Professor Luke Guddat
Professor

Luke Guddat

Email: 
Phone: 
+61 7 336 53549

Availability

Professor Luke Guddat is:
Available for supervision

Fields of research

Biological Sciences

Search Professor Luke Guddat’s works on UQ eSpace

254 works between 1985 and 2025
All (254) Journal Article (222) Book Chapter (3) Conference Publication (23) Other Outputs (6)

101 - 120 of 254 works

2018

Journal Article

Acyclic nucleoside phosphonates with unnatural nucleobases, favipiravir and allopurinol, designed as potential inhibitors of the human and Plasmodium falciparum 6-oxopurine phosphoribosyltransferases

Klejch, Tomáš, Pohl, Radek, Janeba, Zlatko, Sun, Minghan, Keough, Dianne T., Guddat, Luke W. and Hocková, Dana (2018). Acyclic nucleoside phosphonates with unnatural nucleobases, favipiravir and allopurinol, designed as potential inhibitors of the human and Plasmodium falciparum 6-oxopurine phosphoribosyltransferases. Tetrahedron, 74 (40), 5886-5897. doi: 10.1016/j.tet.2018.08.014

Acyclic nucleoside phosphonates with unnatural nucleobases, favipiravir and allopurinol, designed as potential inhibitors of the human and Plasmodium falciparum 6-oxopurine phosphoribosyltransferases

2018

Journal Article

Purple acid phosphatase inhibitors as leads for osteoporosis chemotherapeutics

Hussein, Waleed M., Feder, Daniel, Schenk, Gerhard, Guddat, Luke W. and McGeary, Ross P. (2018). Purple acid phosphatase inhibitors as leads for osteoporosis chemotherapeutics. European Journal of Medicinal Chemistry, 157, 462-479. doi: 10.1016/j.ejmech.2018.08.004

Purple acid phosphatase inhibitors as leads for osteoporosis chemotherapeutics

2018

Journal Article

Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery

Doleželová, Eva, Terán, David, Gahura, Ondřej, Kotrbová, Zuzana, Procházková, Michaela, Keough, Dianne, Špaček, Petr, Hocková, Dana, Guddat, Luke and Zíková, Alena (2018). Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery. PLoS Neglected Tropical Diseases, 12 (2) e0006301, 1-28. doi: 10.1371/journal.pntd.0006301

Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery

2018

Journal Article

Processivity and enzymatic mechanism of a multifunctional family 5 endoglucanase from Bacillus subtilis BS-5 with potential applications in the saccharification of cellulosic substrates

Wu, Bin, Zheng, Shan, Pedroso, Marcelo Monteiro, Guddat, Luke W., Chang, Siyuan, He, Bingfang and Schenk, Gerhard (2018). Processivity and enzymatic mechanism of a multifunctional family 5 endoglucanase from Bacillus subtilis BS-5 with potential applications in the saccharification of cellulosic substrates. Biotechnology for Biofuels, 11 (1) 20, 1-15. doi: 10.1186/s13068-018-1022-2

Processivity and enzymatic mechanism of a multifunctional family 5 endoglucanase from Bacillus subtilis BS-5 with potential applications in the saccharification of cellulosic substrates

2018

Journal Article

Structural insights into the mechanism of inhibition of AHAS by herbicides

Lonhienne, Thierry, Garcia, Mario D., Pierens, Gregory, Mobli, Mehdi, Nouwens, Amanda and Guddat, Luke W. (2018). Structural insights into the mechanism of inhibition of AHAS by herbicides. Proceedings of the National Academy of Sciences of the United States of America, 115 (9), E1945-E1954. doi: 10.1073/pnas.1714392115

Structural insights into the mechanism of inhibition of AHAS by herbicides

2018

Journal Article

Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis: a new antibiotic resistance drug target

Zhang, Qingqing, Liu, Huijuan, Liu, Xiang, Jiang, Dunquan, Zhang, Bingjie, Tian, Hongliang, Yang, Cheng, Guddat, Luke W., Yang, Haitao, Mi, Kaixia and Rao, Zihe (2018). Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis: a new antibiotic resistance drug target. Protein and Cell, 9 (11), 1-5. doi: 10.1007/s13238-017-0502-7

Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis: a new antibiotic resistance drug target

2017

Journal Article

Crystal structures of Staphylococcus aureus ketol-acid reductoisomerase in complex with two transition state analogs that have biocidal activity

Patel, Khushboo, Teran, David, Zheng, Shan, Kandale, Ajit, Garcia, Mario, Lv, You, Schembri, Mark A, McGeary, Ross P, Schenk, Gerhard and Guddat, Luke William (2017). Crystal structures of Staphylococcus aureus ketol-acid reductoisomerase in complex with two transition state analogs that have biocidal activity. Chemistry- A European Journal, 23 (72), 18289-18295. doi: 10.1002/chem.201704481

Crystal structures of Staphylococcus aureus ketol-acid reductoisomerase in complex with two transition state analogs that have biocidal activity

2017

Journal Article

High resolution crystal structures of the acetohydroxyacid synthase-pyruvate complex provide new insights into its catalytic mechanism

Lonhienne, Thierry, Garcia, Mario D., Noble, Chris, Harmer, Jeffrey, Fraser, James A., Williams, Craig M. and Guddat, Luke W. (2017). High resolution crystal structures of the acetohydroxyacid synthase-pyruvate complex provide new insights into its catalytic mechanism. Chemistryselect, 2 (36), 11981-11988. doi: 10.1002/slct.201702128

High resolution crystal structures of the acetohydroxyacid synthase-pyruvate complex provide new insights into its catalytic mechanism

2017

Journal Article

Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics

Keough, Dianne T., Rejman, Dominik, Pohl, Radek, Zborníková, Eva, Hocková, Dana, Croll, Tristan, Edstein, Michael D., Birrell, Geoff W., Chavchich, Marina, Naesens, Lieve M. J., Pierens, Gregory K., Brereton, Ian M. and Guddat, Luke W. (2017). Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics. ACS Chemical Biology, 13 (1), 82-90. doi: 10.1021/acschembio.7b00916

Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics

2017

Journal Article

Deacidification of grass silage press juice by continuous production of acetoin from its lactate via an immobilized enzymatic reaction cascade

Hohagen, Hendrik, Schwarz, Dominik, Schenk, Gerhard, Guddat, Luke W., Schieder, Doris, Carsten, Jörg and Sieber, Volker (2017). Deacidification of grass silage press juice by continuous production of acetoin from its lactate via an immobilized enzymatic reaction cascade. Bioresource Technology, 245 (Pt A), 1084-1092. doi: 10.1016/j.biortech.2017.08.203

Deacidification of grass silage press juice by continuous production of acetoin from its lactate via an immobilized enzymatic reaction cascade

2017

Journal Article

Structural insight into the activation of PknI kinase from M. tuberculosis via dimerization of the extracellular sensor domain

Yan, Qiaoling, Jiang, Dunquan, Qian, Lanfang, Zhang, Qingqing, Zhang, Wei, Zhou, Weihong, Mi, Kaixia, Guddat, Luke, Yang, Haitao and Rao, Zihe (2017). Structural insight into the activation of PknI kinase from M. tuberculosis via dimerization of the extracellular sensor domain. Structure, 25 (8), 1286-1294. doi: 10.1016/j.str.2017.06.010

Structural insight into the activation of PknI kinase from M. tuberculosis via dimerization of the extracellular sensor domain

2017

Journal Article

Acyclic nucleoside phosphonates containing 9-deazahypoxanthine and a five-membered heterocycle as selective inhibitors of plasmodial 6-oxopurine phosphoribosyltransferases

Kaiser, Martin Maxmilian, Baszczynski, Ondrej, Hockova, Dana, Postova-Slavetinska, Lenka, Dracinsky, Martin, Keough, Dianne T., Guddat, Luke W. and Janeba, Zlatko (2017). Acyclic nucleoside phosphonates containing 9-deazahypoxanthine and a five-membered heterocycle as selective inhibitors of plasmodial 6-oxopurine phosphoribosyltransferases. ChemMedChem, 12 (14), 1133-1141. doi: 10.1002/cmdc.201700293

Acyclic nucleoside phosphonates containing 9-deazahypoxanthine and a five-membered heterocycle as selective inhibitors of plasmodial 6-oxopurine phosphoribosyltransferases

2017

Journal Article

High resolution crystal structure of a fluoride-inhibited organophosphate-degrading metallohydrolase

Selleck, Christopher , Guddat, Luke W., Ollis, David L., Schenk, Gerhard and Pedroso, Marcelo Monteiro (2017). High resolution crystal structure of a fluoride-inhibited organophosphate-degrading metallohydrolase. Journal of Inorganic Biochemistry, 177, 287-290. doi: 10.1016/j.jinorgbio.2017.06.013

High resolution crystal structure of a fluoride-inhibited organophosphate-degrading metallohydrolase

2017

Journal Article

Synthesis and evaluation of symmetric acyclic nucleoside bisphosphonates as inhibitors of the Plasmodium falciparum, Plasmodium vivax and human 6-oxopurine phosphoribosyltransferases and the antimalarial activity of their prodrugs

Spacek, Petr, Keough, Dianne T., Chavchich, Marina, Dracinsky, Martin, Janeba, Zlatko, Naesens, Lieve, Edstein, Michael D., Guddat, Luke W. and Hockova, Dana (2017). Synthesis and evaluation of symmetric acyclic nucleoside bisphosphonates as inhibitors of the Plasmodium falciparum, Plasmodium vivax and human 6-oxopurine phosphoribosyltransferases and the antimalarial activity of their prodrugs. Bioorganic & Medicinal Chemistry, 25 (15), 4008-4030. doi: 10.1016/j.bmc.2017.05.048

Synthesis and evaluation of symmetric acyclic nucleoside bisphosphonates as inhibitors of the Plasmodium falciparum, Plasmodium vivax and human 6-oxopurine phosphoribosyltransferases and the antimalarial activity of their prodrugs

2017

Journal Article

Crystal structure of plant acetohydroxyacid synthase, the target for several commercial herbicides

Garcia, Mario Daniel, Wang, Jian-Guo, Lonhienne, Thierry and Guddat, Luke William (2017). Crystal structure of plant acetohydroxyacid synthase, the target for several commercial herbicides. The FEBS Journal, 284 (13), 2037-2051. doi: 10.1111/febs.14102

Crystal structure of plant acetohydroxyacid synthase, the target for several commercial herbicides

2017

Journal Article

Oligomeric state of hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis

Eng, Wai Soon, Keough, Dianne T., Hockova, Dana, Winzor, Donald J. and Guddat, Luke W. (2017). Oligomeric state of hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis. Biochimie, 135, 6-14. doi: 10.1016/j.biochi.2016.12.020

Oligomeric state of hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis

2017

Journal Article

The role of a FAD cofactor in the regulation of acetohydroxyacid synthase by redox signaling molecules

Lonhienne, Thierry, Garcia, Mario D. and Guddat, Luke W. (2017). The role of a FAD cofactor in the regulation of acetohydroxyacid synthase by redox signaling molecules. Journal of Biological Chemistry, 292 (12), 5101-5109. doi: 10.1074/jbc.M116.773242

The role of a FAD cofactor in the regulation of acetohydroxyacid synthase by redox signaling molecules

2017

Journal Article

Visualization of the reaction trajectory and transition state in a hydrolytic reaction catalyzed by a metalloenzyme

Selleck, Christopher, Clayton, Daniel, Gahan, Lawrence R., Mitic, Nataša, McGeary, Ross P., Pedroso, Marcelo Monteiro, Guddat, Luke W. and Schenk, Gerhard (2017). Visualization of the reaction trajectory and transition state in a hydrolytic reaction catalyzed by a metalloenzyme. Chemistry: A European Journal, 23 (20), 4778-4781. doi: 10.1002/chem.201700866

Visualization of the reaction trajectory and transition state in a hydrolytic reaction catalyzed by a metalloenzyme

2017

Journal Article

Novel nucleotide analogues bearing (1H-1,2,3-triazol-4-yl)phosphonic acid moiety as inhibitors of Plasmodium and human 6-oxopurine phosphoribosyltransferases

Lukáč, Miloš, Hocková, Dana, Keough, Dianne T., Guddat, Luke W. and Janeba, Zlatko (2017). Novel nucleotide analogues bearing (1H-1,2,3-triazol-4-yl)phosphonic acid moiety as inhibitors of Plasmodium and human 6-oxopurine phosphoribosyltransferases. Tetrahedron, 73 (6), 692-702. doi: 10.1016/j.tet.2016.12.046

Novel nucleotide analogues bearing (1H-1,2,3-triazol-4-yl)phosphonic acid moiety as inhibitors of Plasmodium and human 6-oxopurine phosphoribosyltransferases

2017

Journal Article

The 2.0 Å X-ray structure for yeast acetohydroxyacid synthase provides new insights into its cofactor and quaternary structure requirements

Lonhienne, Thierry, Garcia, Mario D., Fraser, James A., Williams, Craig M. and Guddat, Luke W. (2017). The 2.0 Å X-ray structure for yeast acetohydroxyacid synthase provides new insights into its cofactor and quaternary structure requirements. PLoS One, 12 (2) e0171443, e0171443.1-e0171443.13. doi: 10.1371/journal.pone.0171443

The 2.0 Å X-ray structure for yeast acetohydroxyacid synthase provides new insights into its cofactor and quaternary structure requirements

Current funding

  • 2025
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2023)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2021 - 2025
    Cryo-EM inspired drug discovery to treat human fungal pathogenic infections
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2024
    The University of Queensland, Griffith University and Charles Sturt University
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2024
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2024)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2024
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2024)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2023
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2023)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2023
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2023)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2023 - 2024
    Nanocrystal Electron Diffraction Facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2023
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2023)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2022
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2022)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2022
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2022)
    Australian Synchrotron Access Program (ANSTO)
    Open grant
  • 2022
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2022)
    Australian Synchrotron Access Program (ANSTO)
    Open grant
  • 2021 - 2022
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2021)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2021 - 2024
    EnzOnomy - an enzyme-based production pipeline for the bioeconomy
    ARC Discovery Projects
    Open grant
  • 2021
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2021)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2021
    The University of Queensland, Griffith University and Charles Sturt University Macromolecular Crystallography CAP (2021)
    Australian Synchrotron Access Program (ANSTO)
    Open grant
  • 2020 - 2022
    Herbicide discovery for Australian WONS based on developments in the bioisostere concept - Phase 2
    Commonwealth Department of Agriculture, Water and the Environment
    Open grant
  • 2020 - 2021
    An integrated, multi-node bio-layer interferometry facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2019 - 2021
    The University of Queensland, Griffith University and Charles Sturt University Collaborative Access Program
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2018 - 2019
    The University of Queensland, Griffith University and Charles Sturt University Collaborative Access Program
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2018 - 2021
    Inhibitors of hypoxanthine-guanine-xanthine phosphoribosyltransferase as versatile drugs to treat infectious diseases
    NHMRC Project Grant
    Open grant
  • 2018 - 2021
    Ketol-acid reductoisomerase: An important antituberculosis drug target
    NHMRC Project Grant
    Open grant
  • 2017 - 2020
    Herbicide Discovery for Australian WONS Based on Developments in the Bioisostere Concept
    Commonwealth Department of Social Services
    Open grant
  • 2016
    Integrative blood coagulation research core facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2018
    Acetohydroxyacid synthase: A new drug target for human fungal pathogens
    NHMRC Project Grant
    Open grant
  • 2015 - 2018
    An integrated approach to combat antibiotic resistance
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Harnessing the potential of metals in biocatalysis (ARC Discovery Project administered by the Australian National University)
    Australian National University
    Open grant
  • 2012
    Rational structure based drug design
    Australian Synchrotron Access Program
    Open grant
  • 2012
    Rational structure based drug design.
    Australian Synchrotron Access Program
    Open grant
  • 2012 - 2015
    An Integrated Study of Acyclic Nucleoside Phosphonates as Antimalarial Drugs
    NHMRC Project Grant
    Open grant
  • 2012 - 2013
    Multi angle light scattering detector for the measurement of absolute molecular weight, size, and conformation of macromolecules in solution
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Rational sturcture based drug design
    Australian Synchrotron Access Program
    Open grant
  • 2011
    Rational structure based drug design
    Australian Synchrotron Access Program
    Open grant
  • 2011
    Rational Structure Based Drug Design
    Australian Synchrotron Access Program
    Open grant
  • 2011
    Structure and inhibition of enzymes that are drug or herbicide targets
    Australian Synchrotron Access Program
    Open grant
  • 2011
    Structure and inhibition of enzymes that are drug or herbicide targets
    Australian Synchrotron Access Program
    Open grant
  • 2011
    Auto-iTC200 microcalorimeter for high-throughput molecular interaction analyses
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2014
    Targeting acetohydroxyacid synthase to discover new antifungal agents
    NHMRC Project Grant
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009 - 2012
    Development of purine nucleoside phosphonates as anti-malarial drugs targeting nuceloside synthesis in Plasmodium
    NHMRC Project Grant
    Open grant
  • 2009
    Infrastructure for biochemistry and infectious disease resarch in molecualr biosciences
    UQ School/Centre Co-Funding
    Open grant
  • 2009 - 2011
    Structure-based design of anti-osteoporotic drug leads: an integrated approach
    ARC Discovery Projects
    Open grant
  • 2008 - 2011
    Pre-clinical evaluation of snake venom proteins with therapeutic potential
    ARC Linkage Projects
    Open grant
  • 2008
    Biosynthesis of Branched-Chain Amino Acids: A Target for the Discovery of New Herbicides
    UQ External Support Enabling Grant
    Open grant
  • 2005 - 2007
    An Integrated Approach Towards Development of Highly Specific Chemotherapeutics
    ARC Discovery Projects
    Open grant
  • 2004 - 2007
    Venomics: Molecular and functional analysis of Australian snake venoms for development of human therapeutics
    ARC Linkage Projects
    Open grant
  • 2004 - 2006
    Structure and inhibition of acetohydroxyacid synthase
    ARC Discovery Projects
    Open grant
  • 2003
    AUSTRALIAN SYNCHROTRON RESEARCH PROGRAM - Support to visit BioCARS 1st - 8th December 2003
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2003
    Dynamic Light Scattering Instrument
    NHMRC Equipment Grant
    Open grant
  • 2003 - 2005
    Virtual Screening In Structure-Based Drug Design For Malaria
    NHMRC Project Grant
    Open grant
  • 2002 - 2003
    AUSTRALIAN SYNCHROTRON RESEARCH PROGRAM: Support for Access to the Advanced Photon Source to visit BIOCARS (9-15 December 2002)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2002
    AUSTRALIAN SYNCHROTRON RESEARCH PROGRAM: Support for access to the Advanced Photon Source to visit BIOCARS
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2002
    AUSTRALIAN SYNCHROTRON RESEARCH PROGRAM: Support for Access to the Advanced Photon Source to visit BIOCARS 21-27 February 2002
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2002
    Analysis of molecular motion in enzyme catalysis: application to purine phosphoribosyltransferase
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002 - 2004
    Snapshots of an enzyme in action: structural and mechanistic studies on the catalytic cycle of Escherichia coli ketol-acid reductoisomerase
    ARC Discovery Projects
    Open grant
  • 2001 - 2003
    X-ray Crystallography of Acetohydroxyacid Synthase: A Target for Herbicide Inhibition.
    ARC Australian Research Council (Large grants)
    Open grant
  • 2000
    Australian Synchrotron Research Program: Travel grant to visit BioCARS, Advanced photon Source, USA (15th - 17th December 2000)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2000 - 2002
    Biochemical analysis of proteases from ginger with commercial potential
    ARC Collaborative Grant (SPIRT)
    Open grant
  • 2000
    Crystallization and preliminary X-ray diffraction analysis of yeast acetohydroxyacid synthase: an enzyme essential for amino acid biosynthesis.
    ARC Australian Research Council (Small grants)
    Open grant
  • 1999 - 2000
    Travel grant to visit BioCARS, Advanced Photon Source, USA (20-21 December 1999)
    Australian Nuclear Science and Technology Organisation
    Open grant

Availability

Professor Luke Guddat is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Enquiries

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