Professor Avril Robertson
Professor

Avril Robertson

Email: 
Phone: 
+61 7 334 60586

Availability

Professor Avril Robertson is:
Available for supervision

Qualifications

  • Masters (Research), University of St Andrews
  • Doctor of Philosophy, University of St Andrews
  • Postgraduate Diploma in Higher Education, The University of Queensland
  • Postgraduate Diploma in Higher Education, Institution to be confirmed

Search Professor Avril Robertson’s works on UQ eSpace

139 works between 1999 and 2025
All (139) Journal Article (101) Book Chapter (1) Conference Publication (30) Other Outputs (7)

81 - 100 of 139 works

2017

Conference Publication

High Fat Diet-Induced Obesity Promotes Steroid-Resistant Asthma Through An Nlrp3 Inflammasome-Dependent Mechanism

Pinkerton, James, Kim, Richard, Mayall, Jemma, Ali, Md. Khadem, Starkey, Malcolm, Robertson, Avril, O'Neill, Luke, Cooper, Matthew, Hansbro, Philip and Horvat, Jay (2017). High Fat Diet-Induced Obesity Promotes Steroid-Resistant Asthma Through An Nlrp3 Inflammasome-Dependent Mechanism. HOBOKEN: WILEY.

High Fat Diet-Induced Obesity Promotes Steroid-Resistant Asthma Through An Nlrp3 Inflammasome-Dependent Mechanism

2017

Journal Article

Clonal hematopoiesis associated with Tet2 deficiency accelerates atherosclerosis development in mice

Fuster, José J., MacLauchlan, Susan, Zuriaga, María A., Polackal, Maya N., Ostriker, Allison C., Chakraborty, Raja, Wu, Chia-Ling, Sano, Soichi, Muralidharan, Sujatha, Rius, Cristina, Vuong, Jacqueline, Jacob, Sophia, Muralidliar, Varsha, Robertson, Avril A. B., Cooper, Matthew A., Andres, Vicente, Hirschi, Karen K., Martin, Kathleen A. and Walsh, Kenneth (2017). Clonal hematopoiesis associated with Tet2 deficiency accelerates atherosclerosis development in mice. Science, 355 (6327), 842-847. doi: 10.1126/science.aag1381

Clonal hematopoiesis associated with Tet2 deficiency accelerates atherosclerosis development in mice

2017

Journal Article

GMP synthase is required for virulence factor production and infection by cryptococcus neoformans

Chitty, Jessica L., Tatzenko, Tayla L. , Williams, Simon J., Koh, Y. Q. Andre E., Corfield, Elizabeth C., Butler, Mark S., Robertson, Avril A. B., Cooper, Matthew A., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2017). GMP synthase is required for virulence factor production and infection by cryptococcus neoformans. Journal of Biological Chemistry, 292 (7), 3049-3059. doi: 10.1074/jbc.M116.767533

GMP synthase is required for virulence factor production and infection by cryptococcus neoformans

2017

Journal Article

Small-molecule inhibitors of the SOX18 transcription factor

Fontaine, Frank, Overman, Jeroen, Moustaqil, Mehdi, Mamidyala, Sreeman, Salim, Angela, Narasimhan, Kamesh, Prokoph, Nina, Robertson, Avril A. B., Lua, Linda, Alexandrov, Kirill, Koopman, Peter, Capon, Robert J., Sierecki, Emma, Gambin, Yann, Jauch, Ralf, Cooper, Matthew A., Zuegg, Johannes and Francois, Mathias (2017). Small-molecule inhibitors of the SOX18 transcription factor. Chemistry Chemical Biology, 24 (3), 346-359. doi: 10.1016/j.chembiol.2017.01.003

Small-molecule inhibitors of the SOX18 transcription factor

2017

Journal Article

Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice

Overman, Jeroen, Fontaine, Frank, Moustaqil, Mehdi, Mittal, Deepak, Sierecki, Emma, Sacilotto, Natalia, Zuegg, Johannes, Robertson, Avril A. B., Holmes, Kelly, Salim, Angela A., Mamidyala, Sreeman, Butler, Mark S., Robinson, Ashley S., Lesieur, Emmanuelle, Johnston, Wayne, Alexandrov, Kirill, Black, Brian L., Hogan, Benjamin M., De Val, Sarah, Capon, Robert J., Carroll, Jason S., Bailey, Timothy L., Koopman, Peter, Jauch, Ralf, Smyth, Mark J., Cooper, Matthew A., Gambin, Yann and Francois, Mathias (2017). Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. eLife, 6 e21221. doi: 10.7554/eLife.21221

Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice

2017

Journal Article

Inflammasomes in the lung

Pinkerton, James W., Kim, Richard Y., Robertson, Avril A. B., Hirota, Jeremy A., Wood, Lisa G., Knight, Darryl A., Cooper, Matthew A., O'Neill, Luke A. J., Horvat, Jay C. and Hansbro, Philip M. (2017). Inflammasomes in the lung. Molecular Immunology, 86, 44-55. doi: 10.1016/j.molimm.2017.01.014

Inflammasomes in the lung

2017

Journal Article

PB1-F2 derived from avian influenza a virus H7N9 induces inflammation via activation of the NLRP3 inflammasome

Pinar, Anita, Dowling, Jennifer K., Bitto, Natalie J., Robertson, Avril B., Latz, Eicke, Stewart, Cameron R., Drummond, Grant R., Cooper, Matthew A., McAuley, Julie L., Tate, Michelle D. and Mansell, Ashley (2017). PB1-F2 derived from avian influenza a virus H7N9 induces inflammation via activation of the NLRP3 inflammasome. The Journal of Biological Chemistry, 292 (3), 826-836. doi: 10.1074/jbc.M116.756379

PB1-F2 derived from avian influenza a virus H7N9 induces inflammation via activation of the NLRP3 inflammasome

2017

Journal Article

Lipocalin-2 induces NLRP3 inflammasome activation via HMGB1 induced TLR4 signaling in heart tissue of mice under pressure overload challenge

Song, Erfei, Jahng, James W. S., Chong, Lisa P., Sung, Hye K., Han, Meng, Luo, Cuiting, Wu, Donghai, Boo, Stellar, Hinz, Boris, Cooper, Matthew A., Robertson, Avril A. B., Berger, Thorsten, Mak, Tak W., George, Isaac, Schulze, P. Christian, Wang, Yu, Xu, Aimin and Sweeney, Gary (2017). Lipocalin-2 induces NLRP3 inflammasome activation via HMGB1 induced TLR4 signaling in heart tissue of mice under pressure overload challenge. American Journal of Translational Research, 9 (6) AJTR0048252, 2723-+.

Lipocalin-2 induces NLRP3 inflammasome activation via HMGB1 induced TLR4 signaling in heart tissue of mice under pressure overload challenge

2016

Journal Article

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

Basiorka, Ashley A., McGraw, Kathy L., Eksioglu, Erika A., Chen, Xianghong, Johnson, Joseph, Zhang, Ling, Zhang, Qing, Irvine, Brittany A., Cluzeau, Thomas, Sallman, David A., Padron, Eric, Komrokji, Rami, Sokol, Lubomir, Coll, Rebecca C., Robertson, Avril A. B., Cooper, Matthew A., Cleveland, John L., O'Neill, Luke A., Wei, Sheng and List, Alan F. (2016). The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype. Blood, 128 (25), 2960-2975. doi: 10.1182/blood-2016-07-730556

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

2016

Journal Article

Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice

Dempsey, C., Rubio Araiz, A., Bryson, K. J., Finucane, O., Larkin, C., Mills, E. L., Robertson, A. A. B., Cooper, M. A., O'Neill, L. A. J. and Lynch, M. A. (2016). Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice. Brain, Behavior, and Immunity, 61, 306-316. doi: 10.1016/j.bbi.2016.12.014

Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice

2016

Journal Article

K+ efflux-independent NLRP3 inflammasome activation by small molecules targeting mitochondria

Groß, Christina J., Mishra, Ritu, Schneider, Katharina S., Médard, Guillaume, Wettmarshausen, Jennifer, Dittlein, Daniela C., Shi, Hexin, Gorka, Oliver, Koenig, Paul-Albert, Fromm, Stephan, Magnani, Giovanni, Ćiković, Tamara, Hartjes, Lara, Smollich, Joachim, Robertson, Avril A. B., Cooper, Matthew A., Schmidt-Supprian, Marc, Schuster, Michael, Schroder, Kate, Broz, Petr, Traidl-Hoffmann, Claudia, Beutler, Bruce, Kuster, Bernhard, Ruland, Jürgen, Schneider, Sabine, Perocchi, Fabiana and Groß, Olaf (2016). K+ efflux-independent NLRP3 inflammasome activation by small molecules targeting mitochondria. Immunity, 45 (4), 761-773. doi: 10.1016/j.immuni.2016.08.010

K+ efflux-independent NLRP3 inflammasome activation by small molecules targeting mitochondria

2016

Journal Article

Identification, synthesis, and biological evaluation of the major human metabolite of NLRP3 inflammasome inhibitor MCC950

Salla, Manohar, Butler, Mark S., Pelingon, Ruby, Kaeslin, Geraldine, Croker, Daniel E., Reid, Janet C., Baek, Jong-Min, Bernhardt, Paul V., Gillam, Elizabeth M. J., Cooper, Matthew A. and Robertson, Avril A. B. (2016). Identification, synthesis, and biological evaluation of the major human metabolite of NLRP3 inflammasome inhibitor MCC950. ACS Medicinal Chemistry Letters, 7 (12), 1034-1038. doi: 10.1021/acsmedchemlett.6b00198

Identification, synthesis, and biological evaluation of the major human metabolite of NLRP3 inflammasome inhibitor MCC950

2016

Journal Article

Disruption of de novo adenosine triphosphate (ATP) biosynthesis abolishes virulence in Cryptococcus neoformans

Blundell, Ross D., Williams, Simon J., Arras, Samantha D. M., Chitty, Jessica L., Blake, Kirsten L., Ericsson, Daniel J., Tibrewal, Nidhi, Rohr, Jurgen, Koh, Y. Q. Andre, Kappler, Ulrike, Robertson, Avril A. B., Butler, Mark S., Cooper, Matthew A., Kobe, Bostjan and Fraser, James A. (2016). Disruption of de novo adenosine triphosphate (ATP) biosynthesis abolishes virulence in Cryptococcus neoformans. ACS Infectious Diseases, 2 (9), 651-663. doi: 10.1021/acsinfecdis.6b00121

Disruption of de novo adenosine triphosphate (ATP) biosynthesis abolishes virulence in Cryptococcus neoformans

2016

Other Outputs

Sulfonylureas and related compounds and use of the same

O'Neill, Luke, Coll, Rebecca, Cooper, Matt, Robertson, Avril and Schroder, Kate (2016). Sulfonylureas and related compounds and use of the same. WO2016131098.

Sulfonylureas and related compounds and use of the same

2016

Journal Article

IL-1beta is an innate immune sensor of microbial proteolysis

LaRock, Christopher N., Todd, Jordan, LaRock, Doris L., Olson, Joshua, O’Donoghue, Anthony J., Robertson, Avril A. B., Cooper, Matthew A., Hoffman, Hal M. and Nizet, Victor (2016). IL-1beta is an innate immune sensor of microbial proteolysis. Science Immunology, 1 (2) eaah3539, eaah3539-eaah3539. doi: 10.1126/sciimmunol.aah3539

IL-1beta is an innate immune sensor of microbial proteolysis

2016

Conference Publication

Targeting the NLRP3 inflammasome is a viable option for the treatment of pathogenic influenza virus infection

Tate, M., Ong, J., Dowling, J., Robertson, A., Cooper, M. and Mansell, A. (2016). Targeting the NLRP3 inflammasome is a viable option for the treatment of pathogenic influenza virus infection. International Congress of Immunology (ICI), Melbourne Australia, Aug 21-26, 2016. HOBOKEN: WILEY-BLACKWELL.

Targeting the NLRP3 inflammasome is a viable option for the treatment of pathogenic influenza virus infection

2016

Conference Publication

Delayed inhibition of the NLRP3 inflammasome during pathogenic influenza A virus infection in mice reduces disease severity and prolongs survival

Tate, M., Pinar, A., Dowling, J., McAuley, J., Robertson, A., Cooper, M. and Mansell, A. (2016). Delayed inhibition of the NLRP3 inflammasome during pathogenic influenza A virus infection in mice reduces disease severity and prolongs survival. International Congress of Immunology (ICI), Melbourne Australia, Aug 21-26, 2016. HOBOKEN: WILEY-BLACKWELL.

Delayed inhibition of the NLRP3 inflammasome during pathogenic influenza A virus infection in mice reduces disease severity and prolongs survival

2016

Journal Article

The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction

van Hout, Gerardus P. J., Bosch, Lena, Ellenbroek, Guilielmus H. J. M., de Haan, Judith J., van Solinge, Wouter W., Cooper, Matthew A., Arslan, Fatih, de Jager, Saskia C. A., Robertson, Avril A. B., Pasterkamp, Gerard and Hoefer, Imo E. (2016). The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction. European Heart Journal, 38 (11), 1-10. doi: 10.1093/eurheartj/ehw247

The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction

2016

Journal Article

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

Arbore, Giuseppina, West, Erin E., Spolski, Rosanne, Robertson, Avril A. B., Klos, Andreas, Rheinheimer, Claudia, Dutow, Pavel, Woodruff, Trent M., Yu, Zu Xi, O'Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Koehl, Jorg, Monk, Pete, Cooper, Matthew A., Arno, Matthew, Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin D. and Kemper, Claudia (2016). T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells. Science, 352 (6292) aad1210, 1424+-U95. doi: 10.1126/science.aad1210

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

2016

Journal Article

Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition

Tate, Michelle D., Ong, James D. H., Dowling, Jennifer K., McAuley, Julie L., Robertson, Avril B., Latz, Eicke, Drummond, Grant R., Cooper, Matthew A., Hertzog, Paul J. and Mansell, Ashley (2016). Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition. Scientific Reports, 6 (1) 27912, 27912. doi: 10.1038/srep27912

Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition

Current funding

  • 2022 - 2025
    Inhibiting ASC with small molecules for treatment of inflammatory diseases
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2022 - 2023
    Targeting inflammation to treat dementia (Lead by La Trobe)
    The Cass Foundation Limited
    Open grant
  • 2021 - 2024
    The NLRP3 inflammasome in the pathogenesis of polycystic kidney disease (PKD Australia administered by La Trobe University)
    La Trobe University
    Open grant
  • 2020 - 2023
    Novel Broad Spectrum Antifungals Active Against Drug Resistant Candida Auris
    NHMRC IDEAS Grants
    Open grant
  • 2018 - 2022
    Validating the NLRP3 Inflammasome as a Therapeutic Target in Motor Neuron Disease
    NHMRC Project Grant
    Open grant
  • 2017 - 2018
    A Pharmacology Screening Facility to Accelerate Drug Discovery and Development
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2019
    Inflammatory pathways to liver fibrosis in non-alcoholic and alcoholic steatohepatitis: reversal by NLRP3 inhibitors (NHMRC Project Grant administered by ANU)
    Australian National University
    Open grant
  • 2017 - 2021
    Novel NLRP3 inhibitors for asthma therapy
    NHMRC Development Grant
    Open grant
  • 2016 - 2020
    Blocking inflammasome-induced neuroinflammation in PD with a potent, orally available small molecule
    The Michael J Fox Foundation Therapeutic Pipeline Program
    Open grant
  • 2015 - 2017
    Pharmacological targeting of the NLRP3 inflammasome in pre-clinical models of Parkinson's disease using a potent orally active inhibitor
    The Michael J Fox Foundation for Parkinsons Research
    Open grant
  • 2015 - 2017
    Inhibitors of NLRP3 activation for treatment of inflammatory CNS diseases
    NHMRC Project Grant
    Open grant
  • 2013 - 2016
    Novel immunomodulatory agents for type II diabetes through targeting the NLRP3 inflammasome signalling cascade
    Department of Innovation, Industry, Science and Research - Australia-India Strategic Research Fund
    Open grant
  • 2012 - 2013
    IMPDH as an antifungal drug target
    Therapeutic Innovation Australia Limited
    Open grant

Availability

Professor Avril Robertson is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Breaking the chain of inflammation through targetting NLR proteins

    Principal Advisor

    Other advisors: Professor Kate Schroder, Professor David Ascher

  • Doctor Philosophy

    Therapeutic Resolution of Inflammation in the Central Nervous System for Neuroprotection in Parkinson's Disease

    Principal Advisor

    Other advisors: Professor David Ascher

  • Doctor Philosophy

    Aiming at Inflammasomes

    Principal Advisor

  • Doctor Philosophy

    The role of metabolic adaptation for virulence and persistence of Haemophilus influenzae in the host

    Associate Advisor

    Other advisors: Professor Ulrike Kappler

  • Doctor Philosophy

    Biosimilar litigation and market entry

    Associate Advisor

    Other advisors: Emeritus Professor Stephen Mahler, Dr Lisette Pregelj

  • Doctor Philosophy

    Inflammasome inhibitors in disease: Is there a therapeutic trade-off of compromised host defence?

    Associate Advisor

    Other advisors: Professor Kate Schroder, Dr Sabrina Sofia Burgener

  • Doctor Philosophy

    Development of anti-inflammatory therapeutics by targeting cytoplasmic Toll-like receptors (TLRs) signalling

    Associate Advisor

    Other advisors: Mr Gilbert Song, Professor Bostjan Kobe

Completed supervision

Enquiries

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