Professor Avril Robertson
Professor

Avril Robertson

Email: 
Phone: 
+61 7 334 60586

Availability

Professor Avril Robertson is:
Available for supervision

Qualifications

  • Masters (Research), University of St Andrews
  • Doctor of Philosophy, University of St Andrews
  • Postgraduate Diploma in Higher Education, The University of Queensland
  • Postgraduate Diploma in Higher Education, unknown

Search Professor Avril Robertson’s works on UQ eSpace

128 works between 1999 and 2024
All (128) Journal Article (94) Book Chapter (1) Conference Publication (26) Other Outputs (7)

61 - 80 of 128 works

2017

Other Outputs

Sulfonylureas and related compounds and use of the same

O'Neill, Luke , Coll, Rebecca , Cooper, Matt , Robertson, Avril , Schroder, Kate , Macleod, Angus Murray and Miller, David John (2017). Sulfonylureas and related compounds and use of the same. WO2017140778.

Sulfonylureas and related compounds and use of the same

2017

Journal Article

Sulfonylureas as concomitant insulin secretagogues and NLRP3 inflammasome inhibitors

Hill, James R., Coll, Rebecca C., Sue, Nancy, Reid, Janet C., Dou, Jennifer, Holley, Caroline L., Pelingon, Ruby, Dickinson, Joshua B., Biden, Trevor J., Schroder, Kate, Cooper, Matthew A. and Robertson, Avril A. B. (2017). Sulfonylureas as concomitant insulin secretagogues and NLRP3 inflammasome inhibitors. ChemMedChem, 12 (17), 1449-1457. doi: 10.1002/cmdc.201700270

Sulfonylureas as concomitant insulin secretagogues and NLRP3 inflammasome inhibitors

2017

Journal Article

Role for NLRP3 inflammasome-mediated, IL-1β-dependent responses in severe, steroid-resistant asthma

Kim, Richard Y., Pinkerton, James W., Essilfie, Ama T., Robertson, Avril A. B., Baines, Katherine J., Brown, Alexandra C., Mayall, Jemma R., Ali, M. Khadem, Starkey, Malcolm R., Hansbro, Nicole G., Hirota, Jeremy A., Wood, Lisa G. , Simpson, Jodie L., Knight, Darryl A., Wark, Peter A., Gibson, Peter G., O'Neill, Luke A. J., Cooper, Matthew A., Horvat, Jay C. and Hansbro, Philip M. (2017). Role for NLRP3 inflammasome-mediated, IL-1β-dependent responses in severe, steroid-resistant asthma. American Journal of Respiratory and Critical Care Medicine, 196 (3), 283-297. doi: 10.1164/rccm.201609-1830OC

Role for NLRP3 inflammasome-mediated, IL-1β-dependent responses in severe, steroid-resistant asthma

2017

Journal Article

Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design

Chitty, Jessica L., Blake, Kirsten L., Blundell, Ross D., Koh, Y. Q. Andre E., Thompson, Merinda, Robertson, Avril A. B., Butler, Mark S., Cooper, Matthew A., Kappler, Ulrike, Williams, Simon J., Kobe, Bostjan and Fraser, James A. (2017). Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design. Journal of Biological Chemistry, 292 (28), 11829-11839. doi: 10.1074/jbc.M117.787994

Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design

2017

Journal Article

NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction

Pavillard, Luis E., Cañadas-Lozano, Diego, Alcocer-Gómez, Elísabet, Marín-Aguilar, Fabiola, Pereira, Sheila, Robertson, Avril A. B., Muntané, Jordi, Ryffel, Bernhard, Cooper, Matthew A., Quiles, José L., Bullón, Pedro, Ruiz-Cabello, Jesús and Cordero, Mario D. (2017). NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction. Oncotarget, 8 (59), 99740-99756. doi: 10.18632/oncotarget.20763

NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction

2017

Journal Article

Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome

Neudecker, Viola, Haneklaus, Moritz, Jensen, Owen, Khailova, Ludmila, Masterson, Joanne C., Tye, Hazel, Biette, Kathryn, Jedlicka, Paul, Brodsky, Kelley S., Gerich, Mark E., Mack, Matthias, Robertson, Avril A. B., Cooper, Matthew A., Furuta, Glenn T., Dinarello, Charles A., O'Neill, Luke A., Eltzschig, Holger K., Masters, Seth L. and McNamee, Eoin N. (2017). Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome. Journal of Experimental Medicine, 214 (6), 1737-1752. doi: 10.1084/jem.20160462

Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome

2017

Journal Article

Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress

Dinh, Quynh Nhu, Drummond, Grant R., Kemp-Harper, Barbara K., Diep, Henry, De Silva, T. Michael, Kim, Hyun Ah, Vinh, Antony, Robertson, Avril A. B., Cooper, Matthew A., Mansell, Ashley, Chrissobolis, Sophocles and Sobey, Christopher G. (2017). Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress. Aging, 9 (6), 1595-1606. doi: 10.18632/aging.101255

Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress

2017

Other Outputs

Preparation of sulfonylureas, especially N-[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl]benzenesulfonamides, as dual insulin secretagogues and NLRP3 inflammasome inhibitors.

O'Neill, Luke , Coll, Rebecca , Robertson, Avril , Cooper, Matthew , Schroder, Kate , Macleod, Angus Murray and Miller, David John (2017). Preparation of sulfonylureas, especially N-[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl]benzenesulfonamides, as dual insulin secretagogues and NLRP3 inflammasome inhibitors.. WO2018215818.

Preparation of sulfonylureas, especially N-[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl]benzenesulfonamides, as dual insulin secretagogues and NLRP3 inflammasome inhibitors.

2017

Other Outputs

Novel compounds and uses

O'Neill, L. A., Coll, R. C., Cooper, M. A., Robertson, A. A. B., Schroder, K., MacLeod, A. M. and Miller, D. J. (2017). Novel compounds and uses. PCT/IB2017/053059.

Novel compounds and uses

2017

Journal Article

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

Mridha, Auvro R., Wree, Alexander, Robertson, Avril A. B., Yeh, Matthew M., Johnson, Casey D., Van Rooyen, Derrick M., Haczeyni, Fahrettin, Teoh, Narci C. -H., Savard, Christopher, Ioannou, George N., Masters, Seth L., Schroder, Kate, Cooper, Matthew A., Feldstein, Ariel E. and Farrell, Geoffrey C. (2017). NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. Journal of Hepatology, 66 (5), 1037-1046. doi: 10.1016/j.jhep.2017.01.022

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

2017

Conference Publication

High Fat Diet-Induced Obesity Promotes Steroid-Resistant Asthma Through An Nlrp3 Inflammasome-Dependent Mechanism

Pinkerton, James, Kim, Richard, Mayall, Jemma, Ali, Md. Khadem, Starkey, Malcolm, Robertson, Avril, O'Neill, Luke, Cooper, Matthew, Hansbro, Philip and Horvat, Jay (2017). High Fat Diet-Induced Obesity Promotes Steroid-Resistant Asthma Through An Nlrp3 Inflammasome-Dependent Mechanism. HOBOKEN: WILEY.

High Fat Diet-Induced Obesity Promotes Steroid-Resistant Asthma Through An Nlrp3 Inflammasome-Dependent Mechanism

2017

Journal Article

Clonal hematopoiesis associated with Tet2 deficiency accelerates atherosclerosis development in mice

Fuster, José J., MacLauchlan, Susan, Zuriaga, María A., Polackal, Maya N., Ostriker, Allison C., Chakraborty, Raja, Wu, Chia-Ling, Sano, Soichi, Muralidharan, Sujatha, Rius, Cristina, Vuong, Jacqueline, Jacob, Sophia, Muralidliar, Varsha, Robertson, Avril A. B., Cooper, Matthew A., Andres, Vicente, Hirschi, Karen K., Martin, Kathleen A. and Walsh, Kenneth (2017). Clonal hematopoiesis associated with Tet2 deficiency accelerates atherosclerosis development in mice. Science, 355 (6327), 842-847. doi: 10.1126/science.aag1381

Clonal hematopoiesis associated with Tet2 deficiency accelerates atherosclerosis development in mice

2017

Journal Article

GMP synthase is required for virulence factor production and infection by cryptococcus neoformans

Chitty, Jessica L., Tatzenko, Tayla L. , Williams, Simon J., Koh, Y. Q. Andre E., Corfield, Elizabeth C., Butler, Mark S., Robertson, Avril A. B., Cooper, Matthew A., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2017). GMP synthase is required for virulence factor production and infection by cryptococcus neoformans. Journal of Biological Chemistry, 292 (7), 3049-3059. doi: 10.1074/jbc.M116.767533

GMP synthase is required for virulence factor production and infection by cryptococcus neoformans

2017

Journal Article

Small-molecule inhibitors of the SOX18 transcription factor

Fontaine, Frank, Overman, Jeroen, Moustaqil, Mehdi, Mamidyala, Sreeman, Salim, Angela, Narasimhan, Kamesh, Prokoph, Nina, Robertson, Avril A. B., Lua, Linda, Alexandrov, Kirill, Koopman, Peter, Capon, Robert J., Sierecki, Emma, Gambin, Yann, Jauch, Ralf, Cooper, Matthew A., Zuegg, Johannes and Francois, Mathias (2017). Small-molecule inhibitors of the SOX18 transcription factor. Chemistry Chemical Biology, 24 (3), 346-359. doi: 10.1016/j.chembiol.2017.01.003

Small-molecule inhibitors of the SOX18 transcription factor

2017

Journal Article

Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice

Overman, Jeroen, Fontaine, Frank, Moustaqil, Mehdi, Mittal, Deepak, Sierecki, Emma, Sacilotto, Natalia, Zuegg, Johannes, Robertson, Avril A. B., Holmes, Kelly, Salim, Angela A., Mamidyala, Sreeman, Butler, Mark S., Robinson, Ashley S., Lesieur, Emmanuelle, Johnston, Wayne, Alexandrov, Kirill, Black, Brian L., Hogan, Benjamin M., De Val, Sarah, Capon, Robert J., Carroll, Jason S., Bailey, Timothy L., Koopman, Peter, Jauch, Ralf, Smyth, Mark J., Cooper, Matthew A., Gambin, Yann and Francois, Mathias (2017). Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. eLife, 6 e21221. doi: 10.7554/eLife.21221

Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice

2017

Journal Article

Inflammasomes in the lung

Pinkerton, James W., Kim, Richard Y., Robertson, Avril A. B., Hirota, Jeremy A., Wood, Lisa G., Knight, Darryl A., Cooper, Matthew A., O'Neill, Luke A. J., Horvat, Jay C. and Hansbro, Philip M. (2017). Inflammasomes in the lung. Molecular Immunology, 86, 44-55. doi: 10.1016/j.molimm.2017.01.014

Inflammasomes in the lung

2017

Journal Article

PB1-F2 derived from avian influenza a virus H7N9 induces inflammation via activation of the NLRP3 inflammasome

Pinar, Anita, Dowling, Jennifer K., Bitto, Natalie J., Robertson, Avril B., Latz, Eicke, Stewart, Cameron R., Drummond, Grant R., Cooper, Matthew A., McAuley, Julie L., Tate, Michelle D. and Mansell, Ashley (2017). PB1-F2 derived from avian influenza a virus H7N9 induces inflammation via activation of the NLRP3 inflammasome. The Journal of Biological Chemistry, 292 (3), 826-836. doi: 10.1074/jbc.M116.756379

PB1-F2 derived from avian influenza a virus H7N9 induces inflammation via activation of the NLRP3 inflammasome

2017

Journal Article

Lipocalin-2 induces NLRP3 inflammasome activation via HMGB1 induced TLR4 signaling in heart tissue of mice under pressure overload challenge

Song, Erfei, Jahng, James W. S., Chong, Lisa P., Sung, Hye K., Han, Meng, Luo, Cuiting, Wu, Donghai, Boo, Stellar, Hinz, Boris, Cooper, Matthew A., Robertson, Avril A. B., Berger, Thorsten, Mak, Tak W., George, Isaac, Schulze, P. Christian, Wang, Yu, Xu, Aimin and Sweeney, Gary (2017). Lipocalin-2 induces NLRP3 inflammasome activation via HMGB1 induced TLR4 signaling in heart tissue of mice under pressure overload challenge. American Journal of Translational Research, 9 (6) AJTR0048252, 2723-+.

Lipocalin-2 induces NLRP3 inflammasome activation via HMGB1 induced TLR4 signaling in heart tissue of mice under pressure overload challenge

2016

Journal Article

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

Basiorka, Ashley A., McGraw, Kathy L., Eksioglu, Erika A., Chen, Xianghong, Johnson, Joseph, Zhang, Ling, Zhang, Qing, Irvine, Brittany A., Cluzeau, Thomas, Sallman, David A., Padron, Eric, Komrokji, Rami, Sokol, Lubomir, Coll, Rebecca C., Robertson, Avril A. B., Cooper, Matthew A., Cleveland, John L., O'Neill, Luke A., Wei, Sheng and List, Alan F. (2016). The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype. Blood, 128 (25), 2960-2975. doi: 10.1182/blood-2016-07-730556

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

2016

Journal Article

Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice

Dempsey, C., Rubio Araiz, A., Bryson, K. J., Finucane, O., Larkin, C., Mills, E. L., Robertson, A. A. B., Cooper, M. A., O'Neill, L. A. J. and Lynch, M. A. (2016). Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice. Brain, Behavior, and Immunity, 61, 306-316. doi: 10.1016/j.bbi.2016.12.014

Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice

Current funding

  • 2022 - 2024
    Inhibiting ASC with small molecules for treatment of inflammatory diseases
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2022 - 2023
    Targeting inflammation to treat dementia (Lead by La Trobe)
    The Cass Foundation Limited
    Open grant
  • 2021 - 2024
    The NLRP3 inflammasome in the pathogenesis of polycystic kidney disease (PKD Australia administered by La Trobe University)
    La Trobe University
    Open grant
  • 2020 - 2023
    Novel Broad Spectrum Antifungals Active Against Drug Resistant Candida Auris
    NHMRC IDEAS Grants
    Open grant
  • 2018 - 2022
    Validating the NLRP3 Inflammasome as a Therapeutic Target in Motor Neuron Disease
    NHMRC Project Grant
    Open grant
  • 2017 - 2018
    A Pharmacology Screening Facility to Accelerate Drug Discovery and Development
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2019
    Inflammatory pathways to liver fibrosis in non-alcoholic and alcoholic steatohepatitis: reversal by NLRP3 inhibitors (NHMRC Project Grant administered by ANU)
    Australian National University
    Open grant
  • 2017 - 2021
    Novel NLRP3 inhibitors for asthma therapy
    NHMRC Development Grant
    Open grant
  • 2016 - 2020
    Blocking inflammasome-induced neuroinflammation in PD with a potent, orally available small molecule
    The Michael J Fox Foundation Therapeutic Pipeline Program
    Open grant
  • 2015 - 2017
    Pharmacological targeting of the NLRP3 inflammasome in pre-clinical models of Parkinson's disease using a potent orally active inhibitor
    The Michael J Fox Foundation for Parkinsons Research
    Open grant
  • 2015 - 2017
    Inhibitors of NLRP3 activation for treatment of inflammatory CNS diseases
    NHMRC Project Grant
    Open grant
  • 2013 - 2016
    Novel immunomodulatory agents for type II diabetes through targeting the NLRP3 inflammasome signalling cascade
    Department of Innovation, Industry, Science and Research - Australia-India Strategic Research Fund
    Open grant
  • 2012 - 2013
    IMPDH as an antifungal drug target
    Therapeutic Innovation Australia Limited
    Open grant

Availability

Professor Avril Robertson is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Enquiries

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