Overview
Availability
- Professor Avril Robertson is:
- Available for supervision
Works
Search Professor Avril Robertson’s works on UQ eSpace
2024
Journal Article
Insights into the structure of NLR family member X1: Paving the way for innovative drug discovery
Jewell, Shannon, Nguyen, Thanh Binh, Ascher, David B. and Robertson, Avril A.B. (2024). Insights into the structure of NLR family member X1: Paving the way for innovative drug discovery. Computational and Structural Biotechnology Journal, 23, 3506-3513. doi: 10.1016/j.csbj.2024.09.013
2024
Journal Article
Author Correction: Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration
Wooff, Yvette, Fernando, Nilisha, Wong, Josephine H. C., Dietrich, Catherine, Aggio-Bruce, Riemke, Chu-Tan, Joshua A., Robertson, Avril A. B., Doyle, Sarah L., Man, Si Ming and Natoli, Riccardo (2024). Author Correction: Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration. Scientific Reports, 14 (1) 21585, 21585. doi: 10.1038/s41598-024-71519-8
2024
Journal Article
Are manufacturing patents to blame for biosimilar market launch delays?
Williamson, Rhys, Munro, Trent, Ascher, David, Robertson, Avril and Pregelj, Lisette (2024). Are manufacturing patents to blame for biosimilar market launch delays?. Value in Health, 27 (3), 287-293. doi: 10.1016/j.jval.2023.12.005
2024
Journal Article
o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2
Rahaman, Md. Habibur, Thygesen, Sara J., Maxwell, Michael J., Kim, Hyoyoung, Mudai, Prerna, Nanson, Jeffrey D., Jia, Xinying, Vajjhala, Parimala R., Hedger, Andrew, Vetter, Irina, Haselhorst, Thomas, Robertson, Avril A. B., Dymock, Brian, Ve, Thomas, Mobli, Mehdi, Stacey, Katryn J. and Kobe, Bostjan (2024). o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2. Journal of Enzyme Inhibition and Medicinal Chemistry, 39 (1) 2313055, 2313055. doi: 10.1080/14756366.2024.2313055
2024
Journal Article
MCC950 reduces autophagy and improves cognitive function by inhibiting NLRP3-dependent neuroinflammation in a rat model of Alzheimer's disease
Naeem, Abdul, Prakash, Ravi, Kumari, Neha, Ali Khan, Mohsin, Quaiyoom Khan, Abdul, Uddin, Shahab, Verma, Sandeep, Robertson, Avril A.B., Boltze, Johannes and Shadab Raza, Syed (2024). MCC950 reduces autophagy and improves cognitive function by inhibiting NLRP3-dependent neuroinflammation in a rat model of Alzheimer's disease. Brain, Behavior, and Immunity, 116, 70-84. doi: 10.1016/j.bbi.2023.11.031
2024
Journal Article
The design, synthesis, and biological evaluation of 5,6,7,8-tetrahydropteridines as anti-inflammatory compounds
Chen, Rachel M., Emming, Stefan, Cinnamon, Roseanna, Cameron, Jacob P., Schroder, Kate, Kobe, Bostjan and Robertson, Avril A. B. (2024). The design, synthesis, and biological evaluation of 5,6,7,8-tetrahydropteridines as anti-inflammatory compounds. Organic & Biomolecular Chemistry. doi: 10.1039/d4ob01453g
2023
Journal Article
Characterization and inhibition of inflammasome responses in severe and non-severe asthma
Horvat, Jay C., Kim, Richard Y., Weaver, Natasha, Augood, Christopher, Brown, Alexandra C., Donovan, Chantal, Dupre, Pierrick, Gunawardhana, Lakshitha, Mayall, Jemma R., Hansbro, Nicole G., Robertson, Avril A. B., O’Neill, Luke A. J., Cooper, Matthew A., Holliday, Elizabeth G., Hansbro, Philip M. and Gibson, Peter G. (2023). Characterization and inhibition of inflammasome responses in severe and non-severe asthma. Respiratory Research, 24 (1) 303, 1-14. doi: 10.1186/s12931-023-02603-2
2023
Journal Article
Correction: Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice
Overman, Jeroen, Fontaine, Frank, Moustaqil, Mehdi, Mittal, Deepak, Sierecki, Emma, Sacilotto, Natalia, Zuegg, Johannes, Robertson, Avril AB, Holmes, Kelly, Salim, Angela A, Mamidyala, Sreeman, Butler, Mark S, Robinson, Ashley S, Lesieur, Emmanuelle, Johnston, Wayne, Alexandrov, Kirill, Black, Brian L, Hogan, Benjamin M, De Val, Sarah, Capon, Robert J, Carroll, Jason S, Bailey, Timothy L, Koopman, Peter, Jauch, Ralf, Cooper, Matthew A, Gambin, Yann and Francois, Mathias (2023). Correction: Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. eLife, 12 ARTN e90408. doi: 10.7554/elife.90408
2023
Journal Article
Response to comment on “Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice”
Albornoz, Eduardo A., Gordon, Richard, Kumar, Vinod, Robertson, Avril A. B., Schroder, Kate and Woodruff, Trent M. (2023). Response to comment on “Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice”. Science Translational Medicine, 15 (696) adh0604, 1-4. doi: 10.1126/scitranslmed.adh0604
2023
Journal Article
NLRP3 inflammasome-targeting nanomicelles for preventing ischemia–reperfusion-induced inflammatory injury
Prakash, Ravi, Vyawahare, Akshay, Sakla, Rahul, Kumari, Neha, Kumar, Ajay, Ansari, Md. Meraj, Kanika,, Jori, Chandrashekhar, Waseem, Arshi, Siddiqui, Abu Junaid, Khan, Mohsin Ali, Robertson, Avril A.B., Khan, Rehan and Raza, Syed Shadab (2023). NLRP3 inflammasome-targeting nanomicelles for preventing ischemia–reperfusion-induced inflammatory injury. ACS Nano, 17 (9), 8680-8693. doi: 10.1021/acsnano.3c01760
2023
Journal Article
Clostridium perfringens virulence factors are nonredundant activators of the NLRP3 inflammasome
Mathur, Anukriti, Kay, Callum, Xue, Yansong, Pandey, Abhimanu, Lee, Jiwon, Jing, Weidong, Enosi Tuipulotu, Daniel, Lo Pilato, Jordan, Feng, Shouya, Ngo, Chinh, Zhao, Anyang, Shen, Cheng, Rug, Melanie, Miosge, Lisa A, Atmosukarto, Ines I, Price, Jason D, Ali, Sidra A, Gardiner, Elizabeth E, Robertson, Avril AB, Awad, Milena M, Lyras, Dena, Kaakoush, Nadeem O and Man, Si Ming (2023). Clostridium perfringens virulence factors are nonredundant activators of the NLRP3 inflammasome. EMBO Reports, 24 (6) e54600, e54600. doi: 10.15252/embr.202254600
2023
Journal Article
MCC950 regulates stem cells destiny through modulating SIRT3-NLRP3 inflammasome dynamics during oxygen glucose deprivation
Prakash, Ravi, Kumari, Neha, Siddiqui, Abu Junaid, Khan, Abdul Quaiyoom, Khan, Mohsin Ali, Khan, Rehan, Haque, Rizwanul, Robertson, Avril A. B., Boltze, Johannes and Raza, Syed Shadab (2023). MCC950 regulates stem cells destiny through modulating SIRT3-NLRP3 inflammasome dynamics during oxygen glucose deprivation. Stem Cell Reviews and Reports, 19 (5), 1415-1426. doi: 10.1007/s12015-023-10520-6
2023
Journal Article
Immunity against Moraxella catarrhalis requires guanylate‐binding proteins and caspase‐11‐ NLRP3 inflammasomes
Enosi Tuipulotu, Daniel, Feng, Shouya, Pandey, Abhimanu, Zhao, Anyang, Ngo, Chinh, Mathur, Anukriti, Lee, Jiwon, Shen, Cheng, Fox, Daniel, Xue, Yansong, Kay, Callum, Kirkby, Max, Lo Pilato, Jordan, Kaakoush, Nadeem O, Webb, Daryl, Rug, Melanie, Robertson, Avril AB, Tessema, Melkamu B, Pang, Stanley, Degrandi, Daniel, Pfeffer, Klaus, Augustyniak, Daria, Blumenthal, Antje, Miosge, Lisa A, Brüstle, Anne, Yamamoto, Masahiro, Reading, Patrick C, Burgio, Gaetan and Man, Si Ming (2023). Immunity against Moraxella catarrhalis requires guanylate‐binding proteins and caspase‐11‐ NLRP3 inflammasomes. The EMBO Journal, 42 (6) e112558, e112558. doi: 10.15252/embj.2022112558
2022
Journal Article
Increased core body temperature exacerbates defective protein prenylation in mouse models of mevalonate kinase deficiency
Munoz, Marcia A., Skinner, Oliver P., Masle-Farquhar, Etienne, Jurczyluk, Julie, Xiao, Ya, Fletcher, Emma K., Kristianto, Esther, Hodson, Mark P., O’Donoghue, Seán I., Kaur, Sandeep, Brink, Robert, Zahra, David G., Deenick, Elissa K., Perry, Kristen A., Robertson, Avril A.B., Mehr, Sam, Hissaria, Pravin, Mulders-Manders, Catharina M., Simon, Anna and Rogers, Michael J. (2022). Increased core body temperature exacerbates defective protein prenylation in mouse models of mevalonate kinase deficiency. Journal of Clinical Investigation, 132 (19) e160929, 1-16. doi: 10.1172/jci160929
2022
Journal Article
AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans
Wizrah, Maha S. I., Chua, Sheena M. H., Luo, Zhenyao, Manik, Mohammad K., Pan, Mengqi, Whyte, Jessica M. L., Robertson, Avril A. B., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2022). AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans. Journal of Biological Chemistry, 298 (10) 102453, 102453. doi: 10.1016/j.jbc.2022.102453
2022
Conference Publication
Interaction between type 2 cytokine and inflammasome responses in the pathogenesis of obesity-associated asthma
Pinkerton, J., Kim, R., Brown, A., Rae, B., Donovan, C., Mayall, J., Ali, M. K., Scott, H., Berthon, B., Baines, K., Starkey, M., Kermani, N., Guo, Y., Robertson, A., O'Neill, L., Adcock, , Cooper, M., Gibson, P., Wood, L., Hansbro, P. and Horvat, J. (2022). Interaction between type 2 cytokine and inflammasome responses in the pathogenesis of obesity-associated asthma. International Congress of the European-Respiratory-Society (ERS), Barcelona Spain, Sep 04-06, 2022. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. doi: 10.1183/13993003.congress-2022.871
2022
Journal Article
Clostridium septicum α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins
Jing, Weidong, Pilato, Jordan Lo, Kay, Callum, Feng, Shouya, Tuipulotu, Daniel Enosi, Mathur, Anukriti, Shen, Cheng, Ngo, Chinh, Zhao, Anyang, Miosge, Lisa A., Ali, Sidra A., Gardiner, Elizabeth E., Awad, Milena M., Lyras, Dena, Robertson, Avril A. B., Kaakoush, Nadeem O. and Man, Si Ming (2022). Clostridium septicum α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins. Science Immunology, 7 (71) eabm1803, 1-17. doi: 10.1126/sciimmunol.abm1803
2022
Journal Article
Prevention of the foreign body response to implantable medical devices by inflammasome inhibition
Barone, Damiano G., Carnicer-Lombarte, Alejandro, Tourlomousis, Panagiotis, Hamilton, Russell S., Prater, Malwina, Rutz, Alexandra L., Dimov, Ivan B., Malliaras, George G., Lacour, Stephanie P., Robertson, Avril A. B., Franze, Kristian, Fawcett, James W. and Bryant, Clare E. (2022). Prevention of the foreign body response to implantable medical devices by inflammasome inhibition. Proceedings of the National Academy of Sciences, 119 (12) e2115857119, e2115857119. doi: 10.1073/pnas.2115857119
2022
Journal Article
Interleukin-1β suppression dampens inflammatory leukocyte production and uptake in atherosclerosis
Hettwer, Jan, Hinterdobler, Julia, Miritsch, Benedikt, Deutsch, Marcus-André, Li, Xinghai, Mauersberger, Carina, Moggio, Aldo, Braster, Quinte, Gram, Hermann, Robertson, Avril A. B., Cooper, Matthew A., Groß, Olaf, Krane, Markus, Weber, Christian, Koenig, Wolfgang, Soehnlein, Oliver, Adamstein, Nicholas H., Ridker, Paul, Schunkert, Heribert, Libby, Peter, Kessler, Thorsten and Sager, Hendrik B. (2022). Interleukin-1β suppression dampens inflammatory leukocyte production and uptake in atherosclerosis. Cardiovascular Research, 118 (13) ARTN cvab337, 2778-2791. doi: 10.1093/cvr/cvab337
2022
Journal Article
Aim2 suppresses cigarette smoke-induced neutrophil recruitment, neutrophil caspase-1 activation and anti-Ly6G-mediated neutrophil depletion
Donovan, Chantal, Kim, Richard Y, Galvao, Izabela, Jarnicki, Andrew G, Brown, Alexandra C, Jones-Freeman, Bernadette, Gomez, Henry M, Wadhwa, Ridhima, Hortle, Elinor, Jayaraman, Ranjith, Khan, Haroon, Pickles, Sophie, Sahu, Priyanka, Chimankar, Vrushali, Tu, Xiaofan, Ali, Md Khadem, Mayall, Jemma R, Nguyen, Duc H, Budden, Kurtis F, Kumar, Vinod, Schroder, Kate, Robertson, Avril AB, Cooper, Matthew A, Wark, Peter AB, Oliver, Brian G, Horvat, Jay C and Hansbro, Philip M (2022). Aim2 suppresses cigarette smoke-induced neutrophil recruitment, neutrophil caspase-1 activation and anti-Ly6G-mediated neutrophil depletion. Immunology and Cell Biology, 100 (4), 235-249. doi: 10.1111/imcb.12537
Funding
Current funding
Supervision
Availability
- Professor Avril Robertson is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Breaking the chain of inflammation through targetting NLR proteins
Principal Advisor
Other advisors: Professor David Ascher
-
Doctor Philosophy
Targeting Deadly Mycotic Infection
Principal Advisor
Other advisors: Dr Kylie Agnew-Francis, Professor James Fraser
-
Doctor Philosophy
Therapeutic Resolution of Inflammation in the Central Nervous System for Neuroprotection in Parkinson's Disease
Principal Advisor
Other advisors: Professor David Ascher
-
Doctor Philosophy
Novel antifungal peptides targeting deadly mycotic infections
Principal Advisor
Other advisors: Dr Kylie Agnew-Francis, Professor James Fraser
-
Doctor Philosophy
Targetting Candida Auris
Principal Advisor
Other advisors: Dr Kylie Agnew-Francis, Professor James Fraser
-
Doctor Philosophy
Aiming at Inflammasomes
Principal Advisor
-
Doctor Philosophy
Antifungal agents to target disseminated mycoses
Associate Advisor
Other advisors: Dr Kylie Agnew-Francis, Professor James Fraser
-
Doctor Philosophy
Biosimilar litigation and market entry
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler, Dr Lisette Pregelj
-
Doctor Philosophy
The role of metabolic adaptation for virulence and persistence of Haemophilus influenzae in the host
Associate Advisor
Other advisors: Professor Ulrike Kappler
-
Doctor Philosophy
Inflammasome inhibitors in disease: Is there a therapeutic trade-off of compromised host defence?
Associate Advisor
Other advisors: Professor Kate Schroder, Dr Sabrina Sofia Burgener
-
Master Philosophy
Therapeutic targetting of proteins involved in Toll-like receptor signalling
Associate Advisor
Other advisors: Professor Bostjan Kobe
-
Doctor Philosophy
Antifungal agents to target disseminated mycoses
Associate Advisor
Other advisors: Dr Kylie Agnew-Francis, Professor James Fraser
Completed supervision
-
2023
Doctor Philosophy
Targeting NLRP3 and Dopamine Receptors for Treatment Resistant Depression
Principal Advisor
Other advisors: Associate Professor Susannah Tye
-
2023
Doctor Philosophy
Kinase Inhibitors for the Treatment of Inflammatory Disease
Principal Advisor
Other advisors: Professor Bostjan Kobe
-
2020
Doctor Philosophy
Teaching Old Molecules New Tricks: Repurposing Investigational Drugs as Chemical Probes
Principal Advisor
-
2017
Doctor Philosophy
Synthesis and biological activity of sulfonylurea derivatives as NLRP3 inhibitors
Principal Advisor
-
2023
Doctor Philosophy
Biomarkers of Treatment-Resistant Depression and Predictors of Antidepressant Response
Associate Advisor
Other advisors: Associate Professor Susannah Tye
-
2023
Doctor Philosophy
Decontamination of fentanyl and fentanyl analogues
Associate Advisor
Other advisors: Professor Joanne Blanchfield
-
2019
Doctor Philosophy
Novel antifungals selectively targeting the purine metabolic pathway
Associate Advisor
Other advisors: Professor James Fraser, Professor Bostjan Kobe
-
2019
Doctor Philosophy
Pharmacological targeting of the inflammasome: towards novel therapeutics for Parkinson's disease
Associate Advisor
Other advisors: Dr Richard Gordon, Professor Trent Woodruff
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