
Overview
Availability
- Professor Luke Guddat is:
- Available for supervision
Fields of research
Works
Search Professor Luke Guddat’s works on UQ eSpace
2020
Other Outputs
Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target
Gao, Yan, Yan, Liming, Huang, Yucen, Liu, Fengjiang, Zhao, Yao, Cao, Lin, Wang, Tao, Sun, Qianqian, Ming, Zhenhua, Zhang, Lianqi, Ge, Ji, Zheng, Litao, Zhang, Ying, Wang, Haofeng, Zhu, Yan, Zhu, Chen, Hu, Tianyu, Hua, Tian, Zhang, Bing, Yang, Xiuna, Li, Jun, Yang, Haitao, Liu, Zhijie, Xu, Wenqing, Guddat, Luke W., Wang, Quan, Lou, Zhiyong and Rao, Zihe (2020). Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target. doi: 10.1101/2020.03.16.993386
2020
Other Outputs
Structure of Mpro from COVID-19 virus and discovery of its inhibitors
Jin, Zhenming, Du, Xiaoyu, Xu, Yechun, Deng, Yongqiang, Liu, Meiqin, Zhao, Yao, Zhang, Bing, Li, Xiaofeng, Zhang, Leike, Peng, Chao, Duan, Yinkai, Yu, Jing, Wang, Lin, Yang, Kailin, Liu, Fengjiang, Jiang, Rendi, Yang, Xinglou, You, Tian, Liu, Xiaoce, Yang, Xiuna, Bai, Fang, Liu, Hong, Liu, Xiang, Guddat, Luke W., Xu, Wenqing, Xiao, Gengfu, Qin, Chengfeng, Shi, Zhengli, Jiang, Hualiang ... Yang, Haitao (2020). Structure of Mpro from COVID-19 virus and discovery of its inhibitors. doi: 10.1101/2020.02.26.964882
2020
Journal Article
Structural elements that modulate the substrate specificity of plant purple acid phosphatases: avenues for improved phosphorus acquisition in crops
Feder, Daniel, McGeary, Ross P., Mitić, Natasa, Lonhienne, Thierry, Furtado, Agnelo, Schulz, Benjamin L., Henry, Robert J., Schmidt, Susanne, Guddat, Luke W. and Schenk, Gerhard (2020). Structural elements that modulate the substrate specificity of plant purple acid phosphatases: avenues for improved phosphorus acquisition in crops. Plant Science, 294 110445, 110445. doi: 10.1016/j.plantsci.2020.110445
2020
Journal Article
Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2
Zhang, Lu, Zhao, Yao, Gao, Ruogu, Li, Jun, Yang, Xiuna, Gao, Yan, Zhao, Wei, Gurcha, Sudagar S., Veerapen, Natacha, Batt, Sarah M., Besra, Kajelle Kaur, Xu, Wenqing, Bi, Lijun, Zhang, Xian’en, Guddat, Luke W., Yang, Haitao, Wang, Quan, Besra, Gurdyal S. and Rao, Zihe (2020). Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2. Protein and Cell, 11 (7), 505-517. doi: 10.1007/s13238-020-00726-6
2019
Journal Article
Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: synthesis and evaluation
Klejch, Tomáš, Keough, Dianne T., Chavchich, Marina, Travis, Jye, Skácel, Jan, Pohl, Radek, Janeba, Zlatko, Edstein, Michael D., Avery, Vicky M., Guddat, Luke W. and Hocková, Dana (2019). Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: synthesis and evaluation. European Journal of Medicinal Chemistry, 183 111667, 111667. doi: 10.1016/j.ejmech.2019.111667
2019
Journal Article
Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis
Feder, Daniel, Kan, Meng-Wei, Hussein, Waleed M., Guddat, Luke W., Schenk, Gerhard and McGeary, Ross P. (2019). Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis. European Journal of Medicinal Chemistry, 182 111611, 111611. doi: 10.1016/j.ejmech.2019.111611
2019
Journal Article
Mycobacterial dynamin-like protein IniA mediates membrane fission
Wang, Manfu, Guo, Xiangyang, Yang, Xiuna, Zhang, Bing, Ren, Jie, Liu, Aijun, Ran, Yajun, Yan, Bing, Chen, Fang, Guddat, Luke W., Hu, Junjie, Li, Jun and Rao, Zihe (2019). Mycobacterial dynamin-like protein IniA mediates membrane fission. Nature Communications, 10 (1) 3906, 3906. doi: 10.1038/s41467-019-11860-z
2019
Other Outputs
Structural elements that modulate the substrate specificity of plant purple acid phosphatases: avenues for improved phosphorus acquisition in crops
Feder, Daniel, McGeary, Ross P., Mitić, Natasa, Lonhienne, Thierry, Furtado, Agnelo, Schulz, Benjamin L., Henry, Robert J., Schmidt, Susanne, Guddat, Luke W. and Schenk, Gerhard (2019). Structural elements that modulate the substrate specificity of plant purple acid phosphatases: avenues for improved phosphorus acquisition in crops. doi: 10.1101/749564
2019
Journal Article
Crystal structures of Trypanosoma brucei hypoxanthine – guanine – xanthine phosphoribosyltransferase in complex with IMP , GMP and XMP
Terán, David, Doleželová, Eva, Keough, Dianne T., Hocková, Dana, Zíková, Alena and Guddat, Luke W. (2019). Crystal structures of Trypanosoma brucei hypoxanthine – guanine – xanthine phosphoribosyltransferase in complex with IMP , GMP and XMP. The FEBS Journal, 286 (23) febs.14987, 4721-4736. doi: 10.1111/febs.14987
2019
Journal Article
The binding mode of an ADP analogue to a metallohydrolase mimics the likely transition state
Feder, Daniel, Gahan, Lawrence R., McGeary, Ross P., Guddat, Luke W. and Schenk, Gerhard (2019). The binding mode of an ADP analogue to a metallohydrolase mimics the likely transition state. ChemBioChem, 20 (12), 1536-1540. doi: 10.1002/cbic.201900077
2019
Journal Article
Relative catalytic efficiencies and transcript levels of three D‐ and two L‐lactate dehydrogenases for optically pure D‐lactate production in Sporolactobacillus inulinus
Wu, Bin, Yu, Qi, Zheng, Shan, Pedroso, Marcelo Monteiro, Guddat, Luke W., He, Bingfang and Schenk, Gerhard (2019). Relative catalytic efficiencies and transcript levels of three D‐ and two L‐lactate dehydrogenases for optically pure D‐lactate production in Sporolactobacillus inulinus. MicrobiologyOpen, 8 (5) e00704, e00704. doi: 10.1002/mbo3.704
2019
Journal Article
Discovery and evaluation of novel Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors as therapeutic drug leads
Krishna, Vagolu Siva, Zheng, Shan, Rekha, Estharla Madhu, Guddat, Luke W. and Sriram, Dharmarajan (2019). Discovery and evaluation of novel Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors as therapeutic drug leads. Journal of Computer-Aided Molecular Design, 33 (3), 357-366. doi: 10.1007/s10822-019-00184-1
2019
Journal Article
Synthesis of the seco-limonoid BCD ring system identifies a Hsp90 chaperon machinery (p23) inhibitor
Pinkerton, David M., Chow, Sharon, Eisa, Nada H., Kainth, Kashish, Vanden Berg, Timothy J., Burns, Jed M., Guddat, Luke W., Savage, G. Paul, Chadli, Ahmed and Williams, Craig M. (2019). Synthesis of the seco-limonoid BCD ring system identifies a Hsp90 chaperon machinery (p23) inhibitor. Chemistry - A European Journal, 25 (6), 1451-1455. doi: 10.1002/chem.201805420
2019
Journal Article
Crystal structures of membrane transporter MmpL3, an Anti-TB drug target
Zhang, Bing, Li, Jun, Yang, Xiaolin, Wu, Lijie, Zhang, Jia, Yang, Yang, Zhao, Yao, Zhang, Lu, Yang, Xiuna, Yang, Xiaobao, Cheng, Xi, Liu, Zhijie, Jiang, Biao, Jiang, Hualiang, Guddat, Luke W., Yang, Haitao and Rao, Zihe (2019). Crystal structures of membrane transporter MmpL3, an Anti-TB drug target. Cell, 176 (3), 636-648.e13. doi: 10.1016/j.cell.2019.01.003
2019
Journal Article
Structural insights into substrate recognition by the type VII secretion system
Wang, Shuhui, Zhou, Kaixuan, Yang, Xiaolin, Zhang, Bing, Zhao, Yao, Xiao, Yu, Yang, Xiuna, Yang, Haitao, Guddat, Luke W., Li, Jun and Rao, Zihe (2019). Structural insights into substrate recognition by the type VII secretion system. Protein and Cell, 11 (2), 124-137. doi: 10.1007/s13238-019-00671-z
2019
Journal Article
Synthesis and evaluation of novel purple acid phosphatase inhibitors
Hussein, Waleed M., Feder, Daniel, Schenk, Gerhard, Guddat, Luke W. and McGeary, Ross P. (2019). Synthesis and evaluation of novel purple acid phosphatase inhibitors. MedChemComm, 10 (1), 61-71. doi: 10.1039/c8md00491a
2018
Journal Article
An electron transfer path connects subunits of a mycobacterial respiratory supercomplex
Gong, Hongri, Li, Jun, Xu, Ao, Tang, Yanting, Ji, Wenxin, Gao, Ruogu, Wang, Shuhui, Yu, Lu, Tian, Changlin, Li, Jingwen, Yen, Hsin-Yung, Lam, Sin Man, Shui, Guanghou, Yang, Xiuna, Sun, Yuna, Li, Xuemei, Jia, Minze, Yang, Cheng, Jiang, Biao, Lou, Zhiyong, Robinson, Carol V., Wong, Luet-Lok, Guddat, Luke W., Sun, Fei, Wang, Quan and Rao, Zihe (2018). An electron transfer path connects subunits of a mycobacterial respiratory supercomplex. Science, 362 (6418) eaat8923, eaat8923-+. doi: 10.1126/science.aat8923
2018
Journal Article
Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase
Eng, Wai Soon, Rejman, Dominik, Pohl, Radek, West, Nicholas P., Woods, Kyra, Naesens, Lieve M.J., Keough, Dianne T. and Guddat, Luke W. (2018). Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase. European Journal of Medicinal Chemistry, 159, 10-22. doi: 10.1016/j.ejmech.2018.09.039
2018
Journal Article
Engineering highly functional thermostable proteins using ancestral sequence reconstruction
Gumulya, Yosephin, Baek, Jong-Min, Wun, Shun-Jie, Thomson, Raine E. S., Harris, Kurt L., Hunter, Dominic J. B., Behrendorff, James B. Y. H., Kulig, Justyna, Zheng, Shan, Wu, Xueming, Wu, Bin, Stok, Jeanette E., De Voss, James J., Schenk, Gerhard, Jurva, Ulrik, Andersson, Shalini, Isin, Emre M., Bodén, Mikael, Guddat, Luke and Gillam, Elizabeth M. J. (2018). Engineering highly functional thermostable proteins using ancestral sequence reconstruction. Nature Catalysis, 1 (11), 878-888. doi: 10.1038/s41929-018-0159-5
2018
Journal Article
Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections
Garcia, Mario D., Chua, Sheena M. H., Low, Yu-Shang, Lee, Yu-Ting, Agnew-Francis, Kylie, Wang, Jian-Guo, Nouwens, Amanda, Lonhienne, Thierry, Williams, Craig M., Fraser, James A. and Guddat, Luke W. (2018). Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections. Proceedings of the National Academy of Sciences of the United States of America, 115 (41), E9649-E9658. doi: 10.1073/pnas.1809422115
Funding
Current funding
Past funding
Supervision
Availability
- Professor Luke Guddat is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Antimicrobial Drug Discovery
Principal Advisor
Other advisors: Professor Gary Schenk
-
Doctor Philosophy
Developing next generation green herbicides
Principal Advisor
Other advisors: Professor Craig Williams
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-
Doctor Philosophy
Cryo-EM inspired antifungal drug discovery
Principal Advisor
Other advisors: Professor Gary Schenk, Professor Craig Williams
-
Doctor Philosophy
Cryo-EM inspired antifungal drug discovery
Principal Advisor
Other advisors: Professor Gary Schenk, Professor Craig Williams
-
Doctor Philosophy
Acetohydroxyacid Synthase and The Discovery of Novel Herbicides
Principal Advisor
Other advisors: Professor Gary Schenk
-
Doctor Philosophy
Acetohydroxyacid Synthase and The Discovery of Novel Herbicides
Principal Advisor
Other advisors: Professor Gary Schenk
-
Doctor Philosophy
Discovery of New Herbicides
Associate Advisor
Other advisors: Professor Craig Williams
Completed supervision
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2025
Doctor Philosophy
Acetohydroxyacid Synthase and The Discovery of Novel Herbicides
Principal Advisor
Other advisors: Professor Gary Schenk
-
2024
Doctor Philosophy
Structure and function of ketol-acid reductoisomerases
Principal Advisor
Other advisors: Professor Gary Schenk
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2024
Doctor Philosophy
Drug discovery targeting branched chain amino acid biosynthesis.
Principal Advisor
Other advisors: Professor Gary Schenk
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2023
Doctor Philosophy
New Antimicrobial Drug Targets
Principal Advisor
Other advisors: Professor Nick West
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2021
Doctor Philosophy
Structure and function of plant and fungal acetohydroxyacid synthases
Principal Advisor
Other advisors: Professor James Fraser
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2021
Doctor Philosophy
Ketol-acid Reductoisomerase as a target for antimicrobial drug discovery
Principal Advisor
Other advisors: Professor Gary Schenk
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2018
Doctor Philosophy
Structure, mechanism and inhibition of plant and fungal acetohydroxyacid synthases
Principal Advisor
Other advisors: Professor Gary Schenk
-
2017
Doctor Philosophy
Acyclic nucleoside phosphonates as possible chemotherapeutic agents against parasitic diseases
Principal Advisor
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2017
Doctor Philosophy
Bacterial ketol-acid reductoisomerase: structure, catalytic mechanism and thermal stability
Principal Advisor
Other advisors: Professor Bostjan Kobe, Professor Mark Schembri
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2017
Doctor Philosophy
Targeting acetohydroxyacid synthase for the discovery of antifungal and herbicidal agents
Principal Advisor
Other advisors: Professor Gary Schenk
-
2016
Doctor Philosophy
Inhibition of Bacterial 6-Oxopurine Phosphoribosyltransferase as Potential Antibacterial Target
Principal Advisor
Other advisors: Professor Nick West
-
2014
Doctor Philosophy
A study of the anticoagulant mechanisms of three biological compounds in vitro and in vivo
Principal Advisor
-
2013
Master Philosophy
Functional studies of rice KARI and inhibitor discovery
Principal Advisor
Other advisors: Professor Gary Schenk
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2023
Doctor Philosophy
Structure, function and inhibition of Fe-S cluster-dependent dehydratases from the ilvD/EDD family
Associate Advisor
Other advisors: Professor Mikael Boden, Professor Gary Schenk
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2022
Doctor Philosophy
Design, Synthesis, and Evaluation of Ketol-Acid Reductoisomerase Inhibitors: Potential Anti-Tuberculosis Drug Leads
Associate Advisor
Other advisors: Professor Gary Schenk
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2021
Doctor Philosophy
Binuclear Metallohydrolases: Diversity in Structure and Function
Associate Advisor
Other advisors: Professor Gary Schenk
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2021
Doctor Philosophy
Engineering stable cytochrome P450 2D forms as competent biocatalysts for industrial applications
Associate Advisor
Other advisors: Professor Elizabeth Gillam
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2021
Doctor Philosophy
Structural and functional characterisation of ancestral cytochromes P450 from family 2 in tetrapods
Associate Advisor
Other advisors: Professor Elizabeth Gillam
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2019
Doctor Philosophy
Acetohydroxyacid synthase AHAS: A new drug target for human fungal pathogens
Associate Advisor
Other advisors: Professor Craig Williams
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2019
Doctor Philosophy
Drug Discovery Using Rational Structure-Based Design Approaches
Associate Advisor
Other advisors: Professor Gary Schenk
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2012
Doctor Philosophy
IMPROVING OUTCOMES OF BIOCHEMICAL TESTING IN THE PATHOLOGY LABORATORY
Associate Advisor
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2010
Doctor Philosophy
Characterisation of the first bacterial purple acid phosphates from Mycobacterium marinum
Associate Advisor
Other advisors: Professor Gary Schenk
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2005
Doctor Philosophy
CRYSTAL STRUCTURE DETERMINATION AND SITE-DIRECTED MUTAGENESIS OF ACTIVE SITE RESIDUES IN ESCHERICHIA COLI KETOL-ACID REDUCTOISOMERASE
Associate Advisor
Media
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