Professor Luke Guddat
Professor

Luke Guddat

Email: 
Phone: 
+61 7 336 53549

Availability

Professor Luke Guddat is:
Available for supervision

Fields of research

Biological Sciences

Search Professor Luke Guddat’s works on UQ eSpace

254 works between 1985 and 2025
All (254) Journal Article (222) Book Chapter (3) Conference Publication (23) Other Outputs (6)

181 - 200 of 254 works

2006

Journal Article

The Catalytic Mechanisms of Binuclear Metallohydrolases

Mitic, Natasa, Smith, Sarah J., Neves, Ademir, Guddat, Luke W., Gahan, Lawrence R. and Schenk, Gerhard (2006). The Catalytic Mechanisms of Binuclear Metallohydrolases. Chemical Reviews, 106 (8), 3338-3363. doi: 10.1021/cr050318f

The Catalytic Mechanisms of Binuclear Metallohydrolases

2006

Journal Article

Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase

Flanagan, J. U., Cassady, A. I., Schenk, G., Guddat, L. W. and Hume, D. A. (2006). Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase. Gene, 377 (1), 12-20. doi: 10.1016/j.gene.2006.02.031

Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase

2006

Journal Article

Herbicide-binding Sites Revealed in the Structure of Plant Acetohydroxyacid Synthase

McCourt, J. A., Pang, S. S., King-Scott, J., Guddat, L. W. and Duggleby, R. G. (2006). Herbicide-binding Sites Revealed in the Structure of Plant Acetohydroxyacid Synthase. Proceedings of The National Academy of Sciences of The United States of America, 103 (3), 569-573. doi: 10.1073/pnas.0508701103

Herbicide-binding Sites Revealed in the Structure of Plant Acetohydroxyacid Synthase

2006

Journal Article

Inhibition studies of purple acid phosphatases: Implications for the catalytic mechanism

Elliott, T. W., Mitic, N., Gahan, L. R., Guddat, L. W. and Schenk, G. (2006). Inhibition studies of purple acid phosphatases: Implications for the catalytic mechanism. Journal of the Brazilian Chemical Society, 17 (8), 1558-1565. doi: 10.1590/S0103-50532006000800011

Inhibition studies of purple acid phosphatases: Implications for the catalytic mechanism

2006

Journal Article

Mammalian-like purple acid phosphatases in plants

De Jersey, J., Zheng, Yuan-Zhi, Fan, H. K., Schenk, G., Guddat, L. and Hamilton, S. (2006). Mammalian-like purple acid phosphatases in plants. Chemical Research In Chinese Universities, 22 (2), 263-264. doi: 10.1016/S1005-9040(06)60093-7

Mammalian-like purple acid phosphatases in plants

2006

Conference Publication

Inhibition studies of purple acid phosphatases: Implications for the catalytic mechanism

Elliott, Tristan W., Mitić, Nataša, Gahan, Lawrence R., Guddat, Luke W. and Schenk, Gerhard (2006). Inhibition studies of purple acid phosphatases: Implications for the catalytic mechanism. Sociedade Brasileira de Quimica. doi: 10.1590/S0103-50532006000800011

Inhibition studies of purple acid phosphatases: Implications for the catalytic mechanism

2005

Journal Article

The crystal structure of a bacterial Class II ketol-acid reductolsomerase: Domain conservation and evolution

Tyagi, R., Duquerroy, S., Navaza, J., Guddat, L. W. and Duggleby, R. G. (2005). The crystal structure of a bacterial Class II ketol-acid reductolsomerase: Domain conservation and evolution. Protein Science, 14 (12), 3089-3100. doi: 10.1110/ps.051791305

The crystal structure of a bacterial Class II ketol-acid reductolsomerase: Domain conservation and evolution

2005

Journal Article

Structure-activity relationships for a new family of sulfonylurea herbicides

Wang, Jian-Guo, Li, Zheng-Ming, Ma, Zheng-Ming, Wang, Bao-Lei, Jiang, Lin, Pang, Siew Siew, Lee, Yu-Ting, Guddat, Luke W. and Duggleby, Ronald G. (2005). Structure-activity relationships for a new family of sulfonylurea herbicides. Journal of Computer-aided Molecular Design, 19 (11), 801-820. doi: 10.1007/s10822-005-9028-9

Structure-activity relationships for a new family of sulfonylurea herbicides

2005

Journal Article

Aspartic proteases of Plasmodium falciparum as the target of HIV-1 protease inhibitors - Reply

Skinner-Adams, Tina S., Guddat, Luke W., Gardiner, Donald L., McCarthy, James S. and Andrews, Katherine T. (2005). Aspartic proteases of Plasmodium falciparum as the target of HIV-1 protease inhibitors - Reply. Journal of Infectious Diseases, 191 (8), 1382-1383. doi: 10.1086/428782

Aspartic proteases of Plasmodium falciparum as the target of HIV-1 protease inhibitors - Reply

2005

Journal Article

Aspartic proteases of Plasmodium falciparum as the target of HIV-1 protease inhibitors [3] (multiple letters)

Savarino, Andrea, Cauda, Roberto, Cassone, Antonio, Skinner-Adams, Tina S., Guddat, Luke W., Gardiner, Donald L., McCarthy, J. James S. and Andrews, Katherine T. (2005). Aspartic proteases of Plasmodium falciparum as the target of HIV-1 protease inhibitors [3] (multiple letters). Journal of Infectious Diseases, 191 (8), 1381-1383. doi: 10.1086/428781

Aspartic proteases of Plasmodium falciparum as the target of HIV-1 protease inhibitors [3] (multiple letters)

2005

Journal Article

Phosphate forms an unusual tripodal complex with the Fe-Mn center of sweet potato purple acid phosphatase

Schenk, G., Gahan, L. R., Carrington, L. E., Mitic, N., Valizadeh, M., Hamilton, S. E., de Jersey, J. and Guddat, L. W. (2005). Phosphate forms an unusual tripodal complex with the Fe-Mn center of sweet potato purple acid phosphatase. Proceedings of The National Academy of Sciences of The United States of America, 102 (2), 273-278. doi: 10.1073/pnas.0407239102

Phosphate forms an unusual tripodal complex with the Fe-Mn center of sweet potato purple acid phosphatase

2005

Journal Article

Probing the mechanism of the bifunctional enzyme ketol-acid reductoisomerase by site-directed mutagenesis of the active site

Tyagi, Rajiv, Lee, Yu-Ting, Guddat, Luke W. and Duggleby, Ronald G. (2005). Probing the mechanism of the bifunctional enzyme ketol-acid reductoisomerase by site-directed mutagenesis of the active site. Febs Journal, 272 (2), 593-602. doi: 10.1111/j.1742-4658.2004.04506.x

Probing the mechanism of the bifunctional enzyme ketol-acid reductoisomerase by site-directed mutagenesis of the active site

2005

Conference Publication

Elucidation of the binding site for five sulfonylurea herbicides in Arabidopsis thaliana

McCourt, J. A., Pang, S. S., King-Scott, J., Guddat, L. W. and Duggleby, R.G. (2005). Elucidation of the binding site for five sulfonylurea herbicides in Arabidopsis thaliana. 30th Annual Lorne Conference on Protein Structure and Function, Lorne, 6-11 Feb, 2005.

Elucidation of the binding site for five sulfonylurea herbicides in Arabidopsis thaliana

2005

Conference Publication

Crystal structure of textilinin-1

Millers, E. I., Masci, P., Lavin, M. F., De Jersey, J. and Guddat, L. W. (2005). Crystal structure of textilinin-1. East Coast Protein Meeting, Coffs Harbour, 24-26 June, 2005.

Crystal structure of textilinin-1

2005

Journal Article

Elucidating the specificity of binding of sulfonylurea herbicides to acetohydroxyacid synthase

McCourt, J. A., Pang, S. S., Guddat, L. W. and Duggleby, R. G. (2005). Elucidating the specificity of binding of sulfonylurea herbicides to acetohydroxyacid synthase. Biochemistry, 44 (7), 2330-2338. doi: 10.1021/bi047980a

Elucidating the specificity of binding of sulfonylurea herbicides to acetohydroxyacid synthase

2005

Conference Publication

Overlapping sulfonylurea and imidazolinone herbicide binding sites in Arabidopsis thaliana acetohydroxyacid synthase

McCourt, J. A., Pang, S. S., King-Scott, J., Guddat, L. W. and Duggleby, R.G. (2005). Overlapping sulfonylurea and imidazolinone herbicide binding sites in Arabidopsis thaliana acetohydroxyacid synthase. East Coast Protein Meeting, Coffs Harbour, 24-26 June, 2005.

Overlapping sulfonylurea and imidazolinone herbicide binding sites in Arabidopsis thaliana acetohydroxyacid synthase

2005

Conference Publication

3D structure of the overlapping sulfonylurea and imidazolinone herbicide binding sites in acetohydroxyacid synthase

Duggleby, R.G., McCourt, J. A. and Guddat, L. W. (2005). 3D structure of the overlapping sulfonylurea and imidazolinone herbicide binding sites in acetohydroxyacid synthase. 9th Int Congress on Amino Acids & Proteins, Vienna, 8-12 Aug, 2005.

3D structure of the overlapping sulfonylurea and imidazolinone herbicide binding sites in acetohydroxyacid synthase

2005

Journal Article

The crystal structure of free human hypoxanthineguanine phosphoribosyltransferase reveals extensive conformational plasticity throughout the catalytic cycle

Keough, Dianne T., Brereton, Ian M., De Jersey, John and Guddat, Luke W. (2005). The crystal structure of free human hypoxanthineguanine phosphoribosyltransferase reveals extensive conformational plasticity throughout the catalytic cycle. Journal of Molecular Biology, 351 (1), 170-181. doi: 10.1016/j.jmb.2005.05.061

The crystal structure of free human hypoxanthineguanine phosphoribosyltransferase reveals extensive conformational plasticity throughout the catalytic cycle

2005

Conference Publication

Crystal structure of Escherichia coli ketol-acid reductoisomerase

Duggleby, R.G., Tyagi, R., Duquerroy, S., Navaza, J. and Guddat, L. W. (2005). Crystal structure of Escherichia coli ketol-acid reductoisomerase. East Coast Protein Meeting, Coffs Harbour, 24-26 June, 2005.

Crystal structure of Escherichia coli ketol-acid reductoisomerase

2004

Journal Article

Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases

Valizadeh, Mohsen, Schenk, Gerhard, Nash, Kevin, Oddie, Geoff W., Guddat, Luke W., Hume, David A., de Jersey, John, Burke, Terrence R. and Hamilton, Susan (2004). Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases. Archives of Biochemistry And Biophysics, 424 (2), 154-162. doi: 10.1016/j.abb.2004.01.008

Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases

Current funding

  • 2025
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2023)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2021 - 2025
    Cryo-EM inspired drug discovery to treat human fungal pathogenic infections
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2024
    The University of Queensland, Griffith University and Charles Sturt University
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2024
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2024)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2024
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2024)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2023
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2023)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2023
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2023)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2023 - 2024
    Nanocrystal Electron Diffraction Facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2023
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2023)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2022
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2022)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2022
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2022)
    Australian Synchrotron Access Program (ANSTO)
    Open grant
  • 2022
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2022)
    Australian Synchrotron Access Program (ANSTO)
    Open grant
  • 2021 - 2022
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2021)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2021 - 2024
    EnzOnomy - an enzyme-based production pipeline for the bioeconomy
    ARC Discovery Projects
    Open grant
  • 2021
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2021)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2021
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2021)
    Australian Synchrotron Access Program (ANSTO)
    Open grant
  • 2020 - 2022
    Herbicide discovery for Australian WONS based on developments in the bioisostere concept - Phase 2
    Commonwealth Department of Agriculture, Water and the Environment
    Open grant
  • 2020 - 2021
    An integrated, multi-node bio-layer interferometry facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2019 - 2021
    The University of Queensland, Griffith University and Charles Sturt University Collaborative Access Program
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2018 - 2019
    The University of Queensland, Griffith University and Charles Sturt University Collaborative Access Program
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2018 - 2021
    Inhibitors of hypoxanthine-guanine-xanthine phosphoribosyltransferase as versatile drugs to treat infectious diseases
    NHMRC Project Grant
    Open grant
  • 2018 - 2021
    Ketol-acid reductoisomerase: An important antituberculosis drug target
    NHMRC Project Grant
    Open grant
  • 2017 - 2020
    Herbicide Discovery for Australian WONS Based on Developments in the Bioisostere Concept
    Commonwealth Department of Social Services
    Open grant
  • 2016
    Integrative blood coagulation research core facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2018
    Acetohydroxyacid synthase: A new drug target for human fungal pathogens
    NHMRC Project Grant
    Open grant
  • 2015 - 2018
    An integrated approach to combat antibiotic resistance
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Harnessing the potential of metals in biocatalysis (ARC Discovery Project administered by the Australian National University)
    Australian National University
    Open grant
  • 2012
    Rational structure based drug design
    Australian Synchrotron Access Program
    Open grant
  • 2012
    Rational structure based drug design.
    Australian Synchrotron Access Program
    Open grant
  • 2012 - 2015
    An Integrated Study of Acyclic Nucleoside Phosphonates as Antimalarial Drugs
    NHMRC Project Grant
    Open grant
  • 2012 - 2013
    Multi angle light scattering detector for the measurement of absolute molecular weight, size, and conformation of macromolecules in solution
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Rational sturcture based drug design
    Australian Synchrotron Access Program
    Open grant
  • 2011
    Rational structure based drug design
    Australian Synchrotron Access Program
    Open grant
  • 2011
    Rational Structure Based Drug Design
    Australian Synchrotron Access Program
    Open grant
  • 2011
    Structure and inhibition of enzymes that are drug or herbicide targets
    Australian Synchrotron Access Program
    Open grant
  • 2011
    Structure and inhibition of enzymes that are drug or herbicide targets
    Australian Synchrotron Access Program
    Open grant
  • 2011
    Auto-iTC200 microcalorimeter for high-throughput molecular interaction analyses
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2014
    Targeting acetohydroxyacid synthase to discover new antifungal agents
    NHMRC Project Grant
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009 - 2012
    Development of purine nucleoside phosphonates as anti-malarial drugs targeting nuceloside synthesis in Plasmodium
    NHMRC Project Grant
    Open grant
  • 2009
    Infrastructure for biochemistry and infectious disease resarch in molecualr biosciences
    UQ School/Centre Co-Funding
    Open grant
  • 2009 - 2011
    Structure-based design of anti-osteoporotic drug leads: an integrated approach
    ARC Discovery Projects
    Open grant
  • 2008 - 2011
    Pre-clinical evaluation of snake venom proteins with therapeutic potential
    ARC Linkage Projects
    Open grant
  • 2008
    Biosynthesis of Branched-Chain Amino Acids: A Target for the Discovery of New Herbicides
    UQ External Support Enabling Grant
    Open grant
  • 2005 - 2007
    An Integrated Approach Towards Development of Highly Specific Chemotherapeutics
    ARC Discovery Projects
    Open grant
  • 2004 - 2007
    Venomics: Molecular and functional analysis of Australian snake venoms for development of human therapeutics
    ARC Linkage Projects
    Open grant
  • 2004 - 2006
    Structure and inhibition of acetohydroxyacid synthase
    ARC Discovery Projects
    Open grant
  • 2003
    AUSTRALIAN SYNCHROTRON RESEARCH PROGRAM - Support to visit BioCARS 1st - 8th December 2003
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2003
    Dynamic Light Scattering Instrument
    NHMRC Equipment Grant
    Open grant
  • 2003 - 2005
    Virtual Screening In Structure-Based Drug Design For Malaria
    NHMRC Project Grant
    Open grant
  • 2002 - 2003
    AUSTRALIAN SYNCHROTRON RESEARCH PROGRAM: Support for Access to the Advanced Photon Source to visit BIOCARS (9-15 December 2002)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2002
    AUSTRALIAN SYNCHROTRON RESEARCH PROGRAM: Support for access to the Advanced Photon Source to visit BIOCARS
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2002
    AUSTRALIAN SYNCHROTRON RESEARCH PROGRAM: Support for Access to the Advanced Photon Source to visit BIOCARS 21-27 February 2002
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2002
    Analysis of molecular motion in enzyme catalysis: application to purine phosphoribosyltransferase
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002 - 2004
    Snapshots of an enzyme in action: structural and mechanistic studies on the catalytic cycle of Escherichia coli ketol-acid reductoisomerase
    ARC Discovery Projects
    Open grant
  • 2001 - 2003
    X-ray Crystallography of Acetohydroxyacid Synthase: A Target for Herbicide Inhibition.
    ARC Australian Research Council (Large grants)
    Open grant
  • 2000
    Australian Synchrotron Research Program: Travel grant to visit BioCARS, Advanced photon Source, USA (15th - 17th December 2000)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2000 - 2002
    Biochemical analysis of proteases from ginger with commercial potential
    ARC Collaborative Grant (SPIRT)
    Open grant
  • 2000
    Crystallization and preliminary X-ray diffraction analysis of yeast acetohydroxyacid synthase: an enzyme essential for amino acid biosynthesis.
    ARC Australian Research Council (Small grants)
    Open grant
  • 1999 - 2000
    Travel grant to visit BioCARS, Advanced Photon Source, USA (20-21 December 1999)
    Australian Nuclear Science and Technology Organisation
    Open grant

Availability

Professor Luke Guddat is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

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