
Overview
Availability
- Professor Luke Guddat is:
- Available for supervision
Fields of research
Works
Search Professor Luke Guddat’s works on UQ eSpace
2011
Journal Article
Drug targets for the treatment of protozoan parasitic diseases
Guddat, L (2011). Drug targets for the treatment of protozoan parasitic diseases. Current Topics in Medicinal Chemistry, 11 (16), 2010-2011. doi: 10.2174/156802611796575920
2011
Journal Article
6-Oxopurine phosphoribosyltransferase: A target for the development of antimalarial drugs
de Jersey, John, Holý, Antonín, Hocková, Dana, Naesens, Lieve, Keough, Dianne T. and Guddat, Luke W. (2011). 6-Oxopurine phosphoribosyltransferase: A target for the development of antimalarial drugs. Current Topics in Medicinal Chemistry, 11 (16), 2085-2102. doi: 10.2174/156802611796575911
2010
Journal Article
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy
Keough, Dianne T., Hockova, Daná, Krečmerová, Marcela, Česnek, Michal, Holý, Antonín, Naesens, Lieve, Brereton, Ian M., Winzor, Donald J., de Jersey, John and Guddat, Luke W. (2010). Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy. Molecular and Biochemical Parasitology, 173 (2), 165-169. doi: 10.1016/j.molbiopara.2010.05.018
2010
Journal Article
The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysis
Ely, Fernanda, Hadler, Kieran S., Gahan, Lawrence R., Guddat, Luke W., Ollis, David L. and Schenk, Gerhard (2010). The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysis. Biochemical Journal, 432 (3), 565-573. doi: 10.1042/BJ20101054
2009
Journal Article
Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase
Hockova, Dana, Holy, Antonín, Masojidkova, Milena, Keough, Dianne T., de Jersey, John and Guddat, Luke W. (2009). Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. Bioorganic & Medicinal Chemistry, 17 (17), 6218-6232. doi: 10.1016/j.bmc.2009.07.044
2009
Journal Article
Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: A new class of antimalarial therapeutics
Keough, Dianne T., Hockova, Dana, Holy, Antonin, Naesens, Lieve M. J., Skinner-Adams, Tina S., de Jersey, John and Guddat, Luke W. (2009). Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: A new class of antimalarial therapeutics. Journal of Medicinal Chemistry, 52 (14), 4391-4399. doi: 10.1021/jm900267n
2009
Journal Article
Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis)
Millers, Emma-Karin K., Trabi, Manuela, Masci, Paul P., Lavin, Martin F., de Jersey, John and Guddat, Luke W. (2009). Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis). FEBS Journal, 276 (11), 3163-3175. doi: 10.1111/j.1742-4658.2009.07034.x
2009
Journal Article
Conformational changes in a plant ketol-acid reductoisomerase upon Mg2+ and NADPH binding as revealed by two crystal structures
Leung, Eleanor W. W. and Guddat, Luke W. (2009). Conformational changes in a plant ketol-acid reductoisomerase upon Mg2+ and NADPH binding as revealed by two crystal structures. Journal of Molecular Biology, 389 (1), 167-182. doi: 10.1016/j.jmb.2009.04.012
2009
Journal Article
Crystal structures of two novel sulfonylurea herbicides in complex with Arabidopsis thaliana acetohydroxyacid synthase
Wang, Jian-Guo, Lee, Patrick K.-M., Dong, Yu-Hui, Pang, Siew Siew, Duggleby, Ronald G., Li, Zheng-Ming and Guddat, Luke W. (2009). Crystal structures of two novel sulfonylurea herbicides in complex with Arabidopsis thaliana acetohydroxyacid synthase. FEBS Journal, 276 (5), 1282-1290. doi: 10.1111/j.1742-4658.2009.06863.x
2009
Book Chapter
Snake venom nerve growth factors
Lavin, Martin F., Earl, Stephen, Birrell, Geoff, St. Pierre, Liam, Guddat, Luke W., John de Jersey and Masci, Paul (2009). Snake venom nerve growth factors. Handbook of Venoms and Toxins of Reptiles. (pp. 377-392) edited by Stephen P Mackessy. United States of America: CRC Press, Taylor & Francis Group.
2009
Journal Article
Inhibition of purple acid phosphatase with alpha-alkoxynaphthylmethylphosphonic acids
McGeary, Ross P., Vella, Peter, Mak, Jeffery Y. W., Guddat, Luke W. and Schenk, Gerhard (2009). Inhibition of purple acid phosphatase with alpha-alkoxynaphthylmethylphosphonic acids. Bioorganic & Medicinal Chemistry Letters, 19 (1), 163-166. doi: 10.1016/j.bmcl.2008.10.125
2008
Journal Article
Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes
Hadler, K., Tanifum, E.A., Yip, S.H.-C., Mitic, N., Guddat, L.W., Jackson, C.J., Gahan, L.R., Nguyen, K., Carr, P.D., Ollis, D.L., Hengge, A.C., Larrabee, J.A. and Schenk, G. (2008). Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes. Journal of the American Chemical Society, 130 (43), 14129-14138. doi: 10.1021/ja803346w
2008
Journal Article
Identification of a non-purple tartrate-resistant acid phosphatase: An evolutionary link to Ser/Thr protein phosphatases?
Hadler, K.ieran S., Huber, Thomas, Cassady, A. Ian, Weber, Jane, Robinson, Jodie, Burrows, Allan, Kelly, Gregory, Guddat, Luke W., Hume, David A., Schenk, Gerhard and Flanagan, Jack U. (2008). Identification of a non-purple tartrate-resistant acid phosphatase: An evolutionary link to Ser/Thr protein phosphatases?. BMC Research Notes, 1 (1) 78, 1-8. doi: 10.1186/1756-0500-1-78
2008
Journal Article
Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle
Schenk, Gerhard, Elliott, Tristan W., Leung, Eleanor, Carrington, Lyle E., Mitic, Natasa, Gahan, Lawrence R. and Guddat, Luke W. (2008). Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle. BMC Structural Biology, 8 (6) 6, 1-13. doi: 10.1186/1472-6807-8-6
2008
Journal Article
Structure and mechanism of inhibition of plant acetohydroxyacid synthase
Duggleby, R.G., McCourt, J.A. and Guddat, Luke W. (2008). Structure and mechanism of inhibition of plant acetohydroxyacid synthase. Plant Physiology and Biochemistry, 2008 (46), 309-324. doi: 10.1016/j.plaphy.2007.12.004
2007
Journal Article
Plant collagenase: Unique collagenolytic activity of cysteine proteases from ginger
Kim, M., Hamilton, S. E., Guddat, L. W. and Overall, C. M. (2007). Plant collagenase: Unique collagenolytic activity of cysteine proteases from ginger. Biochimica Et Biophysica Acta General Subjects, 1770 (12), 1627-1635. doi: 10.1016/j.bbagen.2007.08.003
2007
Journal Article
Structure, function and diversity of plant purple acid phosphatases
Leung, Eleanor W. W., Teixeira, Marina, Guddat, Luke W., Mitić, Natasa and Schenk, Gerhard (2007). Structure, function and diversity of plant purple acid phosphatases. Current Topics in Plant Biology, 8, 21-31.
2006
Journal Article
Lead compounds for antimalarial chemotherapy: Purine base analogs discriminate between human and P-falciparum 6-oxopurine phosphoribosyltransferases
Keough, Dianne T., Skinner-Adams, Tina, Jones, Malcolm K., Ng, Ai-Lin., Brereton, Ian M., Guddat, Luke W. and de Jersey, John (2006). Lead compounds for antimalarial chemotherapy: Purine base analogs discriminate between human and P-falciparum 6-oxopurine phosphoribosyltransferases. Journal of Medicinal Chemistry, 49 (25), 7479-7486. doi: 10.1021/jm061012j
2006
Journal Article
Structure-function relationships in human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) by random mutagenesis
Zheng, Yuan-Zhi, Guddat, Luke, Farlow, Anthony and de Jersey, John (2006). Structure-function relationships in human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) by random mutagenesis. Chemical Research in Chinese Universities, 22 (2), 251-252. doi: 10.1016/S1005-9040(06)60090-1
2006
Journal Article
Crystallization and preliminary X-ray analysis of a Kunitz-type inhibitor, textilinin-1 from Pseudonaja textilis textilis
Millers, E. K. I., Masci, P. P., Lavin, M. F., de Jersey, J. and Guddat, L. W. (2006). Crystallization and preliminary X-ray analysis of a Kunitz-type inhibitor, textilinin-1 from Pseudonaja textilis textilis. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 62 (Pt 7), 642-645. doi: 10.1107/S1744309106019099
Funding
Current funding
Past funding
Supervision
Availability
- Professor Luke Guddat is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Cryo-EM inspired antifungal drug discovery
Principal Advisor
Other advisors: Professor Gary Schenk, Professor Craig Williams
-
Doctor Philosophy
Acetohydroxyacid Synthase and The Discovery of Novel Herbicides
Principal Advisor
Other advisors: Professor Gary Schenk
-
Doctor Philosophy
Acetohydroxyacid Synthase and The Discovery of Novel Herbicides
Principal Advisor
Other advisors: Professor Gary Schenk
-
-
Doctor Philosophy
Antimicrobial Drug Discovery
Principal Advisor
Other advisors: Professor Gary Schenk
-
Doctor Philosophy
Developing next generation green herbicides
Principal Advisor
Other advisors: Professor Craig Williams
-
-
Doctor Philosophy
Cryo-EM inspired antifungal drug discovery
Principal Advisor
Other advisors: Professor Gary Schenk, Professor Craig Williams
-
Doctor Philosophy
Discovery of New Herbicides
Associate Advisor
Other advisors: Professor Craig Williams
Completed supervision
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2025
Doctor Philosophy
Acetohydroxyacid Synthase and The Discovery of Novel Herbicides
Principal Advisor
Other advisors: Professor Gary Schenk
-
2024
Doctor Philosophy
Structure and function of ketol-acid reductoisomerases
Principal Advisor
Other advisors: Professor Gary Schenk
-
2024
Doctor Philosophy
Drug discovery targeting branched chain amino acid biosynthesis.
Principal Advisor
Other advisors: Professor Gary Schenk
-
2023
Doctor Philosophy
New Antimicrobial Drug Targets
Principal Advisor
Other advisors: Professor Nick West
-
2021
Doctor Philosophy
Structure and function of plant and fungal acetohydroxyacid synthases
Principal Advisor
Other advisors: Professor James Fraser
-
2021
Doctor Philosophy
Ketol-acid Reductoisomerase as a target for antimicrobial drug discovery
Principal Advisor
Other advisors: Professor Gary Schenk
-
2018
Doctor Philosophy
Structure, mechanism and inhibition of plant and fungal acetohydroxyacid synthases
Principal Advisor
Other advisors: Professor Gary Schenk
-
2017
Doctor Philosophy
Acyclic nucleoside phosphonates as possible chemotherapeutic agents against parasitic diseases
Principal Advisor
-
2017
Doctor Philosophy
Bacterial ketol-acid reductoisomerase: structure, catalytic mechanism and thermal stability
Principal Advisor
Other advisors: Professor Bostjan Kobe, Professor Mark Schembri
-
2017
Doctor Philosophy
Targeting acetohydroxyacid synthase for the discovery of antifungal and herbicidal agents
Principal Advisor
Other advisors: Professor Gary Schenk
-
2016
Doctor Philosophy
Inhibition of Bacterial 6-Oxopurine Phosphoribosyltransferase as Potential Antibacterial Target
Principal Advisor
Other advisors: Professor Nick West
-
2014
Doctor Philosophy
A study of the anticoagulant mechanisms of three biological compounds in vitro and in vivo
Principal Advisor
-
2013
Master Philosophy
Functional studies of rice KARI and inhibitor discovery
Principal Advisor
Other advisors: Professor Gary Schenk
-
-
2023
Doctor Philosophy
Structure, function and inhibition of Fe-S cluster-dependent dehydratases from the ilvD/EDD family
Associate Advisor
Other advisors: Professor Mikael Boden, Professor Gary Schenk
-
2022
Doctor Philosophy
Design, Synthesis, and Evaluation of Ketol-Acid Reductoisomerase Inhibitors: Potential Anti-Tuberculosis Drug Leads
Associate Advisor
Other advisors: Professor Gary Schenk
-
2021
Doctor Philosophy
Binuclear Metallohydrolases: Diversity in Structure and Function
Associate Advisor
Other advisors: Professor Gary Schenk
-
2021
Doctor Philosophy
Engineering stable cytochrome P450 2D forms as competent biocatalysts for industrial applications
Associate Advisor
Other advisors: Professor Elizabeth Gillam
-
2021
Doctor Philosophy
Structural and functional characterisation of ancestral cytochromes P450 from family 2 in tetrapods
Associate Advisor
Other advisors: Professor Elizabeth Gillam
-
2019
Doctor Philosophy
Acetohydroxyacid synthase AHAS: A new drug target for human fungal pathogens
Associate Advisor
Other advisors: Professor Craig Williams
-
2019
Doctor Philosophy
Drug Discovery Using Rational Structure-Based Design Approaches
Associate Advisor
Other advisors: Professor Gary Schenk
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2012
Doctor Philosophy
IMPROVING OUTCOMES OF BIOCHEMICAL TESTING IN THE PATHOLOGY LABORATORY
Associate Advisor
-
2010
Doctor Philosophy
Characterisation of the first bacterial purple acid phosphates from Mycobacterium marinum
Associate Advisor
Other advisors: Professor Gary Schenk
-
2005
Doctor Philosophy
CRYSTAL STRUCTURE DETERMINATION AND SITE-DIRECTED MUTAGENESIS OF ACTIVE SITE RESIDUES IN ESCHERICHIA COLI KETOL-ACID REDUCTOISOMERASE
Associate Advisor
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