Overview
Availability
- Professor Luke Guddat is:
- Available for supervision
Fields of research
Works
Search Professor Luke Guddat’s works on UQ eSpace
2024
Journal Article
Chemical Synthesis, Herbicidal Activity, Crop Safety, and Molecular Basis of <i>ortho</i>-Fluoroalkoxy Substituted Sulfonylureas as Novel Acetohydroxyacid Synthase Inhibitors
Xu, Qing, Gao, Yanhua, Sun, Zhongjie, Shi, Jin-Rui, Tang, Jin-Yin, Wang, Yuan, Liu, Yun, Sun, Xue-Wen, Li, Hao-Ran, Lonhienne, Thierry G., Niu, Cong-Wei, Li, Yong-Hong, Guddat, Luke W. and Wang, Jian-Guo (2024). Chemical Synthesis, Herbicidal Activity, Crop Safety, and Molecular Basis of ortho-Fluoroalkoxy Substituted Sulfonylureas as Novel Acetohydroxyacid Synthase Inhibitors. Journal of Agricultural and Food Chemistry, 72 (41), 22595-22605. doi: 10.1021/acs.jafc.4c05201
2024
Journal Article
Crystal Structures of <i>Arabidopsis thaliana</i> Acetohydroxyacid Synthase in Complex with the Herbicide Triasulfuron and Two Analogues with Herbicidal Activity in Field Trials
Cheng, Yan, Wang, Yuan, Lonhienne, Thierry, Wang, Jian-Guo and Guddat, Luke W. (2024). Crystal Structures of Arabidopsis thaliana Acetohydroxyacid Synthase in Complex with the Herbicide Triasulfuron and Two Analogues with Herbicidal Activity in Field Trials. Journal of Agricultural and Food Chemistry, 72 (41), 22487-22498. doi: 10.1021/acs.jafc.4c04990
2024
Journal Article
Inherent symmetry and flexibility in hepatitis B virus subviral particles
Wang, Quan, Wang, Tao, Cao, Lin, Mu, An, Fu, Sheng, Wang, Peipei, Gao, Yan, Ji, Wenxin, Liu, Zhenyu, Du, Zhanqiang, Guddat, Luke W., Zhang, Wenchi, Li, Shuang, Li, Xuemei, Lou, Zhiyong, Wang, Xiangxi, Hu, Zhongyu and Rao, Zihe (2024). Inherent symmetry and flexibility in hepatitis B virus subviral particles. Science, 385 (6714), 1217-1224. doi: 10.1126/science.adp1453
2024
Journal Article
Cryo-EM structures of a mycobacterial ABC transporter that mediates rifampicin resistance
Wang, Yinan, Gao, Shan, Wu, Fangyu, Gong, Yicheng, Mu, Nengjiang, Wei, Chuancun, Wu, Chengyao, Wang, Jun, Yan, Ning, Yang, Huifang, Zhang, Yifan, Liu, Jiayi, Wang, Zeyu, Yang, Xiuna, Lam, Sin Man, Shui, Guanghou, Li, Siyuan, Da, Lintai, Guddat, Luke W., Rao, Zihe and Zhang, Lu (2024). Cryo-EM structures of a mycobacterial ABC transporter that mediates rifampicin resistance. Proceedings of the National Academy of Sciences, 121 (37) e2403421121, e2403421121. doi: 10.1073/pnas.2403421121
2024
Journal Article
MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer
Meena, Jitendra K., Wang, Jarey H., Neill, Nicholas J., Keough, Dianne, Putluri, Nagireddy, Katsonis, Panagiotis, Koire, Amanda M., Lee, Hyemin, Bowling, Elizabeth A., Tyagi, Siddhartha, Orellana, Mayra, Dominguez-Vidaña, Rocio, Li, Heyuan, Eagle, Kenneth, Danan, Charles, Chung, Hsiang-Ching, Yang, Andrew D., Wu, William, Kurley, Sarah J., Ho, Brian M., Zoeller, Joseph R., Olson, Calla M., Meerbrey, Kristen L., Lichtarge, Olivier, Sreekumar, Arun, Dacso, Clifford C., Guddat, Luke W., Rejman, Dominik, Hocková, Dana ... Westbrook, Thomas F. (2024). MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer. Cancer Discovery, 14 (9), OF1-OF18. doi: 10.1158/2159-8290.cd-22-0649
2024
Journal Article
Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587
Zhang, Yuying, Lai, Yuezheng, Zhou, Shan, Ran, Ting, Zhang, Yue, Zhao, Ziqing, Feng, Ziyan, Yu, Long, Xu, Jinxu, Shi, Kun, Wang, Jianyun, Pang, Yu, Li, Liang, Chen, Hongming, Guddat, Luke W., Gao, Yan, Liu, Fengjiang, Rao, Zihe and Gong, Hongri (2024). Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587. Nature, 631 (8020), 1-6. doi: 10.1038/s41586-024-07605-8
2024
Journal Article
TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry
Wang, Haofeng, Liu, Xiaoce, Zhang, Xiang, Zhao, Zhuoqian, Lu, Yuchi, Pu, Dingzhe, Zhang, Zeyang, Chen, Jie, Wang, Yajie, Li, Mengfei, Dong, Xuxue, Duan, Yinkai, He, Yujia, Mao, Qiyu, Guo, Hangtian, Sun, Haoran, Zhou, Yihan, Yang, Qi, Gao, Yan, Yang, Xiuna, Cao, Hongzhi, Guddat, Luke, Sun, Lei, Rao, Zihe and Yang, Haitao (2024). TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry. Cell, 187 (16), 4261-4271.e17. doi: 10.1016/j.cell.2024.06.016
2024
Journal Article
Development of Prolinol Containing Inhibitors of Hypoxanthine–Guanine–Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design
Keough, Dianne T., Petrová, Magdalena, King, Gordon, Kratochvíl, Michal, Pohl, Radek, Doleželová, Eva, Zíková, Alena, Guddat, Luke W. and Rejman, Dominik (2024). Development of Prolinol Containing Inhibitors of Hypoxanthine–Guanine–Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design. Journal of Medicinal Chemistry, 67 (9), 7158-7175. doi: 10.1021/acs.jmedchem.4c00021
2024
Journal Article
Mapping of the reaction trajectory catalyzed by class I ketol-acid reductoisomerase
Lin, Xin, Lonhienne, Thierry, Lv, You, Kurz, Julia L., McGeary, Ross P., Schenk, Gerhard and Guddat, Luke W. (2024). Mapping of the reaction trajectory catalyzed by class I ketol-acid reductoisomerase. ACS Catalysis, 14 (9), 6827-6841. doi: 10.1021/acscatal.4c00958
2024
Journal Article
An oligopeptide permease, OppABCD, requires an iron–sulfur cluster domain for functionality
Yang, Xiaolin, Hu, Tianyu, Liang, Jingxi, Xiong, Zhiqi, Lin, Zhenli, Zhao, Yao, Zhou, Xiaoting, Gao, Yan, Sun, Shan, Yang, Xiuna, Guddat, Luke W., Yang, Haitao, Rao, Zihe and Zhang, Bing (2024). An oligopeptide permease, OppABCD, requires an iron–sulfur cluster domain for functionality. Nature Structural & Molecular Biology, 31 (7), 1-11. doi: 10.1038/s41594-024-01256-z
2024
Journal Article
Molecular basis for substrate transport of Mycobacterium tuberculosis ABC importer DppABCD
Hu, Tianyu, Yang, Xiaolin, Zhu, Yuanchen, Liu, Fengjiang, Yang, Xiuna, Xiong, Zhiqi, Liang, Jingxi, Lin, Zhenli, Ran, Yuting, Guddat, Luke W., Rao, Zihe and Zhang, Bing (2024). Molecular basis for substrate transport of Mycobacterium tuberculosis ABC importer DppABCD. Science Advances, 10 (12) eadk8521, eadk8521. doi: 10.1126/sciadv.adk8521
2024
Journal Article
Targeting the hSSB1-INTS3 interface: a computational screening driven approach to identify potential modulators
Barbhuiya, Tabassum Khair, Beard, Sam, Shah, Esha T., Mason, Steven, Bolderson, Emma, O’Byrne, Ken, Guddat, Luke W., Richard, Derek J., Adams, Mark N. and Gandhi, Neha S. (2024). Targeting the hSSB1-INTS3 interface: a computational screening driven approach to identify potential modulators. ACS Omega, 9 (7), 8362-8373. doi: 10.1021/acsomega.3c09267
2023
Journal Article
Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry
Wang, Haofeng, Yang, Qi, Liu, Xiaoce, Xu, Zili, Shao, Maolin, Li, Dongxu, Duan, Yinkai, Tang, Jielin, Yu, Xianqiang, Zhang, Yumin, Hao, Aihua, Wang, Yajie, Chen, Jie, Zhu, Chenghao, Guddat, Luke, Chen, Hongli, Zhang, Leike, Chen, Xinwen, Jiang, Biao, Sun, Lei, Rao, Zihe and Yang, Haitao (2023). Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry. Nature Communications, 14 (1) 7574, 1-14. doi: 10.1038/s41467-023-42527-5
2023
Journal Article
Structure-activity relationships of bensulfuron methyl and its derivatives as novel agents against drug-resistant Candida auris
Sun, Xue-Wen, Liu, Yixuan, Wang, Xiaofang, Li, Hao-Ran, Lin, Xin, Tang, Jin-Yin, Xu, Qing, Agnew-Francis, Kylie A., Fraser, James A., Sun, Zhi-Juan, Guddat, Luke W. and Wang, Jian-Guo (2023). Structure-activity relationships of bensulfuron methyl and its derivatives as novel agents against drug-resistant Candida auris. Chemical Biology & Drug Design, 103 (1) e14364, e14364. doi: 10.1111/cbdd.14364
2023
Journal Article
Structural insights into trehalose capture and translocation by mycobacterial LpqY-SugABC
Liang, Jingxi, Yang, Xiuna, Hu, Tianyu, Gao, Yan, Yang, Qi, Yang, Haitao, Peng, Wei, Zhou, Xiaoting, Guddat, Luke W., Zhang, Bing, Rao, Zihe and Liu, Fengjiang (2023). Structural insights into trehalose capture and translocation by mycobacterial LpqY-SugABC. Structure, 31 (10), 1158-1165.e3. doi: 10.1016/j.str.2023.07.014
2023
Conference Publication
Structural investigation of two commercial herbicides that target acetohydroxyacid synthase
Zhao, Qi, Cheng, Yan, Lonhienne, Thierry and Guddat, Luke W. (2023). Structural investigation of two commercial herbicides that target acetohydroxyacid synthase. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s205327332308556x
2023
Conference Publication
Targeting acetohydroxyacid synthase to discover new therapeutics for Cryptococcus neoformans infections
Ge, Xiaoling, Lonhienne, Thierry, Garcia, Mario D. and Guddat, Luke W. (2023). Targeting acetohydroxyacid synthase to discover new therapeutics for Cryptococcus neoformans infections. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323085546
2023
Conference Publication
Acetohydroxyacid synthase: structure, function, regulation and inhibition
Guddat, Luke W. (2023). Acetohydroxyacid synthase: structure, function, regulation and inhibition. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323095050
2023
Conference Publication
Structural basis of resistance to herbicides that target acetohydroxyacid synthase
Cheng, Yan, Lonhienne, Thierry, Garcia, Mario, Hu, Shu Hong, Low, Yu Shang, Schenk, Gerhard, Williams, Craig M. and Guddat, Luke W. (2023). Structural basis of resistance to herbicides that target acetohydroxyacid synthase. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323085571
2023
Conference Publication
Investigations of Mycobacterium tuberculosis acetohydroxyacid synthases as therapeutic drug targets
Gao, Yanhua, Wu, Shunjie, Lonhienne, Thierry, Lin, Xin and Guddat, Luke (2023). Investigations of Mycobacterium tuberculosis acetohydroxyacid synthases as therapeutic drug targets. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323085583
Funding
Current funding
Past funding
Supervision
Availability
- Professor Luke Guddat is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Antimicrobial Drug Discovery
Principal Advisor
Other advisors: Professor Gary Schenk
-
Doctor Philosophy
Developing next generation green herbicides
Principal Advisor
Other advisors: Professor Craig Williams
-
-
Doctor Philosophy
Cryo-EM inspired antifungal drug discovery
Principal Advisor
Other advisors: Professor Gary Schenk, Professor Craig Williams
-
Doctor Philosophy
Cryo-EM inspired antifungal drug discovery
Principal Advisor
Other advisors: Professor Gary Schenk, Professor Craig Williams
-
Doctor Philosophy
Acetohydroxyacid Synthase and The Discovery of Novel Herbicides
Principal Advisor
Other advisors: Professor Gary Schenk
Completed supervision
-
2024
Doctor Philosophy
Structure and function of ketol-acid reductoisomerases
Principal Advisor
Other advisors: Professor Gary Schenk
-
2024
Doctor Philosophy
Drug discovery targeting branched chain amino acid biosynthesis.
Principal Advisor
Other advisors: Professor Gary Schenk
-
2023
Doctor Philosophy
New Antimicrobial Drug Targets
Principal Advisor
Other advisors: Professor Nick West
-
2021
Doctor Philosophy
Structure and function of plant and fungal acetohydroxyacid synthases
Principal Advisor
Other advisors: Professor James Fraser
-
2021
Doctor Philosophy
Ketol-acid Reductoisomerase as a target for antimicrobial drug discovery
Principal Advisor
Other advisors: Professor Gary Schenk
-
2018
Doctor Philosophy
Structure, mechanism and inhibition of plant and fungal acetohydroxyacid synthases
Principal Advisor
Other advisors: Professor Gary Schenk
-
2017
Doctor Philosophy
Acyclic nucleoside phosphonates as possible chemotherapeutic agents against parasitic diseases
Principal Advisor
-
2017
Doctor Philosophy
Bacterial ketol-acid reductoisomerase: structure, catalytic mechanism and thermal stability
Principal Advisor
Other advisors: Professor Bostjan Kobe, Professor Mark Schembri
-
2017
Doctor Philosophy
Targeting acetohydroxyacid synthase for the discovery of antifungal and herbicidal agents
Principal Advisor
Other advisors: Professor Gary Schenk
-
2016
Doctor Philosophy
Inhibition of Bacterial 6-Oxopurine Phosphoribosyltransferase as Potential Antibacterial Target
Principal Advisor
Other advisors: Professor Nick West
-
2014
Doctor Philosophy
A study of the anticoagulant mechanisms of three biological compounds in vitro and in vivo
Principal Advisor
-
2013
Master Philosophy
Functional studies of rice KARI and inhibitor discovery
Principal Advisor
Other advisors: Professor Gary Schenk
-
-
2023
Doctor Philosophy
Structure, function and inhibition of Fe-S cluster-dependent dehydratases from the ilvD/EDD family
Associate Advisor
Other advisors: Professor Mikael Boden, Professor Gary Schenk
-
2022
Doctor Philosophy
Design, Synthesis, and Evaluation of Ketol-Acid Reductoisomerase Inhibitors: Potential Anti-Tuberculosis Drug Leads
Associate Advisor
Other advisors: Professor Gary Schenk
-
2021
Doctor Philosophy
Binuclear Metallohydrolases: Diversity in Structure and Function
Associate Advisor
Other advisors: Professor Gary Schenk
-
2021
Doctor Philosophy
Engineering stable cytochrome P450 2D forms as competent biocatalysts for industrial applications
Associate Advisor
Other advisors: Professor Elizabeth Gillam
-
2021
Doctor Philosophy
Structural and functional characterisation of ancestral cytochromes P450 from family 2 in tetrapods
Associate Advisor
Other advisors: Professor Elizabeth Gillam
-
2019
Doctor Philosophy
Acetohydroxyacid synthase AHAS: A new drug target for human fungal pathogens
Associate Advisor
Other advisors: Professor Craig Williams
-
2019
Doctor Philosophy
Drug Discovery Using Rational Structure-Based Design Approaches
Associate Advisor
Other advisors: Professor Gary Schenk
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2012
Doctor Philosophy
IMPROVING OUTCOMES OF BIOCHEMICAL TESTING IN THE PATHOLOGY LABORATORY
Associate Advisor
-
2010
Doctor Philosophy
Characterisation of the first bacterial purple acid phosphates from Mycobacterium marinum
Associate Advisor
Other advisors: Professor Gary Schenk
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2005
Doctor Philosophy
CRYSTAL STRUCTURE DETERMINATION AND SITE-DIRECTED MUTAGENESIS OF ACTIVE SITE RESIDUES IN ESCHERICHIA COLI KETOL-ACID REDUCTOISOMERASE
Associate Advisor
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