Professor James Fraser
Professor

James Fraser

Email: 
Phone: 
+61 7 336 54868

Availability

Professor James Fraser is:
Available for supervision

Fields of research

Genetics Medical microbiology Microbiology

Qualifications

  • Bachelor (Honours) of Science (Advanced), University of Melbourne
  • Doctor of Philosophy, unknown

Search Professor James Fraser’s works on UQ eSpace

102 works between 1984 and 2024
All (102) Journal Article (94) Book Chapter (2) Conference Publication (6)

61 - 80 of 102 works

2013

Journal Article

Reactive oxygen species homeostasis and virulence of the fungal pathogen Cryptococcus neoformans requires an intact proline catabolism pathway

Lee, I. Russel, Lui, Edmund Y. L., Chow, Eve W. L., Arras, Samantha D. M., Morrow, Carl A. and Fraser, James A. (2013). Reactive oxygen species homeostasis and virulence of the fungal pathogen Cryptococcus neoformans requires an intact proline catabolism pathway. Genetics, 194 (2), 421-U199. doi: 10.1534/genetics.113.150326

Reactive oxygen species homeostasis and virulence of the fungal pathogen Cryptococcus neoformans requires an intact proline catabolism pathway

2013

Journal Article

Characterization of the complete uric acid degradation pathway in the fungal pathogen Cryptococcus neoformans

Lee, I. Russel, Yang, Liting, Sebetso, Gaseene, Allen, Rebecca, Doan, Thi H. N., Blundell, Ross, Lui, Edmund Y. L., Morrow, Carl A. and Fraser, James A. (2013). Characterization of the complete uric acid degradation pathway in the fungal pathogen Cryptococcus neoformans. PLoS ONE, 8 (5) e64292, e64292.1-e64292.13. doi: 10.1371/journal.pone.0064292

Characterization of the complete uric acid degradation pathway in the fungal pathogen Cryptococcus neoformans

2013

Journal Article

Comparative Genomics of Serial Isolates of Cryptococcus neoformans Reveals Gene Associated With Carbon Utilization and Virulence

Ormerod, Kate L., Morrow, Carl A., Chow, Eve W. L., Lee, I. Russel, Arras, Samantha D. M., Schirra, Horst Joachim, Cox, Gary M., Fries, Bettina C. and Fraser, James A. (2013). Comparative Genomics of Serial Isolates of Cryptococcus neoformans Reveals Gene Associated With Carbon Utilization and Virulence. G3: Genes, Genomes, Genetics, 3 (4), 675-686. doi: 10.1534/g3.113.005660

Comparative Genomics of Serial Isolates of Cryptococcus neoformans Reveals Gene Associated With Carbon Utilization and Virulence

2013

Journal Article

Ploidy variation as an adaptive mechanism in human pathogenic fungi

Morrow, Carl A. and Fraser, James A. (2013). Ploidy variation as an adaptive mechanism in human pathogenic fungi. Seminars in Cell and Developmental Biology, 24 (4), 339-346. doi: 10.1016/j.semcdb.2013.01.008

Ploidy variation as an adaptive mechanism in human pathogenic fungi

2013

Journal Article

Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase

Lee, Yu-Ting, Cui, Chang-Jun, Chow, Eve W. L., Pue, Nason, Lonhienne, Thierry, Wang, Jian-Guo, Fraser, James A. and Guddat, Luke W. (2013). Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase. Journal of Medicinal Chemistry, 56 (1), 210-219. doi: 10.1021/jm301501k

Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase

2012

Journal Article

De novo GTP biosynthesis is critical for virulence of the fungal pathogen cryptococcus neoformans

Morrow, Carl A., Valkov, Eugene, Stamp, Anna, Chow, Eve W. L., Lee, I. Russel, Wronski, Ania, Williams, Simon J., Hill, Justine M., Djordjevic, Julianne T., Kappler, Ulrke, Kobe, Bostjan and Fraser, James A. (2012). De novo GTP biosynthesis is critical for virulence of the fungal pathogen cryptococcus neoformans. PLoS Pathogens, 8 (10) e1002957, e1002957. doi: 10.1371/journal.ppat.1002957

De novo GTP biosynthesis is critical for virulence of the fungal pathogen cryptococcus neoformans

2012

Journal Article

Characterization of an Nmr homolog that modulates gata factor-mediated nitrogen metabolite repression in Cryptococcus neoformans

Lee, I. Russel, Lim, Jonathan W. C., Ormerod, Kate L., Morrow, Carl A. and Fraser, James A. (2012). Characterization of an Nmr homolog that modulates gata factor-mediated nitrogen metabolite repression in Cryptococcus neoformans. PLoS One, 7 (3) e32585, e32585.1-e32585.15. doi: 10.1371/journal.pone.0032585

Characterization of an Nmr homolog that modulates gata factor-mediated nitrogen metabolite repression in Cryptococcus neoformans

2012

Journal Article

A unique chromosomal rearrangement in the Cryptococcus neoformans var. grubii type strain enhances key phenotypes associated with virulence

Morrow, Carl A., Lee, I. Russell, Chow, Eve W. L., Ormerod, Kate L., Goldinger, Anita, Byrnes III, Edmond J., Nielsen, Kirsten, Heitman, Joseph, Schirra, Horst Joachim and Fraser, James A. (2012). A unique chromosomal rearrangement in the Cryptococcus neoformans var. grubii type strain enhances key phenotypes associated with virulence. mBio, 3 (2) e00310-11, e00310.1-e00310.11. doi: 10.1128/mBio.00310-11

A unique chromosomal rearrangement in the Cryptococcus neoformans var. grubii type strain enhances key phenotypes associated with virulence

2012

Journal Article

Discovery of a Modified Tetrapolar Sexual Cycle in Cryptococcus amylolentus and the Evolution of MAT in the Cryptococcus Species Complex

Findley, Keisha, Sun, Sheng, Fraser, James A., Hsueh, Yen-Ping, Averette, Anna Floyd, Li, Wenjun, Dietrich, Fred S. and Heitman, Joseph (2012). Discovery of a Modified Tetrapolar Sexual Cycle in Cryptococcus amylolentus and the Evolution of MAT in the Cryptococcus Species Complex. PLoS Genetics, 8 (2) e1002528, e1002528-1-e1002528-19. doi: 10.1371/journal.pgen.1002528

Discovery of a Modified Tetrapolar Sexual Cycle in Cryptococcus amylolentus and the Evolution of MAT in the Cryptococcus Species Complex

2012

Journal Article

Microevolution of Cryptococcus neoformans driven by massive tandem gene amplification

Chow, Eve W. L., Morrow, Carl A., Djordjevic, Julianne T., Wood, Ian A. and Fraser, James A. (2012). Microevolution of Cryptococcus neoformans driven by massive tandem gene amplification. Molecular Biology and Evolution, 29 (8), 1987-2000. doi: 10.1093/molbev/mss066

Microevolution of Cryptococcus neoformans driven by massive tandem gene amplification

2011

Journal Article

A diverse population of Cryptococcus gattii molecular type VGIII in Southern Californian HIV/AIDS patients

Byrnes, Edmond J., Li, Wenjun, Ren, Ping, Lewit, Yonathan, Voelz, Kerstin, Fraser, James A., Dietrich, Fred S., May, Robin C., Chatuverdi, Sudha, Chatuverdi, Vishnu and Heitman, Joseph (2011). A diverse population of Cryptococcus gattii molecular type VGIII in Southern Californian HIV/AIDS patients. PLoS Pathogens, 7 (9) e1002205, 134-1. doi: 10.1371/journal.ppat.1002205

A diverse population of Cryptococcus gattii molecular type VGIII in Southern Californian HIV/AIDS patients

2011

Journal Article

Nitrogen Metabolite Repression of Metabolism and Virulence in the Human Fungal Pathogen Cryptococcus neoformans

Lee, I. Russel, Chow, Eve W. L., Morrow, Carl A., Djordjevic, Julianne T. and Fraser, James A. (2011). Nitrogen Metabolite Repression of Metabolism and Virulence in the Human Fungal Pathogen Cryptococcus neoformans. Genetics, 188 (2), 309-323. doi: 10.1534/genetics.111.128538

Nitrogen Metabolite Repression of Metabolism and Virulence in the Human Fungal Pathogen Cryptococcus neoformans

2011

Journal Article

Genome Variation in Cryptococcus gattii, an Emerging Pathogen of Immunocompetent Hosts

D'Souza, C.A., Kronstad, J.W., Taylor, G., Warrne, R., Yuen, M., Hu, G., Jung, W.H., Sham, A., Kidd, S.E., Tangen, K., Lee, N., Zeilmaker, T., Sawkins, J., McVicker, G., Shah, S., Gnerre, S., Griggs, A., Zeng, Q., Bartlett, K., Li, W., Wang, X., Heitman, J., Stajich, J.E., Fraser, J.A., Meyer, W., Carter, D., Schein, J., Krzywinski, M., Kwon-Chung, K.J. ... Cuomo, C.A. (2011). Genome Variation in Cryptococcus gattii, an Emerging Pathogen of Immunocompetent Hosts. mBio, 2 (1) e00342-10, e00342-1-e00342-10. doi: 10.1128/mBio.00342-10

Genome Variation in Cryptococcus gattii, an Emerging Pathogen of Immunocompetent Hosts

2011

Conference Publication

Secondary metabolites from saltwater culture of the sponge-derived fungus Acremonium persicinum

Suciati, Fraser, James A. and Garson, Mary J. (2011). Secondary metabolites from saltwater culture of the sponge-derived fungus Acremonium persicinum. International Symposium on the Chemistry of Natural Products (27th, ISCNP, 2011) and the 7th International Conference on Biodiversity (7th, ICOB, 2011), South Bank, QLD, Australia, 10-15 July 2011.

Secondary metabolites from saltwater culture of the sponge-derived fungus Acremonium persicinum

2010

Journal Article

Crystallization and preliminary X-ray analysis of mycophenolic acid-resistant and mycophenolic acid-sensitive forms of IMP dehydrogenase from the human fungal pathogen Cryptococcus

Morrow, CA, Stamp, A, Valkov, E, Kobe, B and Fraser, JA (2010). Crystallization and preliminary X-ray analysis of mycophenolic acid-resistant and mycophenolic acid-sensitive forms of IMP dehydrogenase from the human fungal pathogen Cryptococcus. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66 (9), 1104-1107. doi: 10.1107/S1744309110031659

Crystallization and preliminary X-ray analysis of mycophenolic acid-resistant and mycophenolic acid-sensitive forms of IMP dehydrogenase from the human fungal pathogen Cryptococcus

2009

Journal Article

Sexual reproduction and dimorphism in the pathogenic basidiomycetes

Morrow, Carl A. and Fraser, James A. (2009). Sexual reproduction and dimorphism in the pathogenic basidiomycetes. FEMS Yeast Research, 9 (2), 161-177. doi: 10.1111/j.1567-1364.2008.00475.x

Sexual reproduction and dimorphism in the pathogenic basidiomycetes

2008

Journal Article

Transitions in sexuality: recapitulation of an ancestral tri- and tetrapolar mating system in Cryptococcus neoformans

Hsueh, Yen-Ping, Fraser, James A. and Heitman, Joseph (2008). Transitions in sexuality: recapitulation of an ancestral tri- and tetrapolar mating system in Cryptococcus neoformans. Eukaryotic Cell, 7 (10), 1847-1855. doi: 10.1128/EC.00271-08

Transitions in sexuality: recapitulation of an ancestral tri- and tetrapolar mating system in Cryptococcus neoformans

2007

Journal Article

First contemporary case of human infection with Cryptococcus gattii in Puget Sound: Evidence for spread of the Vancouver Island outbreak

Upton, A., Fraser, J., Kidd, S., Bretz, C., Bartlett, K., Heitman, J. and Marr, K. (2007). First contemporary case of human infection with Cryptococcus gattii in Puget Sound: Evidence for spread of the Vancouver Island outbreak. Journal of Clinical Microbiology, 45 (9), 3086-3088. doi: 10.1128/JCM.00593-07

First contemporary case of human infection with Cryptococcus gattii in Puget Sound: Evidence for spread of the Vancouver Island outbreak

2007

Journal Article

Evolution of the mating type locus: Insights gained from the dimorphic primary fungal pathogens Histoplasma capsulatum, Coccidioides immitis, and Coccidioides posadasii

Fraser, James A., Stajich, Jason E., Tarcha, Eric J., Cole, Garry T., Inglis, Diane O., Sil, Anita and Heitman, Joseph (2007). Evolution of the mating type locus: Insights gained from the dimorphic primary fungal pathogens Histoplasma capsulatum, Coccidioides immitis, and Coccidioides posadasii. Eukaryotic Cell, 6 (4), 622-629. doi: 10.1128/EC.00018-07

Evolution of the mating type locus: Insights gained from the dimorphic primary fungal pathogens Histoplasma capsulatum, Coccidioides immitis, and Coccidioides posadasii

2007

Book Chapter

Evolution of the Mating-Type Locus: The Basidiomycetes

Fraser, J., Hsueh, Y., Findley, K. and Heitman, J. (2007). Evolution of the Mating-Type Locus: The Basidiomycetes. Sex in Fungi: Molecular Determination and Evolutionary Implications. (pp. 19-34) edited by Heitman, J., Kronstad, J., Taylor, J. and Casselton, L.. Washington, DC: ASM Press. doi: 10.1037/11499-002

Evolution of the Mating-Type Locus: The Basidiomycetes

Past funding

  • 2020 - 2023
    Novel Broad Spectrum Antifungals Active Against Drug Resistant Candida Auris
    NHMRC IDEAS Grants
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    Epifluorescent and live-cell imaging microscopes for the investigation of host-pathogen interactions and for molecular and cellular biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2021
    Microevolution of Cryptococcus neoformans
    NHMRC Project Grant
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2018
    Acetohydroxyacid synthase: A new drug target for human fungal pathogens
    NHMRC Project Grant
    Open grant
  • 2014
    A confocal microscope for investigation of live bacterial and viral pathogens and for molecular cell biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013 - 2016
    Purine metabolism as an antifungal drug target
    NHMRC Project Grant
    Open grant
  • 2012 - 2013
    IMPDH as an antifungal drug target
    Therapeutic Innovation Australia Limited
    Open grant
  • 2011 - 2014
    Targeting acetohydroxyacid synthase to discover new antifungal agents
    NHMRC Project Grant
    Open grant
  • 2010 - 2012
    ResTeach 2010 0.1 FTE School of Chemistry and Molecular Biosciences
    UQ ResTeach
    Open grant
  • 2010 - 2012
    Understanding an exotic disease: Initiation of sex and infection by the sugarcane smut Ustilago scitaminea
    ARC Discovery Projects
    Open grant
  • 2007 - 2010
    Transposable element mobility and chromosomal rearrangement in the fungal pathogen Cryptococcus during human infection
    NHMRC Project Grant
    Open grant

Availability

Professor James Fraser is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    The role of the cotranscriptional activator complex SAGA in virulence of Cryptococcus neoformans

    Principal Advisor

    Other advisors: Professor Benjamin Schulz

  • Doctor Philosophy

    Advanced Genetic Toolkit for Cryptococcus neoformans: Iterating Upon Currently Used Techniques in the WHO¿s Top-Ranked Fungal Pathogen

    Principal Advisor

    Other advisors: Associate Professor Nick West

  • Doctor Philosophy

    Resolving a Dichotomy: A Journey between the Laboratory and the Classroom

    Principal Advisor

    Other advisors: Professor Bostjan Kobe

  • Doctor Philosophy

    The Cryptococcus neoformans SAGA: Investigating the SAGA associated Histone acetyltransferase and Deubiquitinase modules opposing influence on virulence

    Principal Advisor

    Other advisors: Professor Benjamin Schulz

  • Doctor Philosophy

    Antifungal agents to target disseminated mycoses

    Principal Advisor

    Other advisors: Dr Kylie Agnew-Francis, Professor Avril Robertson

  • Doctor Philosophy

    Purine biosynthesis as an anti fungal target

    Principal Advisor

    Other advisors: Professor Bostjan Kobe

  • Doctor Philosophy

    Targetting Candida Auris

    Associate Advisor

    Other advisors: Dr Kylie Agnew-Francis, Professor Avril Robertson

  • Doctor Philosophy

    Developing a cell-free, structural model of fungal cell walls

    Associate Advisor

    Other advisors: Dr Evelyne Deplazes

  • Doctor Philosophy

    Targeting Deadly Mycotic Infection

    Associate Advisor

    Other advisors: Dr Kylie Agnew-Francis, Professor Avril Robertson

  • Doctor Philosophy

    Characterising the membrane interactions and cytotoxic activity of the anti-fungal peptide Lactofungin

    Associate Advisor

    Other advisors: Dr Evelyne Deplazes

Completed supervision

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