Harnessing the potential of metals in biocatalysis (ARC Discovery Project administered by the Australian National University) (2015-2017)
Abstract
We will use an integrated, multi-disciplinary approach to study the properties of a group of related but functionally diverse enzymes, binuclear metallohydrolases (BMHs). These enzymes are of great relevance to protein engineers aiming to produce potent agents for bioremediation and pharmacologists interested in developing drugs. Elucidating and modulating the mode of action of BMHs is thus our main objective and will provide essential information to fully exploit the potential of these enzymes for practical applications. In particular, understanding how metal ions interact with BMHs and how this contributes to their reactivity is crucial to optimally garner their biotechnological potential.
