Professor Luke Guddat
Professor

Luke Guddat

Email: 
Phone: 
+61 7 336 53549

Availability

Professor Luke Guddat is:
Available for supervision

Fields of research

Biological Sciences

Search Professor Luke Guddat’s works on UQ eSpace

254 works between 1985 and 2025
All (254) Journal Article (222) Book Chapter (3) Conference Publication (23) Other Outputs (6)

241 - 254 of 254 works

1994

Journal Article

Local and transmitted conformational changes on complexation of an anti-sweetener Fab

Guddat, Luke W., Shan, Lin, Anchin, Jerry M., Linthicum, D. Scott and Edmundson, Allen B. (1994). Local and transmitted conformational changes on complexation of an anti-sweetener Fab. Journal of Molecular Biology, 236 (1), 247-274. doi: 10.1006/jmbi.1994.1133

Local and transmitted conformational changes on complexation of an anti-sweetener Fab

1994

Journal Article

High resolution structures of the 4–4-20 Fab-fluorescein complex in two solvent systems: effects of solvent on structure and antigen-binding affinity

Herron, J. N., Terry, A. H., Johnston, S., He, X. M., Guddat, L. W., Voss, E. W. and Edmundson, A. B. (1994). High resolution structures of the 4–4-20 Fab-fluorescein complex in two solvent systems: effects of solvent on structure and antigen-binding affinity. Biophysical Journal, 67 (6), 2167-2183. doi: 10.1016/S0006-3495(94)80738-6

High resolution structures of the 4–4-20 Fab-fluorescein complex in two solvent systems: effects of solvent on structure and antigen-binding affinity

1994

Journal Article

Structural aspects of conformational changes in ligand binding by antibody fragments

Edmundson, A. B., Guddat, L. W., Shan, L., Fan, Z. c. and Hanson, B. L. (1994). Structural aspects of conformational changes in ligand binding by antibody fragments. Research in Immunology, 145 (1), 56-61. doi: 10.1016/S0923-2494(94)80045-6

Structural aspects of conformational changes in ligand binding by antibody fragments

1993

Journal Article

Crystal Structures of Intact IgG Antibodies

Edmundson, Allen B., Guddat, Luke W. and Andersen, Kim N. (1993). Crystal Structures of Intact IgG Antibodies. ImmunoMethods, 3 (3), 197-210. doi: 10.1006/immu.1993.1054

Crystal Structures of Intact IgG Antibodies

1993

Journal Article

Crystallization of an Fv fragment from a human IgM cryoglobulin by a microseeding technique

Shan, L., Guddat, L. W., Raison, R. L. and Edmundson, A. B. (1993). Crystallization of an Fv fragment from a human IgM cryoglobulin by a microseeding technique. Journal of Crystal Growth, 126 (2-3), 229-244. doi: 10.1016/0022-0248(93)90030-Z

Crystallization of an Fv fragment from a human IgM cryoglobulin by a microseeding technique

1993

Journal Article

Three-dimensional structure of a human immunoglobulin with a hinge deletion

Guddat, L. W., Herron, J. N. and Edmundson, A. B. (1993). Three-dimensional structure of a human immunoglobulin with a hinge deletion. Proceedings of the National Academy of Sciences of the United States of America, 90 (9), 4271-4275. doi: 10.1073/pnas.90.9.4271

Three-dimensional structure of a human immunoglobulin with a hinge deletion

1993

Journal Article

Principles and pitfalls in designing site‐directed peptide ligands

Edmundson, A. B., Harris, D. L., Fan, Z. ‐C, Guddat, L. W., Schley, B. T., Hanson, B. L., Tribbick, G. and Geysen, H. M. (1993). Principles and pitfalls in designing site‐directed peptide ligands. Proteins: Structure, Function, and Bioinformatics, 16 (3), 246-267. doi: 10.1002/prot.340160304

Principles and pitfalls in designing site‐directed peptide ligands

1992

Journal Article

Three-dimensional structure of an Fv from a human IgM immunoglobulin

Fan, Zhao-chang, Shan, Lin, Guddat, Luke W., He, Xiao-min, Gray, William R., Raison, Robert L. and Edmundson, Allen B. (1992). Three-dimensional structure of an Fv from a human IgM immunoglobulin. Journal of Molecular Biology, 228 (1), 188-207. doi: 10.1016/0022-2836(92)90500-J

Three-dimensional structure of an Fv from a human IgM immunoglobulin

1989

Journal Article

Difunctionalization of primary aromatic amines with ethylene; synthesis of μ-arylnitrilobis(ethane-2,1-diyl)dimercury(II) complexes. Crystal structure of 2,4,6-Me3C6H2N-(CH2CH2HgCl)2

Deacon, G. B., Gatehouse, B. M., Guddat, L. W. and Ney, S. C. (1989). Difunctionalization of primary aromatic amines with ethylene; synthesis of μ-arylnitrilobis(ethane-2,1-diyl)dimercury(II) complexes. Crystal structure of 2,4,6-Me3C6H2N-(CH2CH2HgCl)2 . Journal of Organometallic Chemistry, 375 (1), C1-C4. doi: 10.1016/0022-328X(89)85095-8

Difunctionalization of primary aromatic amines with ethylene; synthesis of μ-arylnitrilobis(ethane-2,1-diyl)dimercury(II) complexes. Crystal structure of 2,4,6-Me3C6H2N-(CH2CH2HgCl)2

1988

Journal Article

The effect of fast protein liquid chromatography (FPLC) cationic exchange purification on the crystallization of a monoclonal Fab fragment

Orbell, John D., Guddat, Luke W., Machin, Ken J. and Isaacs, Neil W. (1988). The effect of fast protein liquid chromatography (FPLC) cationic exchange purification on the crystallization of a monoclonal Fab fragment. Analytical Biochemistry, 170 (2), 390-392. doi: 10.1016/0003-2697(88)90649-5

The effect of fast protein liquid chromatography (FPLC) cationic exchange purification on the crystallization of a monoclonal Fab fragment

1987

Journal Article

CRYSTAL STRUCTURE OF Ba//3V//4O//1//3

Gatehouse, B. M., Guddat, L. W. and Roth, R. S. (1987). CRYSTAL STRUCTURE OF Ba//3V//4O//1//3. CHEMTECH, 17 (8), 390-395.

CRYSTAL STRUCTURE OF Ba//3V//4O//1//3

1987

Journal Article

The crystal structure of Ba3V4O13

Gatehouse, B. M., Guddat, L. W. and Roth, R. S. (1987). The crystal structure of Ba3V4O13. Journal of Solid State Chemistry, 71 (2), 390-395. doi: 10.1016/0022-4596(87)90247-7

The crystal structure of Ba3V4O13

1986

Journal Article

Crystal structures of some niobium and tantalum oxides. IX. K3Nb7O19: A new potassium niobium oxide tunnel structure

Fallon, G. D., Gatehouse, B. M. and Guddat, L. (1986). Crystal structures of some niobium and tantalum oxides. IX. K3Nb7O19: A new potassium niobium oxide tunnel structure. Journal of Solid State Chemistry, 61 (2), 181-187. doi: 10.1016/0022-4596(86)90020-4

Crystal structures of some niobium and tantalum oxides. IX. K3Nb7O19: A new potassium niobium oxide tunnel structure

1985

Journal Article

Crystallization and preliminary crystallographic data of the fab fragment of an anti-phenylalanine hydroxylase monoclonal antibody

Guddat, L. W., Cowan, S. W., Machin, K. J., Isaacs, N. W. and Cotton, R. G H (1985). Crystallization and preliminary crystallographic data of the fab fragment of an anti-phenylalanine hydroxylase monoclonal antibody. Journal of Molecular Biology, 186 (2), 479-480. doi: 10.1016/0022-2836(85)90121-4

Crystallization and preliminary crystallographic data of the fab fragment of an anti-phenylalanine hydroxylase monoclonal antibody

Current funding

  • 2025
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2023)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2021 - 2025
    Cryo-EM inspired drug discovery to treat human fungal pathogenic infections
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2024
    The University of Queensland, Griffith University and Charles Sturt University
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2024
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2024)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2024
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2024)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2023
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2023)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2023
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2023)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2023 - 2024
    Nanocrystal Electron Diffraction Facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2023
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2023)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2022
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2022)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2022
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2022)
    Australian Synchrotron Access Program (ANSTO)
    Open grant
  • 2022
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2022)
    Australian Synchrotron Access Program (ANSTO)
    Open grant
  • 2021 - 2022
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2021)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2021 - 2024
    EnzOnomy - an enzyme-based production pipeline for the bioeconomy
    ARC Discovery Projects
    Open grant
  • 2021
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2021)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2021
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2021)
    Australian Synchrotron Access Program (ANSTO)
    Open grant
  • 2020 - 2022
    Herbicide discovery for Australian WONS based on developments in the bioisostere concept - Phase 2
    Commonwealth Department of Agriculture, Water and the Environment
    Open grant
  • 2020 - 2021
    An integrated, multi-node bio-layer interferometry facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2019 - 2021
    The University of Queensland, Griffith University and Charles Sturt University Collaborative Access Program
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2018 - 2019
    The University of Queensland, Griffith University and Charles Sturt University Collaborative Access Program
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2018 - 2021
    Inhibitors of hypoxanthine-guanine-xanthine phosphoribosyltransferase as versatile drugs to treat infectious diseases
    NHMRC Project Grant
    Open grant
  • 2018 - 2021
    Ketol-acid reductoisomerase: An important antituberculosis drug target
    NHMRC Project Grant
    Open grant
  • 2017 - 2020
    Herbicide Discovery for Australian WONS Based on Developments in the Bioisostere Concept
    Commonwealth Department of Social Services
    Open grant
  • 2016
    Integrative blood coagulation research core facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2018
    Acetohydroxyacid synthase: A new drug target for human fungal pathogens
    NHMRC Project Grant
    Open grant
  • 2015 - 2018
    An integrated approach to combat antibiotic resistance
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Harnessing the potential of metals in biocatalysis (ARC Discovery Project administered by the Australian National University)
    Australian National University
    Open grant
  • 2012
    Rational structure based drug design
    Australian Synchrotron Access Program
    Open grant
  • 2012
    Rational structure based drug design.
    Australian Synchrotron Access Program
    Open grant
  • 2012 - 2015
    An Integrated Study of Acyclic Nucleoside Phosphonates as Antimalarial Drugs
    NHMRC Project Grant
    Open grant
  • 2012 - 2013
    Multi angle light scattering detector for the measurement of absolute molecular weight, size, and conformation of macromolecules in solution
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Rational sturcture based drug design
    Australian Synchrotron Access Program
    Open grant
  • 2011
    Rational structure based drug design
    Australian Synchrotron Access Program
    Open grant
  • 2011
    Rational Structure Based Drug Design
    Australian Synchrotron Access Program
    Open grant
  • 2011
    Structure and inhibition of enzymes that are drug or herbicide targets
    Australian Synchrotron Access Program
    Open grant
  • 2011
    Structure and inhibition of enzymes that are drug or herbicide targets
    Australian Synchrotron Access Program
    Open grant
  • 2011
    Auto-iTC200 microcalorimeter for high-throughput molecular interaction analyses
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2014
    Targeting acetohydroxyacid synthase to discover new antifungal agents
    NHMRC Project Grant
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009 - 2012
    Development of purine nucleoside phosphonates as anti-malarial drugs targeting nuceloside synthesis in Plasmodium
    NHMRC Project Grant
    Open grant
  • 2009
    Infrastructure for biochemistry and infectious disease resarch in molecualr biosciences
    UQ School/Centre Co-Funding
    Open grant
  • 2009 - 2011
    Structure-based design of anti-osteoporotic drug leads: an integrated approach
    ARC Discovery Projects
    Open grant
  • 2008 - 2011
    Pre-clinical evaluation of snake venom proteins with therapeutic potential
    ARC Linkage Projects
    Open grant
  • 2008
    Biosynthesis of Branched-Chain Amino Acids: A Target for the Discovery of New Herbicides
    UQ External Support Enabling Grant
    Open grant
  • 2005 - 2007
    An Integrated Approach Towards Development of Highly Specific Chemotherapeutics
    ARC Discovery Projects
    Open grant
  • 2004 - 2007
    Venomics: Molecular and functional analysis of Australian snake venoms for development of human therapeutics
    ARC Linkage Projects
    Open grant
  • 2004 - 2006
    Structure and inhibition of acetohydroxyacid synthase
    ARC Discovery Projects
    Open grant
  • 2003
    AUSTRALIAN SYNCHROTRON RESEARCH PROGRAM - Support to visit BioCARS 1st - 8th December 2003
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2003
    Dynamic Light Scattering Instrument
    NHMRC Equipment Grant
    Open grant
  • 2003 - 2005
    Virtual Screening In Structure-Based Drug Design For Malaria
    NHMRC Project Grant
    Open grant
  • 2002 - 2003
    AUSTRALIAN SYNCHROTRON RESEARCH PROGRAM: Support for Access to the Advanced Photon Source to visit BIOCARS (9-15 December 2002)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2002
    AUSTRALIAN SYNCHROTRON RESEARCH PROGRAM: Support for access to the Advanced Photon Source to visit BIOCARS
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2002
    AUSTRALIAN SYNCHROTRON RESEARCH PROGRAM: Support for Access to the Advanced Photon Source to visit BIOCARS 21-27 February 2002
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2002
    Analysis of molecular motion in enzyme catalysis: application to purine phosphoribosyltransferase
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002 - 2004
    Snapshots of an enzyme in action: structural and mechanistic studies on the catalytic cycle of Escherichia coli ketol-acid reductoisomerase
    ARC Discovery Projects
    Open grant
  • 2001 - 2003
    X-ray Crystallography of Acetohydroxyacid Synthase: A Target for Herbicide Inhibition.
    ARC Australian Research Council (Large grants)
    Open grant
  • 2000
    Australian Synchrotron Research Program: Travel grant to visit BioCARS, Advanced photon Source, USA (15th - 17th December 2000)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2000 - 2002
    Biochemical analysis of proteases from ginger with commercial potential
    ARC Collaborative Grant (SPIRT)
    Open grant
  • 2000
    Crystallization and preliminary X-ray diffraction analysis of yeast acetohydroxyacid synthase: an enzyme essential for amino acid biosynthesis.
    ARC Australian Research Council (Small grants)
    Open grant
  • 1999 - 2000
    Travel grant to visit BioCARS, Advanced Photon Source, USA (20-21 December 1999)
    Australian Nuclear Science and Technology Organisation
    Open grant

Availability

Professor Luke Guddat is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

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