Professor James Fraser
Professor

James Fraser

Email: 
Phone: 
+61 7 336 54868

Availability

Professor James Fraser is:
Available for supervision

Fields of research

Genetics Medical microbiology Microbiology

Qualifications

  • Bachelor (Honours) of Science (Advanced), University of Melbourne
  • Doctor of Philosophy, unknown

Search Professor James Fraser’s works on UQ eSpace

102 works between 1984 and 2024
All (102) Journal Article (94) Book Chapter (2) Conference Publication (6)

21 - 40 of 102 works

2018

Journal Article

Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles

Kummari, Lalith K., Butler, Mark S., Furlong, Emily, Blundell, Ross, Nouwens, Amanda, Silva, Alberto B., Kappler, Ulrike, Fraser, James A., Kobe, Bostjan, Cooper, Matthew A. and Robertson, Avril A.B. (2018). Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles. Bioorganic and Medicinal Chemistry, 26 (20), 5408-5419. doi: 10.1016/j.bmc.2018.09.004

Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles

2018

Journal Article

Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators

Hommel, Benjamin, Mukaremera, Liliane, Cordero, Radames J. B., Coelho, Carolina, Desjardins, Christopher A., Sturny-Leclère, Aude, Janbon, Guilhem, Perfect, John R., Fraser, James A., Casadevall, Arturo, Cuomo, Christina A., Dromer, Françoise, Nielsen, Kirsten and Alanio, Alexandre (2018). Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators. PLoS Pathogens, 14 (5) e1006982, e1006982. doi: 10.1371/journal.ppat.1006982

Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators

2018

Journal Article

The long history of the diverse roles of short ORFs: sPEPs in fungi

Erpf, Paige E. and Fraser, James A. (2018). The long history of the diverse roles of short ORFs: sPEPs in fungi. Proteomics, 18 (10) 1700219, e1700219. doi: 10.1002/pmic.201700219

The long history of the diverse roles of short ORFs: sPEPs in fungi

2018

Journal Article

The beer and biofuels laboratory: a report on implementing and supporting a large, interdisciplinary, yeast-focused course-based undergraduate research experience

Pedwell, Rhianna K., Fraser, James A., Wang, Jack T. H., Clegg, Jack K., Chartres, Jy D. and Rowland, Susan L. (2018). The beer and biofuels laboratory: a report on implementing and supporting a large, interdisciplinary, yeast-focused course-based undergraduate research experience. Biochemistry and Molecular Biology Education , 46 (3), 213-222. doi: 10.1002/bmb.21111

The beer and biofuels laboratory: a report on implementing and supporting a large, interdisciplinary, yeast-focused course-based undergraduate research experience

2017

Journal Article

High resolution crystal structures of the acetohydroxyacid synthase-pyruvate complex provide new insights into its catalytic mechanism

Lonhienne, Thierry, Garcia, Mario D., Noble, Chris, Harmer, Jeffrey, Fraser, James A., Williams, Craig M. and Guddat, Luke W. (2017). High resolution crystal structures of the acetohydroxyacid synthase-pyruvate complex provide new insights into its catalytic mechanism. Chemistryselect, 2 (36), 11981-11988. doi: 10.1002/slct.201702128

High resolution crystal structures of the acetohydroxyacid synthase-pyruvate complex provide new insights into its catalytic mechanism

2017

Journal Article

Convergent microevolution of Cryptococcus neoformans hypervirulence in the laboratory and the clinic

Arras, Samantha D. M., Ormerod, Kate L., Erpf, Paige E., Espinosa, Monica I., Carpenter, Alex C., Blundell, Ross D., Stowasser, Samantha R., Schulz, Benjamin L., Tanurdzic, Milos and Fraser, James A. (2017). Convergent microevolution of Cryptococcus neoformans hypervirulence in the laboratory and the clinic. Scientific Reports, 7 (1) 17918, 1-14. doi: 10.1038/s41598-017-18106-2

Convergent microevolution of Cryptococcus neoformans hypervirulence in the laboratory and the clinic

2017

Journal Article

Antimicrobial octapeptin C4 analogues active against Cryptococcus species

Chitty, Jessica L., Butler, Mark S., Suboh, Azzah, Edwards, David J., Cooper, Matthew A., Fraser, James A. and Robertson, Avril A. B. (2017). Antimicrobial octapeptin C4 analogues active against Cryptococcus species. Antimicrobial agents and chemotherapy, 62 (2) e00986-17, 1-10. doi: 10.1128/AAC.00986-17

Antimicrobial octapeptin C4 analogues active against Cryptococcus species

2017

Journal Article

A fluorogenic C. neoformans reporter strain with a robust expression of m-cherry expressed from a safe haven site in the genome

Upadhya, Rajendra, Lam, Woei C., Maybruck, Brian T., Donlin, Maureen J., Chang, Andrew L., Kayode, Sarah, Ormerod, Kate L., Fraser, James A., Doering, Tamara L. and Lodge, Jennifer K. (2017). A fluorogenic C. neoformans reporter strain with a robust expression of m-cherry expressed from a safe haven site in the genome. Fungal Genetics and Biology : FG & B, 108, 13-25. doi: 10.1016/j.fgb.2017.08.008

A fluorogenic C. neoformans reporter strain with a robust expression of m-cherry expressed from a safe haven site in the genome

2017

Journal Article

Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design

Chitty, Jessica L., Blake, Kirsten L., Blundell, Ross D., Koh, Y. Q. Andre E., Thompson, Merinda, Robertson, Avril A. B., Butler, Mark S., Cooper, Matthew A., Kappler, Ulrike, Williams, Simon J., Kobe, Bostjan and Fraser, James A. (2017). Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design. Journal of Biological Chemistry, 292 (28), 11829-11839. doi: 10.1074/jbc.M117.787994

Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design

2017

Journal Article

Importance of resolving fungal nomenclature: the case of multiple pathogenic species in the Cryptococcus genus

Hagen, Ferry, Lumbsch, H. Thorsten, Arsenijevic, Valentina Arsic, Badali, Hamid, Bertout, Sebastien, Billmyre, R. Blake, Rosa Bragulat, M., Javier Cabanes, F., Carbia, Mauricio, Chakrabarti, Arunaloke, Chaturvedi, Sudha, Chaturvedi, Vishnu, Chen, Min, Chowdhary, Anuradha, Colom, Maria-Francisca, Cornely, Oliver A., Crous, Pedro W., Cuetara, Maria S., Diaz, Mara R., Espinel-Ingroff, Ana, Fakhim, Hamed, Falk, Rama, Fang, Wenjie, Herkert, Patricia F., Ferrer Rodriguez, Consuelo, Fraser, James A., Gene, Josepa, Guarro, Josep, Idnurm, Alexander ... Boekhoutiii, Teun (2017). Importance of resolving fungal nomenclature: the case of multiple pathogenic species in the Cryptococcus genus. Msphere, 2 (4) e00238-17. doi: 10.1128/mSphere.00238-17

Importance of resolving fungal nomenclature: the case of multiple pathogenic species in the Cryptococcus genus

2017

Journal Article

Purine acquisition and synthesis by human fungal pathogens

Chitty, Jessica L. and Fraser, James A. (2017). Purine acquisition and synthesis by human fungal pathogens. Microorganisms, 5 (2) 33, 33.1-33.16. doi: 10.3390/microorganisms5020033

Purine acquisition and synthesis by human fungal pathogens

2017

Journal Article

Sirtuins in the phylum Basidiomycota: A role in virulence in Cryptococcus neoformans

Arras, Samantha D. M., Chitty, Jessica L., Wizrah, Maha S. I., Erpf, Paige E., Schulz, Benjamin L., Tanurdzic, Milos and Fraser, James A. (2017). Sirtuins in the phylum Basidiomycota: A role in virulence in Cryptococcus neoformans. Scientific Reports, 7 (1) 46567, 46567.1-46567.14. doi: 10.1038/srep46567

Sirtuins in the phylum Basidiomycota: A role in virulence in Cryptococcus neoformans

2017

Journal Article

GMP synthase is required for virulence factor production and infection by cryptococcus neoformans

Chitty, Jessica L., Tatzenko, Tayla L. , Williams, Simon J., Koh, Y. Q. Andre E., Corfield, Elizabeth C., Butler, Mark S., Robertson, Avril A. B., Cooper, Matthew A., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2017). GMP synthase is required for virulence factor production and infection by cryptococcus neoformans. Journal of Biological Chemistry, 292 (7), 3049-3059. doi: 10.1074/jbc.M116.767533

GMP synthase is required for virulence factor production and infection by cryptococcus neoformans

2017

Journal Article

The 2.0 Å X-ray structure for yeast acetohydroxyacid synthase provides new insights into its cofactor and quaternary structure requirements

Lonhienne, Thierry, Garcia, Mario D., Fraser, James A., Williams, Craig M. and Guddat, Luke W. (2017). The 2.0 Å X-ray structure for yeast acetohydroxyacid synthase provides new insights into its cofactor and quaternary structure requirements. PLoS One, 12 (2) e0171443, e0171443.1-e0171443.13. doi: 10.1371/journal.pone.0171443

The 2.0 Å X-ray structure for yeast acetohydroxyacid synthase provides new insights into its cofactor and quaternary structure requirements

2017

Journal Article

Corrigendum: Whole Genome Comparison Reveals High Levels of Inbreeding and Strain Redundancy Across the Spectrum of CommercialWine Strains of Saccharomyces cerevisiae [G3 Genes|Genomes|Genetics, 6 (957-971)]

Borneman, A. R., Forgan, A.H., Kolouchova, R., Fraser, J. A. and Schmidt, S.A. (2017). Corrigendum: Whole Genome Comparison Reveals High Levels of Inbreeding and Strain Redundancy Across the Spectrum of CommercialWine Strains of Saccharomyces cerevisiae [G3 Genes|Genomes|Genetics, 6 (957-971)]. G3: Genes, Genomes, Genetics, 7 (1), 319-319. doi: 10.1534/g3.116.036038

Corrigendum: Whole Genome Comparison Reveals High Levels of Inbreeding and Strain Redundancy Across the Spectrum of CommercialWine Strains of Saccharomyces cerevisiae [G3 Genes|Genomes|Genetics, 6 (957-971)]

2016

Journal Article

Targeted genome editing via CRISPR in the pathogen Cryptococcus neoformans

Arras, Samantha D. M., Chua, Sheena M. H., Wizrah, Maha S. I., Faint, Joshua A., Yap, Amy S. and Fraser, James A. (2016). Targeted genome editing via CRISPR in the pathogen Cryptococcus neoformans. PloS One, 11 (10) e0164322, e0164322. doi: 10.1371/journal.pone.0164322

Targeted genome editing via CRISPR in the pathogen Cryptococcus neoformans

2016

Journal Article

Chemical inhibitors of non-homologous end joining increase targeted construct integration in Cryptococcus neoformans

Arras, Samantha D. M. and Fraser, James A. (2016). Chemical inhibitors of non-homologous end joining increase targeted construct integration in Cryptococcus neoformans. PLoS One, 11 (9) e0163049, e0163049. doi: 10.1371/journal.pone.0163049

Chemical inhibitors of non-homologous end joining increase targeted construct integration in Cryptococcus neoformans

2016

Journal Article

Disruption of de novo adenosine triphosphate (ATP) biosynthesis abolishes virulence in Cryptococcus neoformans

Blundell, Ross D., Williams, Simon J., Arras, Samantha D. M., Chitty, Jessica L., Blake, Kirsten L., Ericsson, Daniel J., Tibrewal, Nidhi, Rohr, Jurgen, Koh, Y. Q. Andre, Kappler, Ulrike, Robertson, Avril A. B., Butler, Mark S., Cooper, Matthew A., Kobe, Bostjan and Fraser, James A. (2016). Disruption of de novo adenosine triphosphate (ATP) biosynthesis abolishes virulence in Cryptococcus neoformans. ACS Infectious Diseases, 2 (9), 651-663. doi: 10.1021/acsinfecdis.6b00121

Disruption of de novo adenosine triphosphate (ATP) biosynthesis abolishes virulence in Cryptococcus neoformans

2016

Journal Article

Whole genome comparison reveals high levels of inbreeding and strain redundancy across the spectrum of commercial wine strains of Saccharomyces cerevisiae

Borneman, Anthony R., Forgan, Angus H., Kolouchova, Radka, Fraser, James A. and Schmidt, Simon A. (2016). Whole genome comparison reveals high levels of inbreeding and strain redundancy across the spectrum of commercial wine strains of Saccharomyces cerevisiae. G3: Genes, Genomes, Genetics, 6 (4), 957-971. doi: 10.1534/g3.115.025692

Whole genome comparison reveals high levels of inbreeding and strain redundancy across the spectrum of commercial wine strains of Saccharomyces cerevisiae

2016

Journal Article

Antibacterial and antifungal screening of natural products sourced from Australian fungi and characterisation of pestalactams D-F

Beattie, Karren D., Ellwood, Nicola, Kumar, Rohitesh, Yang, Xinzhou, Healy, Peter C., Choomuenwai, Vanida, Quinn, Ronald J., Elliott, Alysha G., Huang, Johnny X., Chitty, Jessica L., Fraser, James A., Cooper, Matthew A. and Davis, Rohan A. (2016). Antibacterial and antifungal screening of natural products sourced from Australian fungi and characterisation of pestalactams D-F. Phytochemistry, 124, 79-85. doi: 10.1016/j.phytochem.2015.12.014

Antibacterial and antifungal screening of natural products sourced from Australian fungi and characterisation of pestalactams D-F

Past funding

  • 2020 - 2023
    Novel Broad Spectrum Antifungals Active Against Drug Resistant Candida Auris
    NHMRC IDEAS Grants
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    Epifluorescent and live-cell imaging microscopes for the investigation of host-pathogen interactions and for molecular and cellular biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2021
    Microevolution of Cryptococcus neoformans
    NHMRC Project Grant
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2018
    Acetohydroxyacid synthase: A new drug target for human fungal pathogens
    NHMRC Project Grant
    Open grant
  • 2014
    A confocal microscope for investigation of live bacterial and viral pathogens and for molecular cell biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013 - 2016
    Purine metabolism as an antifungal drug target
    NHMRC Project Grant
    Open grant
  • 2012 - 2013
    IMPDH as an antifungal drug target
    Therapeutic Innovation Australia Limited
    Open grant
  • 2011 - 2014
    Targeting acetohydroxyacid synthase to discover new antifungal agents
    NHMRC Project Grant
    Open grant
  • 2010 - 2012
    ResTeach 2010 0.1 FTE School of Chemistry and Molecular Biosciences
    UQ ResTeach
    Open grant
  • 2010 - 2012
    Understanding an exotic disease: Initiation of sex and infection by the sugarcane smut Ustilago scitaminea
    ARC Discovery Projects
    Open grant
  • 2007 - 2010
    Transposable element mobility and chromosomal rearrangement in the fungal pathogen Cryptococcus during human infection
    NHMRC Project Grant
    Open grant

Availability

Professor James Fraser is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Purine biosynthesis as an anti fungal target

    Principal Advisor

    Other advisors: Professor Bostjan Kobe

  • Doctor Philosophy

    The role of the cotranscriptional activator complex SAGA in virulence of Cryptococcus neoformans

    Principal Advisor

    Other advisors: Professor Benjamin Schulz

  • Doctor Philosophy

    Advanced Genetic Toolkit for Cryptococcus neoformans: Iterating Upon Currently Used Techniques in the WHO¿s Top-Ranked Fungal Pathogen

    Principal Advisor

    Other advisors: Associate Professor Nick West

  • Doctor Philosophy

    Resolving a Dichotomy: A Journey between the Laboratory and the Classroom

    Principal Advisor

    Other advisors: Professor Bostjan Kobe

  • Doctor Philosophy

    The Cryptococcus neoformans SAGA: Investigating the SAGA associated Histone acetyltransferase and Deubiquitinase modules opposing influence on virulence

    Principal Advisor

    Other advisors: Professor Benjamin Schulz

  • Doctor Philosophy

    Antifungal agents to target disseminated mycoses

    Principal Advisor

    Other advisors: Dr Kylie Agnew-Francis, Professor Avril Robertson

  • Doctor Philosophy

    Developing a cell-free, structural model of fungal cell walls

    Associate Advisor

    Other advisors: Dr Evelyne Deplazes

  • Doctor Philosophy

    Targeting Deadly Mycotic Infection

    Associate Advisor

    Other advisors: Dr Kylie Agnew-Francis, Professor Avril Robertson

  • Doctor Philosophy

    Characterising the membrane interactions and cytotoxic activity of the anti-fungal peptide Lactofungin

    Associate Advisor

    Other advisors: Dr Evelyne Deplazes

  • Doctor Philosophy

    Targetting Candida Auris

    Associate Advisor

    Other advisors: Dr Kylie Agnew-Francis, Professor Avril Robertson

Completed supervision

Enquiries

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