
Overview
Availability
- Professor Luke Guddat is:
- Available for supervision
Fields of research
Works
Search Professor Luke Guddat’s works on UQ eSpace
2004
Journal Article
Facile crystallization of Escherichia coli ketol-acid reductoisomerase
McCourt, J. A., Tyagi, R., Guddat, L. W., Biou, V. and Duggleby, R. G. (2004). Facile crystallization of Escherichia coli ketol-acid reductoisomerase. Acta Crystallographica Section D: Biological Crystallography, 60 (8), 1432-1434. doi: 10.1107/S0907444904012247
2004
Journal Article
The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate
Pang, S. S., Duggleby, R. G., Schowen, R. L. and Guddat, L. W. (2004). The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate. Journal of Biological Chemistry, 279 (3), 2242-2253. doi: 10.1074/jbc.M304038200
2004
Book Chapter
Structure and properties of acetohydroxyacid synthase
Duggleby, R.G., Guddat, L. W. and Pang, S. S. (2004). Structure and properties of acetohydroxyacid synthase. Thiamine. Catalytic Mechanisms. (pp. 251-274) edited by F. Jordan and M. S. Patel. USA: Marcel Dekker.
2004
Journal Article
Crystallization of Arabidopsis thaliana acetohydroxyacid synthase in complex with the sulfonylurea herbicide chlorimuron ethyl
Pang, S. S., Guddat, L. W. and Duggleby, R. G. (2004). Crystallization of Arabidopsis thaliana acetohydroxyacid synthase in complex with the sulfonylurea herbicide chlorimuron ethyl. Acta Crystallographica Section D: Biological Crystallography, 60 (1), 153-155. doi: 10.1107/S0907444903025423
2003
Journal Article
Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase
Pang, S. S., Guddat, L. W. and Duggleby, R. G. (2003). Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase. Journal of Biological Chemistry, 278 (9), 7639-7644. doi: 10.1074/jbc.M211648200
2003
Conference Publication
Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase
Pang, S. S., Guddat, L. W. and Duggleby, R.G. (2003). Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase. East Coast Protein Meeting, Coffs Harbour, 27-29 June, 2003.
2003
Journal Article
Systematic characterization of mutations in yeast acetohydroxyacid synthase: Interpretation of herbicide-resistance data
Duggleby, Ronald G., Pang, Siew Siew, Yu, Hongqi and Guddat, Luke W. (2003). Systematic characterization of mutations in yeast acetohydroxyacid synthase: Interpretation of herbicide-resistance data. European Journal of Biochemistry, 270 (13), 2895-2904. doi: 10.1046/j.1432-1033.2003.03671.x
2003
Conference Publication
The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate
Duggleby, R.G., Pang, S. S., Schowen, R. L. and Guddat, L. W. (2003). The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate. East Coast Protein Meeting, Coffs Harbour, 27-29 June, 2003.
2003
Conference Publication
Crystal structure and mechanism of a purple acid phosphatase from sweet potato: an enzyme with a novel Fe-Mn binuclear metal centre
Schenk, G., Carrington, L., Valizadeh, M., De Jersey, J., Hamilton, S. E. and Guddat, L.W. (2003). Crystal structure and mechanism of a purple acid phosphatase from sweet potato: an enzyme with a novel Fe-Mn binuclear metal centre. International Conference on Biological Inorganic Chemistry, Cairns, 19-23 July, 2003.
2002
Journal Article
Crystallization of the FAD-independent acetolactate synthase of Klebsiella pneumoniae
Pang, S. S., Guddat, L. W. and Duggleby, R.G. (2002). Crystallization of the FAD-independent acetolactate synthase of Klebsiella pneumoniae. Acta Crystallographica Section D - Biological Crystallography, D58 (7), 1237-1239. doi: 10.1107/S0907444902008132
2002
Journal Article
Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties
Bourne, P. C., Ramsland, P. A., Shan, L., Fan, Z. C., DeWitt, C. R., Shultz, B. B., Terzyan, S. S., Moomaw, C. R., Slaughter, C. A., Guddat, L. W. and Edmundson, A. B. (2002). Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties. Acta Crystallographica Section D: Biological Crystallography, 58 (5), 815-823. doi: 10.1107/S0907444902004183
2002
Journal Article
Crystal structure of yeast acetohydroxyacid synthase: A target for herbicidal inhibitors
Pang, S. S., Duggleby, R. G. and Guddat, L. W. (2002). Crystal structure of yeast acetohydroxyacid synthase: A target for herbicidal inhibitors. Journal of Molecular Biology, 317 (2), 249-262. doi: 10.1006/jmbi.2001.5419
2002
Journal Article
Structure of CcmG/DsbE at 1.14 angstrom resolution: High-fidelity reducing activity in an indiscriminately oxidizing environment
Edeling, M. A., Guddat, L. W., Fabianek, R. A., Thony-Meyer, L. and Martin, J. L. (2002). Structure of CcmG/DsbE at 1.14 angstrom resolution: High-fidelity reducing activity in an indiscriminately oxidizing environment. Structure, 10 (7), 973-979. doi: 10.1016/S0969-2126(02)00794-3
2002
Journal Article
Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase
Guddat, L. W., Vos, S., Martin, J. L., Keough, D. T. and De Jersey, J. (2002). Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase. Protein Science, 11 (7), 1626-1638. doi: 10.1110/ps.0201002
2002
Conference Publication
Substrate analogues discriminate between human and Plasmodium falciparum 6-oxopurine phosphoribosyltransferases
Keough, D. T., Dulley, G., Guddat, L. W., Naesens, L. and De Jersey, J. (2002). Substrate analogues discriminate between human and Plasmodium falciparum 6-oxopurine phosphoribosyltransferases. ComBio 2002, Sydney, 29 September - 3 October, 2002.
2002
Conference Publication
Yeast acetohydroxyacid synthase. Crystal structure of an enzyme containing non-catalytic FAD
Pang, S. S., Guddat, L. W. and Duggleby, R.G. (2002). Yeast acetohydroxyacid synthase. Crystal structure of an enzyme containing non-catalytic FAD. 14th Int Symposium on Flavins and Flavoproteins, Cambridge, UK, 14-18 July, 2002.
2001
Journal Article
Crystallization of the catalytic subunit of Saccharomyces cerevisiae acetohydroyacid synthase
Pang, S. S., Guddat, L. W. and Duggleby, R.G. (2001). Crystallization of the catalytic subunit of Saccharomyces cerevisiae acetohydroyacid synthase. Acta Crystallographica Section D: Biological Crystallography, 57 (9), 1321-1323. doi: 10.1107/S0907444901011635
2001
Journal Article
Crystallization and preliminary diffraction studies of native and selenomethionine CcmG (CycY, DsbE)
Edeling, M. A., Guddat, L. W., Fabianek, R. A., Halliday, J. A., Jones, A., Thony-Meyer, L. and Martin, J. L. (2001). Crystallization and preliminary diffraction studies of native and selenomethionine CcmG (CycY, DsbE). Acta Crystallographica Section D-Biological Crystallography, D57 (9), 1293-1295. doi: 10.1107/S0907444901009982
2001
Conference Publication
Structural analysis of the hnRNP A proteins: Understanding the interaction between hnRNP A2 and the A2RE trafficking element
Landsberg, M., Guddat, L. W., Hawkins, B. L. and Smith, R. W. (2001). Structural analysis of the hnRNP A proteins: Understanding the interaction between hnRNP A2 and the A2RE trafficking element. ASBMB, Canberra, 31 Sept-4 Oct, 2001.
2000
Journal Article
Structure, function and regulation of tartrate-resistant acid phosphatase
Oddie, G. W., Schenk, G., Angel, N. Z., Walsh, N., Guddat, L. W., deJersey, J., Cassady, A. I., Hamilton, S. E. and Hume, D. A. (2000). Structure, function and regulation of tartrate-resistant acid phosphatase. Bone, 27 (5), 575-584. doi: 10.1016/S8756-3282(00)00368-9
Funding
Current funding
Past funding
Supervision
Availability
- Professor Luke Guddat is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Cryo-EM inspired antifungal drug discovery
Principal Advisor
Other advisors: Professor Gary Schenk, Professor Craig Williams
-
Doctor Philosophy
Cryo-EM inspired antifungal drug discovery
Principal Advisor
Other advisors: Professor Gary Schenk, Professor Craig Williams
-
Doctor Philosophy
Acetohydroxyacid Synthase and The Discovery of Novel Herbicides
Principal Advisor
Other advisors: Professor Gary Schenk
-
Doctor Philosophy
Acetohydroxyacid Synthase and The Discovery of Novel Herbicides
Principal Advisor
Other advisors: Professor Gary Schenk
-
-
Doctor Philosophy
Antimicrobial Drug Discovery
Principal Advisor
Other advisors: Professor Gary Schenk
-
Doctor Philosophy
Developing next generation green herbicides
Principal Advisor
Other advisors: Professor Craig Williams
-
Doctor Philosophy
Discovery of New Herbicides
Associate Advisor
Other advisors: Professor Craig Williams
Completed supervision
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2025
Doctor Philosophy
Acetohydroxyacid Synthase and The Discovery of Novel Herbicides
Principal Advisor
Other advisors: Professor Gary Schenk
-
2024
Doctor Philosophy
Structure and function of ketol-acid reductoisomerases
Principal Advisor
Other advisors: Professor Gary Schenk
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2024
Doctor Philosophy
Drug discovery targeting branched chain amino acid biosynthesis.
Principal Advisor
Other advisors: Professor Gary Schenk
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2023
Doctor Philosophy
New Antimicrobial Drug Targets
Principal Advisor
Other advisors: Professor Nick West
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2021
Doctor Philosophy
Structure and function of plant and fungal acetohydroxyacid synthases
Principal Advisor
Other advisors: Professor James Fraser
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2021
Doctor Philosophy
Ketol-acid Reductoisomerase as a target for antimicrobial drug discovery
Principal Advisor
Other advisors: Professor Gary Schenk
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2018
Doctor Philosophy
Structure, mechanism and inhibition of plant and fungal acetohydroxyacid synthases
Principal Advisor
Other advisors: Professor Gary Schenk
-
2017
Doctor Philosophy
Acyclic nucleoside phosphonates as possible chemotherapeutic agents against parasitic diseases
Principal Advisor
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2017
Doctor Philosophy
Bacterial ketol-acid reductoisomerase: structure, catalytic mechanism and thermal stability
Principal Advisor
Other advisors: Professor Bostjan Kobe, Professor Mark Schembri
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2017
Doctor Philosophy
Targeting acetohydroxyacid synthase for the discovery of antifungal and herbicidal agents
Principal Advisor
Other advisors: Professor Gary Schenk
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2016
Doctor Philosophy
Inhibition of Bacterial 6-Oxopurine Phosphoribosyltransferase as Potential Antibacterial Target
Principal Advisor
Other advisors: Professor Nick West
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2014
Doctor Philosophy
A study of the anticoagulant mechanisms of three biological compounds in vitro and in vivo
Principal Advisor
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2013
Master Philosophy
Functional studies of rice KARI and inhibitor discovery
Principal Advisor
Other advisors: Professor Gary Schenk
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2023
Doctor Philosophy
Structure, function and inhibition of Fe-S cluster-dependent dehydratases from the ilvD/EDD family
Associate Advisor
Other advisors: Professor Mikael Boden, Professor Gary Schenk
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2022
Doctor Philosophy
Design, Synthesis, and Evaluation of Ketol-Acid Reductoisomerase Inhibitors: Potential Anti-Tuberculosis Drug Leads
Associate Advisor
Other advisors: Professor Gary Schenk
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2021
Doctor Philosophy
Binuclear Metallohydrolases: Diversity in Structure and Function
Associate Advisor
Other advisors: Professor Gary Schenk
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2021
Doctor Philosophy
Engineering stable cytochrome P450 2D forms as competent biocatalysts for industrial applications
Associate Advisor
Other advisors: Professor Elizabeth Gillam
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2021
Doctor Philosophy
Structural and functional characterisation of ancestral cytochromes P450 from family 2 in tetrapods
Associate Advisor
Other advisors: Professor Elizabeth Gillam
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2019
Doctor Philosophy
Acetohydroxyacid synthase AHAS: A new drug target for human fungal pathogens
Associate Advisor
Other advisors: Professor Craig Williams
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2019
Doctor Philosophy
Drug Discovery Using Rational Structure-Based Design Approaches
Associate Advisor
Other advisors: Professor Gary Schenk
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2012
Doctor Philosophy
IMPROVING OUTCOMES OF BIOCHEMICAL TESTING IN THE PATHOLOGY LABORATORY
Associate Advisor
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2010
Doctor Philosophy
Characterisation of the first bacterial purple acid phosphates from Mycobacterium marinum
Associate Advisor
Other advisors: Professor Gary Schenk
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2005
Doctor Philosophy
CRYSTAL STRUCTURE DETERMINATION AND SITE-DIRECTED MUTAGENESIS OF ACTIVE SITE RESIDUES IN ESCHERICHIA COLI KETOL-ACID REDUCTOISOMERASE
Associate Advisor
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