Professor Luke Guddat
Professor

Luke Guddat

Email: 
Phone: 
+61 7 336 53549

Availability

Professor Luke Guddat is:
Available for supervision

Fields of research

Biological Sciences

Search Professor Luke Guddat’s works on UQ eSpace

249 works between 1985 and 2025
All (249) Journal Article (222) Book Chapter (3) Conference Publication (23) Other Outputs (1)

201 - 220 of 249 works

2003

Conference Publication

Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase

Pang, S. S., Guddat, L. W. and Duggleby, R.G. (2003). Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase. East Coast Protein Meeting, Coffs Harbour, 27-29 June, 2003.

Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase

2003

Journal Article

Systematic characterization of mutations in yeast acetohydroxyacid synthase: Interpretation of herbicide-resistance data

Duggleby, Ronald G., Pang, Siew Siew, Yu, Hongqi and Guddat, Luke W. (2003). Systematic characterization of mutations in yeast acetohydroxyacid synthase: Interpretation of herbicide-resistance data. European Journal of Biochemistry, 270 (13), 2895-2904. doi: 10.1046/j.1432-1033.2003.03671.x

Systematic characterization of mutations in yeast acetohydroxyacid synthase: Interpretation of herbicide-resistance data

2003

Conference Publication

The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate

Duggleby, R.G., Pang, S. S., Schowen, R. L. and Guddat, L. W. (2003). The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate. East Coast Protein Meeting, Coffs Harbour, 27-29 June, 2003.

The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate

2003

Conference Publication

Crystal structure and mechanism of a purple acid phosphatase from sweet potato: an enzyme with a novel Fe-Mn binuclear metal centre

Schenk, G., Carrington, L., Valizadeh, M., De Jersey, J., Hamilton, S. E. and Guddat, L.W. (2003). Crystal structure and mechanism of a purple acid phosphatase from sweet potato: an enzyme with a novel Fe-Mn binuclear metal centre. International Conference on Biological Inorganic Chemistry, Cairns, 19-23 July, 2003.

Crystal structure and mechanism of a purple acid phosphatase from sweet potato: an enzyme with a novel Fe-Mn binuclear metal centre

2002

Journal Article

Crystallization of the FAD-independent acetolactate synthase of Klebsiella pneumoniae

Pang, S. S., Guddat, L. W. and Duggleby, R.G. (2002). Crystallization of the FAD-independent acetolactate synthase of Klebsiella pneumoniae. Acta Crystallographica Section D - Biological Crystallography, D58 (7), 1237-1239. doi: 10.1107/S0907444902008132

Crystallization of the FAD-independent acetolactate synthase of Klebsiella pneumoniae

2002

Journal Article

Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties

Bourne, P. C., Ramsland, P. A., Shan, L., Fan, Z. C., DeWitt, C. R., Shultz, B. B., Terzyan, S. S., Moomaw, C. R., Slaughter, C. A., Guddat, L. W. and Edmundson, A. B. (2002). Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties. Acta Crystallographica Section D: Biological Crystallography, 58 (5), 815-823. doi: 10.1107/S0907444902004183

Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties

2002

Journal Article

Crystal structure of yeast acetohydroxyacid synthase: A target for herbicidal inhibitors

Pang, S. S., Duggleby, R. G. and Guddat, L. W. (2002). Crystal structure of yeast acetohydroxyacid synthase: A target for herbicidal inhibitors. Journal of Molecular Biology, 317 (2), 249-262. doi: 10.1006/jmbi.2001.5419

Crystal structure of yeast acetohydroxyacid synthase: A target for herbicidal inhibitors

2002

Journal Article

Structure of CcmG/DsbE at 1.14 angstrom resolution: High-fidelity reducing activity in an indiscriminately oxidizing environment

Edeling, M. A., Guddat, L. W., Fabianek, R. A., Thony-Meyer, L. and Martin, J. L. (2002). Structure of CcmG/DsbE at 1.14 angstrom resolution: High-fidelity reducing activity in an indiscriminately oxidizing environment. Structure, 10 (7), 973-979. doi: 10.1016/S0969-2126(02)00794-3

Structure of CcmG/DsbE at 1.14 angstrom resolution: High-fidelity reducing activity in an indiscriminately oxidizing environment

2002

Journal Article

Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase

Guddat, L. W., Vos, S., Martin, J. L., Keough, D. T. and De Jersey, J. (2002). Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase. Protein Science, 11 (7), 1626-1638. doi: 10.1110/ps.0201002

Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase

2002

Conference Publication

Substrate analogues discriminate between human and Plasmodium falciparum 6-oxopurine phosphoribosyltransferases

Keough, D. T., Dulley, G., Guddat, L. W., Naesens, L. and De Jersey, J. (2002). Substrate analogues discriminate between human and Plasmodium falciparum 6-oxopurine phosphoribosyltransferases. ComBio 2002, Sydney, 29 September - 3 October, 2002.

Substrate analogues discriminate between human and Plasmodium falciparum 6-oxopurine phosphoribosyltransferases

2002

Conference Publication

Yeast acetohydroxyacid synthase. Crystal structure of an enzyme containing non-catalytic FAD

Pang, S. S., Guddat, L. W. and Duggleby, R.G. (2002). Yeast acetohydroxyacid synthase. Crystal structure of an enzyme containing non-catalytic FAD. 14th Int Symposium on Flavins and Flavoproteins, Cambridge, UK, 14-18 July, 2002.

Yeast acetohydroxyacid synthase. Crystal structure of an enzyme containing non-catalytic FAD

2001

Journal Article

Crystallization of the catalytic subunit of Saccharomyces cerevisiae acetohydroyacid synthase

Pang, S. S., Guddat, L. W. and Duggleby, R.G. (2001). Crystallization of the catalytic subunit of Saccharomyces cerevisiae acetohydroyacid synthase. Acta Crystallographica Section D: Biological Crystallography, 57 (9), 1321-1323. doi: 10.1107/S0907444901011635

Crystallization of the catalytic subunit of Saccharomyces cerevisiae acetohydroyacid synthase

2001

Journal Article

Crystallization and preliminary diffraction studies of native and selenomethionine CcmG (CycY, DsbE)

Edeling, M. A., Guddat, L. W., Fabianek, R. A., Halliday, J. A., Jones, A., Thony-Meyer, L. and Martin, J. L. (2001). Crystallization and preliminary diffraction studies of native and selenomethionine CcmG (CycY, DsbE). Acta Crystallographica Section D-Biological Crystallography, D57 (9), 1293-1295. doi: 10.1107/S0907444901009982

Crystallization and preliminary diffraction studies of native and selenomethionine CcmG (CycY, DsbE)

2001

Conference Publication

Structural analysis of the hnRNP A proteins: Understanding the interaction between hnRNP A2 and the A2RE trafficking element

Landsberg, M., Guddat, L. W., Hawkins, B. L. and Smith, R. W. (2001). Structural analysis of the hnRNP A proteins: Understanding the interaction between hnRNP A2 and the A2RE trafficking element. ASBMB, Canberra, 31 Sept-4 Oct, 2001.

Structural analysis of the hnRNP A proteins: Understanding the interaction between hnRNP A2 and the A2RE trafficking element

2000

Journal Article

Structure, function and regulation of tartrate-resistant acid phosphatase

Oddie, G. W., Schenk, G., Angel, N. Z., Walsh, N., Guddat, L. W., deJersey, J., Cassady, A. I., Hamilton, S. E. and Hume, D. A. (2000). Structure, function and regulation of tartrate-resistant acid phosphatase. Bone, 27 (5), 575-584. doi: 10.1016/S8756-3282(00)00368-9

Structure, function and regulation of tartrate-resistant acid phosphatase

2000

Journal Article

The three-dimensional structure of a complex of a murine Fab (NC10.14) with a potent sweetener (NC174): An illustration of structural diversity in antigen recognition by immunoglobulins

Guddat, Luke W., Shan, Lin, Broomell, Christopher, Ramsland, Paul A., Fan, Zhao-Chang, Anchin, Jerry M., Linthicum, D. Scott and Edmundson, Allen B. (2000). The three-dimensional structure of a complex of a murine Fab (NC10.14) with a potent sweetener (NC174): An illustration of structural diversity in antigen recognition by immunoglobulins. Journal of Molecular Biology, 302 (4), 853-872. doi: 10.1006/jmbi.2000.4083

The three-dimensional structure of a complex of a murine Fab (NC10.14) with a potent sweetener (NC174): An illustration of structural diversity in antigen recognition by immunoglobulins

2000

Conference Publication

Sweet potato purple acid phosphatase: first example of a strongly antiferromagnetically coupled Fe-Mn binuclear centre in a protein

Schenk, G., Boutchard, C., Noble, C. J., Moubaraki, B., Murray, K. S., Hanson, G. R., De Jersey, J., Hamilton, S. E., Guddat, L. W. and Carrington, L. (2000). Sweet potato purple acid phosphatase: first example of a strongly antiferromagnetically coupled Fe-Mn binuclear centre in a protein. EUROBIC-5, Toulouse, France, 17-20 July 2000.

Sweet potato purple acid phosphatase: first example of a strongly antiferromagnetically coupled Fe-Mn binuclear centre in a protein

2000

Journal Article

Identification of mammalian-like purple acid phosphatases in a wide range of plants

Schenk, G., Ge, Y., Guddat, L., Carrington, L. E., Hume, D. A., Hamilton, S. E. and deJersey, J. (2000). Identification of mammalian-like purple acid phosphatases in a wide range of plants. Gene, 250 (1-2), 117-125. doi: 10.1016/S0378-1119(00)00186-4

Identification of mammalian-like purple acid phosphatases in a wide range of plants

1999

Journal Article

Crystallization and preliminary X-ray diffraction data for a purple acid phosphastase from sweet potato

Schenk, G., Carrington, L., Hamilton, S. E., De Jersey, J. and Guddat, L. W. (1999). Crystallization and preliminary X-ray diffraction data for a purple acid phosphastase from sweet potato. Acta Crystallographica Section D: Biological Crystallography, 55 (12), 2051-2052. doi: 10.1107/S0907444999012597

Crystallization and preliminary X-ray diffraction data for a purple acid phosphastase from sweet potato

1999

Conference Publication

Planrtpurple acid phosphatases: Novel forms of the enzyme

Schenk, G., Carrington, L., Guddat, L. W., De Jersey, J. and Hamilton, S. E. (1999). Planrtpurple acid phosphatases: Novel forms of the enzyme. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September, 1999. Kent Town, SA: Aust. Society for Biochemistry and Molecular Biology.

Planrtpurple acid phosphatases: Novel forms of the enzyme

Current funding

  • 2025
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2025)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2021 - 2025
    Cryo-EM inspired drug discovery to treat human fungal pathogenic infections
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2025
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2023)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2024
    The University of Queensland, Griffith University and Charles Sturt University
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2024
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2024)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2024
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2024)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2023
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2023)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2023
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2023)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2023 - 2024
    Nanocrystal Electron Diffraction Facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2023
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2023)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2022
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2022)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2022
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2022)
    Australian Synchrotron Access Program (ANSTO)
    Open grant
  • 2022
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2022)
    Australian Synchrotron Access Program (ANSTO)
    Open grant
  • 2021 - 2022
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2021)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2021 - 2024
    EnzOnomy - an enzyme-based production pipeline for the bioeconomy
    ARC Discovery Projects
    Open grant
  • 2021
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2021)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2021
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2021)
    Australian Synchrotron Access Program (ANSTO)
    Open grant
  • 2020 - 2022
    Herbicide discovery for Australian WONS based on developments in the bioisostere concept - Phase 2
    Commonwealth Department of Agriculture, Water and the Environment
    Open grant
  • 2020 - 2021
    An integrated, multi-node bio-layer interferometry facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2019 - 2021
    The University of Queensland, Griffith University and Charles Sturt University Collaborative Access Program
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2018 - 2019
    The University of Queensland, Griffith University and Charles Sturt University Collaborative Access Program
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2018 - 2021
    Inhibitors of hypoxanthine-guanine-xanthine phosphoribosyltransferase as versatile drugs to treat infectious diseases
    NHMRC Project Grant
    Open grant
  • 2018 - 2021
    Ketol-acid reductoisomerase: An important antituberculosis drug target
    NHMRC Project Grant
    Open grant
  • 2017 - 2020
    Herbicide Discovery for Australian WONS Based on Developments in the Bioisostere Concept
    Commonwealth Department of Social Services
    Open grant
  • 2016
    Integrative blood coagulation research core facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2018
    Acetohydroxyacid synthase: A new drug target for human fungal pathogens
    NHMRC Project Grant
    Open grant
  • 2015 - 2018
    An integrated approach to combat antibiotic resistance
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Harnessing the potential of metals in biocatalysis (ARC Discovery Project administered by the Australian National University)
    Australian National University
    Open grant
  • 2012
    Rational structure based drug design
    Australian Synchrotron Access Program
    Open grant
  • 2012
    Rational structure based drug design.
    Australian Synchrotron Access Program
    Open grant
  • 2012 - 2015
    An Integrated Study of Acyclic Nucleoside Phosphonates as Antimalarial Drugs
    NHMRC Project Grant
    Open grant
  • 2012 - 2013
    Multi angle light scattering detector for the measurement of absolute molecular weight, size, and conformation of macromolecules in solution
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Rational sturcture based drug design
    Australian Synchrotron Access Program
    Open grant
  • 2011
    Rational structure based drug design
    Australian Synchrotron Access Program
    Open grant
  • 2011
    Rational Structure Based Drug Design
    Australian Synchrotron Access Program
    Open grant
  • 2011
    Structure and inhibition of enzymes that are drug or herbicide targets
    Australian Synchrotron Access Program
    Open grant
  • 2011
    Structure and inhibition of enzymes that are drug or herbicide targets
    Australian Synchrotron Access Program
    Open grant
  • 2011
    Auto-iTC200 microcalorimeter for high-throughput molecular interaction analyses
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2014
    Targeting acetohydroxyacid synthase to discover new antifungal agents
    NHMRC Project Grant
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009 - 2012
    Development of purine nucleoside phosphonates as anti-malarial drugs targeting nuceloside synthesis in Plasmodium
    NHMRC Project Grant
    Open grant
  • 2009
    Infrastructure for biochemistry and infectious disease resarch in molecualr biosciences
    UQ School/Centre Co-Funding
    Open grant
  • 2009 - 2011
    Structure-based design of anti-osteoporotic drug leads: an integrated approach
    ARC Discovery Projects
    Open grant
  • 2008 - 2011
    Pre-clinical evaluation of snake venom proteins with therapeutic potential
    ARC Linkage Projects
    Open grant
  • 2008
    Biosynthesis of Branched-Chain Amino Acids: A Target for the Discovery of New Herbicides
    UQ External Support Enabling Grant
    Open grant
  • 2005 - 2007
    An Integrated Approach Towards Development of Highly Specific Chemotherapeutics
    ARC Discovery Projects
    Open grant
  • 2004 - 2007
    Venomics: Molecular and functional analysis of Australian snake venoms for development of human therapeutics
    ARC Linkage Projects
    Open grant
  • 2004 - 2006
    Structure and inhibition of acetohydroxyacid synthase
    ARC Discovery Projects
    Open grant
  • 2003
    AUSTRALIAN SYNCHROTRON RESEARCH PROGRAM - Support to visit BioCARS 1st - 8th December 2003
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2003
    Dynamic Light Scattering Instrument
    NHMRC Equipment Grant
    Open grant
  • 2003 - 2005
    Virtual Screening In Structure-Based Drug Design For Malaria
    NHMRC Project Grant
    Open grant
  • 2002 - 2003
    AUSTRALIAN SYNCHROTRON RESEARCH PROGRAM: Support for Access to the Advanced Photon Source to visit BIOCARS (9-15 December 2002)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2002
    AUSTRALIAN SYNCHROTRON RESEARCH PROGRAM: Support for access to the Advanced Photon Source to visit BIOCARS
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2002
    AUSTRALIAN SYNCHROTRON RESEARCH PROGRAM: Support for Access to the Advanced Photon Source to visit BIOCARS 21-27 February 2002
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2002
    Analysis of molecular motion in enzyme catalysis: application to purine phosphoribosyltransferase
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002 - 2004
    Snapshots of an enzyme in action: structural and mechanistic studies on the catalytic cycle of Escherichia coli ketol-acid reductoisomerase
    ARC Discovery Projects
    Open grant
  • 2001 - 2003
    X-ray Crystallography of Acetohydroxyacid Synthase: A Target for Herbicide Inhibition.
    ARC Australian Research Council (Large grants)
    Open grant
  • 2000
    Australian Synchrotron Research Program: Travel grant to visit BioCARS, Advanced photon Source, USA (15th - 17th December 2000)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2000 - 2002
    Biochemical analysis of proteases from ginger with commercial potential
    ARC Collaborative Grant (SPIRT)
    Open grant
  • 2000
    Crystallization and preliminary X-ray diffraction analysis of yeast acetohydroxyacid synthase: an enzyme essential for amino acid biosynthesis.
    ARC Australian Research Council (Small grants)
    Open grant
  • 1999 - 2000
    Travel grant to visit BioCARS, Advanced Photon Source, USA (20-21 December 1999)
    Australian Nuclear Science and Technology Organisation
    Open grant

Availability

Professor Luke Guddat is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Enquiries

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