
Overview
Availability
- Professor Luke Guddat is:
- Available for supervision
Fields of research
Works
Search Professor Luke Guddat’s works on UQ eSpace
2017
Journal Article
Comprehensive understanding of acetohydroxyacid synthase inhibition by different herbicide families
Garcia, Mario D., Nouwens, Amanda, Lonhienne, Thierry G. and Guddat, Luke W. (2017). Comprehensive understanding of acetohydroxyacid synthase inhibition by different herbicide families. Proceedings of the National Academy of Sciences, 114 (7), E1091-E1100. doi: 10.1073/pnas.1616142114
2017
Conference Publication
Ketol-acid-reductoisomerase, an emerging target for herbicides and novel antimicrobial agents
Schenk, Gerhard and Guddat, Luke W. (2017). Ketol-acid-reductoisomerase, an emerging target for herbicides and novel antimicrobial agents. 18th International Conference on Biological Inorganic Chemistry (ICBIC), Florianopolis Brazil, 31 July - 4 August 2017. New York, NY United States: Springer.
2017
Journal Article
Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase
Špaček, Petr, Keough, Dianne T., Chavchich, Marina, Dračínský, Martin, Janeba, Zlatko, Naesens, Lieve, Edstein, Michael D., Guddat, Luke W. and Hocková, Dana (2017). Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase. Journal of Medicinal Chemistry, 60 (17), 7539-7554. doi: 10.1021/acs.jmedchem.7b00926
2016
Journal Article
AIM-1: an antibiotic-degrading metallohydrolase that displays mechanistic flexibility
Selleck, Christopher, Larrabee James A., Harmer, Jeffrey, Guddat, Luke W., Mitić, Natasa, Helweh, Waleed, Ollis, David L., Craig, Whitney R., Tierney, David L., Monteiro Pedroso, Marcelo and Schenk, Gerhard (2016). AIM-1: an antibiotic-degrading metallohydrolase that displays mechanistic flexibility. Chemistry, 22 (49), 17704-17714. doi: 10.1002/chem.201602762
2016
Journal Article
Crystal structures of acyclic nucleoside phosphonates in complex with Escherichia coli hypoxanthine phosphoribosyltransferase
Eng, Wai Soon, Hocková, Dana, Špaček, Petr, Baszczyňski, Ondřej, Janeba, Zlatko, Naesens, Lieve, Keough, Dianne T. and Guddat, Luke W. (2016). Crystal structures of acyclic nucleoside phosphonates in complex with Escherichia coli hypoxanthine phosphoribosyltransferase. ChemistrySelect, 1 (19), 6267-6276. doi: 10.1002/slct.201601679
2016
Journal Article
Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase
Teran, David, Hockova, Dana, Cesnek, Micha, Zikova, Alena, Naesens, Lieve, Keough, Dianne T. and Guddat, Luke W. (2016). Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase. Scientific Reports, 6 (1) 35894, 35894. doi: 10.1038/srep35894
2016
Journal Article
New strategies to combat tuberculosis
Schenk, Gerhard and Guddat, Luke W. (2016). New strategies to combat tuberculosis. Australasian Biotechnology, 26 (3), 52-53.
2016
Journal Article
Metal ions play an essential catalytic role in the mechanism of ketol-acid reductoisomerase
Tadrowski, Sonya, Pedroso, Marcelo M., Sieber, Volker, Larrabee, James A., Guddat, Luke W. and Schenk, Gerhard (2016). Metal ions play an essential catalytic role in the mechanism of ketol-acid reductoisomerase. Chemistry, 22 (22), 7427-7436. doi: 10.1002/chem.201600620
2016
Journal Article
Characterization and structural analysis of a potent anticoagulant phospholipase A2 from Pseudechis australis snake venom
Du, Qianyun Sharon, Trabi, Manuela, Richards, Renee Stirling, Mirtschin, Peter, Madaras, Frank, Nouwens, Amanda, Zhao, Kong-Nan, De Jersey, John, Lavin, Martin F., Guddat, Luke W. and Masci, Paul P. (2016). Characterization and structural analysis of a potent anticoagulant phospholipase A2 from Pseudechis australis snake venom. Toxicon, 111, 37-49. doi: 10.1016/j.toxicon.2015.12.017
2016
Journal Article
Commercial herbicides can trigger the oxidative inactivation of acetohydroxyacid synthase
Lonhienne, Thierry, Nouwens, Amanda, Williams, Craig M., Fraser, James A., Lee, Yu-Ting, West, Nicholas P. and Guddat, Luke W. (2016). Commercial herbicides can trigger the oxidative inactivation of acetohydroxyacid synthase. Angewandte Chemie, 128 (13), 4319-4323. doi: 10.1002/ange.201511985
2016
Journal Article
Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution: A potential target for anti-tuberculosis drug discovery
You, Lv, Kandale, Ajit, Wun, Shun Jie, McGeary, Ross P., Williams, Simon J., Kobe, Bostjan, Sieber, Volker, Schembri, Mark A., Schenk, Gerhard and Guddat, Luke W. (2016). Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution: A potential target for anti-tuberculosis drug discovery. Febs Journal, 283 (7), 1184-1196. doi: 10.1111/febs.13672
2016
Journal Article
Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase
Lonhienne, Thierry, Nouwens, Amanda, Williams, Craig M., Fraser, James A., Lee, Yu-Ting, West, Nicholas P. and Guddat, Luke W. (2016). Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase. Angewandte Chemie - International Edition, 55 (13), 4247-4251. doi: 10.1002/anie.201511985
2015
Journal Article
Cover Picture: Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6‐Oxopurine Phosphoribosyltransferases (ChemMedChem 10/2015)
Kaiser, Martin M., Hocková, Dana, Wang, Tzu‐Hsuan, Dračínský, Martin, Poštová‐Slavětínská, Lenka, Procházková, Eliška, Edstein, Michael D., Chavchich, Marina, Keough, Dianne T., Guddat, Luke W. and Janeba, Zlatko (2015). Cover Picture: Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6‐Oxopurine Phosphoribosyltransferases (ChemMedChem 10/2015). ChemMedChem, 10 (10), 1589-1589. doi: 10.1002/cmdc.201500388
2015
Journal Article
Synthesis and evaluation of novel acyclic nucleoside phosphonates as inhibitors of Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases
Kaiser, Martin M., Hocková, Dana, Wang, Tzu-Hsuan, Dračínský, Martin, Poštová-Slavětínská, Lenka, Procházková, Eliška, Edstein, Michael D., Chavchich, Marina, Keough, Dianne T., Guddat, Luke W. and Janeba, Zlatko (2015). Synthesis and evaluation of novel acyclic nucleoside phosphonates as inhibitors of Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases. ChemMedChem, 10 (10), 1707-1723. doi: 10.1002/cmdc.201500322
2015
Journal Article
Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferases
Hockova, Dana, Janeba, Zlatko, Naesens, Lieve, Edstein, Michael D., Chavchich, Marina, Keough, Dianne T. and Guddat, Luke W. (2015). Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferases. Bioorganic and Medicinal Chemistry, 23 (17), 5502-5510. doi: 10.1016/j.bmc.2015.07.038
2015
Journal Article
First crystal structures of mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase: complexes with GMP and pyrophosphate and with acyclic nucleoside phosphonates ehose prodrugs have antituberculosis activity
Eng, Wai Soon, Hockova, Dana, Spacek, Petr, Janeba, Zlatko, West, Nicholas P., Woods, Kyra, Naesens, Lieve M. J., Keough, Dianne T. and Guddat, Luke W. (2015). First crystal structures of mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase: complexes with GMP and pyrophosphate and with acyclic nucleoside phosphonates ehose prodrugs have antituberculosis activity. Journal of Medicinal Chemistry, 58 (11), 4822-4838. doi: 10.1021/acs.jmedchem.5b00611
2015
Journal Article
Synthesis, conformational studies, and biological properties of phosphonomethoxyethyl derivatives of nucleobases with a locked conformation via a pyrrolidine ring
Pohl, Radek, Slavetinska, Lenka Postova, Eng, Wai Soon, Keough, Dianne T., Guddat, Luke W. and Rejman, Dominik (2015). Synthesis, conformational studies, and biological properties of phosphonomethoxyethyl derivatives of nucleobases with a locked conformation via a pyrrolidine ring. Organic and Biomolecular Chemistry, 13 (16), 4693-4705. doi: 10.1039/c5ob00097a
2015
Journal Article
Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agents
Keough, Dianne T., Hockova, Dana, Janeba, Zlatko, Wang, Tzu-Hsuan, Naesens, Lieve, Edstein, Michael D., Chavchich, Marina and Guddat, Luke W. (2015). Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agents. Journal of Medicinal Chemistry, 58 (2), 827-846. doi: 10.1021/jm501416t
2014
Journal Article
Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of the 6-oxopurine phosphoribosyltransferases and have antimalarial activity
Keough, Dianne, Špaček, Petr, Hocková, Dana, Tichý, Tomáš, Vrbková, Silvie, Slavětínská, Lenka, Janeba, Zlatko, Naesens, Lieve, Edstein, Michael, Chavchich, Marina, Wang, Tzu, de Jersey, John and Guddat, Luke (2014). Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of the 6-oxopurine phosphoribosyltransferases and have antimalarial activity. Malaria Journal, 13 (Suppl 1). doi: 10.1186/1475-2875-13-s1-p91
2014
Journal Article
The applications of binuclear metallohydrolases in medicine: recent advances in the design and development of novel drug leads for purple acid phosphatases, metallo-beta-lactamases and arginases
McGeary, Ross P., Schenk, Gerhard and Guddat, Luke W. (2014). The applications of binuclear metallohydrolases in medicine: recent advances in the design and development of novel drug leads for purple acid phosphatases, metallo-beta-lactamases and arginases. European Journal of Medicinal Chemistry, 76, 132-144. doi: 10.1016/j.ejmech.2014.02.008
Funding
Current funding
Past funding
Supervision
Availability
- Professor Luke Guddat is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Cryo-EM inspired antifungal drug discovery
Principal Advisor
Other advisors: Professor Gary Schenk, Professor Craig Williams
-
Doctor Philosophy
Acetohydroxyacid Synthase and The Discovery of Novel Herbicides
Principal Advisor
Other advisors: Professor Gary Schenk
-
Doctor Philosophy
Acetohydroxyacid Synthase and The Discovery of Novel Herbicides
Principal Advisor
Other advisors: Professor Gary Schenk
-
-
Doctor Philosophy
Antimicrobial Drug Discovery
Principal Advisor
Other advisors: Professor Gary Schenk
-
Doctor Philosophy
Developing next generation green herbicides
Principal Advisor
Other advisors: Professor Craig Williams
-
-
Doctor Philosophy
Cryo-EM inspired antifungal drug discovery
Principal Advisor
Other advisors: Professor Gary Schenk, Professor Craig Williams
-
Doctor Philosophy
Discovery of New Herbicides
Associate Advisor
Other advisors: Professor Craig Williams
Completed supervision
-
2025
Doctor Philosophy
Acetohydroxyacid Synthase and The Discovery of Novel Herbicides
Principal Advisor
Other advisors: Professor Gary Schenk
-
2024
Doctor Philosophy
Structure and function of ketol-acid reductoisomerases
Principal Advisor
Other advisors: Professor Gary Schenk
-
2024
Doctor Philosophy
Drug discovery targeting branched chain amino acid biosynthesis.
Principal Advisor
Other advisors: Professor Gary Schenk
-
2023
Doctor Philosophy
New Antimicrobial Drug Targets
Principal Advisor
Other advisors: Professor Nick West
-
2021
Doctor Philosophy
Structure and function of plant and fungal acetohydroxyacid synthases
Principal Advisor
Other advisors: Professor James Fraser
-
2021
Doctor Philosophy
Ketol-acid Reductoisomerase as a target for antimicrobial drug discovery
Principal Advisor
Other advisors: Professor Gary Schenk
-
2018
Doctor Philosophy
Structure, mechanism and inhibition of plant and fungal acetohydroxyacid synthases
Principal Advisor
Other advisors: Professor Gary Schenk
-
2017
Doctor Philosophy
Acyclic nucleoside phosphonates as possible chemotherapeutic agents against parasitic diseases
Principal Advisor
-
2017
Doctor Philosophy
Bacterial ketol-acid reductoisomerase: structure, catalytic mechanism and thermal stability
Principal Advisor
Other advisors: Professor Bostjan Kobe, Professor Mark Schembri
-
2017
Doctor Philosophy
Targeting acetohydroxyacid synthase for the discovery of antifungal and herbicidal agents
Principal Advisor
Other advisors: Professor Gary Schenk
-
2016
Doctor Philosophy
Inhibition of Bacterial 6-Oxopurine Phosphoribosyltransferase as Potential Antibacterial Target
Principal Advisor
Other advisors: Professor Nick West
-
2014
Doctor Philosophy
A study of the anticoagulant mechanisms of three biological compounds in vitro and in vivo
Principal Advisor
-
2013
Master Philosophy
Functional studies of rice KARI and inhibitor discovery
Principal Advisor
Other advisors: Professor Gary Schenk
-
-
2023
Doctor Philosophy
Structure, function and inhibition of Fe-S cluster-dependent dehydratases from the ilvD/EDD family
Associate Advisor
Other advisors: Professor Mikael Boden, Professor Gary Schenk
-
2022
Doctor Philosophy
Design, Synthesis, and Evaluation of Ketol-Acid Reductoisomerase Inhibitors: Potential Anti-Tuberculosis Drug Leads
Associate Advisor
Other advisors: Professor Gary Schenk
-
2021
Doctor Philosophy
Binuclear Metallohydrolases: Diversity in Structure and Function
Associate Advisor
Other advisors: Professor Gary Schenk
-
2021
Doctor Philosophy
Engineering stable cytochrome P450 2D forms as competent biocatalysts for industrial applications
Associate Advisor
Other advisors: Professor Elizabeth Gillam
-
2021
Doctor Philosophy
Structural and functional characterisation of ancestral cytochromes P450 from family 2 in tetrapods
Associate Advisor
Other advisors: Professor Elizabeth Gillam
-
2019
Doctor Philosophy
Acetohydroxyacid synthase AHAS: A new drug target for human fungal pathogens
Associate Advisor
Other advisors: Professor Craig Williams
-
2019
Doctor Philosophy
Drug Discovery Using Rational Structure-Based Design Approaches
Associate Advisor
Other advisors: Professor Gary Schenk
-
2012
Doctor Philosophy
IMPROVING OUTCOMES OF BIOCHEMICAL TESTING IN THE PATHOLOGY LABORATORY
Associate Advisor
-
2010
Doctor Philosophy
Characterisation of the first bacterial purple acid phosphates from Mycobacterium marinum
Associate Advisor
Other advisors: Professor Gary Schenk
-
2005
Doctor Philosophy
CRYSTAL STRUCTURE DETERMINATION AND SITE-DIRECTED MUTAGENESIS OF ACTIVE SITE RESIDUES IN ESCHERICHIA COLI KETOL-ACID REDUCTOISOMERASE
Associate Advisor
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