Professor Avril Robertson
Professor

Avril Robertson

Email: 
Phone: 
+61 7 334 60586

Availability

Professor Avril Robertson is:
Available for supervision

Qualifications

  • Masters (Research), University of St Andrews
  • Doctor of Philosophy, University of St Andrews
  • Postgraduate Diploma in Higher Education, The University of Queensland
  • Postgraduate Diploma in Higher Education, Institution to be confirmed

Search Professor Avril Robertson’s works on UQ eSpace

134 works between 1999 and 2025
All (134) Journal Article (99) Book Chapter (1) Conference Publication (27) Other Outputs (7)

41 - 60 of 134 works

2019

Journal Article

NLRP3 inflammasome inhibition by MCC950 in aged mice improves health via enhanced autophagy and PPARα activity

Marín-Aguilar, Fabiola, Castejón-Vega, Beatriz, Alcocer-Gómez, Elísabet, Lendines-Cordero, Debora, Cooper, Matthew A., de la Cruz, Patricia, Andújar-Pulido, Eloísa, Pérez-Alegre, Mónica, Muntané, Jordi, Pérez-Pulido, Antonio J., Ryffel, Bernhard, Robertson, Avril A. B., Ruiz-Cabello, Jesús, Bullón, Pedro and Cordero, Mario D (2019). NLRP3 inflammasome inhibition by MCC950 in aged mice improves health via enhanced autophagy and PPARα activity. Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, 75 (8), 1457-1464. doi: 10.1093/gerona/glz239

NLRP3 inflammasome inhibition by MCC950 in aged mice improves health via enhanced autophagy and PPARα activity

2019

Journal Article

Double-Stranded RNA Is a Novel Molecular Target in Osteomyelitis Pathogenesis: A Translational Avian Model for Human Bacterial Chondronecrosis with Osteomyelitis

Greene, Elizabeth, Flees, Joshua, Dhamad, Ahmed, Alrubaye, Adnan, Hennigan, Stephen, Pleimann, Jason, Smeltzer, Mark, Murray, Sue, Kugel, Jennifer, Goodrich, James, Robertson, Avril, Wideman, Robert, Rhoads, Douglas and Dridi, Sami (2019). Double-Stranded RNA Is a Novel Molecular Target in Osteomyelitis Pathogenesis: A Translational Avian Model for Human Bacterial Chondronecrosis with Osteomyelitis. American Journal of Pathology, 189 (10), 2077-2089. doi: 10.1016/j.ajpath.2019.06.013

Double-Stranded RNA Is a Novel Molecular Target in Osteomyelitis Pathogenesis: A Translational Avian Model for Human Bacterial Chondronecrosis with Osteomyelitis

2019

Journal Article

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

Coll, Rebecca C., Hill, James R., Day, Christopher J., Zamoshnikova, Alina, Boucher, Dave, Massey, Nicholas L., Chitty, Jessica L., Fraser, James A., Jennings, Michael P., Robertson, Avril A. B. and Schroder, Kate (2019). MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition. Nature Chemical Biology, 15 (6), 556-559. doi: 10.1038/s41589-019-0277-7

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

2019

Journal Article

Lack of protein prenylation promotes NLRP3 inflammasome assembly in human monocytes

Skinner, Oliver P., Jurczyluk, Julie, Baker, Paul J., Masters, Seth L., Rios Wilks, Alicia G., Clearwater, Misaki S., Robertson, Avril A. B., Schroder, Kate, Mehr, Sam, Munoz, Marcia A. and Rogers, Michael J. (2019). Lack of protein prenylation promotes NLRP3 inflammasome assembly in human monocytes. Journal of Allergy and Clinical Immunology, 143 (6), 2315-2317.e3. doi: 10.1016/j.jaci.2019.02.013

Lack of protein prenylation promotes NLRP3 inflammasome assembly in human monocytes

2019

Journal Article

Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension

Krishnan, Shalini M, Ling, Yeong H, Huuskes, Brooke M, Ferens, Dorota M, Saini, Narbada, Chan, Christopher T, Diep, Henry, Kett, Michelle M, Samuel, Chrishan S, Kemp-Harper, Barbara K, Robertson, Avril A B, Cooper, Matthew A, Peter, Karlheinz, Latz, Eicke, Mansell, Ashley S, Sobey, Christopher G, Drummond, Grant R and Vinh, Antony (2019). Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension. Cardiovascular Research, 115 (4), 776-787. doi: 10.1093/cvr/cvy252

Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension

2019

Journal Article

A multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasome

Mathur, Anukriti, Feng, Shouya, Hayward, Jenni A., Ngo, Chinh, Fox, Daniel, Atmosukarto, Ines I., Price, Jason D., Schauer, Kristina, Märtlbauer, Erwin, Robertson, Avril A. B., Burgio, Gaetan, Fox, Edward M., Leppla, Stephen H., Kaakoush, Nadeem O. and Man, Si Ming (2019). A multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasome. Nature Microbiology, 4 (2), 362-374. doi: 10.1038/s41564-018-0318-0

A multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasome

2019

Journal Article

Compromised NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages

Thygesen, Sara J., Takizawa, Karli E., Robertson, Avril A. B., Sester, David P. and Stacey, Katryn J. (2019). Compromised NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages. Immunology and cell biology, 97 (1), 17-28. doi: 10.1111/imcb.12193

Compromised NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages

2019

Conference Publication

IL-5/IL-13 drive NLRP3 inflammasome-mediated, steroid-resistant AHR in a model of obesity-associated asthma

Pinkerton, James, Kim, Richard, Brown, Alexandra, Rae, Brittany, Mayall, Jemma, Ali, Md. Khadem, Starkey, Malcolm, Robertson, Avril, Wood, Lisa, Cooper, Matthew, O'Neill, Luke, Hansbro, Philip and Horvat, Jay (2019). IL-5/IL-13 drive NLRP3 inflammasome-mediated, steroid-resistant AHR in a model of obesity-associated asthma. European Respiratory Society (ERS) International Congress, Madrid, Spain, 28 September-2 October 2019. Lausanne, Switzerland: European Respiratory Society. doi: 10.1183/13993003.congress-2019.pa3345

IL-5/IL-13 drive NLRP3 inflammasome-mediated, steroid-resistant AHR in a model of obesity-associated asthma

2019

Journal Article

Quantitation of Purines from Pigeon Guano and Implications for Cryptococcus neoformans Survival During Infection

Chitty, Jessica L., Edwards, David J., Robertson, Avril A. B., Butler, Mark S., Duley, John A., Cooper, Matthew A. and Fraser, James A. (2019). Quantitation of Purines from Pigeon Guano and Implications for Cryptococcus neoformans Survival During Infection. Mycopathologia, 184 (2), 273-281. doi: 10.1007/s11046-018-0315-0

Quantitation of Purines from Pigeon Guano and Implications for Cryptococcus neoformans Survival During Infection

2019

Conference Publication

Inhibition of NLRP3 does not protect against photo-oxidative damage-induced retinal degeneration

Wooff, Yvette, Fernando, Nilisha, Wong, Josephine, Dietrich, Catherine, Aggio-Bruce, Riemke, Chu-Tan, Joshua Aaron, Doyle, Sarah, Robertson, Avril, Man, Si Ming and Natoli, Riccardo Carlo (2019). Inhibition of NLRP3 does not protect against photo-oxidative damage-induced retinal degeneration. Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Vancouver, Canada, 28 April - 2 May 2019. Rockville, MD, United States: Association for Research in Vision and Ophthalmology.

Inhibition of NLRP3 does not protect against photo-oxidative damage-induced retinal degeneration

2018

Journal Article

Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signalling

Schofield, Zoe V., Croker, Daniel, Robertson, Avril A. B., Massey, Nicholas L., Donovan, Chantal, Tee, Ernest, Edwards, David, Woodruff, Trent M., Halai, Reena, Hansbro, Philip M. and Cooper, Matthew A. (2018). Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signalling. Scientific Reports, 8 (1) 17819, 17819. doi: 10.1038/s41598-018-36242-1

Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signalling

2018

Journal Article

The small molecule NLRP3 inflammasome inhibitor MCC950 does not alter wound healing in obese mice

Lee, James S., Robertson, Avril A. B., Cooper, Matthew A. and Khosrotehrani, Kiarash (2018). The small molecule NLRP3 inflammasome inhibitor MCC950 does not alter wound healing in obese mice. International Journal of Molecular Sciences, 19 (11) 3289, 3289. doi: 10.3390/ijms19113289

The small molecule NLRP3 inflammasome inhibitor MCC950 does not alter wound healing in obese mice

2018

Journal Article

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

Gordon, Richard, Albornoz, Eduardo A., Christie, Daniel C., Langley, Monica R., Kumar, Vinod, Mantovani, Susanna, Robertson, Avril A. B., Butler, Mark S., Rowe, Dominic B., O'Neill, Luke A., Kanthasamy, Anumantha G., Schroder, Kate, Cooper, Matthew A. and Woodruff, Trent M. (2018). Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. Science Translational Medicine, 10 (465) aah4066, eaah4066. doi: 10.1126/scitranslmed.aah4066

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

2018

Journal Article

Chick embryo: a preclinical model for understanding ischemia-reperfusion mechanism

Fauzia, Eram, Barbhuyan, Tarun Kumar, Shrivastava, Amit Kumar, Kumar, Manish, Garg, Paarth, Khan, Mohsin Ali, Robertson, Avril A. B. and Raza, Syed Shadab (2018). Chick embryo: a preclinical model for understanding ischemia-reperfusion mechanism. Frontiers in Pharmacology, 9 (SEP) 1034, 1034. doi: 10.3389/fphar.2018.01034

Chick embryo: a preclinical model for understanding ischemia-reperfusion mechanism

2018

Journal Article

Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles

Kummari, Lalith K., Butler, Mark S., Furlong, Emily, Blundell, Ross, Nouwens, Amanda, Silva, Alberto B., Kappler, Ulrike, Fraser, James A., Kobe, Bostjan, Cooper, Matthew A. and Robertson, Avril A.B. (2018). Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles. Bioorganic and Medicinal Chemistry, 26 (20), 5408-5419. doi: 10.1016/j.bmc.2018.09.004

Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles

2018

Journal Article

MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice

Perera, Agampodi Promoda, Fernando, Ruchira, Shinde, Tanvi, Gundamaraju, Rohit, Southam, Benjamin, Sohal, Sukhwinder Singh, Robertson, Avril A. B., Schroder, Kate, Kunde, Dale and Eri, Rajaraman (2018). MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice. Scientific Reports, 8 (1) 8618, 8618. doi: 10.1038/s41598-018-26775-w

MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice

2018

Journal Article

Abstract 317: Inflammasome Inhibitor MCC950 Prevents the Development of Sporadic Thoracic and Abdominal Aortic Aneurysms and Dissections in Mice

Ren, Pingping, Appel, Richard, Zhang, Lin, Luo, Wei, Zhang, Chen, Wang, Yidan, Guo, Jiao, Robertson, Avril A. B., Cooper, Matthew A., Coselli, Joseph S., Shen, Ying H. and LeMaire, Scott A. (2018). Abstract 317: Inflammasome Inhibitor MCC950 Prevents the Development of Sporadic Thoracic and Abdominal Aortic Aneurysms and Dissections in Mice. Arteriosclerosis Thrombosis and Vascular Biology, 38 (Suppl_1). doi: 10.1161/atvb.38.suppl_1.317

Abstract 317: Inflammasome Inhibitor MCC950 Prevents the Development of Sporadic Thoracic and Abdominal Aortic Aneurysms and Dissections in Mice

2018

Journal Article

The NLRP3 inflammasome suppresses protective immunity to gastrointestinal helminth infection

Alhallaf, Rafid, Agha, Zainab, Miller, Catherine M., Robertson, Avril A. B., Sotillo, Javier, Croese, John, Cooper, Matthew A., Masters, Seth L., Kupz, Andreas, Smith, Nicholas C., Loukas, Alex and Giacomin, Paul R. (2018). The NLRP3 inflammasome suppresses protective immunity to gastrointestinal helminth infection. Cell Reports, 23 (4), 1085-1098. doi: 10.1016/j.celrep.2018.03.097

The NLRP3 inflammasome suppresses protective immunity to gastrointestinal helminth infection

2018

Journal Article

Fishing for drug targets: a focus on diazirine photoaffinity probe synthesis

Hill, James R. and Robertson, Avril A. B. (2018). Fishing for drug targets: a focus on diazirine photoaffinity probe synthesis. Journal of Medicinal Chemistry, 61 (16) acs.jmedchem.7b01561, 6945-6963. doi: 10.1021/acs.jmedchem.7b01561

Fishing for drug targets: a focus on diazirine photoaffinity probe synthesis

2018

Journal Article

Synthesis of deuterium-labelled analogues of NLRP3 inflammasome inhibitor MCC950

Salla, Manohar, Butler, Mark S., Massey, Nicholas L., Reid, Janet C., Cooper, Matthew A. and Robertson, Avril A. B. (2018). Synthesis of deuterium-labelled analogues of NLRP3 inflammasome inhibitor MCC950. Bioorganic and Medicinal Chemistry Letters, 28 (4), 793-795. doi: 10.1016/j.bmcl.2017.12.054

Synthesis of deuterium-labelled analogues of NLRP3 inflammasome inhibitor MCC950

Current funding

  • 2022 - 2025
    Inhibiting ASC with small molecules for treatment of inflammatory diseases
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2022 - 2023
    Targeting inflammation to treat dementia (Lead by La Trobe)
    The Cass Foundation Limited
    Open grant
  • 2021 - 2024
    The NLRP3 inflammasome in the pathogenesis of polycystic kidney disease (PKD Australia administered by La Trobe University)
    La Trobe University
    Open grant
  • 2020 - 2023
    Novel Broad Spectrum Antifungals Active Against Drug Resistant Candida Auris
    NHMRC IDEAS Grants
    Open grant
  • 2018 - 2022
    Validating the NLRP3 Inflammasome as a Therapeutic Target in Motor Neuron Disease
    NHMRC Project Grant
    Open grant
  • 2017 - 2018
    A Pharmacology Screening Facility to Accelerate Drug Discovery and Development
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2019
    Inflammatory pathways to liver fibrosis in non-alcoholic and alcoholic steatohepatitis: reversal by NLRP3 inhibitors (NHMRC Project Grant administered by ANU)
    Australian National University
    Open grant
  • 2017 - 2021
    Novel NLRP3 inhibitors for asthma therapy
    NHMRC Development Grant
    Open grant
  • 2016 - 2020
    Blocking inflammasome-induced neuroinflammation in PD with a potent, orally available small molecule
    The Michael J Fox Foundation Therapeutic Pipeline Program
    Open grant
  • 2015 - 2017
    Pharmacological targeting of the NLRP3 inflammasome in pre-clinical models of Parkinson's disease using a potent orally active inhibitor
    The Michael J Fox Foundation for Parkinsons Research
    Open grant
  • 2015 - 2017
    Inhibitors of NLRP3 activation for treatment of inflammatory CNS diseases
    NHMRC Project Grant
    Open grant
  • 2013 - 2016
    Novel immunomodulatory agents for type II diabetes through targeting the NLRP3 inflammasome signalling cascade
    Department of Innovation, Industry, Science and Research - Australia-India Strategic Research Fund
    Open grant
  • 2012 - 2013
    IMPDH as an antifungal drug target
    Therapeutic Innovation Australia Limited
    Open grant

Availability

Professor Avril Robertson is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

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