, Joshua D., Raftery, Lyndon J., Ruder, Tim, Jones, Martina L., de Bakker, Christopher J., Mahler, Stephen M. and Thurecht, Kristofer J. (2016). Overcoming Instability of Antibody-Nanomaterial Conjugates: Next Generation Targeted Nanomedicines Using Bispecific Antibodies. Advanced Healthcare Materials, 5 (16), 2055-2068. doi: 10.1002/adhm.201600263
2016
Journal Article
Targeting membrane proteins for antibody discovery using phage display
Jones, Martina L., Alfaleh, Mohamed A., Kumble, Sumukh, Zhang, Shuo, Osborne, Geoffrey W., Yeh, Michael, Arora, Neetika, Hou, Jeff Jia Cheng, Howard, Christopher B., Chin, David Y. and Mahler, Stephen M. (2016). Targeting membrane proteins for antibody discovery using phage display. Scientific Reports, 6 (1) 26240, 26240. doi: 10.1038/srep26240
2016
Journal Article
CMRF-56+ blood dendritic cells loaded with mRNA induce effective antigen-specific cytotoxic T lymphocyte responses
Fromm, Phillip D., Papadimitrious, Michael S., Hsu, Jennifer L., Van Kooten Losio, Nicolas, Verma, Nirupama D., Lo, Tsun Ho, Silveira, Pablo A., Bryant, Christian E., Turtle, Cameron J., Prue, Rebecca L., Vukovic, Peter, Munster, David J., Nagasaki, Tomoko, Barnard, Ross T., Mahler, Stephen M., Anguille, Sébastien A., Berneman, Zwi, Horvath, Lisa G., Bradstock, Kenneth F., Joshua, Douglas E., Clark, Georgina J. and Hart, Derek N. J. (2016). CMRF-56+ blood dendritic cells loaded with mRNA induce effective antigen-specific cytotoxic T lymphocyte responses. OncoImmunology, 5 (6) e1168555, e1168555. doi: 10.1080/2162402X.2016.1168555
2016
Journal Article
Biosensing made easy with PEG-targeted bi-specific antibodies
Raftery, Lyndon J., Grewal, Yadveer S., Howard, Christopher B., Jones, Martina L., Shiddiky, Muhammad J. A., Carrascosa, Laura G., Thurecht, Kristofer J., Mahler, Stephen M. and Trau, Matt (2016). Biosensing made easy with PEG-targeted bi-specific antibodies. Chemical Communications, 52 (33), 5730-5733. doi: 10.1039/C6CC01916A
2016
Book Chapter
Interleukin-12/23 Inhibitors: Ustekinumab
Pile, Kevin D., Graham, Garry G. and Mahler, Stephen M. (2016). Interleukin-12/23 Inhibitors: Ustekinumab. Encyclopedia of Inflammatory Diseases. (pp. 1-3) edited by Michael J. Parnham. Basel Switzerland: Springer. doi: 10.1007/978-3-0348-0620-6_232-1
2015
Journal Article
Immunosuppressive human anti-CD83 monoclonal antibody depletion of activated dendritic cells in transplantation.
Seldon, T. A., Pryor, R., Palkova, A., Jones, M. L., Verma, N. D., Findova, M., Braet, K., Sheng, Y., Fan, Y., Zhou, Y. Y., Marks, J. D., Munro, T., Mahler, S. M., Barnard, R. T., Fromm, P. D., Silveira, P. A., Elgundi, Z., Ju, X., Clark, G. J., Bradstock, K. F., Munster, D. J. and Hart, D. N. J. (2015). Immunosuppressive human anti-CD83 monoclonal antibody depletion of activated dendritic cells in transplantation.. Leukemia, 30 (3), 692-700. doi: 10.1038/leu.2015.231
2015
Journal Article
Effect of energy source, salt concentration and loading force on colloidal interactions between Acidithiobacillus ferrooxidans cells and mineral surfaces
Diao, Mengxue, Nguyen, Tuan A.H., Taran, Elena, Mahler, Stephen M. and Nguyen, Anh V. (2015). Effect of energy source, salt concentration and loading force on colloidal interactions between Acidithiobacillus ferrooxidans cells and mineral surfaces. Colloids and Surfaces B: Biointerfaces, 132, 271-280. doi: 10.1016/j.colsurfb.2015.05.026
2015
Journal Article
Preparation of optimized lipid-coated calcium phosphate nanoparticles for enhanced in vitro gene delivery to breast cancer cells
Tang, Jie, Li, Li, Howard, Christopher B., Mahler, Stephen M., Huang, Leaf and Xu, Zhi Ping (2015). Preparation of optimized lipid-coated calcium phosphate nanoparticles for enhanced in vitro gene delivery to breast cancer cells. Journal of Materials Chemistry B, 3 (33), 6805-6812. doi: 10.1039/c5tb00912j
Funding
Past funding
Supervision
Availability
- Emeritus Professor Stephen Mahler is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Engineering Novel Theranostics for High Grade Glioma Through Site-Specific EphA2 Antibody Modification
Associate Advisor
Other advisors: Dr Christopher Howard, Dr Martina Jones
-
Doctor Philosophy
Biosimilar litigation and market entry
Associate Advisor
Other advisors: Professor Avril Robertson, Dr Lisette Pregelj
-
Doctor Philosophy
From Target Discovery to Therapeutic Antibodies
Associate Advisor
Other advisors: Associate Professor Jessica Mar, Dr Lucia Zacchi
Completed supervision
-
2021
Doctor Philosophy
Characterising murine red blood cell phenotypes: the impact of genetic variants in Klf1 and Casd1
Principal Advisor
Other advisors: Professor Benjamin Schulz
-
2020
Doctor Philosophy
Engineering Chinese Hamster Ovary Cells for Improved Monoclonal Antibody Productivity by Modulating Feedback Regulation of the Secretory Pathway
Principal Advisor
Other advisors: Dr Marianne Gillard, Professor Peter Gray
-
2019
Doctor Philosophy
Isolation and characterisation of antibodies against human and canine EphA2_ targets for comparative studies in brain cancer
Principal Advisor
Other advisors: Dr Martina Jones, Professor Andrew Whittaker, Dr Christopher Howard
-
2018
Doctor Philosophy
Isolation and development of antibodies for active targeting of nanocells for cancer therapy
Principal Advisor
Other advisors: Dr Martina Jones, Dr Christopher Howard
-
2017
Master Philosophy
Development of anti-PEG bispecific antibodies for targeting PEGylated nanoparticles to tumour cells
Principal Advisor
Other advisors: Dr Christopher Howard
-
2017
Doctor Philosophy
Development and Application of Novel Biosensor Technologies
Principal Advisor
Other advisors: Dr Martina Jones, Dr Christopher Howard
-
2015
Doctor Philosophy
Beyond antibodies: development of a novel molecular scaffold based on human Chaperonin 10
Principal Advisor
-
2015
Doctor Philosophy
Design, Assembly and Characterisation of a Multifunctional, Self-Assembled Nanoparticle incorporating Antibody Fragments
Principal Advisor
Other advisors: Dr Martina Jones, Professor Kristofer Thurecht
-
2015
Doctor Philosophy
Engineering bispecific antibodies for targeted delivery of cytotoxin-loaded nanoparticles to tumour cells
Principal Advisor
Other advisors: Dr Martina Jones
-
2015
Doctor Philosophy
Antibody Discovery for Development of a Serotyping Dengue Virus NS1 Capture Assay
Principal Advisor
Other advisors: Dr Martina Jones
-
2024
Doctor Philosophy
Development of Antibody Delivery Systems Against Intracellular Targets
Associate Advisor
Other advisors: Dr Christopher Howard
-
2023
Doctor Philosophy
Discovery and Development of a Novel Human Glypican-1 Monoclonal Antibody for Targeting Solid Cancers
Associate Advisor
Other advisors: Dr Martina Jones, Dr Christopher Howard
-
2022
Doctor Philosophy
Dielectric spectroscopy and significance of blood analytes in the microwave and millimetre-wave bands
Associate Advisor
Other advisors: Professor Amin Abbosh
-
2022
Doctor Philosophy
Development of monoclonal antibodies against human neutrophil antigen 3 (HNA-3)
Associate Advisor
Other advisors: Dr Martina Jones
-
2022
Doctor Philosophy
Investigating monoclonal antibody targets on P. falciparum and red blood cell antigens using experimental mouse model and phage display technology
Associate Advisor
Other advisors: Dr Martina Jones
-
2021
Doctor Philosophy
The Isolation and Characterisation of Novel Antibodies Against the Murine Beta Common Receptor Using Two Methods of Phage Display Biopanning
Associate Advisor
Other advisors: Dr Martina Jones
-
2021
Doctor Philosophy
An investigation of human antibodies to blood group antigens for the management of haemolytic disease of the fetus and newborn
Associate Advisor
Other advisors: Dr Martina Jones
-
2021
Doctor Philosophy
Structural Studies of MNS Glycophorins to Guide the Discovery of Monoclonal Antibodies
Associate Advisor
Other advisors: Dr Martina Jones
-
2020
Doctor Philosophy
Development of novel bioconjugation strategies for creating cancer-targeting nanomaterials
Associate Advisor
Other advisors: Dr Martina Jones, Dr Christopher Howard
-
2018
Doctor Philosophy
Engineering lipid-coated calcium phosphate nanoparticles with multiple ligands to amplify in vivo tumor target delivery
Associate Advisor
Other advisors: Dr Christopher Howard
-
2015
Doctor Philosophy
Development of monoclonal antibodies as tools for analysis of PTPRJ function.
Associate Advisor
Other advisors: Dr Martina Jones
-
2014
Doctor Philosophy
Surface interactions and biochemical responses to bacterial attachment in bioleaching of minerals
Associate Advisor
Other advisors: Professor Anh Nguyen
Media
Enquiries
Contact Emeritus Professor Stephen Mahler directly for media enquiries about:
- Antibodies
- Biologic medicines
- Pharmaceuticals
Need help?
For help with finding experts, story ideas and media enquiries, contact our Media team: