![Professor James Fraser](/sites/default/files/profiles/1649.png)
Overview
Availability
- Professor James Fraser is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), University of Melbourne
- Doctor of Philosophy, unknown
Works
Search Professor James Fraser’s works on UQ eSpace
2024
Journal Article
A Chimeric ORF Fusion Phenotypic Reporter for Cryptococcus neoformans
Phillips-Rose, Louis S., Yu, Chendi K., West, Nicholas P. and Fraser, James A. (2024). A Chimeric ORF Fusion Phenotypic Reporter for Cryptococcus neoformans. Journal of Fungi, 10 (8) 567, 567. doi: 10.3390/jof10080567
2023
Journal Article
SAGA complex subunit Hfi1 is important in the stress response and pathogenesis of Cryptococcus neoformans
Yu, Chendi K., Stephenson, Christina J., Villamor, Tristan C., Dyba, Taylor G., Schulz, Benjamin L. and Fraser, James A. (2023). SAGA complex subunit Hfi1 is important in the stress response and pathogenesis of Cryptococcus neoformans. Journal of Fungi, 9 (12) 1198, 1-16. doi: 10.3390/jof9121198
2023
Journal Article
Structure-activity relationships of bensulfuron methyl and its derivatives as novel agents against drug-resistant Candida auris
Sun, Xue-Wen, Liu, Yixuan, Wang, Xiaofang, Li, Hao-Ran, Lin, Xin, Tang, Jin-Yin, Xu, Qing, Agnew-Francis, Kylie A., Fraser, James A., Sun, Zhi-Juan, Guddat, Luke W. and Wang, Jian-Guo (2023). Structure-activity relationships of bensulfuron methyl and its derivatives as novel agents against drug-resistant Candida auris. Chemical Biology & Drug Design, 103 (1) e14364, e14364. doi: 10.1111/cbdd.14364
2022
Journal Article
AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans
Wizrah, Maha S. I., Chua, Sheena M. H., Luo, Zhenyao, Manik, Mohammad K., Pan, Mengqi, Whyte, Jessica M. L., Robertson, Avril A. B., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2022). AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans. Journal of Biological Chemistry, 298 (10) 102453, 102453. doi: 10.1016/j.jbc.2022.102453
2022
Journal Article
Lineages derived from Cryptococcus neoformans type strain H99 support a link between the capacity to be pleomorphic and virulence
Fernandes, Kenya E., Fraser, James A. and Carter, Dee A. (2022). Lineages derived from Cryptococcus neoformans type strain H99 support a link between the capacity to be pleomorphic and virulence. mBio, 13 (2). doi: 10.1128/mbio.00283-22
2022
Journal Article
Identification and characterisation of sPEPs in Cryptococcus neoformans
Erpf, Paige E., Chua, Sheena M.H., Phung, Toan K., Kerr, Edward D., Rothnagel, Joseph A., Schulz, Benjamin L. and Fraser, James A. (2022). Identification and characterisation of sPEPs in Cryptococcus neoformans. Fungal Genetics and Biology, 160 103688, 103688. doi: 10.1016/j.fgb.2022.103688
2021
Journal Article
Triazolopyrimidine herbicides are potent inhibitors of Aspergillus fumigatus acetohydroxyacid synthase and potential antifungal drug leads
Low, Y. S., Garcia, M. D., Lonhienne, T., Fraser, J. A., Schenk, G. and Guddat, L. W. (2021). Triazolopyrimidine herbicides are potent inhibitors of Aspergillus fumigatus acetohydroxyacid synthase and potential antifungal drug leads. Scientific Reports, 11 (1) 21055. doi: 10.1038/s41598-021-00349-9
2021
Journal Article
Structural features of Cryptococcus neoformans bifunctional GAR/AIR synthetase may present novel antifungal drug targets
Chua, Sheena M. H., Wizrah, Maha S. I., Luo, Zhenyao, Lim, Bryan Y. J., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2021). Structural features of Cryptococcus neoformans bifunctional GAR/AIR synthetase may present novel antifungal drug targets. Journal of Biological Chemistry, 297 (4) 101091. doi: 10.1016/j.jbc.2021.101091
2020
Journal Article
Surveying purine biosynthesis across the domains of life unveils promising drug targets in pathogens
Chua, Sheena M. H. and Fraser, James A. (2020). Surveying purine biosynthesis across the domains of life unveils promising drug targets in pathogens. Immunology and Cell Biology, 98 (10), 819-831. doi: 10.1111/imcb.12389
2020
Journal Article
Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris
Agnew-Francis, Kylie A., Tang, Yu Cheng, Lin, Xin, Low, Yu Shang, Wun, Shun Jie, Kuo, Andy, Elias, S. M. A. Sayeed Ibn, Lonhienne, Thierry G., Condon, Nicholas, Pimentel, Bruna Natalia Alves da Silva, Vergani, Carlos, Smith, Maree T., Fraser, James A., Williams, Craig M. and Guddat, Luke W (2020). Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris. ACS infectious diseases, 6 (11) acsinfecdis.0c00229, 2901-2912. doi: 10.1021/acsinfecdis.0c00229
Featured
2020
Journal Article
Structures of fungal and plant acetohydroxyacid synthases
Lonhienne, Thierry, Low, Yu Shang, Garcia, Mario D., Croll, Tristan, Gao, Yan, Wang, Quan, Brillault, Lou, Williams, Craig M., Fraser, James A., McGeary, Ross P., West, Nicholas P., Landsberg, Michael J., Rao, Zihe, Schenk, Gerhard and Guddat, Luke W. (2020). Structures of fungal and plant acetohydroxyacid synthases. Nature, 586 (7828), 317-321+. doi: 10.1038/s41586-020-2514-3
2020
Journal Article
Broadening the spectrum of fluorescent protein tools for use in the encapsulated human fungal pathogen Cryptococcus neoformans
Spencer, Garrick W.K., Chua, Sheena M.H., Erpf, Paige E., Wizrah, Maha S.I., Dyba, Taylor G., Condon, Nicholas D. and Fraser, James A. (2020). Broadening the spectrum of fluorescent protein tools for use in the encapsulated human fungal pathogen Cryptococcus neoformans. Fungal Genetics and Biology, 138 103365, 103365. doi: 10.1016/j.fgb.2020.103365
2020
Journal Article
Kalparinol, a Salvialane (Isodaucane) sesquiterpenoid derived from native Australian dysphania species that suggests a putative biogenetic link to zerumbone
Tan, Yuen Ping, Savchenko, Andrei I., Agnew-Francis, Kylie A., Boyle, Glen M., Bernhardt, Paul V., Fraser, James A. and Williams, Craig M. (2020). Kalparinol, a Salvialane (Isodaucane) sesquiterpenoid derived from native Australian dysphania species that suggests a putative biogenetic link to zerumbone. Journal of Natural Products, 83 (5) acs.jnatprod.9b01039, 1473-1479. doi: 10.1021/acs.jnatprod.9b01039
2020
Journal Article
Humulene diepoxides from the Australian arid zone herb Dysphania: assignment of aged hops constituents
Tan, Yuen Ping, Agnew‐Francis, Kylie A., Hofmann, Julian, Savchenko, Andrei I., Lafontaine, Scott R., Boyle, Glen M., Bernhardt, Paul V., Fraser, James A., Shellhammer, Thomas H. and Williams, Craig M. (2020). Humulene diepoxides from the Australian arid zone herb Dysphania: assignment of aged hops constituents. Chemistry: A European Journal, 26 (7) chem.201904420, 1653-1660. doi: 10.1002/chem.201904420
2019
Journal Article
Regulatory mechanism of the atypical AP-1-like transcription factor Yap1 in Cryptococcus neoformans
So, Yee-Seul, Maeng, Shinae, Yang, Dong-Hoon, Kim, Hyelim, Lee, Kyung-Tae, Yu, Seong-Ryong, Tenor, Jennifer L., Giri, Vinay K., Toffaletti, Dena L., Arras, Samantha, Fraser, James A., Perfect, John R. and Bahn, Yong-Sun (2019). Regulatory mechanism of the atypical AP-1-like transcription factor Yap1 in Cryptococcus neoformans. mSphere, 4 (6) e00785, e00785-19. doi: 10.1128/mSphere.00785-19
2019
Journal Article
amdS as a dominant recyclable marker in Cryptococcus neoformans
Erpf, Paige E., Stephenson, Christina J. and Fraser, James A. (2019). amdS as a dominant recyclable marker in Cryptococcus neoformans. Fungal Genetics and Biology, 131 103241, 103241. doi: 10.1016/j.fgb.2019.103241
2019
Journal Article
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
Coll, Rebecca C., Hill, James R., Day, Christopher J., Zamoshnikova, Alina, Boucher, Dave, Massey, Nicholas L., Chitty, Jessica L., Fraser, James A., Jennings, Michael P., Robertson, Avril A. B. and Schroder, Kate (2019). MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition. Nature Chemical Biology, 15 (6), 556-559. doi: 10.1038/s41589-019-0277-7
2019
Journal Article
Quantitation of Purines from Pigeon Guano and Implications for Cryptococcus neoformans Survival During Infection
Chitty, Jessica L., Edwards, David J., Robertson, Avril A. B., Butler, Mark S., Duley, John A., Cooper, Matthew A. and Fraser, James A. (2019). Quantitation of Purines from Pigeon Guano and Implications for Cryptococcus neoformans Survival During Infection. Mycopathologia, 184 (2), 273-281. doi: 10.1007/s11046-018-0315-0
2018
Journal Article
Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections
Garcia, Mario D., Chua, Sheena M. H., Low, Yu-Shang, Lee, Yu-Ting, Agnew-Francis, Kylie, Wang, Jian-Guo, Nouwens, Amanda, Lonhienne, Thierry, Williams, Craig M., Fraser, James A. and Guddat, Luke W. (2018). Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections. Proceedings of the National Academy of Sciences of the United States of America, 115 (41), E9649-E9658. doi: 10.1073/pnas.1809422115
2018
Journal Article
Cell Wall and Whole Cell Proteomes Define Flocculation and Fermentation Behavior of Yeast
Kerr, Edward, McDiarmid, Duin, Fraser, James and Schulz, Benjamin (2018). Cell Wall and Whole Cell Proteomes Define Flocculation and Fermentation Behavior of Yeast. Fermentation, 4 (3) 80, 80. doi: 10.3390/fermentation4030080
Funding
Supervision
Availability
- Professor James Fraser is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Purine biosynthesis as an anti fungal target
Principal Advisor
Other advisors: Professor Bostjan Kobe
-
Doctor Philosophy
The role of the cotranscriptional activator complex SAGA in virulence of Cryptococcus neoformans
Principal Advisor
Other advisors: Professor Benjamin Schulz
-
Doctor Philosophy
Advanced Genetic Toolkit for Cryptococcus neoformans: Iterating Upon Currently Used Techniques in the WHO¿s Top-Ranked Fungal Pathogen
Principal Advisor
Other advisors: Associate Professor Nick West
-
Doctor Philosophy
Resolving a Dichotomy: A Journey between the Laboratory and the Classroom
Principal Advisor
Other advisors: Professor Bostjan Kobe
-
Doctor Philosophy
The Cryptococcus neoformans SAGA: Investigating the SAGA associated Histone acetyltransferase and Deubiquitinase modules opposing influence on virulence
Principal Advisor
Other advisors: Professor Benjamin Schulz
-
Doctor Philosophy
Antifungal agents to target disseminated mycoses
Principal Advisor
Other advisors: Dr Kylie Agnew-Francis, Professor Avril Robertson
-
Doctor Philosophy
Characterising the membrane interactions and cytotoxic activity of the anti-fungal peptide Lactofungin
Associate Advisor
Other advisors: Dr Evelyne Deplazes
-
Doctor Philosophy
Targetting Candida Auris
Associate Advisor
Other advisors: Dr Kylie Agnew-Francis, Professor Avril Robertson
-
Doctor Philosophy
Developing a cell-free, structural model of fungal cell walls
Associate Advisor
Other advisors: Dr Evelyne Deplazes
-
Doctor Philosophy
Targeting Deadly Mycotic Infection
Associate Advisor
Other advisors: Dr Kylie Agnew-Francis, Professor Avril Robertson
Completed supervision
-
2022
Doctor Philosophy
Purine metabolism as an antifungal target
Principal Advisor
Other advisors: Professor Benjamin Schulz, Professor Bostjan Kobe
-
2021
Doctor Philosophy
Targeting metabolic pathways for new antifungals: Purine biosynthesis
Principal Advisor
Other advisors: Professor Bostjan Kobe
-
2021
Doctor Philosophy
The Identification and Characterisation of Short Open Reading Frame-Encoded Polypeptides in Cryptococcus neoformans
Principal Advisor
Other advisors: Professor Benjamin Schulz
-
2017
Doctor Philosophy
Classical and rational approaches to antifungal drug design
Principal Advisor
Other advisors: Professor Bostjan Kobe
-
2017
Doctor Philosophy
Epigenetic regulation of virulence in the fungal pathogen Cryptococcus neoformans
Principal Advisor
Other advisors: Professor Benjamin Schulz
-
2016
Doctor Philosophy
Disruption of de novo ATP biosynthesis abolishes virulence in Cryptococcus neoformans
Principal Advisor
Other advisors: Professor Bostjan Kobe
-
2016
Doctor Philosophy
Moving targets: Microevolution of pathogenic species within the laboratory and the human host
Principal Advisor
Other advisors: Professor Phil Hugenholtz
-
2013
Doctor Philosophy
Regulation of Nitrogen Metabolism in Fungi: The Impact of Nitrogen Catabolism on Virulence in the Fungal Pathogen Cryptococcus neoformans
Principal Advisor
Other advisors: Professor Bernard Carroll
-
2013
Doctor Philosophy
Subtelomeric Microevolution in the Human Fungal Pathogen Cryptococcus neoformans
Principal Advisor
Other advisors: Professor Bernard Carroll
-
2012
Doctor Philosophy
New strategies for antifungal development in Cryptococcus neoformans exploiting purine metabolism and microevolution during infection
Principal Advisor
Other advisors: Professor Bernard Carroll
-
2021
Doctor Philosophy
Structure and function of plant and fungal acetohydroxyacid synthases
Associate Advisor
Other advisors: Professor Luke Guddat
-
2019
Doctor Philosophy
Novel antifungals selectively targeting the purine metabolic pathway
Associate Advisor
Other advisors: Professor Avril Robertson, Professor Bostjan Kobe
-
2018
Doctor Philosophy
Characterization of Caenorhabditis elegans phosphine resistant mutant alh-6(wr3)
Associate Advisor
Other advisors: Associate Professor Paul Ebert
-
2013
Doctor Philosophy
From the Sea to the Jungle: The Search for Bioactive Metabolites from Marine Samples and a Terrestrial Fungus
Associate Advisor
Other advisors: Dr Ben Ross
-
2013
Doctor Philosophy
Characterisation of the DEFECTIVE EMBRYO and MERISTEMS(DEM) genes of plants
Associate Advisor
Other advisors: Professor Bernard Carroll
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