Overview
Availability
- Professor Luke Guddat is:
- Available for supervision
Fields of research
Works
Search Professor Luke Guddat’s works on UQ eSpace
2020
Journal Article
Structural basis of trehalose recycling by the ABC transporter LpqY-SugABC
Liu, Fengjiang, Liang, Jingxi, Zhang, Bing, Gao, Yan, Yang, Xiuna, Hu, Tianyu, Yang, Haitao, Xu, Wenqing, Guddat, Luke W. and Rao, Zihe (2020). Structural basis of trehalose recycling by the ABC transporter LpqY-SugABC. Science Advances, 6 (44) eabb9833, eabb9833. doi: 10.1126/sciadv.abb9833
2020
Journal Article
Inhibition studies of ketol-acid reductoisomerases from pathogenic microorganisms
Wun, Shun Jie, Johnson, Lambro A., You, Lv, McGeary, Ross P., Brueck, Thomas, Schenk, Gerhard and Guddat, Luke W. (2020). Inhibition studies of ketol-acid reductoisomerases from pathogenic microorganisms. Archives of Biochemistry and Biophysics, 692 108516, 108516. doi: 10.1016/j.abb.2020.108516
2020
Journal Article
Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris
Agnew-Francis, Kylie A., Tang, Yu Cheng, Lin, Xin, Low, Yu Shang, Wun, Shun Jie, Kuo, Andy, Elias, S. M. A. Sayeed Ibn, Lonhienne, Thierry G., Condon, Nicholas, Pimentel, Bruna Natalia Alves da Silva, Vergani, Carlos, Smith, Maree T., Fraser, James A., Williams, Craig M. and Guddat, Luke W (2020). Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris. ACS infectious diseases, 6 (11) acsinfecdis.0c00229, 2901-2912. doi: 10.1021/acsinfecdis.0c00229
2020
Journal Article
Towards a sustainable generation of pseudopterosin-type bioactives
Ringel, Marion, Reinbold, Markus, Hirte, Max, Haack, Martina, Huber, Claudia, Eisenreich, Wolfgang, Masri, Mahmoud A., Schenk, Gerhard, Guddat, Luke W., Loll, Bernhard, Kerr, Russell, Garbe, Daniel and Brück, Thomas (2020). Towards a sustainable generation of pseudopterosin-type bioactives. Green Chemistry, 22 (18), 6033-6046. doi: 10.1039/d0gc01697g
Featured
2020
Journal Article
Structures of fungal and plant acetohydroxyacid synthases
Lonhienne, Thierry, Low, Yu Shang, Garcia, Mario D., Croll, Tristan, Gao, Yan, Wang, Quan, Brillault, Lou, Williams, Craig M., Fraser, James A., McGeary, Ross P., West, Nicholas P., Landsberg, Michael J., Rao, Zihe, Schenk, Gerhard and Guddat, Luke W. (2020). Structures of fungal and plant acetohydroxyacid synthases. Nature, 586 (7828), 317-321+. doi: 10.1038/s41586-020-2514-3
2020
Journal Article
Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria
Chen, Xiaobo, Chen, Jiayue, Yan, Bing, Zhang, Wei, Guddat, Luke W., Liu, Xiang and Rao, Zihe (2020). Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria. Proceedings of the National Academy of Sciences, 117 (28), 16324-16332. doi: 10.1073/pnas.2002835117
2020
Journal Article
Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diverse
Pedroso, Marcelo Monteiro, Waite, David W., Melse, Okke, Wilson, Liam, Mitić, Nataša, McGeary, Ross P., Antes, Iris, Guddat, Luke W., Hugenholtz, Philip and Schenk, Gerhard (2020). Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diverse. Protein and Cell, 11 (8), 613-617. doi: 10.1007/s13238-020-00736-4
2020
Journal Article
Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol
Zhang, Lu, Zhao, Yao, Gao, Yan, Wu, Lijie, Gao, Ruogu, Zhang, Qi, Wang, Yinan, Wu, Chengyao, Wu, Fangyu, Gurcha, Sudagar S., Veerapen, Natacha, Batt, Sarah M., Zhao, Wei, Qin, Ling, Yang, Xiuna, Wang, Manfu, Zhu, Yan, Zhang, Bing, Bi, Lijun, Zhang, Xian’en, Yang, Haitao, Guddat, Luke W., Xu, Wenqing, Wang, Quan, Li, Jun, Besra, Gurdyal S. and Rao, Zihe (2020). Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol. Science, 368 (6496), eaba9102-1219. doi: 10.1126/science.aba9102
2020
Journal Article
Structure of Mpro from COVID-19 virus and discovery of its inhibitors
Jin, Zhenming, Du, Xiaoyu, Xu, Yechun, Deng, Yongqiang, Liu, Meiqin, Zhao, Yao, Zhang, Bing, Li, Xiaofeng, Zhang, Leike, Peng, Chao, Duan, Yinkai, Yu, Jing, Wang, Lin, Yang, Kailin, Liu, Fengjiang, Jiang, Rendi, Yang, Xinglou, You, Tian, Liu, Xiaoce, Yang, Xiuna, Bai, Fang, Liu, Hong, Liu, Xiang, Guddat, Luke W., Xu, Wenqing, Xiao, Gengfu, Qin, Chengfeng, Shi, Zhengli, Jiang, Hualiang ... Yang, Haitao (2020). Structure of Mpro from COVID-19 virus and discovery of its inhibitors. Nature, 582 (7811), 289-293. doi: 10.1038/s41586-020-2223-y
2020
Journal Article
Structural basis for the inhibition of mycobacterial MmpL3 by NITD-349 and SPIRO
Yang, Xiaolin, Hu, Tianyu, Yang, Xiuna, Xu, Wenqing, Yang, Haitao, Guddat, Luke W., Zhang, Bing and Rao, Zihe (2020). Structural basis for the inhibition of mycobacterial MmpL3 by NITD-349 and SPIRO. Journal of Molecular Biology, 432 (16), 4426-4434. doi: 10.1016/j.jmb.2020.05.019
2020
Journal Article
Structural basis for RNA replication by the SARS-CoV-2 polymerase
Wang, Quan, Wu, Jiqin, Wang, Haofeng, Gao, Yan, Liu, Qiaojie, Mu, An, Ji, Wenxin, Yan, Liming, Zhu, Yan, Zhu, Chen, Fang, Xiang, Yang, Xiaobao, Huang, Yucen, Gao, Hailong, Liu, Fengjiang, Ge, Ji, Sun, Qianqian, Yang, Xiuna, Xu, Wenqing, Liu, Zhijie, Yang, Haitao, Lou, Zhiyong, Jiang, Biao, Guddat, Luke W., Gong, Peng and Rao, Zihe (2020). Structural basis for RNA replication by the SARS-CoV-2 polymerase. Cell, 182 (2), 417-428.e13. doi: 10.1016/j.cell.2020.05.034
2020
Journal Article
Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur
Jin, Zhenming, Zhao, Yao, Sun, Yuan, Zhang, Bing, Wang, Haofeng, Wu, Yan, Zhu, Yan, Zhu, Chen, Hu, Tianyu, Du, Xiaoyu, Duan, Yinkai, Yu, Jing, Yang, Xiaobao, Yang, Xiuna, Yang, Kailin, Liu, Xiang, Guddat, Luke W., Xiao, Gengfu, Zhang, Leike, Yang, Haitao and Rao, Zihe (2020). Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur. Nature Structural and Molecular Biology, 27 (6), 529-532. doi: 10.1038/s41594-020-0440-6
2020
Journal Article
Design and development of ((4-methoxyphenyl)carbamoyl) (5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl)amide analogues as Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors
Krishna, Vagolu Siva, Zheng, Shan, Rekha, Estharla Madhu, Nallangi, Radhika, Sai Prasad, D. V., George, Shilpa E., Guddat, Luke W. and Sriram, Dharmarajan (2020). Design and development of ((4-methoxyphenyl)carbamoyl) (5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl)amide analogues as Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors. European Journal of Medicinal Chemistry, 193 112178, 112178. doi: 10.1016/j.ejmech.2020.112178
2020
Journal Article
Adaptation of a continuous, calorimetric kinetic assay to study the agmatinase-catalyzed hydrolytic reaction
Wilson, Liam A., Garcia, David, Pedroso, Marcelo Monteiro, Schulz, Benjamin L., Guddat, Luke W. and Schenk, Gerhard (2020). Adaptation of a continuous, calorimetric kinetic assay to study the agmatinase-catalyzed hydrolytic reaction. Analytical Biochemistry, 595 113618, 113618. doi: 10.1016/j.ab.2020.113618
2020
Journal Article
Structure of the RNA-dependent RNA polymerase from COVID-19 virus
Gao, Yan, Yan, Liming, Huang, Yucen, Liu, Fengjiang, Zhao, Yao, Cao, Lin, Wang, Tao, Sun, Qianqian, Ming, Zhenhua, Zhang, Lianqi, Ge, Ji, Zheng, Litao, Zhang, Ying, Wang, Haofeng, Zhu, Yan, Zhu, Chen, Hu, Tianyu, Hua, Tian, Zhang, Bing, Yang, Xiuna, Li, Jun, Yang, Haitao, Liu, Zhijie, Xu, Wenqing, Guddat, Luke W., Wang, Quan, Lou, Zhiyong and Rao, Zihe (2020). Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Science, 368 (6492), abb7498-782. doi: 10.1126/science.abb7498
2020
Journal Article
Structures of Mycobacterium tuberculosis penicillin-binding protein 3 in complex with five β-lactam antibiotics reveal mechanism of inactivation
Lu, Zuokun, Wang, Han, Zhang, Aili, Liu, Xiang, Zhou, Weihong, Yang, Cheng, Guddat, Luke, Yang, Haitao, Schofield, Christopher J. and Rao, Zihe (2020). Structures of Mycobacterium tuberculosis penicillin-binding protein 3 in complex with five β-lactam antibiotics reveal mechanism of inactivation. Molecular Pharmacology, 97 (4), 287-294. doi: 10.1124/mol.119.118042
2020
Journal Article
Discovery, synthesis and evaluation of a novel ketol-acid reductoisomerase inhibitor
Bayaraa, Tenuun, Kurz, Julia L., Patel, Khushboo M., Hussein, Waleed M., Bilyj, Jessica K., West, Nicholas P., Schenk, Gerhard, McGeary, Ross P. and Guddat, Luke William (2020). Discovery, synthesis and evaluation of a novel ketol-acid reductoisomerase inhibitor. Chemistry - A European Journal, 26 (41), 8958-8968. doi: 10.1002/chem.202000899
2020
Journal Article
Structural elements that modulate the substrate specificity of plant purple acid phosphatases: avenues for improved phosphorus acquisition in crops
Feder, Daniel, McGeary, Ross P., Mitić, Natasa, Lonhienne, Thierry, Furtado, Agnelo, Schulz, Benjamin L., Henry, Robert J., Schmidt, Susanne, Guddat, Luke W. and Schenk, Gerhard (2020). Structural elements that modulate the substrate specificity of plant purple acid phosphatases: avenues for improved phosphorus acquisition in crops. Plant Science, 294 110445, 110445. doi: 10.1016/j.plantsci.2020.110445
2020
Journal Article
Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2
Zhang, Lu, Zhao, Yao, Gao, Ruogu, Li, Jun, Yang, Xiuna, Gao, Yan, Zhao, Wei, Gurcha, Sudagar S., Veerapen, Natacha, Batt, Sarah M., Besra, Kajelle Kaur, Xu, Wenqing, Bi, Lijun, Zhang, Xian’en, Guddat, Luke W., Yang, Haitao, Wang, Quan, Besra, Gurdyal S. and Rao, Zihe (2020). Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2. Protein and Cell, 11 (7), 505-517. doi: 10.1007/s13238-020-00726-6
2019
Journal Article
Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: synthesis and evaluation
Klejch, Tomáš, Keough, Dianne T., Chavchich, Marina, Travis, Jye, Skácel, Jan, Pohl, Radek, Janeba, Zlatko, Edstein, Michael D., Avery, Vicky M., Guddat, Luke W. and Hocková, Dana (2019). Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: synthesis and evaluation. European Journal of Medicinal Chemistry, 183 111667, 111667. doi: 10.1016/j.ejmech.2019.111667
Funding
Current funding
Past funding
Supervision
Availability
- Professor Luke Guddat is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Cryo-EM inspired antifungal drug discovery
Principal Advisor
Other advisors: Professor Gary Schenk, Professor Craig Williams
-
Doctor Philosophy
Cryo-EM inspired antifungal drug discovery
Principal Advisor
Other advisors: Professor Gary Schenk, Professor Craig Williams
-
Doctor Philosophy
Acetohydroxyacid Synthase and The Discovery of Novel Herbicides
Principal Advisor
Other advisors: Professor Gary Schenk
-
Doctor Philosophy
Antimicrobial Drug Discovery
Principal Advisor
Other advisors: Professor Gary Schenk
-
Doctor Philosophy
Developing next generation green herbicides
Principal Advisor
Other advisors: Professor Craig Williams
Completed supervision
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2024
Doctor Philosophy
Structure and function of ketol-acid reductoisomerases
Principal Advisor
Other advisors: Professor Gary Schenk
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2024
Doctor Philosophy
Drug discovery targeting branched chain amino acid biosynthesis.
Principal Advisor
Other advisors: Professor Gary Schenk
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2023
Doctor Philosophy
New Antimicrobial Drug Targets
Principal Advisor
Other advisors: Professor Nick West
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2021
Doctor Philosophy
Structure and function of plant and fungal acetohydroxyacid synthases
Principal Advisor
Other advisors: Professor James Fraser
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2021
Doctor Philosophy
Ketol-acid Reductoisomerase as a target for antimicrobial drug discovery
Principal Advisor
Other advisors: Professor Gary Schenk
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2018
Doctor Philosophy
Structure, mechanism and inhibition of plant and fungal acetohydroxyacid synthases
Principal Advisor
Other advisors: Professor Gary Schenk
-
2017
Doctor Philosophy
Acyclic nucleoside phosphonates as possible chemotherapeutic agents against parasitic diseases
Principal Advisor
-
2017
Doctor Philosophy
Bacterial ketol-acid reductoisomerase: structure, catalytic mechanism and thermal stability
Principal Advisor
Other advisors: Professor Bostjan Kobe, Professor Mark Schembri
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2017
Doctor Philosophy
Targeting acetohydroxyacid synthase for the discovery of antifungal and herbicidal agents
Principal Advisor
Other advisors: Professor Gary Schenk
-
2016
Doctor Philosophy
Inhibition of Bacterial 6-Oxopurine Phosphoribosyltransferase as Potential Antibacterial Target
Principal Advisor
Other advisors: Professor Nick West
-
2014
Doctor Philosophy
A study of the anticoagulant mechanisms of three biological compounds in vitro and in vivo
Principal Advisor
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2013
Master Philosophy
Functional studies of rice KARI and inhibitor discovery
Principal Advisor
Other advisors: Professor Gary Schenk
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2023
Doctor Philosophy
Structure, function and inhibition of Fe-S cluster-dependent dehydratases from the ilvD/EDD family
Associate Advisor
Other advisors: Professor Mikael Boden, Professor Gary Schenk
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2022
Doctor Philosophy
Design, Synthesis, and Evaluation of Ketol-Acid Reductoisomerase Inhibitors: Potential Anti-Tuberculosis Drug Leads
Associate Advisor
Other advisors: Professor Gary Schenk
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2021
Doctor Philosophy
Binuclear Metallohydrolases: Diversity in Structure and Function
Associate Advisor
Other advisors: Professor Gary Schenk
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2021
Doctor Philosophy
Engineering stable cytochrome P450 2D forms as competent biocatalysts for industrial applications
Associate Advisor
Other advisors: Professor Elizabeth Gillam
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2021
Doctor Philosophy
Structural and functional characterisation of ancestral cytochromes P450 from family 2 in tetrapods
Associate Advisor
Other advisors: Professor Elizabeth Gillam
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2019
Doctor Philosophy
Acetohydroxyacid synthase AHAS: A new drug target for human fungal pathogens
Associate Advisor
Other advisors: Professor Craig Williams
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2019
Doctor Philosophy
Drug Discovery Using Rational Structure-Based Design Approaches
Associate Advisor
Other advisors: Professor Gary Schenk
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2012
Doctor Philosophy
IMPROVING OUTCOMES OF BIOCHEMICAL TESTING IN THE PATHOLOGY LABORATORY
Associate Advisor
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2010
Doctor Philosophy
Characterisation of the first bacterial purple acid phosphates from Mycobacterium marinum
Associate Advisor
Other advisors: Professor Gary Schenk
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2005
Doctor Philosophy
CRYSTAL STRUCTURE DETERMINATION AND SITE-DIRECTED MUTAGENESIS OF ACTIVE SITE RESIDUES IN ESCHERICHIA COLI KETOL-ACID REDUCTOISOMERASE
Associate Advisor
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