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2021 Journal Article Coupling of N7-methyltransferase and 3′-5′ exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreadingYan, Liming, Yang, Yunxiang, Li, Mingyu, Zhang, Ying, Zheng, Litao, Ge, Ji, Huang, Yucen C., Liu, Zhenyu, Wang, Tao, Gao, Shan, Zhang, Ran, Huang, Yuanyun Y., Guddat, Luke W., Gao, Yan, Rao, Zihe and Lou, Zhiyong (2021). Coupling of N7-methyltransferase and 3′-5′ exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading. Cell, 184 (13), 3474-3485. doi: 10.1016/j.cell.2021.05.033 |
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2021 Journal Article Helicobacter pylori xanthine-guanine-hypoxanthine phosphoribosyltransferase - a putative target for drug discovery against gastrointestinal tract infectionsKeough, Dianne T., Wun, Shun Jie, Baszczyňski, Ondřej, Eng, Wai Soon, Špaček, Petr, Panjikar, Santosh, Naesens, Lieve, Pohl, Radek, Rejman, Dominik, Hocková, Dana, Ferrero, Richard L. and Guddat, Luke W. (2021). Helicobacter pylori xanthine-guanine-hypoxanthine phosphoribosyltransferase - a putative target for drug discovery against gastrointestinal tract infections. Journal of Medicinal Chemistry, 64 (9), 5710-5729. doi: 10.1021/acs.jmedchem.0c02184 |
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2021 Journal Article High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitorsZhao, Yao, Du, Xiaoyu, Duan, Yinkai, Pan, Xiaoyan, Sun, Yifang, You, Tian, Han, Lin, Jin, Zhenming, Shang, Weijuan, Yu, Jing, Guo, Hangtian, Liu, Qianying, Wu, Yan, Peng, Chao, Wang, Jun, Zhu, Chenghao, Yang, Xiuna, Yang, Kailin, Lei, Ying, Guddat, Luke W., Xu, Wenqing, Xiao, Gengfu, Sun, Lei, Zhang, Leike, Rao, Zihe and Yang, Haitao (2021). High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors. Protein and Cell, 12 (11), 877-888. doi: 10.1007/s13238-021-00836-9 |
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2021 Journal Article Architecture of the mycobacterial succinate dehydrogenase with a membrane-embedded rieske FeS clusterZhou, Xiaoting, Gao, Yan, Wang, Weiwei, Yang, Xiaolin, Yang, Xiuna, Liu, Fengjiang, Tang, Yanting, Lam, Sin Man, Shui, Guanghou, Yu, Lu, Tian, Changlin, Guddat, Luke W., Wang, Quan, Rao, Zihe and Gong, Hongri (2021). Architecture of the mycobacterial succinate dehydrogenase with a membrane-embedded rieske FeS cluster. Proceedings of the National Academy of Sciences of the United States of America, 118 (15) e2022308118, 1-6. doi: 10.1073/pnas.2022308118 |
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2021 Journal Article Discovery of a pyrimidine-dione derivative with potent inhibitory activity against Mycobacterium tuberculosis ketol-acid reductoisomeraseLin, Xin, Kurz, Julia, Patel, Khushboo, Wun, Shun Jie, Hussein, Waleed, Lonhienne, Thierry, West, Nicholas P., McGeary, Ross P., Schenk, Gerhard and Guddat, Luke William (2021). Discovery of a pyrimidine-dione derivative with potent inhibitory activity against Mycobacterium tuberculosis ketol-acid reductoisomerase. Chemistry: A European Journal, 27 (9) chem.202004665, 3130-3141. doi: 10.1002/chem.202004665 |
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2021 Journal Article Analogues of the herbicide, N-hydroxy-N-isopropyloxamate, inhibit Mycobacterium tuberculosis ketol-acid reductoisomerase and their prodrugs are promising anti-TB drug leadsKandale, Ajit, Patel, Khushboo, Hussein, Waleed M., Wun, Shun Jie, Zheng, Shan, Tan, Lendl, West, Nicholas P., Schenk, Gerhard, Guddat, Luke W. and McGeary, Ross P. (2021). Analogues of the herbicide, N-hydroxy-N-isopropyloxamate, inhibit Mycobacterium tuberculosis ketol-acid reductoisomerase and their prodrugs are promising anti-TB drug leads. Journal of Medicinal Chemistry, 64 (3) acs.jmedchem.0c01919, 1670-1684. doi: 10.1021/acs.jmedchem.0c01919 |
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2021 Journal Article Cryo-EM structure of an extended SARS-CoV-2 replication and transcription complex reveals an intermediate state in cap synthesisYan, Liming, Ge, Ji, Zheng, Litao, Zhang, Ying, Gao, Yan, Wang, Tao, Huang, Yucen, Yang, Yunxiang, Gao, Shan, Li, Mingyu, Liu, Zhenyu, Wang, Haofeng, Li, Yingjian, Chen, Yu, Guddat, Luke W., Wang, Quan, Rao, Zihe and Lou, Zhiyong (2021). Cryo-EM structure of an extended SARS-CoV-2 replication and transcription complex reveals an intermediate state in cap synthesis. Cell, 184 (1), 184-193.e10. doi: 10.1016/j.cell.2020.11.016 |
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2020 Journal Article Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhFGong, Hongri, Gao, Yan, Zhou, Xiaoting, Xiao, Yu, Wang, Weiwei, Tang, Yanting, Zhou, Shan, Zhang, Yuying, Ji, Wenxin, Yu, Lu, Tian, Changlin, Lam, Sin Man, Shui, Guanghou, Guddat, Luke W., Wong, Luet-Lok, Wang, Quan and Rao, Zihe (2020). Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhF. Nature Communications, 11 (1) 4245, 4245. doi: 10.1038/s41467-020-18011-9 |
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2020 Journal Article Structure and mechanism of potent bifunctional β-lactam- and homoserine lactone-degrading enzymes from marine microorganismsSelleck, Christopher, Pedroso, Marcelo Monteiro, Wilson, Liam, Krco, Stefan, Knaven, Esmée Gianna, Miraula, Manfredi, Mitić, Nataša, Larrabee, James A., Brück, Thomas, Clark, Alice, Guddat, Luke W. and Schenk, Gerhard (2020). Structure and mechanism of potent bifunctional β-lactam- and homoserine lactone-degrading enzymes from marine microorganisms. Scientific Reports, 10 (1) 12882, 12882. doi: 10.1038/s41598-020-68612-z |
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2020 Journal Article Inhibition studies of ketol-acid reductoisomerases from pathogenic microorganismsWun, Shun Jie, Johnson, Lambro A., You, Lv, McGeary, Ross P., Brueck, Thomas, Schenk, Gerhard and Guddat, Luke W. (2020). Inhibition studies of ketol-acid reductoisomerases from pathogenic microorganisms. Archives of Biochemistry and Biophysics, 692 108516, 108516. doi: 10.1016/j.abb.2020.108516 |
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2020 Journal Article Structural basis of trehalose recycling by the ABC transporter LpqY-SugABCLiu, Fengjiang, Liang, Jingxi, Zhang, Bing, Gao, Yan, Yang, Xiuna, Hu, Tianyu, Yang, Haitao, Xu, Wenqing, Guddat, Luke W. and Rao, Zihe (2020). Structural basis of trehalose recycling by the ABC transporter LpqY-SugABC. Science Advances, 6 (44) eabb9833, eabb9833. doi: 10.1126/sciadv.abb9833 |
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2020 Journal Article Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida aurisAgnew-Francis, Kylie A., Tang, Yu Cheng, Lin, Xin, Low, Yu Shang, Wun, Shun Jie, Kuo, Andy, Elias, S. M. A. Sayeed Ibn, Lonhienne, Thierry G., Condon, Nicholas, Pimentel, Bruna Natalia Alves da Silva, Vergani, Carlos, Smith, Maree T., Fraser, James A., Williams, Craig M. and Guddat, Luke W (2020). Herbicides that target acetohydroxyacid synthase are potent inhibitors of the growth of drug resistant Candida auris. ACS infectious diseases, 6 (11) acsinfecdis.0c00229, 2901-2912. doi: 10.1021/acsinfecdis.0c00229 |
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2020 Journal Article Towards a sustainable generation of pseudopterosin-type bioactivesRingel, Marion, Reinbold, Markus, Hirte, Max, Haack, Martina, Huber, Claudia, Eisenreich, Wolfgang, Masri, Mahmoud A., Schenk, Gerhard, Guddat, Luke W., Loll, Bernhard, Kerr, Russell, Garbe, Daniel and Brück, Thomas (2020). Towards a sustainable generation of pseudopterosin-type bioactives. Green Chemistry, 22 (18), 6033-6046. doi: 10.1039/d0gc01697g |
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2020 Journal Article Structures of fungal and plant acetohydroxyacid synthasesLonhienne, Thierry, Low, Yu Shang, Garcia, Mario D., Croll, Tristan, Gao, Yan, Wang, Quan, Brillault, Lou, Williams, Craig M., Fraser, James A., McGeary, Ross P., West, Nicholas P., Landsberg, Michael J., Rao, Zihe, Schenk, Gerhard and Guddat, Luke W. (2020). Structures of fungal and plant acetohydroxyacid synthases. Nature, 586 (7828), 317-321+. doi: 10.1038/s41586-020-2514-3 |
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2020 Journal Article Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteriaChen, Xiaobo, Chen, Jiayue, Yan, Bing, Zhang, Wei, Guddat, Luke W., Liu, Xiang and Rao, Zihe (2020). Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria. Proceedings of the National Academy of Sciences, 117 (28), 16324-16332. doi: 10.1073/pnas.2002835117 |
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2020 Journal Article Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diversePedroso, Marcelo Monteiro, Waite, David W., Melse, Okke, Wilson, Liam, Mitić, Nataša, McGeary, Ross P., Antes, Iris, Guddat, Luke W., Hugenholtz, Philip and Schenk, Gerhard (2020). Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diverse. Protein and Cell, 11 (8), 613-617. doi: 10.1007/s13238-020-00736-4 |
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2020 Journal Article Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutolZhang, Lu, Zhao, Yao, Gao, Yan, Wu, Lijie, Gao, Ruogu, Zhang, Qi, Wang, Yinan, Wu, Chengyao, Wu, Fangyu, Gurcha, Sudagar S., Veerapen, Natacha, Batt, Sarah M., Zhao, Wei, Qin, Ling, Yang, Xiuna, Wang, Manfu, Zhu, Yan, Zhang, Bing, Bi, Lijun, Zhang, Xian’en, Yang, Haitao, Guddat, Luke W., Xu, Wenqing, Wang, Quan, Li, Jun, Besra, Gurdyal S. and Rao, Zihe (2020). Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol. Science, 368 (6496), eaba9102-1219. doi: 10.1126/science.aba9102 |
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2020 Journal Article Structure of Mpro from COVID-19 virus and discovery of its inhibitorsJin, Zhenming, Du, Xiaoyu, Xu, Yechun, Deng, Yongqiang, Liu, Meiqin, Zhao, Yao, Zhang, Bing, Li, Xiaofeng, Zhang, Leike, Peng, Chao, Duan, Yinkai, Yu, Jing, Wang, Lin, Yang, Kailin, Liu, Fengjiang, Jiang, Rendi, Yang, Xinglou, You, Tian, Liu, Xiaoce, Yang, Xiuna, Bai, Fang, Liu, Hong, Liu, Xiang, Guddat, Luke W., Xu, Wenqing, Xiao, Gengfu, Qin, Chengfeng, Shi, Zhengli, Jiang, Hualiang ... Yang, Haitao (2020). Structure of Mpro from COVID-19 virus and discovery of its inhibitors. Nature, 582 (7811), 289-293. doi: 10.1038/s41586-020-2223-y |
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2020 Journal Article Structural basis for the inhibition of mycobacterial MmpL3 by NITD-349 and SPIROYang, Xiaolin, Hu, Tianyu, Yang, Xiuna, Xu, Wenqing, Yang, Haitao, Guddat, Luke W., Zhang, Bing and Rao, Zihe (2020). Structural basis for the inhibition of mycobacterial MmpL3 by NITD-349 and SPIRO. Journal of Molecular Biology, 432 (16), 4426-4434. doi: 10.1016/j.jmb.2020.05.019 |
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2020 Journal Article Structural basis for RNA replication by the SARS-CoV-2 polymeraseWang, Quan, Wu, Jiqin, Wang, Haofeng, Gao, Yan, Liu, Qiaojie, Mu, An, Ji, Wenxin, Yan, Liming, Zhu, Yan, Zhu, Chen, Fang, Xiang, Yang, Xiaobao, Huang, Yucen, Gao, Hailong, Liu, Fengjiang, Ge, Ji, Sun, Qianqian, Yang, Xiuna, Xu, Wenqing, Liu, Zhijie, Yang, Haitao, Lou, Zhiyong, Jiang, Biao, Guddat, Luke W., Gong, Peng and Rao, Zihe (2020). Structural basis for RNA replication by the SARS-CoV-2 polymerase. Cell, 182 (2), 417-428.e13. doi: 10.1016/j.cell.2020.05.034 |
