Professor James Fraser
Professor

James Fraser

Email: 
Phone: 
+61 7 336 54868

Availability

Professor James Fraser is:
Available for supervision

Fields of research

Genetics Medical microbiology Microbiology

Qualifications

  • Bachelor (Honours) of Science (Advanced), University of Melbourne
  • Doctor of Philosophy, unknown

Search Professor James Fraser’s works on UQ eSpace

102 works between 1984 and 2024
All (102) Journal Article (94) Book Chapter (2) Conference Publication (6)

1 - 20 of 102 works

2024

Journal Article

A Chimeric ORF Fusion Phenotypic Reporter for Cryptococcus neoformans

Phillips-Rose, Louis S., Yu, Chendi K., West, Nicholas P. and Fraser, James A. (2024). A Chimeric ORF Fusion Phenotypic Reporter for Cryptococcus neoformans. Journal of Fungi, 10 (8) 567, 567. doi: 10.3390/jof10080567

A Chimeric ORF Fusion Phenotypic Reporter for Cryptococcus neoformans

2023

Journal Article

SAGA complex subunit Hfi1 is important in the stress response and pathogenesis of Cryptococcus neoformans

Yu, Chendi K., Stephenson, Christina J., Villamor, Tristan C., Dyba, Taylor G., Schulz, Benjamin L. and Fraser, James A. (2023). SAGA complex subunit Hfi1 is important in the stress response and pathogenesis of Cryptococcus neoformans. Journal of Fungi, 9 (12) 1198, 1-16. doi: 10.3390/jof9121198

SAGA complex subunit Hfi1 is important in the stress response and pathogenesis of Cryptococcus neoformans

2023

Journal Article

Structure-activity relationships of bensulfuron methyl and its derivatives as novel agents against drug-resistant Candida auris

Sun, Xue-Wen, Liu, Yixuan, Wang, Xiaofang, Li, Hao-Ran, Lin, Xin, Tang, Jin-Yin, Xu, Qing, Agnew-Francis, Kylie A., Fraser, James A., Sun, Zhi-Juan, Guddat, Luke W. and Wang, Jian-Guo (2023). Structure-activity relationships of bensulfuron methyl and its derivatives as novel agents against drug-resistant Candida auris. Chemical Biology & Drug Design, 103 (1) e14364, e14364. doi: 10.1111/cbdd.14364

Structure-activity relationships of bensulfuron methyl and its derivatives as novel agents against drug-resistant Candida auris

2022

Journal Article

AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans

Wizrah, Maha S. I., Chua, Sheena M. H., Luo, Zhenyao, Manik, Mohammad K., Pan, Mengqi, Whyte, Jessica M. L., Robertson, Avril A. B., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2022). AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans. Journal of Biological Chemistry, 298 (10) 102453, 102453. doi: 10.1016/j.jbc.2022.102453

AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans

2022

Journal Article

Lineages derived from Cryptococcus neoformans type strain H99 support a link between the capacity to be pleomorphic and virulence

Fernandes, Kenya E., Fraser, James A. and Carter, Dee A. (2022). Lineages derived from Cryptococcus neoformans type strain H99 support a link between the capacity to be pleomorphic and virulence. mBio, 13 (2). doi: 10.1128/mbio.00283-22

Lineages derived from Cryptococcus neoformans type strain H99 support a link between the capacity to be pleomorphic and virulence

2022

Journal Article

Identification and characterisation of sPEPs in Cryptococcus neoformans

Erpf, Paige E., Chua, Sheena M.H., Phung, Toan K., Kerr, Edward D., Rothnagel, Joseph A., Schulz, Benjamin L. and Fraser, James A. (2022). Identification and characterisation of sPEPs in Cryptococcus neoformans. Fungal Genetics and Biology, 160 103688, 103688. doi: 10.1016/j.fgb.2022.103688

Identification and characterisation of sPEPs in Cryptococcus neoformans

2021

Journal Article

Triazolopyrimidine herbicides are potent inhibitors of Aspergillus fumigatus acetohydroxyacid synthase and potential antifungal drug leads

Low, Y. S., Garcia, M. D., Lonhienne, T., Fraser, J. A., Schenk, G. and Guddat, L. W. (2021). Triazolopyrimidine herbicides are potent inhibitors of Aspergillus fumigatus acetohydroxyacid synthase and potential antifungal drug leads. Scientific Reports, 11 (1) 21055. doi: 10.1038/s41598-021-00349-9

Triazolopyrimidine herbicides are potent inhibitors of Aspergillus fumigatus acetohydroxyacid synthase and potential antifungal drug leads

2021

Journal Article

Structural features of Cryptococcus neoformans bifunctional GAR/AIR synthetase may present novel antifungal drug targets

Chua, Sheena M. H., Wizrah, Maha S. I., Luo, Zhenyao, Lim, Bryan Y. J., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2021). Structural features of Cryptococcus neoformans bifunctional GAR/AIR synthetase may present novel antifungal drug targets. Journal of Biological Chemistry, 297 (4) 101091. doi: 10.1016/j.jbc.2021.101091

Structural features of Cryptococcus neoformans bifunctional GAR/AIR synthetase may present novel antifungal drug targets

2020

Journal Article

Surveying purine biosynthesis across the domains of life unveils promising drug targets in pathogens

Chua, Sheena M. H. and Fraser, James A. (2020). Surveying purine biosynthesis across the domains of life unveils promising drug targets in pathogens. Immunology and Cell Biology, 98 (10), 819-831. doi: 10.1111/imcb.12389

Surveying purine biosynthesis across the domains of life unveils promising drug targets in pathogens

2020

Journal Article

Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris

Agnew-Francis, Kylie A., Tang, Yu Cheng, Lin, Xin, Low, Yu Shang, Wun, Shun Jie, Kuo, Andy, Elias, S. M. A. Sayeed Ibn, Lonhienne, Thierry G., Condon, Nicholas, Pimentel, Bruna Natalia Alves da Silva, Vergani, Carlos, Smith, Maree T., Fraser, James A., Williams, Craig M. and Guddat, Luke W (2020). Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris. ACS infectious diseases, 6 (11) acsinfecdis.0c00229, 2901-2912. doi: 10.1021/acsinfecdis.0c00229

Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris

Featured

2020

Journal Article

Structures of fungal and plant acetohydroxyacid synthases

Lonhienne, Thierry, Low, Yu Shang, Garcia, Mario D., Croll, Tristan, Gao, Yan, Wang, Quan, Brillault, Lou, Williams, Craig M., Fraser, James A., McGeary, Ross P., West, Nicholas P., Landsberg, Michael J., Rao, Zihe, Schenk, Gerhard and Guddat, Luke W. (2020). Structures of fungal and plant acetohydroxyacid synthases. Nature, 586 (7828), 317-321+. doi: 10.1038/s41586-020-2514-3

Structures of fungal and plant acetohydroxyacid synthases

2020

Journal Article

Broadening the spectrum of fluorescent protein tools for use in the encapsulated human fungal pathogen Cryptococcus neoformans

Spencer, Garrick W.K., Chua, Sheena M.H., Erpf, Paige E., Wizrah, Maha S.I., Dyba, Taylor G., Condon, Nicholas D. and Fraser, James A. (2020). Broadening the spectrum of fluorescent protein tools for use in the encapsulated human fungal pathogen Cryptococcus neoformans. Fungal Genetics and Biology, 138 103365, 103365. doi: 10.1016/j.fgb.2020.103365

Broadening the spectrum of fluorescent protein tools for use in the encapsulated human fungal pathogen Cryptococcus neoformans

2020

Journal Article

Kalparinol, a Salvialane (Isodaucane) sesquiterpenoid derived from native Australian dysphania species that suggests a putative biogenetic link to zerumbone

Tan, Yuen Ping, Savchenko, Andrei I., Agnew-Francis, Kylie A., Boyle, Glen M., Bernhardt, Paul V., Fraser, James A. and Williams, Craig M. (2020). Kalparinol, a Salvialane (Isodaucane) sesquiterpenoid derived from native Australian dysphania species that suggests a putative biogenetic link to zerumbone. Journal of Natural Products, 83 (5) acs.jnatprod.9b01039, 1473-1479. doi: 10.1021/acs.jnatprod.9b01039

Kalparinol, a Salvialane (Isodaucane) sesquiterpenoid derived from native Australian dysphania species that suggests a putative biogenetic link to zerumbone

2020

Journal Article

Humulene diepoxides from the Australian arid zone herb Dysphania: assignment of aged hops constituents

Tan, Yuen Ping, Agnew‐Francis, Kylie A., Hofmann, Julian, Savchenko, Andrei I., Lafontaine, Scott R., Boyle, Glen M., Bernhardt, Paul V., Fraser, James A., Shellhammer, Thomas H. and Williams, Craig M. (2020). Humulene diepoxides from the Australian arid zone herb Dysphania: assignment of aged hops constituents. Chemistry: A European Journal, 26 (7) chem.201904420, 1653-1660. doi: 10.1002/chem.201904420

Humulene diepoxides from the Australian arid zone herb Dysphania: assignment of aged hops constituents

2019

Journal Article

Regulatory mechanism of the atypical AP-1-like transcription factor Yap1 in Cryptococcus neoformans

So, Yee-Seul, Maeng, Shinae, Yang, Dong-Hoon, Kim, Hyelim, Lee, Kyung-Tae, Yu, Seong-Ryong, Tenor, Jennifer L., Giri, Vinay K., Toffaletti, Dena L., Arras, Samantha, Fraser, James A., Perfect, John R. and Bahn, Yong-Sun (2019). Regulatory mechanism of the atypical AP-1-like transcription factor Yap1 in Cryptococcus neoformans. mSphere, 4 (6) e00785, e00785-19. doi: 10.1128/mSphere.00785-19

Regulatory mechanism of the atypical AP-1-like transcription factor Yap1 in Cryptococcus neoformans

2019

Journal Article

amdS as a dominant recyclable marker in Cryptococcus neoformans

Erpf, Paige E., Stephenson, Christina J. and Fraser, James A. (2019). amdS as a dominant recyclable marker in Cryptococcus neoformans. Fungal Genetics and Biology, 131 103241, 103241. doi: 10.1016/j.fgb.2019.103241

amdS as a dominant recyclable marker in Cryptococcus neoformans

2019

Journal Article

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

Coll, Rebecca C., Hill, James R., Day, Christopher J., Zamoshnikova, Alina, Boucher, Dave, Massey, Nicholas L., Chitty, Jessica L., Fraser, James A., Jennings, Michael P., Robertson, Avril A. B. and Schroder, Kate (2019). MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition. Nature Chemical Biology, 15 (6), 556-559. doi: 10.1038/s41589-019-0277-7

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

2019

Journal Article

Quantitation of Purines from Pigeon Guano and Implications for Cryptococcus neoformans Survival During Infection

Chitty, Jessica L., Edwards, David J., Robertson, Avril A. B., Butler, Mark S., Duley, John A., Cooper, Matthew A. and Fraser, James A. (2019). Quantitation of Purines from Pigeon Guano and Implications for Cryptococcus neoformans Survival During Infection. Mycopathologia, 184 (2), 273-281. doi: 10.1007/s11046-018-0315-0

Quantitation of Purines from Pigeon Guano and Implications for Cryptococcus neoformans Survival During Infection

2018

Journal Article

Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections

Garcia, Mario D., Chua, Sheena M. H., Low, Yu-Shang, Lee, Yu-Ting, Agnew-Francis, Kylie, Wang, Jian-Guo, Nouwens, Amanda, Lonhienne, Thierry, Williams, Craig M., Fraser, James A. and Guddat, Luke W. (2018). Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections. Proceedings of the National Academy of Sciences of the United States of America, 115 (41), E9649-E9658. doi: 10.1073/pnas.1809422115

Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections

2018

Journal Article

Cell Wall and Whole Cell Proteomes Define Flocculation and Fermentation Behavior of Yeast

Kerr, Edward, McDiarmid, Duin, Fraser, James and Schulz, Benjamin (2018). Cell Wall and Whole Cell Proteomes Define Flocculation and Fermentation Behavior of Yeast. Fermentation, 4 (3) 80, 80. doi: 10.3390/fermentation4030080

Cell Wall and Whole Cell Proteomes Define Flocculation and Fermentation Behavior of Yeast

Past funding

  • 2020 - 2023
    Novel Broad Spectrum Antifungals Active Against Drug Resistant Candida Auris
    NHMRC IDEAS Grants
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    Epifluorescent and live-cell imaging microscopes for the investigation of host-pathogen interactions and for molecular and cellular biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2021
    Microevolution of Cryptococcus neoformans
    NHMRC Project Grant
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2018
    Acetohydroxyacid synthase: A new drug target for human fungal pathogens
    NHMRC Project Grant
    Open grant
  • 2014
    A confocal microscope for investigation of live bacterial and viral pathogens and for molecular cell biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013 - 2016
    Purine metabolism as an antifungal drug target
    NHMRC Project Grant
    Open grant
  • 2012 - 2013
    IMPDH as an antifungal drug target
    Therapeutic Innovation Australia Limited
    Open grant
  • 2011 - 2014
    Targeting acetohydroxyacid synthase to discover new antifungal agents
    NHMRC Project Grant
    Open grant
  • 2010 - 2012
    ResTeach 2010 0.1 FTE School of Chemistry and Molecular Biosciences
    UQ ResTeach
    Open grant
  • 2010 - 2012
    Understanding an exotic disease: Initiation of sex and infection by the sugarcane smut Ustilago scitaminea
    ARC Discovery Projects
    Open grant
  • 2007 - 2010
    Transposable element mobility and chromosomal rearrangement in the fungal pathogen Cryptococcus during human infection
    NHMRC Project Grant
    Open grant

Availability

Professor James Fraser is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Purine biosynthesis as an anti fungal target

    Principal Advisor

    Other advisors: Professor Bostjan Kobe

  • Doctor Philosophy

    The role of the cotranscriptional activator complex SAGA in virulence of Cryptococcus neoformans

    Principal Advisor

    Other advisors: Professor Benjamin Schulz

  • Doctor Philosophy

    Advanced Genetic Toolkit for Cryptococcus neoformans: Iterating Upon Currently Used Techniques in the WHO¿s Top-Ranked Fungal Pathogen

    Principal Advisor

    Other advisors: Associate Professor Nick West

  • Doctor Philosophy

    Resolving a Dichotomy: A Journey between the Laboratory and the Classroom

    Principal Advisor

    Other advisors: Professor Bostjan Kobe

  • Doctor Philosophy

    The Cryptococcus neoformans SAGA: Investigating the SAGA associated Histone acetyltransferase and Deubiquitinase modules opposing influence on virulence

    Principal Advisor

    Other advisors: Professor Benjamin Schulz

  • Doctor Philosophy

    Antifungal agents to target disseminated mycoses

    Principal Advisor

    Other advisors: Dr Kylie Agnew-Francis, Professor Avril Robertson

  • Doctor Philosophy

    Characterising the membrane interactions and cytotoxic activity of the anti-fungal peptide Lactofungin

    Associate Advisor

    Other advisors: Dr Evelyne Deplazes

  • Doctor Philosophy

    Targetting Candida Auris

    Associate Advisor

    Other advisors: Dr Kylie Agnew-Francis, Professor Avril Robertson

  • Doctor Philosophy

    Developing a cell-free, structural model of fungal cell walls

    Associate Advisor

    Other advisors: Dr Evelyne Deplazes

  • Doctor Philosophy

    Targeting Deadly Mycotic Infection

    Associate Advisor

    Other advisors: Dr Kylie Agnew-Francis, Professor Avril Robertson

Completed supervision

Enquiries

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