Professor James Fraser
Professor

James Fraser

Email: 
Phone: 
+61 7 336 54868

Availability

Professor James Fraser is:
Available for supervision

Fields of research

Genetics Medical microbiology Microbiology

Qualifications

  • Bachelor (Honours) of Science (Advanced), University of Melbourne
  • Doctor of Philosophy, Institution to be confirmed

Search Professor James Fraser’s works on UQ eSpace

115 works between 1984 and 2025
All (115) Journal Article (103) Conference Publication (10) Book Chapter (2)

61 - 80 of 115 works

2014

Journal Article

Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation

Janbon, Guilhem, Ormerod, Kate L., Paulet, Damien, Byrnes III, Edmond J., Yadav, Vikas, Chatterjee, Gautam, Mullapudi, Nandita, Hon, Chung-Chau, Billmyre, R. Blake, Brunel, François, Bahn, Yong-Sun, Chen, Weidong, Chen, Yuan, Chow, Eve W. L., Coppée, Jean-Yves, Floyd-Averette, Anna, Gaillardin, Claude, Gerik, Kimberly J., Goldberg, Jonathan, Gonzalez-Hilarion, Sara, Gujja, Sharvari, Hamlin, Joyce L., Hsueh, Yen-Ping, Ianiri, Giuseppe, Jones, Steven, Kodira, Chinnappa D., Kozubowski, Lukasz, Lam, Woei, Marra, Marco ... Dietrich, Fred S. (2014). Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation. PLoS Genetics, 10 (4) e1004261, e1004261.1-e1004261.26. doi: 10.1371/journal.pgen.1004261

Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation

2014

Journal Article

Multiple nuclear localization signals mediate nuclear localization of the GATA transcription factor AreA

Hunter, Cameron C., Siebert, Kendra S., Downes, Damien J., Wong, Koon Ho, Kreutzberger, Sara D., Fraser, James A., Clarke, David F., Hynes, Michael J., Davis, Meryl A. and Todd, Richard B. (2014). Multiple nuclear localization signals mediate nuclear localization of the GATA transcription factor AreA. Eukaryotic Cell, 13 (4), 527-538. doi: 10.1128/EC.00040-14

Multiple nuclear localization signals mediate nuclear localization of the GATA transcription factor AreA

2014

Conference Publication

Discovering and Manipulating Protein Conformational Heterogeneity and Function

Keedy, Daniel, van den Bedem, Henry, Rettenmaier, Justin, Wells, James and Fraser, James (2014). Discovering and Manipulating Protein Conformational Heterogeneity and Function. 58th Annual Meeting of the Biophysical-Society, San Francisco Ca, Feb 15-19, 2014. CAMBRIDGE: CELL PRESS. doi: 10.1016/j.bpj.2013.11.3515

Discovering and Manipulating Protein Conformational Heterogeneity and Function

2014

Conference Publication

Enhancing the complementation process in Cryptococcus neoformans

Arras, S. D. M. and Fraser, J. A. (2014). Enhancing the complementation process in Cryptococcus neoformans. 9th International Conference on Cryptococcus and Cryptococcosis, Amsterdam, The Netherlands, 15-19 May 2014. Berlin, Germany: Wiley-Blackwell Verlag GmbH. doi: 10.1111/myc.12196

Enhancing the complementation process in Cryptococcus neoformans

2014

Conference Publication

The H99 family tree: variation in the common laboratory reference strains of Cryptococcus neoformans var. grubii characterised through whole-genome sequencing

Ormerod, K. L., Byrnes, E. J., III, Wood, I. A., Lodge, J. K., Heitman, J. and Fraser, J. A. (2014). The H99 family tree: variation in the common laboratory reference strains of Cryptococcus neoformans var. grubii characterised through whole-genome sequencing. 9th International Conference on Cryptococcus and Cryptococcosis, Amsterdam, The Netherlands, 15-19 May 2014. Berlin, Germany: Wiley-Blackwell Verlag GmbH. doi: 10.1111/myc.12196

The H99 family tree: variation in the common laboratory reference strains of Cryptococcus neoformans var. grubii characterised through whole-genome sequencing

2014

Conference Publication

Purine biosynthetic enzymes as antifungal drug targets

Blundell, R. B., Arras, S. D. M., Williams, S. J. and Fraser, J. A. (2014). Purine biosynthetic enzymes as antifungal drug targets. 9th International Conference on Cryptococcus and Cryptococcosis, Amsterdam, The Netherlands, 15-19 May 2014. Berlin, Germany: Wiley-Blackwell Verlag GmbH. doi: 10.1111/myc.12196

Purine biosynthetic enzymes as antifungal drug targets

2013

Journal Article

Balancing stability and flexibility within the genome of the pathogen Cryptococcus neoformans

Ormerod, Kate L. and Fraser, James A. (2013). Balancing stability and flexibility within the genome of the pathogen Cryptococcus neoformans. PLoS Pathogens, 9 (12) e1003764, 1-4. doi: 10.1371/journal.ppat.1003764

Balancing stability and flexibility within the genome of the pathogen Cryptococcus neoformans

2013

Journal Article

Purification, crystallization and preliminary X-ray analysis of adenylosuccinate synthetase from the fungal pathogen Cryptococcus neoformans

Blundell, Ross D., Williams, Simon J., Morrow, Carl A., Ericsson, Daniel J., Kobe, Bostjan and Fraser, James A. (2013). Purification, crystallization and preliminary X-ray analysis of adenylosuccinate synthetase from the fungal pathogen Cryptococcus neoformans. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69 (Pt. 9), 1033-1036. doi: 10.1107/S1744309113021921

Purification, crystallization and preliminary X-ray analysis of adenylosuccinate synthetase from the fungal pathogen Cryptococcus neoformans

2013

Journal Article

Secondary metabolites of the sponge-derived fungus Acremonium persicinum

Suciati, Fraser, James A., Lambert, Lynette K., Pierens, Gregory K., Bernhardt, Paul V. and Garson, Mary J. (2013). Secondary metabolites of the sponge-derived fungus Acremonium persicinum. Journal of Natural Products, 76 (8), 1432-1440. doi: 10.1021/np4002114

Secondary metabolites of the sponge-derived fungus Acremonium persicinum

2013

Journal Article

Nitrogen regulation of virulence in clinically prevalent fungal pathogens

Lee, I. Russel, Morrow, Carl A. and Fraser, James A. (2013). Nitrogen regulation of virulence in clinically prevalent fungal pathogens. FEMS Microbiology Letters, 345 (2), 77-84. doi: 10.1111/1574-6968.12181

Nitrogen regulation of virulence in clinically prevalent fungal pathogens

2013

Journal Article

Is the nickel-dependent urease complex of Cryptococcus the pathogen's Achilles' heel?

Morrow, Carl A. and Fraser, James A. (2013). Is the nickel-dependent urease complex of Cryptococcus the pathogen's Achilles' heel?. MBio, 4 (4) e00408-13, e00408-13.1-e00408-13.3. doi: 10.1128/mBio.00408-13

Is the nickel-dependent urease complex of Cryptococcus the pathogen's Achilles' heel?

2013

Journal Article

Reactive oxygen species homeostasis and virulence of the fungal pathogen Cryptococcus neoformans requires an intact proline catabolism pathway

Lee, I. Russel, Lui, Edmund Y. L., Chow, Eve W. L., Arras, Samantha D. M., Morrow, Carl A. and Fraser, James A. (2013). Reactive oxygen species homeostasis and virulence of the fungal pathogen Cryptococcus neoformans requires an intact proline catabolism pathway. Genetics, 194 (2), 421-U199. doi: 10.1534/genetics.113.150326

Reactive oxygen species homeostasis and virulence of the fungal pathogen Cryptococcus neoformans requires an intact proline catabolism pathway

2013

Journal Article

Characterization of the complete uric acid degradation pathway in the fungal pathogen Cryptococcus neoformans

Lee, I. Russel, Yang, Liting, Sebetso, Gaseene, Allen, Rebecca, Doan, Thi H. N., Blundell, Ross, Lui, Edmund Y. L., Morrow, Carl A. and Fraser, James A. (2013). Characterization of the complete uric acid degradation pathway in the fungal pathogen Cryptococcus neoformans. PLoS ONE, 8 (5) e64292, e64292.1-e64292.13. doi: 10.1371/journal.pone.0064292

Characterization of the complete uric acid degradation pathway in the fungal pathogen Cryptococcus neoformans

2013

Journal Article

Comparative Genomics of Serial Isolates of Cryptococcus neoformans Reveals Gene Associated With Carbon Utilization and Virulence

Ormerod, Kate L., Morrow, Carl A., Chow, Eve W. L., Lee, I. Russel, Arras, Samantha D. M., Schirra, Horst Joachim, Cox, Gary M., Fries, Bettina C. and Fraser, James A. (2013). Comparative Genomics of Serial Isolates of Cryptococcus neoformans Reveals Gene Associated With Carbon Utilization and Virulence. G3: Genes, Genomes, Genetics, 3 (4), 675-686. doi: 10.1534/g3.113.005660

Comparative Genomics of Serial Isolates of Cryptococcus neoformans Reveals Gene Associated With Carbon Utilization and Virulence

2013

Journal Article

Ploidy variation as an adaptive mechanism in human pathogenic fungi

Morrow, Carl A. and Fraser, James A. (2013). Ploidy variation as an adaptive mechanism in human pathogenic fungi. Seminars in Cell and Developmental Biology, 24 (4), 339-346. doi: 10.1016/j.semcdb.2013.01.008

Ploidy variation as an adaptive mechanism in human pathogenic fungi

2013

Journal Article

Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase

Lee, Yu-Ting, Cui, Chang-Jun, Chow, Eve W. L., Pue, Nason, Lonhienne, Thierry, Wang, Jian-Guo, Fraser, James A. and Guddat, Luke W. (2013). Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase. Journal of Medicinal Chemistry, 56 (1), 210-219. doi: 10.1021/jm301501k

Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase

2012

Journal Article

De novo GTP biosynthesis is critical for virulence of the fungal pathogen cryptococcus neoformans

Morrow, Carl A., Valkov, Eugene, Stamp, Anna, Chow, Eve W. L., Lee, I. Russel, Wronski, Ania, Williams, Simon J., Hill, Justine M., Djordjevic, Julianne T., Kappler, Ulrke, Kobe, Bostjan and Fraser, James A. (2012). De novo GTP biosynthesis is critical for virulence of the fungal pathogen cryptococcus neoformans. PLoS Pathogens, 8 (10) e1002957, e1002957. doi: 10.1371/journal.ppat.1002957

De novo GTP biosynthesis is critical for virulence of the fungal pathogen cryptococcus neoformans

2012

Journal Article

Complexity of chromatin folding is captured by the strings and binders switch model

Barbieri, Mariano, Chotalia, Mita, Fraser, James, Lavitas, Liron-Mark, Dostie, Josée, Pombo, Ana and Nicodemi, Mario (2012). Complexity of chromatin folding is captured by the strings and binders switch model. Proceedings of the National Academy of Sciences of the United States of America, 109 (40), 16173-16178. doi: 10.1073/pnas.1204799109

Complexity of chromatin folding is captured by the strings and binders switch model

2012

Journal Article

A unique chromosomal rearrangement in the Cryptococcus neoformans var. grubii type strain enhances key phenotypes associated with virulence

Morrow, Carl A., Lee, I. Russell, Chow, Eve W. L., Ormerod, Kate L., Goldinger, Anita, Byrnes III, Edmond J., Nielsen, Kirsten, Heitman, Joseph, Schirra, Horst Joachim and Fraser, James A. (2012). A unique chromosomal rearrangement in the Cryptococcus neoformans var. grubii type strain enhances key phenotypes associated with virulence. mBio, 3 (2) e00310-11, e00310.1-e00310.11. doi: 10.1128/mBio.00310-11

A unique chromosomal rearrangement in the Cryptococcus neoformans var. grubii type strain enhances key phenotypes associated with virulence

2012

Journal Article

Characterization of an Nmr homolog that modulates gata factor-mediated nitrogen metabolite repression in Cryptococcus neoformans

Lee, I. Russel, Lim, Jonathan W. C., Ormerod, Kate L., Morrow, Carl A. and Fraser, James A. (2012). Characterization of an Nmr homolog that modulates gata factor-mediated nitrogen metabolite repression in Cryptococcus neoformans. PLoS One, 7 (3) e32585, e32585.1-e32585.15. doi: 10.1371/journal.pone.0032585

Characterization of an Nmr homolog that modulates gata factor-mediated nitrogen metabolite repression in Cryptococcus neoformans

Past funding

  • 2020 - 2023
    Novel Broad Spectrum Antifungals Active Against Drug Resistant Candida Auris
    NHMRC IDEAS Grants
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    Epifluorescent and live-cell imaging microscopes for the investigation of host-pathogen interactions and for molecular and cellular biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2021
    Microevolution of Cryptococcus neoformans
    NHMRC Project Grant
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2018
    Acetohydroxyacid synthase: A new drug target for human fungal pathogens
    NHMRC Project Grant
    Open grant
  • 2014
    A confocal microscope for investigation of live bacterial and viral pathogens and for molecular cell biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013 - 2016
    Purine metabolism as an antifungal drug target
    NHMRC Project Grant
    Open grant
  • 2012 - 2013
    IMPDH as an antifungal drug target
    Therapeutic Innovation Australia Limited
    Open grant
  • 2011 - 2014
    Targeting acetohydroxyacid synthase to discover new antifungal agents
    NHMRC Project Grant
    Open grant
  • 2010 - 2012
    ResTeach 2010 0.1 FTE School of Chemistry and Molecular Biosciences
    UQ ResTeach
    Open grant
  • 2010 - 2012
    Understanding an exotic disease: Initiation of sex and infection by the sugarcane smut Ustilago scitaminea
    ARC Discovery Projects
    Open grant
  • 2007 - 2010
    Transposable element mobility and chromosomal rearrangement in the fungal pathogen Cryptococcus during human infection
    NHMRC Project Grant
    Open grant

Availability

Professor James Fraser is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    The role of the cotranscriptional activator complex SAGA in virulence of Cryptococcus neoformans

    Principal Advisor

    Other advisors: Professor Benjamin Schulz

  • Doctor Philosophy

    Proteins in innate immunity pathways: from protein structure to therapeutic targeting

    Associate Advisor

    Other advisors: Associate Professor Michael Landsberg, Professor Bostjan Kobe

  • Doctor Philosophy

    Developing a cell-free, structural model of fungal cell walls

    Associate Advisor

    Other advisors: Dr Evelyne Deplazes

  • Doctor Philosophy

    Characterising the membrane interactions and cytotoxic activity of the anti-fungal peptide Lactofungin

    Associate Advisor

    Other advisors: Dr Evelyne Deplazes

Completed supervision

Enquiries

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