Professor James Fraser
Professor

James Fraser

Email: 
Phone: 
+61 7 336 54868

Availability

Professor James Fraser is:
Available for supervision

Fields of research

Genetics Medical microbiology Microbiology

Qualifications

  • Bachelor (Honours) of Science (Advanced), University of Melbourne
  • Doctor of Philosophy, Institution to be confirmed

Search Professor James Fraser’s works on UQ eSpace

107 works between 2001 and 2026
All (107) Journal Article (98) Conference Publication (7) Book Chapter (2)

81 - 100 of 107 works

2010

Journal Article

Crystallization and preliminary X-ray analysis of mycophenolic acid-resistant and mycophenolic acid-sensitive forms of IMP dehydrogenase from the human fungal pathogen Cryptococcus

Morrow, CA, Stamp, A, Valkov, E, Kobe, B and Fraser, JA (2010). Crystallization and preliminary X-ray analysis of mycophenolic acid-resistant and mycophenolic acid-sensitive forms of IMP dehydrogenase from the human fungal pathogen Cryptococcus. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66 (9), 1104-1107. doi: 10.1107/S1744309110031659

Crystallization and preliminary X-ray analysis of mycophenolic acid-resistant and mycophenolic acid-sensitive forms of IMP dehydrogenase from the human fungal pathogen Cryptococcus

2009

Journal Article

Sexual reproduction and dimorphism in the pathogenic basidiomycetes

Morrow, Carl A. and Fraser, James A. (2009). Sexual reproduction and dimorphism in the pathogenic basidiomycetes. FEMS Yeast Research, 9 (2), 161-177. doi: 10.1111/j.1567-1364.2008.00475.x

Sexual reproduction and dimorphism in the pathogenic basidiomycetes

2008

Journal Article

Transitions in sexuality: recapitulation of an ancestral tri- and tetrapolar mating system in Cryptococcus neoformans

Hsueh, Yen-Ping, Fraser, James A. and Heitman, Joseph (2008). Transitions in sexuality: recapitulation of an ancestral tri- and tetrapolar mating system in Cryptococcus neoformans. Eukaryotic Cell, 7 (10), 1847-1855. doi: 10.1128/EC.00271-08

Transitions in sexuality: recapitulation of an ancestral tri- and tetrapolar mating system in Cryptococcus neoformans

2007

Journal Article

First contemporary case of human infection with Cryptococcus gattii in Puget Sound: Evidence for spread of the Vancouver Island outbreak

Upton, A., Fraser, J., Kidd, S., Bretz, C., Bartlett, K., Heitman, J. and Marr, K. (2007). First contemporary case of human infection with Cryptococcus gattii in Puget Sound: Evidence for spread of the Vancouver Island outbreak. Journal of Clinical Microbiology, 45 (9), 3086-3088. doi: 10.1128/JCM.00593-07

First contemporary case of human infection with Cryptococcus gattii in Puget Sound: Evidence for spread of the Vancouver Island outbreak

2007

Journal Article

Evolution of the mating type locus: Insights gained from the dimorphic primary fungal pathogens Histoplasma capsulatum, Coccidioides immitis, and Coccidioides posadasii

Fraser, James A., Stajich, Jason E., Tarcha, Eric J., Cole, Garry T., Inglis, Diane O., Sil, Anita and Heitman, Joseph (2007). Evolution of the mating type locus: Insights gained from the dimorphic primary fungal pathogens Histoplasma capsulatum, Coccidioides immitis, and Coccidioides posadasii. Eukaryotic Cell, 6 (4), 622-629. doi: 10.1128/EC.00018-07

Evolution of the mating type locus: Insights gained from the dimorphic primary fungal pathogens Histoplasma capsulatum, Coccidioides immitis, and Coccidioides posadasii

2007

Book Chapter

Evolution of the Mating-Type Locus: The Basidiomycetes

Fraser, J., Hsueh, Y., Findley, K. and Heitman, J. (2007). Evolution of the Mating-Type Locus: The Basidiomycetes. Sex in Fungi: Molecular Determination and Evolutionary Implications. (pp. 19-34) edited by Heitman, J., Kronstad, J., Taylor, J. and Casselton, L.. Washington, DC: ASM Press. doi: 10.1037/11499-002

Evolution of the Mating-Type Locus: The Basidiomycetes

2006

Journal Article

Yeast diversity sampling on the San Juan Islands reveals no evidence for the spread of the Vancouver Island Cryptococcus gattii outbreak to this locale

Fraser, J. A., Lim, S. M. C., Diezmann, S., Wenink, E. C., Arndt, C. G., Cox, G. M., Dietrich, F. S. and Heitman, J. (2006). Yeast diversity sampling on the San Juan Islands reveals no evidence for the spread of the Vancouver Island Cryptococcus gattii outbreak to this locale. Fems Yeast Research, 6 (4), 620-624. doi: 10.1111/j.1567-1364.2006.00075.x

Yeast diversity sampling on the San Juan Islands reveals no evidence for the spread of the Vancouver Island Cryptococcus gattii outbreak to this locale

2006

Conference Publication

The Cryptococcus neoformans mating-type locus: evolutionary insights from related species

Fraser, J (2006). The Cryptococcus neoformans mating-type locus: evolutionary insights from related species. 8th International Mycological Conference, Cairns, August, 2006.

The Cryptococcus neoformans mating-type locus: evolutionary insights from related species

2006

Journal Article

Recent evolution of the human pathogen Cryptococcus neoformans by intervarietal transfer of a 14-gene fragment

Kavanaugh, L. A., Fraser, J. A. and Dietrich, F. S. (2006). Recent evolution of the human pathogen Cryptococcus neoformans by intervarietal transfer of a 14-gene fragment. Molecular Biology And Evolution, 23 (10), 1879-1890. doi: 10.1093/molbev/msl070

Recent evolution of the human pathogen Cryptococcus neoformans by intervarietal transfer of a 14-gene fragment

2006

Book Chapter

Sex, MAT, and the Evolution of Fungal Virulence

Fraser, James A. and Heitman, Joseph (2006). Sex, MAT, and the Evolution of Fungal Virulence. Sex, MAT, and the Evolution of Fungal Virulence. (pp. 13-33) edited by Heitman, J, Filler, SG, Edwards, JE and Mitchell, AP. WASHINGTON: AMER SOC MICROBIOLOGY. doi: 10.1128/9781555815776.ch2

Sex, MAT, and the Evolution of Fungal Virulence

2005

Journal Article

The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans

Loftus, B. J., Fung, E., Roncaglia, P., Rowley, D., Amedeo, P., Bruno, D., Vamathevan, J., Miranda, M., Anderson, I. J., Fraser, J. A., Allen, J. E., Bosdet, I. E., Brent, M. R., Chiu, R., Doering, T. L., Dontin, M. J., D'Souza, C. A., Fox, D. S., Grinberg, V., Fu, J. M., Fukushima, M., Haas, B. J., Huang, J. C., Janbon, G., Jones, S. J. M., Koo, H. L., Krzywinski, M. I., Kwon-Chung, J. K., Lengeler, K. B. and Maiti, R. (2005). The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. Science, 307 (5713), 1321-1324. doi: 10.1126/science.1103773

The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans

2005

Journal Article

Chromosomal sex-determining regions in animals, plants and fungi

Fraser, J. A. and Heitman, J. (2005). Chromosomal sex-determining regions in animals, plants and fungi. Current Opinion In Genetics & Development, 15 (6), 645-651. doi: 10.1016/j.gde.2005.09.002

Chromosomal sex-determining regions in animals, plants and fungi

2005

Journal Article

Clinical and environmental isolates of Cryptococcus gattii from Australia that retain sexual fecundity

Campbell, L. T., Fraser, J. A., Nichols, C. B., Dietrich, F. S., Dietrich and Heitman, J. (2005). Clinical and environmental isolates of Cryptococcus gattii from Australia that retain sexual fecundity. Eukaryotic Cell, 4 (8), 1410-1419. doi: 10.1128/EC.4.8.1410-1419.2005

Clinical and environmental isolates of Cryptococcus gattii from Australia that retain sexual fecundity

2005

Journal Article

Nuclear accumulation of the GATA factor AreA in response to complete nitrogen starvation by regulation of nuclear export

Todd, R. B., Fraser, J. A., Wong, K. H., Davis, M. A. and Hynes, M. J. (2005). Nuclear accumulation of the GATA factor AreA in response to complete nitrogen starvation by regulation of nuclear export. Eukaryotic Cell, 4 (10), 1646-1653. doi: 10.1128/EC.4.10.1646-1653.2005

Nuclear accumulation of the GATA factor AreA in response to complete nitrogen starvation by regulation of nuclear export

2005

Journal Article

Chromosomal translocation and segmental duplication in Cryptococcus neoformans

Fraser, J. A., Huang, J. C., Pukkila-Worley, R., Alspaugh, J. A., Mitchell, T. G. and Heitman, J. (2005). Chromosomal translocation and segmental duplication in Cryptococcus neoformans. Eukaryotic Cell, 4 (2), 401-406. doi: 10.1128/EC.4.2.401-406.2005

Chromosomal translocation and segmental duplication in Cryptococcus neoformans

2005

Journal Article

Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak

Fraser, J. A., Giles, S. S., Wenink, E. C., Geunes-Boyer, S. G., Wright, J. R., Diezmann, S., Allen, A., Stajich, J. E., Dietrich, F. S., Perfect, J. R. and Heitman, J. (2005). Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak. Nature, 437 (7063), 1360-1364. doi: 10.1038/nature04220

Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak

2005

Journal Article

Deciphering the model pathogenic fungus Cryptococcus neoformans

Idnurm, A., Bahn, Y. S., Nielsen, K., Lin, X. R., Fraser, J. A. and Heitman, J. (2005). Deciphering the model pathogenic fungus Cryptococcus neoformans. Nature Reviews Microbiology, 3 (10), 753-764. doi: 10.1038/nrmicro1245

Deciphering the model pathogenic fungus Cryptococcus neoformans

2004

Journal Article

Convergent evolution of chromosomal sex-determining regions in the animal and fungal kingdoms

Fraser, James A., Diezmann, Stephanie, Subaran, Ryan L., Allen, Andria, Lengeler, Klaus B., Dietrich, Fred S. and Heitman, Joseph (2004). Convergent evolution of chromosomal sex-determining regions in the animal and fungal kingdoms. Plos Biology, 2 (12) e384, 2243-2255. doi: 10.1371/journal.pbio.0020384

Convergent evolution of chromosomal sex-determining regions in the animal and fungal kingdoms

2004

Journal Article

Evolution of fungal sex chromosomes

Fraser, J. A. and Heitman, J. (2004). Evolution of fungal sex chromosomes. Molecular Microbiology, 51 (2), 299-306. doi: 10.1046/j.1365-2958.2003.03874.x

Evolution of fungal sex chromosomes

2004

Journal Article

PAK kinases Ste20 and Pak1 govern cell polarity at different stages of mating in Cryptococcus neoformans

Nichols, C. B., Fraser, J. A. and Heitman, J. (2004). PAK kinases Ste20 and Pak1 govern cell polarity at different stages of mating in Cryptococcus neoformans. Molecular Biology of The Cell, 15 (10), 4476-4489. doi: 10.1091/mbc.E04-05-0370

PAK kinases Ste20 and Pak1 govern cell polarity at different stages of mating in Cryptococcus neoformans

Past funding

  • 2020 - 2023
    Novel Broad Spectrum Antifungals Active Against Drug Resistant Candida Auris
    NHMRC IDEAS Grants
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    Epifluorescent and live-cell imaging microscopes for the investigation of host-pathogen interactions and for molecular and cellular biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2021
    Microevolution of Cryptococcus neoformans
    NHMRC Project Grant
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2018
    Acetohydroxyacid synthase: A new drug target for human fungal pathogens
    NHMRC Project Grant
    Open grant
  • 2014
    A confocal microscope for investigation of live bacterial and viral pathogens and for molecular cell biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013 - 2016
    Purine metabolism as an antifungal drug target
    NHMRC Project Grant
    Open grant
  • 2012 - 2013
    IMPDH as an antifungal drug target
    Therapeutic Innovation Australia Limited
    Open grant
  • 2011 - 2014
    Targeting acetohydroxyacid synthase to discover new antifungal agents
    NHMRC Project Grant
    Open grant
  • 2010 - 2012
    ResTeach 2010 0.1 FTE School of Chemistry and Molecular Biosciences
    UQ ResTeach
    Open grant
  • 2010 - 2012
    Understanding an exotic disease: Initiation of sex and infection by the sugarcane smut Ustilago scitaminea
    ARC Discovery Projects
    Open grant
  • 2007 - 2010
    Transposable element mobility and chromosomal rearrangement in the fungal pathogen Cryptococcus during human infection
    NHMRC Project Grant
    Open grant

Availability

Professor James Fraser is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Multi-layered regulation of virulence in Cryptococcus neoformans: from the SAGA complex to purine metabolism

    Principal Advisor

    Other advisors: Professor Benjamin Schulz

  • Doctor Philosophy

    Characterising the membrane interactions and cytotoxic activity of the anti-fungal peptide Lactofungin

    Associate Advisor

    Other advisors: Dr Evelyne Deplazes

  • Doctor Philosophy

    Proteins in innate immunity pathways: from protein structure to therapeutic targeting

    Associate Advisor

    Other advisors: Associate Professor Michael Landsberg, Professor Bostjan Kobe

  • Doctor Philosophy

    Developing a cell-free, structural model of fungal cell walls

    Associate Advisor

    Other advisors: Dr Evelyne Deplazes

Completed supervision

Enquiries

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