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2026 Journal Article Rational discovery of potent sulfonylureas against resistant weed incorporating highly conserved waters in the binding-site of acetohydroxyacid synthaseShang, Ming-Hao, Gao, Yanhua, Huang, Xiao-Hui, Sun, Xue-Wen, Yuan, Jing, Hardy, Jackson, Lonhienne, Thierry G., Niu, Cong-Wei, Li, Yong-Hong, Chen, Jie, Guddat, Luke W. and Wang, Jian-Guo (2026). Rational discovery of potent sulfonylureas against resistant weed incorporating highly conserved waters in the binding-site of acetohydroxyacid synthase. Advanced Agrochem. doi: 10.1016/j.aac.2026.10.011 |
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2026 Journal Article Structural and Functional Characterisation of a Metagenome‐Derived <scp>CYP108D18</scp> Reveals an Unusual Dioxygen‐Bound State and Selective Hydrocarbon HydroxylationKundral, Simran, Giang, Peter D., Kirk, Alicia M., Buczynski, Julia B., Arachchige, Kasun S. A., Khare, Sunil K., Bernhardt, Paul V., Evans, Paul N., Guddat, Luke W., Bell, Stephen G. and De Voss, James J. (2026). Structural and Functional Characterisation of a Metagenome‐Derived CYP108D18 Reveals an Unusual Dioxygen‐Bound State and Selective Hydrocarbon Hydroxylation. Microbial Biotechnology, 19 (10) e70451, e70451-e70451. doi: 10.1111/1751-7915.70451 |
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2026 Journal Article The active component of dehydrophos covalently binds to acetohydroxyacid synthase and inhibits the growth of uropathogenic Escherichia coliLin, Xin, Chow, Sharon, Mirzayans, Paul Malek, Tng, Jiahui, Schenk, Gerhard, Williams, Craig M. and Guddat, Luke W. (2026). The active component of dehydrophos covalently binds to acetohydroxyacid synthase and inhibits the growth of uropathogenic Escherichia coli. Biochemistry. doi: 10.1021/acs.biochem.6c00555 |
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2026 Journal Article Rapid assessment of early-stage herbicide-rust compatibility to support integrated management of Cryptostegia grandifloraBatista, Bruna D., Guddat, Luke W., Williams, Craig M. and Rafter, Michelle A. (2026). Rapid assessment of early-stage herbicide-rust compatibility to support integrated management of Cryptostegia grandiflora. Australasian Plant Pathology, 55 (4) 102, 1-4. doi: 10.1007/s13313-026-01180-4 |
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2026 Journal Article Cofactor specificity and extreme robustness in the catalytic landscape of ketol-acid reductoisomerase: an evolutionary reconstructionTrujillo, Oscar Paredes, Foley, Gabriel, Porras, Sebastian, Joyce, Georgina H., Douw, Andrew, Tule, Sanjana, Ehlert, Hannes, Asser, Lachlan, Adhikary, Ulban, Davis, Samuel, Hine, Damian, Marzo, Matthew, Evans, Kent, Ley, Joe, Sieber, Volker, Guddat, Luke, Boden, Mikael and Schenk, Gerhard (2026). Cofactor specificity and extreme robustness in the catalytic landscape of ketol-acid reductoisomerase: an evolutionary reconstruction. ACS Catalysis, 16 (14) acscatal.6c01957, 13200-13210. doi: 10.1021/acscatal.6c01957 |
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2026 Journal Article An in vitro assay for post‐emergence herbicide screening of large‐seedling weeds: a case study with Cryptostegia grandifloraBatista, Bruna D., McGregor, Sarah, Murray, Cody‐Ellen, Vance, Timothy J., Guddat, Luke W., Williams, Craig M. and Rafter, Michelle A. (2026). An in vitro assay for post‐emergence herbicide screening of large‐seedling weeds: a case study with Cryptostegia grandiflora. Weed Research, 66 (2) e70081, 1-9. doi: 10.1111/wre.70081 |
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2026 Book Chapter Heparan-N-sulfatase and N-acetyl-α-glucosaminidase: Mechanisms, mutations, biophysical studies, and chaperone developmentDorsett, Lauren R., Gandhi, Neha S., Ferro, Vito and Guddat, Luke (2026). Heparan-N-sulfatase and N-acetyl-α-glucosaminidase: Mechanisms, mutations, biophysical studies, and chaperone development. Protein Dynamics. (pp. 303-314) Elsevier. doi: 10.1016/b978-0-443-30042-4.00014-6 |
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2026 Book Chapter Plant and fungal acetohydroxyacid synthases (AHAS): Methods for heterologous expression, kinetic characterization, and structural analysisGarcia, Mario Daniel, Cerda-Mejía, Liliana, Gavilanes-Flores, Vivian, Lonhienne, Thierry and Guddat, Luke (2026). Plant and fungal acetohydroxyacid synthases (AHAS): Methods for heterologous expression, kinetic characterization, and structural analysis. Methods in Enzymology. Academic Press Inc.. doi: 10.1016/bs.mie.2026.07.018 |
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2025 Journal Article Structural basis for the concurrence of template recycling and RNA capping in SARS-CoV-2Yan, Liming, Huang, Yucen, Liu, Yixiao, Ge, Ji, Gao, Shan, Tan, Liping, Liu, Lu, Liu, Zhenyu, Ye, Sihan, Wang, Junbo, Xiong, Jiangran, Zhou, Yu, Zhao, Hesheng, Zhao, Xiaoyue, Guddat, Luke W., Gao, Yan, Zhu, Lan, Rao, Zihe and Lou, Zhiyong (2025). Structural basis for the concurrence of template recycling and RNA capping in SARS-CoV-2. Cell, 188 (25), 7194-7205. doi: 10.1016/j.cell.2025.09.022 |
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2025 Journal Article Synthesis of cube-2,4-D, cube-3,4-D and cube-4-D, and their herbicidal assessment against Cryptostegia grandiflora (rubber vine)Houston, Sevan D., Batista, Bruna D., McGregor, Sarah K. M., Lin, Xin, Whitefield, Cassidy, Xing, Hui, Stone, Isobella S. J., Murray, Cody-Ellen, Hurst, Rebecca M., Su, Chuyi, Lonhienne, Thierry, Bernhardt, Paul V., Savage, G. Paul, Walter, Gimme H., Guddat, Luke W., Rafter, Michelle A. and Williams, Craig M. (2025). Synthesis of cube-2,4-D, cube-3,4-D and cube-4-D, and their herbicidal assessment against Cryptostegia grandiflora (rubber vine). Australian Journal of Chemistry, 78 (12) CH25127. doi: 10.1071/ch25127 |
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2025 Journal Article Coupling of polymerase-nucleoprotein-RNA in an influenza virus mini ribonucleoprotein complexKang, Huiling, Yang, Yunxiang, Liu, Yixiao, Li, Mingyu, Zhang, Lejin, Lin, Yuqi, Witte, Leander, Chen, Kuang-Yu, Song, Wenya, Xu, Zhili, He, Xiaojing, Guddat, Luke W., Guo, Yu, Yan, Liming, Gao, Yan, Fodor, Ervin, Rao, Zihe and Lou, Zhiyong (2025). Coupling of polymerase-nucleoprotein-RNA in an influenza virus mini ribonucleoprotein complex. Nature Communications, 16 (1) 9741, 1-10. doi: 10.1038/s41467-025-64741-z |
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2025 Journal Article C1′‐branched acyclic nucleoside phosphonates as inhibitors of plasmodium falciparum 6‐oxopurine phosphoribosyltransferaseFrydrych, Jan, Keough, Dianne T., Xia, Haojun, Slavětínská, Lenka Poštová, Dračínský, Martin, Česnek, Michal, Travis, Jye, Chavchich, Marina, Edstein, Michael, Hocková, Dana, Guddat, Luke W. and Janeba, Zlatko (2025). C1′‐branched acyclic nucleoside phosphonates as inhibitors of plasmodium falciparum 6‐oxopurine phosphoribosyltransferase. ChemMedChem, 20 (19) 202500575, 1-19. doi: 10.1002/cmdc.202500575 |
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2025 Journal Article A ketol‐acid reductoisomerase inhibitor that has antituberculosis and herbicidal activityGuddat, Luke William, Lin, Xin, Kurz, Julia L., Li, Yong-Hong, Wun, Shun Jie, Lonhienne, Thierry, McGeary, Ross P., West, Nicholas P., Schenk, Gerhard and Wang, Jian-Guo (2025). A ketol‐acid reductoisomerase inhibitor that has antituberculosis and herbicidal activity. Chemistry: A European Journal, 31 (36) e202501158, 1-14. doi: 10.1002/chem.202501158 |
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2025 Journal Article Structure and assembly of the MmpL5/MmpS5 efflux transporter from Mycobacterium tuberculosisXiong, Zhiqi, Yang, Xiaolin, Wang, Shule, Smart, Caitlan J., Sisson, Hazel M., Lin, Zhenli, Hu, Tianyu, Ran, Yuting, Xu, Chuyao, Yang, Xiuna, Zhao, Yao, Jowsey, William J., Cook, Gregory M., McNeil, Matthew B., Guddat, Luke W., Rao, Zihe and Zhang, Bing (2025). Structure and assembly of the MmpL5/MmpS5 efflux transporter from Mycobacterium tuberculosis. Nature Communications, 16 (1) 4976, 4976. doi: 10.1038/s41467-025-60365-5 |
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2025 Journal Article Structure and mechanism of a mycobacterial isoniazid efflux pump MsRv1273c/72c with a degenerate nucleotide-binding siteYu, Jing, Lan, Yuhui, Zhu, Chen, Chen, Zhendong, Pan, Junyi, Shi, Yanfeng, Yang, Lan, Hu, Tianyu, Gao, Yan, Zhao, Yao, Chen, Xiaobo, Yang, Xiuna, Lu, Shuihua, Guddat, Luke W., Yang, Haitao, Rao, Zihe and Li, Jun (2025). Structure and mechanism of a mycobacterial isoniazid efflux pump MsRv1273c/72c with a degenerate nucleotide-binding site. Nature Communications, 16 (1) 3969, 3969. doi: 10.1038/s41467-025-59300-5 |
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2025 Journal Article Florasulam is a potent inhibitor of Mycobacterium tuberculosis acetohydroxyacid synthase and possesses in vivo antituberculosis activityWun, Shun Jie, Tan, Lendl, Lonhienne, Thierry G., Low, Yu Shang, Josh, Peter, Kuo, Andy, Smith, Maree T., Gao, Yanhua, Pierens, Gregory K., Guddat, Luke W. and West, Nicholas P. (2025). Florasulam is a potent inhibitor of Mycobacterium tuberculosis acetohydroxyacid synthase and possesses in vivo antituberculosis activity. ACS Infectious Diseases, 11 (5), 1180-1189. doi: 10.1021/acsinfecdis.4c01028 |
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2025 Journal Article In search of herbistasis: COT-metsulfuron methyl displays rare herbistatic propertiesXing, Hui, McGregor, Sarah K. M., Batista, Bruna D., Whitefield, Cassidy, Stone, Isobella S. J., Murray, Cody-Ellen, Hurst, Rebecca M., Liu, Yizhou, Chow, Sharon, Fahrenhorst-Jones, Tyler, Zhao, Qi, Houston, Sevan D., Hu, Shu-Hong, Lonhienne, Thierry, Nouwens, Amanda, Burns, Jed M., Savage, G. Paul, Walter, Gimme H., Guddat, Luke W., Rafter, Michelle A. and Williams, Craig M. (2025). In search of herbistasis: COT-metsulfuron methyl displays rare herbistatic properties. Chemical Science, 16 (2), 649-658. doi: 10.1039/d4sc06923d |
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2024 Journal Article The structural and functional analysis of mycobacteria cysteine desulfurase-loaded encapsulinTang, Yanting, Liu, Yanyan, Zhang, Mingjing, Lan, Weiqi, Ma, Mengyuan, Chen, Cheng, Wu, Saibin, Chen, Rong, Yan, Yiran, Feng, Lu, Li, Ying, Guddat, Luke W., Gao, Yan, Liu, Xiang and Rao, Zihe (2024). The structural and functional analysis of mycobacteria cysteine desulfurase-loaded encapsulin. Communications Biology, 7 (1) 1656, 1656. doi: 10.1038/s42003-024-07299-8 |
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2024 Journal Article Crystal structures of Arabidopsis thaliana acetohydroxyacid synthase in complex with the herbicide triasulfuron and two analogues with herbicidal activity in field trialsCheng, Yan, Wang, Yuan, Lonhienne, Thierry, Wang, Jian-Guo and Guddat, Luke W. (2024). Crystal structures of Arabidopsis thaliana acetohydroxyacid synthase in complex with the herbicide triasulfuron and two analogues with herbicidal activity in field trials. Journal of Agricultural and Food Chemistry, 72 (41), 22487-22498. doi: 10.1021/acs.jafc.4c04990 |
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2024 Journal Article Chemical synthesis, herbicidal activity, crop safety, and molecular basis of ortho-fluoroalkoxy substituted sulfonylureas as novel acetohydroxyacid synthase inhibitorsXu, Qing, Gao, Yanhua, Sun, Zhongjie, Shi, Jin-Rui, Tang, Jin-Yin, Wang, Yuan, Liu, Yun, Sun, Xue-Wen, Li, Hao-Ran, Lonhienne, Thierry G., Niu, Cong-Wei, Li, Yong-Hong, Guddat, Luke W. and Wang, Jian-Guo (2024). Chemical synthesis, herbicidal activity, crop safety, and molecular basis of ortho-fluoroalkoxy substituted sulfonylureas as novel acetohydroxyacid synthase inhibitors. Journal of Agricultural and Food Chemistry, 72 (41), 22595-22605. doi: 10.1021/acs.jafc.4c05201 |
