Professor Avril Robertson
Professor

Avril Robertson

Email: 
Phone: 
+61 7 334 60586

Availability

Professor Avril Robertson is:
Available for supervision

Qualifications

  • Masters (Research), University of St Andrews
  • Doctor of Philosophy, University of St Andrews
  • Postgraduate Diploma in Higher Education, The University of Queensland
  • Postgraduate Diploma in Higher Education, Institution to be confirmed

Search Professor Avril Robertson’s works on UQ eSpace

139 works between 1999 and 2025
All (139) Journal Article (101) Book Chapter (1) Conference Publication (30) Other Outputs (7)

61 - 80 of 139 works

2018

Journal Article

The NLRP3 inflammasome suppresses protective immunity to gastrointestinal helminth infection

Alhallaf, Rafid, Agha, Zainab, Miller, Catherine M., Robertson, Avril A. B., Sotillo, Javier, Croese, John, Cooper, Matthew A., Masters, Seth L., Kupz, Andreas, Smith, Nicholas C., Loukas, Alex and Giacomin, Paul R. (2018). The NLRP3 inflammasome suppresses protective immunity to gastrointestinal helminth infection. Cell Reports, 23 (4), 1085-1098. doi: 10.1016/j.celrep.2018.03.097

The NLRP3 inflammasome suppresses protective immunity to gastrointestinal helminth infection

2018

Journal Article

Fishing for drug targets: a focus on diazirine photoaffinity probe synthesis

Hill, James R. and Robertson, Avril A. B. (2018). Fishing for drug targets: a focus on diazirine photoaffinity probe synthesis. Journal of Medicinal Chemistry, 61 (16) acs.jmedchem.7b01561, 6945-6963. doi: 10.1021/acs.jmedchem.7b01561

Fishing for drug targets: a focus on diazirine photoaffinity probe synthesis

2018

Journal Article

Synthesis of deuterium-labelled analogues of NLRP3 inflammasome inhibitor MCC950

Salla, Manohar, Butler, Mark S., Massey, Nicholas L., Reid, Janet C., Cooper, Matthew A. and Robertson, Avril A. B. (2018). Synthesis of deuterium-labelled analogues of NLRP3 inflammasome inhibitor MCC950. Bioorganic and Medicinal Chemistry Letters, 28 (4), 793-795. doi: 10.1016/j.bmcl.2017.12.054

Synthesis of deuterium-labelled analogues of NLRP3 inflammasome inhibitor MCC950

2018

Journal Article

Evidence against a role for NLRP3-driven islet inflammation in db/db mice

Kammoun, H. L., Allen, T. L., Henstridge, D. C., Barre, S., Coll, R. C., Lancaster, G. I., Cron, L., Reibe, S., Chan, J. Y., Bensellam, M., Laybutt, D. R., Butler, M. S., Robertson, A. A. B., O'Neill, L. A., Cooper, M. A. and Febbraio, M. A. (2018). Evidence against a role for NLRP3-driven islet inflammation in db/db mice. Molecular Metabolism, 10, 66-73. doi: 10.1016/j.molmet.2018.02.001

Evidence against a role for NLRP3-driven islet inflammation in db/db mice

2018

Book Chapter

Inhibiting inflammasomes with small molecules

Robertson, Avril A. B. (2018). Inhibiting inflammasomes with small molecules. Inflammasomes: clinical and therapeutic implications. (pp. 343-400) edited by Mario D. Cordero and Elísabet Alcocer-Gómez. Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-319-89390-7_15

Inhibiting inflammasomes with small molecules

2018

Journal Article

Multiple inflammasomes may regulate the interleukin-1-driven inflammation in protracted bacterial bronchitis

Chen, Alice C. -H., Tran, Hai B., Xi, Yang, Yerkovich, Stephanie T., Baines, Katherine J., Pizzutto, Susan J., Carroll, Melanie, Robertson, Avril A. B., Cooper, Matthew A., Schroder, Kate, Simpson, Jodie L., Gibson, Peter G., Hodge, Greg, Masters, Ian B., Buntain, Helen M., Petsky, Helen L., Prime, Samantha J., Chang, Anne B., Hodge, Sandra and Upham, John W. (2018). Multiple inflammasomes may regulate the interleukin-1-driven inflammation in protracted bacterial bronchitis. ERJ Open Research, 4 (1) 00130-2017, 00130-2017. doi: 10.1183/23120541.00130-2017

Multiple inflammasomes may regulate the interleukin-1-driven inflammation in protracted bacterial bronchitis

2017

Other Outputs

Inhibitors of SOX 18 protein activity for treating angiogenesis- and/or lymphangiogenesis

Francois, Mathias, Zuegg, Johannes, Overman, Jeroen, Mamidyala, Sreeman Kumar, Salim, Angela Aguslyarti, Fontaine, Frank Roger, Cooper, Matthew Allister, Capon, Robert John and Robertson, Avril Alexis Barbara (2017). Inhibitors of SOX 18 protein activity for treating angiogenesis- and/or lymphangiogenesis. WO2018112545.

Inhibitors of SOX 18 protein activity for treating angiogenesis- and/or lymphangiogenesis

2017

Journal Article

An optimized whole blood assay measuring expression and activity of NLRP3, NLRC4 and AIM2 inflammasomes

Grinstein, Lev, Luksch, Hella, Schulze, Felix, Robertson, Avril A. B., Cooper, Matthew A., Rösen-Wolff, Angela and Winkler, Stefan (2017). An optimized whole blood assay measuring expression and activity of NLRP3, NLRC4 and AIM2 inflammasomes. Clinical Immunology, 191, 100-109. doi: 10.1016/j.clim.2017.11.011

An optimized whole blood assay measuring expression and activity of NLRP3, NLRC4 and AIM2 inflammasomes

2017

Journal Article

Antimicrobial octapeptin C4 analogues active against Cryptococcus species

Chitty, Jessica L., Butler, Mark S., Suboh, Azzah, Edwards, David J., Cooper, Matthew A., Fraser, James A. and Robertson, Avril A. B. (2017). Antimicrobial octapeptin C4 analogues active against Cryptococcus species. Antimicrobial agents and chemotherapy, 62 (2) e00986-17, 1-10. doi: 10.1128/AAC.00986-17

Antimicrobial octapeptin C4 analogues active against Cryptococcus species

2017

Journal Article

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation

Chen, Weiqiang, Foo, Suan-Sin, Zaid, Ali, Teng, Terk-Shin, Herrero, Lara J., Wolf, Stefan, Tharmarajah, Kothila, Vu, Luan D., van Vreden, Caryn, Taylor, Adam, Freitas, Joseph R., Li, Rachel W., Woodruff, Trent M., Gordon, Richard, Ojcius, David M., Nakaya, Helder I., Kanneganti, Thirumala-Devi, O’Neill, Luke A. J., Robertson, Avril A. B., King, Nicholas J., Suhrbier, Andreas, Cooper, Matthew A., Ng, Lisa F. P. and Mahalingam, Suresh (2017). Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation. Nature Microbiology, 2 (10), 1-11. doi: 10.1038/s41564-017-0015-4

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation

2017

Other Outputs

Sulfonylureas and related compounds and use of the same

O'Neill, Luke , Coll, Rebecca , Cooper, Matt , Robertson, Avril , Schroder, Kate , Macleod, Angus Murray and Miller, David John (2017). Sulfonylureas and related compounds and use of the same. WO2017140778.

Sulfonylureas and related compounds and use of the same

2017

Journal Article

Sulfonylureas as concomitant insulin secretagogues and NLRP3 inflammasome inhibitors

Hill, James R., Coll, Rebecca C., Sue, Nancy, Reid, Janet C., Dou, Jennifer, Holley, Caroline L., Pelingon, Ruby, Dickinson, Joshua B., Biden, Trevor J., Schroder, Kate, Cooper, Matthew A. and Robertson, Avril A. B. (2017). Sulfonylureas as concomitant insulin secretagogues and NLRP3 inflammasome inhibitors. ChemMedChem, 12 (17), 1449-1457. doi: 10.1002/cmdc.201700270

Sulfonylureas as concomitant insulin secretagogues and NLRP3 inflammasome inhibitors

2017

Journal Article

Role for NLRP3 inflammasome-mediated, IL-1β-dependent responses in severe, steroid-resistant asthma

Kim, Richard Y., Pinkerton, James W., Essilfie, Ama T., Robertson, Avril A. B., Baines, Katherine J., Brown, Alexandra C., Mayall, Jemma R., Ali, M. Khadem, Starkey, Malcolm R., Hansbro, Nicole G., Hirota, Jeremy A., Wood, Lisa G. , Simpson, Jodie L., Knight, Darryl A., Wark, Peter A., Gibson, Peter G., O'Neill, Luke A. J., Cooper, Matthew A., Horvat, Jay C. and Hansbro, Philip M. (2017). Role for NLRP3 inflammasome-mediated, IL-1β-dependent responses in severe, steroid-resistant asthma. American Journal of Respiratory and Critical Care Medicine, 196 (3), 283-297. doi: 10.1164/rccm.201609-1830OC

Role for NLRP3 inflammasome-mediated, IL-1β-dependent responses in severe, steroid-resistant asthma

2017

Journal Article

Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design

Chitty, Jessica L., Blake, Kirsten L., Blundell, Ross D., Koh, Y. Q. Andre E., Thompson, Merinda, Robertson, Avril A. B., Butler, Mark S., Cooper, Matthew A., Kappler, Ulrike, Williams, Simon J., Kobe, Bostjan and Fraser, James A. (2017). Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design. Journal of Biological Chemistry, 292 (28), 11829-11839. doi: 10.1074/jbc.M117.787994

Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design

2017

Journal Article

NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction

Pavillard, Luis E., Cañadas-Lozano, Diego, Alcocer-Gómez, Elísabet, Marín-Aguilar, Fabiola, Pereira, Sheila, Robertson, Avril A. B., Muntané, Jordi, Ryffel, Bernhard, Cooper, Matthew A., Quiles, José L., Bullón, Pedro, Ruiz-Cabello, Jesús and Cordero, Mario D. (2017). NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction. Oncotarget, 8 (59), 99740-99756. doi: 10.18632/oncotarget.20763

NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction

2017

Journal Article

Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome

Neudecker, Viola, Haneklaus, Moritz, Jensen, Owen, Khailova, Ludmila, Masterson, Joanne C., Tye, Hazel, Biette, Kathryn, Jedlicka, Paul, Brodsky, Kelley S., Gerich, Mark E., Mack, Matthias, Robertson, Avril A. B., Cooper, Matthew A., Furuta, Glenn T., Dinarello, Charles A., O'Neill, Luke A., Eltzschig, Holger K., Masters, Seth L. and McNamee, Eoin N. (2017). Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome. Journal of Experimental Medicine, 214 (6), 1737-1752. doi: 10.1084/jem.20160462

Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome

2017

Journal Article

Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress

Dinh, Quynh Nhu, Drummond, Grant R., Kemp-Harper, Barbara K., Diep, Henry, De Silva, T. Michael, Kim, Hyun Ah, Vinh, Antony, Robertson, Avril A. B., Cooper, Matthew A., Mansell, Ashley, Chrissobolis, Sophocles and Sobey, Christopher G. (2017). Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress. Aging, 9 (6), 1595-1606. doi: 10.18632/aging.101255

Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress

2017

Other Outputs

Preparation of sulfonylureas, especially N-[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl]benzenesulfonamides, as dual insulin secretagogues and NLRP3 inflammasome inhibitors.

O'Neill, Luke , Coll, Rebecca , Robertson, Avril , Cooper, Matthew , Schroder, Kate , Macleod, Angus Murray and Miller, David John (2017). Preparation of sulfonylureas, especially N-[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl]benzenesulfonamides, as dual insulin secretagogues and NLRP3 inflammasome inhibitors.. WO2018215818.

Preparation of sulfonylureas, especially N-[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl]benzenesulfonamides, as dual insulin secretagogues and NLRP3 inflammasome inhibitors.

2017

Other Outputs

Novel compounds and uses

O'Neill, L. A., Coll, R. C., Cooper, M. A., Robertson, A. A. B., Schroder, K., MacLeod, A. M. and Miller, D. J. (2017). Novel compounds and uses. PCT/IB2017/053059.

Novel compounds and uses

2017

Journal Article

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

Mridha, Auvro R., Wree, Alexander, Robertson, Avril A. B., Yeh, Matthew M., Johnson, Casey D., Van Rooyen, Derrick M., Haczeyni, Fahrettin, Teoh, Narci C. -H., Savard, Christopher, Ioannou, George N., Masters, Seth L., Schroder, Kate, Cooper, Matthew A., Feldstein, Ariel E. and Farrell, Geoffrey C. (2017). NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. Journal of Hepatology, 66 (5), 1037-1046. doi: 10.1016/j.jhep.2017.01.022

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

Current funding

  • 2022 - 2025
    Inhibiting ASC with small molecules for treatment of inflammatory diseases
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2022 - 2023
    Targeting inflammation to treat dementia (Lead by La Trobe)
    The Cass Foundation Limited
    Open grant
  • 2021 - 2024
    The NLRP3 inflammasome in the pathogenesis of polycystic kidney disease (PKD Australia administered by La Trobe University)
    La Trobe University
    Open grant
  • 2020 - 2023
    Novel Broad Spectrum Antifungals Active Against Drug Resistant Candida Auris
    NHMRC IDEAS Grants
    Open grant
  • 2018 - 2022
    Validating the NLRP3 Inflammasome as a Therapeutic Target in Motor Neuron Disease
    NHMRC Project Grant
    Open grant
  • 2017 - 2018
    A Pharmacology Screening Facility to Accelerate Drug Discovery and Development
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2019
    Inflammatory pathways to liver fibrosis in non-alcoholic and alcoholic steatohepatitis: reversal by NLRP3 inhibitors (NHMRC Project Grant administered by ANU)
    Australian National University
    Open grant
  • 2017 - 2021
    Novel NLRP3 inhibitors for asthma therapy
    NHMRC Development Grant
    Open grant
  • 2016 - 2020
    Blocking inflammasome-induced neuroinflammation in PD with a potent, orally available small molecule
    The Michael J Fox Foundation Therapeutic Pipeline Program
    Open grant
  • 2015 - 2017
    Pharmacological targeting of the NLRP3 inflammasome in pre-clinical models of Parkinson's disease using a potent orally active inhibitor
    The Michael J Fox Foundation for Parkinsons Research
    Open grant
  • 2015 - 2017
    Inhibitors of NLRP3 activation for treatment of inflammatory CNS diseases
    NHMRC Project Grant
    Open grant
  • 2013 - 2016
    Novel immunomodulatory agents for type II diabetes through targeting the NLRP3 inflammasome signalling cascade
    Department of Innovation, Industry, Science and Research - Australia-India Strategic Research Fund
    Open grant
  • 2012 - 2013
    IMPDH as an antifungal drug target
    Therapeutic Innovation Australia Limited
    Open grant

Availability

Professor Avril Robertson is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Breaking the chain of inflammation through targetting NLR proteins

    Principal Advisor

    Other advisors: Professor Kate Schroder, Professor David Ascher

  • Doctor Philosophy

    Therapeutic Resolution of Inflammation in the Central Nervous System for Neuroprotection in Parkinson's Disease

    Principal Advisor

    Other advisors: Professor David Ascher

  • Doctor Philosophy

    Aiming at Inflammasomes

    Principal Advisor

  • Doctor Philosophy

    Inflammasome inhibitors in disease: Is there a therapeutic trade-off of compromised host defence?

    Associate Advisor

    Other advisors: Professor Kate Schroder, Dr Sabrina Sofia Burgener

  • Doctor Philosophy

    Development of anti-inflammatory therapeutics by targeting cytoplasmic Toll-like receptors (TLRs) signalling

    Associate Advisor

    Other advisors: Mr Gilbert Song, Professor Bostjan Kobe

  • Doctor Philosophy

    The role of metabolic adaptation for virulence and persistence of Haemophilus influenzae in the host

    Associate Advisor

    Other advisors: Professor Ulrike Kappler

  • Doctor Philosophy

    Biosimilar litigation and market entry

    Associate Advisor

    Other advisors: Emeritus Professor Stephen Mahler, Dr Lisette Pregelj

Completed supervision

Enquiries

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