Professor Avril Robertson
Professor

Avril Robertson

Email: 
Phone: 
+61 7 334 60586

Availability

Professor Avril Robertson is:
Available for supervision

Qualifications

  • Masters (Research), University of St Andrews
  • Doctor of Philosophy, University of St Andrews
  • Postgraduate Diploma in Higher Education, The University of Queensland
  • Postgraduate Diploma in Higher Education, Institution to be confirmed

Search Professor Avril Robertson’s works on UQ eSpace

139 works between 1999 and 2025
All (139) Journal Article (101) Book Chapter (1) Conference Publication (30) Other Outputs (7)

21 - 40 of 139 works

2022

Journal Article

AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans

Wizrah, Maha S. I., Chua, Sheena M. H., Luo, Zhenyao, Manik, Mohammad K., Pan, Mengqi, Whyte, Jessica M. L., Robertson, Avril A. B., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2022). AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans. Journal of Biological Chemistry, 298 (10) 102453, 102453. doi: 10.1016/j.jbc.2022.102453

AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans

2022

Conference Publication

Interaction between type 2 cytokine and inflammasome responses in the pathogenesis of obesity-associated asthma

Pinkerton, J., Kim, R., Brown, A., Rae, B., Donovan, C., Mayall, J., Ali, M. K., Scott, H., Berthon, B., Baines, K., Starkey, M., Kermani, N., Guo, Y., Robertson, A., O'Neill, L., Adcock, , Cooper, M., Gibson, P., Wood, L., Hansbro, P. and Horvat, J. (2022). Interaction between type 2 cytokine and inflammasome responses in the pathogenesis of obesity-associated asthma. International Congress of the European-Respiratory-Society (ERS), Barcelona Spain, Sep 04-06, 2022. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. doi: 10.1183/13993003.congress-2022.871

Interaction between type 2 cytokine and inflammasome responses in the pathogenesis of obesity-associated asthma

2022

Journal Article

Clostridium septicum α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins

Jing, Weidong, Pilato, Jordan Lo, Kay, Callum, Feng, Shouya, Tuipulotu, Daniel Enosi, Mathur, Anukriti, Shen, Cheng, Ngo, Chinh, Zhao, Anyang, Miosge, Lisa A., Ali, Sidra A., Gardiner, Elizabeth E., Awad, Milena M., Lyras, Dena, Robertson, Avril A. B., Kaakoush, Nadeem O. and Man, Si Ming (2022). Clostridium septicum α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins. Science Immunology, 7 (71) eabm1803, 1-17. doi: 10.1126/sciimmunol.abm1803

Clostridium septicum α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins

2022

Journal Article

Prevention of the foreign body response to implantable medical devices by inflammasome inhibition

Barone, Damiano G., Carnicer-Lombarte, Alejandro, Tourlomousis, Panagiotis, Hamilton, Russell S., Prater, Malwina, Rutz, Alexandra L., Dimov, Ivan B., Malliaras, George G., Lacour, Stephanie P., Robertson, Avril A. B., Franze, Kristian, Fawcett, James W. and Bryant, Clare E. (2022). Prevention of the foreign body response to implantable medical devices by inflammasome inhibition. Proceedings of the National Academy of Sciences, 119 (12) e2115857119, e2115857119. doi: 10.1073/pnas.2115857119

Prevention of the foreign body response to implantable medical devices by inflammasome inhibition

2022

Journal Article

Interleukin-1β suppression dampens inflammatory leukocyte production and uptake in atherosclerosis

Hettwer, Jan, Hinterdobler, Julia, Miritsch, Benedikt, Deutsch, Marcus-André, Li, Xinghai, Mauersberger, Carina, Moggio, Aldo, Braster, Quinte, Gram, Hermann, Robertson, Avril A. B., Cooper, Matthew A., Groß, Olaf, Krane, Markus, Weber, Christian, Koenig, Wolfgang, Soehnlein, Oliver, Adamstein, Nicholas H., Ridker, Paul, Schunkert, Heribert, Libby, Peter, Kessler, Thorsten and Sager, Hendrik B. (2022). Interleukin-1β suppression dampens inflammatory leukocyte production and uptake in atherosclerosis. Cardiovascular Research, 118 (13) cvab337, 2778-2791. doi: 10.1093/cvr/cvab337

Interleukin-1β suppression dampens inflammatory leukocyte production and uptake in atherosclerosis

2022

Journal Article

Aim2 suppresses cigarette smoke-induced neutrophil recruitment, neutrophil caspase-1 activation and anti-Ly6G-mediated neutrophil depletion

Donovan, Chantal, Kim, Richard Y, Galvao, Izabela, Jarnicki, Andrew G, Brown, Alexandra C, Jones-Freeman, Bernadette, Gomez, Henry M, Wadhwa, Ridhima, Hortle, Elinor, Jayaraman, Ranjith, Khan, Haroon, Pickles, Sophie, Sahu, Priyanka, Chimankar, Vrushali, Tu, Xiaofan, Ali, Md Khadem, Mayall, Jemma R, Nguyen, Duc H, Budden, Kurtis F, Kumar, Vinod, Schroder, Kate, Robertson, Avril AB, Cooper, Matthew A, Wark, Peter AB, Oliver, Brian G, Horvat, Jay C and Hansbro, Philip M (2022). Aim2 suppresses cigarette smoke-induced neutrophil recruitment, neutrophil caspase-1 activation and anti-Ly6G-mediated neutrophil depletion. Immunology and Cell Biology, 100 (4), 235-249. doi: 10.1111/imcb.12537

Aim2 suppresses cigarette smoke-induced neutrophil recruitment, neutrophil caspase-1 activation and anti-Ly6G-mediated neutrophil depletion

2021

Journal Article

Relationship between type 2 cytokine and inflammasome responses in obesity-associated asthma

Pinkerton, James W., Kim, Richard Y., Brown, Alexandra C., Rae, Brittany E., Donovan, Chantal, Mayall, Jemma R., Carroll, Olivia R., Ali, Md Khadem, Scott, Hayley A., Berthon, Bronwyn S., Baines, Katherine J., Starkey, Malcolm R., Kermani, Nazanin Z., Guo, Yi-Ke, Robertson, Avril A. B., O'Neill, Luke A. J., Adcock, Ian M., Cooper, Matthew A., Gibson, Peter G., Wood, Lisa G., Hansbro, Philip M. and Horvat, Jay C. (2021). Relationship between type 2 cytokine and inflammasome responses in obesity-associated asthma. The Journal of Allergy and Clinical Immunology, 149 (4), 1270-1280. doi: 10.1016/j.jaci.2021.10.003

Relationship between type 2 cytokine and inflammasome responses in obesity-associated asthma

2021

Journal Article

Modulating neuroplasticity: lessons learned from antidepressants and emerging novel therapeutics

Yates, Clarissa, Kruse, Jennifer L., Price, J. Blair, Robertson, Avril A. B. and Tye, Susannah J. (2021). Modulating neuroplasticity: lessons learned from antidepressants and emerging novel therapeutics. Current Treatment Options in Psychiatry, 8 (4), 229-257. doi: 10.1007/s40501-021-00249-9

Modulating neuroplasticity: lessons learned from antidepressants and emerging novel therapeutics

2020

Journal Article

NLRP3 inflammasome inhibition with MCC950 improves insulin sensitivity and inflammation in a mouse model of frontotemporal dementia

Hull, Claire, Dekeryte, Ruta, Buchanan, Heather, Kamli-Salino, Sarah, Robertson, Avril, Delibegovic, Mirela and Platt, Bettina (2020). NLRP3 inflammasome inhibition with MCC950 improves insulin sensitivity and inflammation in a mouse model of frontotemporal dementia. Neuropharmacology, 180 108305, 108305. doi: 10.1016/j.neuropharm.2020.108305

NLRP3 inflammasome inhibition with MCC950 improves insulin sensitivity and inflammation in a mouse model of frontotemporal dementia

2020

Journal Article

Metabolic competition between host and pathogen dictates inflammasome responses to fungal infection

Tucey, Timothy M., Verma, Jiyoti, Olivier, Françios A. B., Lo, Tricia L., Robertson, Avril A. B., Naderer, Thomas and Traven, Ana (2020). Metabolic competition between host and pathogen dictates inflammasome responses to fungal infection. PLoS Pathogens, 16 (8) e1008695, e1008695. doi: 10.1371/journal.ppat.1008695

Metabolic competition between host and pathogen dictates inflammasome responses to fungal infection

2020

Journal Article

Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and function

Li, Xaria X., Lee, John D., Massey, Nicholas L., Guan, Carolyn, Robertson, Avril A. B., Clark, Richard J. and Woodruff, Trent M. (2020). Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and function. Biochemical Pharmacology, 180 114156, 114156. doi: 10.1016/j.bcp.2020.114156

Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and function

2020

Journal Article

Decontamination of fentanyl and fentanyl analogues in field and laboratory settings: a review of fentanyl degradation

Bazley, Mikaela M., Logan, Michael, Baxter, Christina, Robertson, Avril A. B. and Blanchfield, Joanne T. (2020). Decontamination of fentanyl and fentanyl analogues in field and laboratory settings: a review of fentanyl degradation. Australian Journal of Chemistry, 73 (10), 868-879. doi: 10.1071/CH19669

Decontamination of fentanyl and fentanyl analogues in field and laboratory settings: a review of fentanyl degradation

2020

Journal Article

Synthesis and evaluation of NLRP3-inhibitory sulfonylurea [11C]MCC950 in healthy animals

Hill, James R., Shao, Xia, Massey, Nicholas L., Stauff, Jenelle, Sherman, Phillip S., Robertson, Avril A. B. and J. H. Scott, Peter (2020). Synthesis and evaluation of NLRP3-inhibitory sulfonylurea [11C]MCC950 in healthy animals. Bioorganic and Medicinal Chemistry Letters, 30 (12) 127186, 127186. doi: 10.1016/j.bmcl.2020.127186

Synthesis and evaluation of NLRP3-inhibitory sulfonylurea [11C]MCC950 in healthy animals

2020

Journal Article

Targeting NLRP3 and staphylococcal pore-forming toxin receptors in human-induced pluripotent stem cell-derived macrophages

Chow, Seong H., Deo, Pankaj, Yeung, Amy T. Y., Kostoulias, Xenia P., Jeon, Yusun, Gao, Mei-Ling, Seidi, Azadeh, Olivier, Françios Alwyn Benson, Sridhar, Sushmita, Nethercott, Cara, Cameron, David, Robertson, Avril A. B., Robert, Remy, Mackay, Charles R., Traven, Ana, Jin, Zi-Bing, Hale, Christine, Dougan, Gordon, Peleg, Anton Y. and Naderer, Thomas (2020). Targeting NLRP3 and staphylococcal pore-forming toxin receptors in human-induced pluripotent stem cell-derived macrophages. Journal of Leukocyte Biology, 108 (3) JLB.4MA0420-497R, 967-981. doi: 10.1002/jlb.4ma0420-497r

Targeting NLRP3 and staphylococcal pore-forming toxin receptors in human-induced pluripotent stem cell-derived macrophages

2020

Journal Article

Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathway

Ipseiz, Natacha, Pickering, Robert J., Rosas, Marcela, Tyrrell, Victoria J., Davies, Luke C., Orr, Selinda J., Czubala, Magdalena A., Fathalla, Dina, Robertson, Avril A. B., Bryant, Clare E., O'Donnell, Valerie and Taylor, Philip R. (2020). Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathway. EMBO Journal, 39 (14) e103454, e103454. doi: 10.15252/embj.2019103454

Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathway

2020

Journal Article

NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients

Malhotra, Sunny, Costa, Carme, Eixarch, Herena, Keller, Christian W., Amman, Lukas, Martínez-Banaclocha, Helios, Midaglia, Luciana, Sarró, Eduard, Machín-Díaz, Isabel, Villar, Luisa M., Triviño, Juan Carlos, Oliver-Martos, Begoña, Parladé, Laura Navarro, Calvo-Barreiro, Laura, Matesanz, Fuencisla, Vandenbroeck, Koen, Urcelay, Elena, Martínez-Ginés, María-Luisa, Tejeda-Velarde, Amalia, Fissolo, Nicolás, Castilló, Joaquín, Sanchez, Alex, Robertson, Avril A. B., Clemente, Diego, Prinz, Marco, Pelegrin, Pablo, Lünemann, Jan D., Espejo, Carmen, Montalban, Xavier and Comabella, Manuel (2020). NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients. Brain, 143 (5), 1414-1430. doi: 10.1093/brain/awaa084

NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients

2020

Journal Article

Targeting the NLRP3 inflammasome with inhibitor MCC950 prevents aortic aneurysms and dissections in mice

Ren, Pingping, Wu, Darrell, Appel, Richard, Zhang, Lin, Zhang, Chen, Luo, Wei, Robertson, Avril A B, Cooper, Matthew A., Coselli, Joseph S., Milewicz, Dianna M., Shen, Ying H. and LeMaire, Scott A. (2020). Targeting the NLRP3 inflammasome with inhibitor MCC950 prevents aortic aneurysms and dissections in mice. Journal of the American Heart Association, 9 (7) e014044. doi: 10.1161/JAHA.119.014044

Targeting the NLRP3 inflammasome with inhibitor MCC950 prevents aortic aneurysms and dissections in mice

2020

Journal Article

Design, synthesis and evaluation of an NLRP3 inhibitor diazirine photoaffinity probe

Hill, James R., Coll, Rebecca C., Schroder, Kate and Robertson, Avril A.B. (2020). Design, synthesis and evaluation of an NLRP3 inhibitor diazirine photoaffinity probe. Tetrahedron Letters, 61 (19) 151849, 151849. doi: 10.1016/j.tetlet.2020.151849

Design, synthesis and evaluation of an NLRP3 inhibitor diazirine photoaffinity probe

2020

Journal Article

Non-canonical Caspase-1 signaling drives RIP2-dependent and TNF-α-mediated inflammation in vivo

Reinke, Sören, Linge, Mary, Diebner, Hans H., Luksch, Hella, Glage, Silke, Gocht, Anne, Robertson, Avril A.B., Cooper, Matthew A., Hofmann, Sigrun R., Naumann, Ronald, Sarov, Mihail, Behrendt, Rayk, Roers, Axel, Pessler, Frank, Roesler, Joachim, Rösen-Wolff, Angela and Winkler, Stefan (2020). Non-canonical Caspase-1 signaling drives RIP2-dependent and TNF-α-mediated inflammation in vivo. Cell Reports, 30 (8), 2501-2511. doi: 10.1016/j.celrep.2020.01.090

Non-canonical Caspase-1 signaling drives RIP2-dependent and TNF-α-mediated inflammation in vivo

2020

Journal Article

Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration

Wooff, Yvette, Fernando, Nilisha, Wong, Josephine H. C., Dietrich, Catherine, Aggio-Bruce, Riemke, Chu-Tan, Joshua A., Robertson, Avril A. B., Doyle, Sarah L., Man, Si Ming and Natoli, Riccardo (2020). Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration. Scientific Reports, 10 (1) 2263, 2263. doi: 10.1038/s41598-020-58849-z

Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration

Current funding

  • 2022 - 2025
    Inhibiting ASC with small molecules for treatment of inflammatory diseases
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2022 - 2023
    Targeting inflammation to treat dementia (Lead by La Trobe)
    The Cass Foundation Limited
    Open grant
  • 2021 - 2024
    The NLRP3 inflammasome in the pathogenesis of polycystic kidney disease (PKD Australia administered by La Trobe University)
    La Trobe University
    Open grant
  • 2020 - 2023
    Novel Broad Spectrum Antifungals Active Against Drug Resistant Candida Auris
    NHMRC IDEAS Grants
    Open grant
  • 2018 - 2022
    Validating the NLRP3 Inflammasome as a Therapeutic Target in Motor Neuron Disease
    NHMRC Project Grant
    Open grant
  • 2017 - 2018
    A Pharmacology Screening Facility to Accelerate Drug Discovery and Development
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2019
    Inflammatory pathways to liver fibrosis in non-alcoholic and alcoholic steatohepatitis: reversal by NLRP3 inhibitors (NHMRC Project Grant administered by ANU)
    Australian National University
    Open grant
  • 2017 - 2021
    Novel NLRP3 inhibitors for asthma therapy
    NHMRC Development Grant
    Open grant
  • 2016 - 2020
    Blocking inflammasome-induced neuroinflammation in PD with a potent, orally available small molecule
    The Michael J Fox Foundation Therapeutic Pipeline Program
    Open grant
  • 2015 - 2017
    Pharmacological targeting of the NLRP3 inflammasome in pre-clinical models of Parkinson's disease using a potent orally active inhibitor
    The Michael J Fox Foundation for Parkinsons Research
    Open grant
  • 2015 - 2017
    Inhibitors of NLRP3 activation for treatment of inflammatory CNS diseases
    NHMRC Project Grant
    Open grant
  • 2013 - 2016
    Novel immunomodulatory agents for type II diabetes through targeting the NLRP3 inflammasome signalling cascade
    Department of Innovation, Industry, Science and Research - Australia-India Strategic Research Fund
    Open grant
  • 2012 - 2013
    IMPDH as an antifungal drug target
    Therapeutic Innovation Australia Limited
    Open grant

Availability

Professor Avril Robertson is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Therapeutic Resolution of Inflammation in the Central Nervous System for Neuroprotection in Parkinson's Disease

    Principal Advisor

    Other advisors: Professor David Ascher

  • Doctor Philosophy

    Aiming at Inflammasomes

    Principal Advisor

  • Doctor Philosophy

    Breaking the chain of inflammation through targetting NLR proteins

    Principal Advisor

    Other advisors: Professor Kate Schroder, Professor David Ascher

  • Doctor Philosophy

    Inflammasome inhibitors in disease: Is there a therapeutic trade-off of compromised host defence?

    Associate Advisor

    Other advisors: Professor Kate Schroder, Dr Sabrina Sofia Burgener

  • Doctor Philosophy

    Development of anti-inflammatory therapeutics by targeting cytoplasmic Toll-like receptors (TLRs) signalling

    Associate Advisor

    Other advisors: Mr Gilbert Song, Professor Bostjan Kobe

  • Doctor Philosophy

    The role of metabolic adaptation for virulence and persistence of Haemophilus influenzae in the host

    Associate Advisor

    Other advisors: Professor Ulrike Kappler

  • Doctor Philosophy

    Biosimilar litigation and market entry

    Associate Advisor

    Other advisors: Emeritus Professor Stephen Mahler, Dr Lisette Pregelj

Completed supervision

Enquiries

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