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Associate Professor Susannah Tye
Associate Professor

Susannah Tye

Email: 
Phone: 
+61 7 344 32493

Overview

Background

Dr. Susannah Tye joined the Queensland Brain Institute in 2017 and has established a research program within the Asia Pacific Centre for Neuromodulation (QLD, Australia). Before returning to Australia, Dr. Tye directed the Translational Neuroscience Laboratory at the Mayo Clinic (2012-2017). While there she led efforts to develop brain stimulation devices (for rodents and humans) that can quantify neural activity and neurotransmitter dynamics in the living brain. This body of work now forms the basis of the neuropsychiatric arm of the Mayo Clinic’s Deep Brain Stimulation Consortium. Her specific research expertise are in utilising voltammetric (electrochemical) recording techniques to monitor rapid, synaptic neurotransmission in the living brain.

Dr. Tye has over ten years of experience studying neuromodulation in preclinical rodent models and human patients. Her long-term goal is to bridge preclinical and clinical studies to maximise translational impact, specifically in terms of improving patient outcomes for those with severe refractory psychiatric illness. Towards this end, she maintains many international collaborations with both clinical and basic science researchers. Dr. Tye also has a longstanding interest in mentoring young scientists to help them expand their skills in preclinical and basic science research and achieve a successful research career.

Availability

Associate Professor Susannah Tye is:
Available for supervision

Qualifications

  • Doctor of Philosophy, Macquarie University

Research interests

  • Deep Brain Stimulation

  • Neuromodulation

  • Depression

  • Bipolar Disorder

  • Stress Disorders

  • Parkinson's Disease

  • Biomarkers

  • Refractory Psychiatric Illness

Research impacts

The Tye group develops and applies novel technologies to modulate neuronal function. This work helps inform our basic understanding of signalling in the brain in both health and disease, with specific implications for understanding and correcting abnormal neuronal activity and neurotransmitter dynamics in chronic, unremitting brain-based illness. Working with both local and international collaborations in across clinical, engineering, and basic science fields, we work towards the long-term goal of translating cutting-edge brain stimulation technologies to the clinic to optimise therapeutic outcomes.

Works

Search Professor Susannah Tye’s works on UQ eSpace

109 works between 2009 and 2024

1 - 20 of 109 works

2024

Journal Article

The Wnt signaling pathway in major depressive disorder: A systematic review of human studies

Sanchez-Ruiz, Jorge A., Treviño-Alvarez, Andres M., Zambrano-Lucio, Miguel, Lozano Díaz, Sofía T., Wang, Ning, Biernacka, Joanna M., Tye, Susannah J. and Cuellar-Barboza, Alfredo B. (2024). The Wnt signaling pathway in major depressive disorder: A systematic review of human studies. Psychiatry Research, 339 115983, 115983. doi: 10.1016/j.psychres.2024.115983

The Wnt signaling pathway in major depressive disorder: A systematic review of human studies

2024

Journal Article

Anti‐manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine

Varela, Roger B., Boschen, Suelen L., Yates, Nathanael, Houghton, Tristan, Blaha, Charles D., Lee, Kendall H., Bennet, Kevin E., Kouzani, Abbas Z., Berk, Michael, Quevedo, João, Valvassori, Samira S. and Tye, Susannah J. (2024). Anti‐manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine. Bipolar Disorders, 26 (4), 376-387. doi: 10.1111/bdi.13423

Anti‐manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine

2024

Journal Article

Clinical outcomes in the biomarkers of ketamine (Bio-K) study of open-label IV ketamine for refractory depression

Parikh, Sagar V., Vande Voort, Jennifer L., Yocum, Anastasia K., Achtyes, Eric, Goes, Fernando S., Nykamp, Louis, Singh, Balwinder, Lopez-Vives, Daniela, Sera, Cortney E., Maixner, Daniel, Tarnal, Vijay, Severe, Jennifer, Bartek, Steven, Tye, Susannah J., Rico, Jose, Stoppel, Cynthia J., Becerra, Alexis, Smart, LeAnn, Miller, Christina R., Frye, Mark A., Greden, John F. and Bobo, William V. (2024). Clinical outcomes in the biomarkers of ketamine (Bio-K) study of open-label IV ketamine for refractory depression. Journal of Affective Disorders, 348, 143-151. doi: 10.1016/j.jad.2023.12.033

Clinical outcomes in the biomarkers of ketamine (Bio-K) study of open-label IV ketamine for refractory depression

2024

Journal Article

Pharmacogenomic overlap between antidepressant treatment response in major depression & antidepressant associated treatment emergent mania in bipolar disorder

Nuñez, Nicolas A., Coombes, Brandon J., Beaupre, Lindsay Melhuish, Ozerdem, Aysegul, Resendez, Manuel Gardea, Romo-Nava, Francisco, Bond, David J., Veldic, Marin, Singh, Balwinder, Moore, Katherine M., Betcher, Hannah K., Kung, Simon, Prieto, Miguel L., Fuentes, Manuel, Ercis, Mete, Miola, Alessandro, Sanchez Ruiz, Jorge A., Jenkins, Gregory, Batzler, Anthony, Leung, Jonathan G., Cuellar-Barboza, Alfredo, Tye, Susannah J., McElroy, Susan L., Biernacka, Joanna M. and Frye, Mark A. (2024). Pharmacogenomic overlap between antidepressant treatment response in major depression & antidepressant associated treatment emergent mania in bipolar disorder. Translational Psychiatry, 14 (1) 93, 93. doi: 10.1038/s41398-024-02798-y

Pharmacogenomic overlap between antidepressant treatment response in major depression & antidepressant associated treatment emergent mania in bipolar disorder

2024

Journal Article

SmartStim: An Artificial Intelligence Enabled Deep Brain Stimulation Device

Corva, Dean M., Parke, Brenna, West, Alyssa, Doeven, Egan H., Adams, Scott D., Tye, Susannah J., Hashemi, Parastoo, Berk, Michael and Kouzani, Abbas Z. (2024). SmartStim: An Artificial Intelligence Enabled Deep Brain Stimulation Device. IEEE Transactions on Medical Robotics and Bionics, PP (99), 1-1. doi: 10.1109/tmrb.2024.3381341

SmartStim: An Artificial Intelligence Enabled Deep Brain Stimulation Device

2024

Journal Article

SmartFSCV: An Artificial Intelligence Enabled Miniaturised FSCV Device Targeting Serotonin

Corva, Dean M., Doeven, Egan H., Parke, Brenna, Adams, Scott D., Tye, Susannah J., Hashemi, Parastoo, Berk, Michael and Kouzani, Abbas Z. (2024). SmartFSCV: An Artificial Intelligence Enabled Miniaturised FSCV Device Targeting Serotonin. IEEE Open Journal of Engineering in Medicine and Biology, PP (99), 1-12. doi: 10.1109/OJEMB.2024.3356177

SmartFSCV: An Artificial Intelligence Enabled Miniaturised FSCV Device Targeting Serotonin

2023

Conference Publication

Circuit-Based Manipulation of Striatal Dopamine: A State-Dependent and Mood Stabilizing Approach

Tye, Susannah (2023). Circuit-Based Manipulation of Striatal Dopamine: A State-Dependent and Mood Stabilizing Approach. 62nd Annual Meeting of the American-College-of-Neuropsychopharmacology (ACNP), Tampa Fl, Dec 03-06, 2023. LONDON: SPRINGERNATURE.

Circuit-Based Manipulation of Striatal Dopamine: A State-Dependent and Mood Stabilizing Approach

2023

Journal Article

Oxycodone-induced dopaminergic and respiratory effects are modulated by deep brain stimulation

Yuen, Jason, Goyal, Abhinav, Rusheen, Aaron E., Kouzani, Abbas Z., Berk, Michael, Kim, Jee Hyun, Tye, Susannah J., Abulseoud, Osama A., Oesterle, Tyler S., Blaha, Charles D., Bennet, Kevin E., Lee, Kendall H., Oh, Yoonbae and Shin, Hojin (2023). Oxycodone-induced dopaminergic and respiratory effects are modulated by deep brain stimulation. Frontiers in Pharmacology, 14 1199655. doi: 10.3389/fphar.2023.1199655

Oxycodone-induced dopaminergic and respiratory effects are modulated by deep brain stimulation

2023

Conference Publication

Ketamine Associated Change in Anhedonia and Suicidal Ideation are Associated With Peripheral Immune Cell mTOR Expression and Kynurenine Levels and Treatment Resistant Depression

Voort, Jennifer Vande, Singh, Balwinder, Riva-Posse, Patricio, Erhardt, Sophie, Schwieler, Lilly, Pazdernik, Vanessa, Frye, Mark and Tye, Susannah (2023). Ketamine Associated Change in Anhedonia and Suicidal Ideation are Associated With Peripheral Immune Cell mTOR Expression and Kynurenine Levels and Treatment Resistant Depression. NEW YORK: ELSEVIER SCIENCE INC.

Ketamine Associated Change in Anhedonia and Suicidal Ideation are Associated With Peripheral Immune Cell mTOR Expression and Kynurenine Levels and Treatment Resistant Depression

2023

Conference Publication

Critical Role of Insulin as an Immunomodulatory Target in Treatment Resistant Depression

Tye, Susannah, Price, Joshua, Walker, Adam, Sutor, Shari, Erhardt, Sophie, Schwieler, Lilly, Cullen, Kathryn, Voort, Jennifer Vande, Frye, Mark, Bobo, William and Shiroma, Paulo (2023). Critical Role of Insulin as an Immunomodulatory Target in Treatment Resistant Depression. 78th Annual Meeting of the Society of Biological Psychiatry, San Diego, CA United States, 27-29 April 2023. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.biopsych.2023.02.076

Critical Role of Insulin as an Immunomodulatory Target in Treatment Resistant Depression

2023

Conference Publication

Critical Role of Insulin as an Immunomodulatory Target in Treatment Resistant Depression

Tye, Susannah, Price, Joshua, Walker, Adam, Sutor, Shari, Erhardt, Sophie, Schwieler, Lilly, Cullen, Kathryn, Voort, Jennifer Vande, Frye, Mark, Bobo, William and Shiroma, Paulo (2023). Critical Role of Insulin as an Immunomodulatory Target in Treatment Resistant Depression. NEW YORK: ELSEVIER SCIENCE INC.

Critical Role of Insulin as an Immunomodulatory Target in Treatment Resistant Depression

2023

Conference Publication

Ketamine Associated Change in Anhedonia and Suicidal Ideation are Associated With Peripheral Immune Cell mTOR Expression and Kynurenine Levels and Treatment Resistant Depression

Voort, Jennifer Vande, Singh, Balwinder, Riva-Posse, Patricio, Erhardt, Sophie, Schwieler, Lilly, Pazdernik, Vanessa, Frye, Mark and Tye, Susannah (2023). Ketamine Associated Change in Anhedonia and Suicidal Ideation are Associated With Peripheral Immune Cell mTOR Expression and Kynurenine Levels and Treatment Resistant Depression. 78th Annual Meeting of the Society of Biological Psychiatry, San Diego, CA United States, 27-29 April 2023. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.biopsych.2023.02.077

Ketamine Associated Change in Anhedonia and Suicidal Ideation are Associated With Peripheral Immune Cell mTOR Expression and Kynurenine Levels and Treatment Resistant Depression

2023

Conference Publication

PRECISION PSYCHIATRY IN MILITARY MENTAL HEALTH CARE

Tye, S., Nasrallah, Fatima and Lim, Alex (2023). PRECISION PSYCHIATRY IN MILITARY MENTAL HEALTH CARE. LONDON: SAGE PUBLICATIONS LTD.

PRECISION PSYCHIATRY IN MILITARY MENTAL HEALTH CARE

2023

Journal Article

High frequency deep brain stimulation can mitigate the acute effects of cocaine administration on tonic dopamine levels in the rat nucleus accumbens

Yuen, Jason, Goyal, Abhinav, Rusheen, Aaron E., Kouzani, Abbas Z., Berk, Michael, Kim, Jee Hyun, Tye, Susannah J., Blaha, Charles D., Bennet, Kevin E., Lee, Kendall H., Shin, Hojin and Oh, Yoonbae (2023). High frequency deep brain stimulation can mitigate the acute effects of cocaine administration on tonic dopamine levels in the rat nucleus accumbens. Frontiers in Neuroscience, 17 1061578, 1-12. doi: 10.3389/fnins.2023.1061578

High frequency deep brain stimulation can mitigate the acute effects of cocaine administration on tonic dopamine levels in the rat nucleus accumbens

2023

Journal Article

Ketamine-associated change in anhedonia and mTOR expression in treatment-resistant depression

Singh, Balwinder, Vande Voort, Jennifer L., Riva-Posse, Patricio, Pazdernik, Vanessa M., Frye, Mark A. and Tye, Susannah J. (2023). Ketamine-associated change in anhedonia and mTOR expression in treatment-resistant depression. Biological Psychiatry, 93 (12), e65-e68. doi: 10.1016/j.biopsych.2022.10.007

Ketamine-associated change in anhedonia and mTOR expression in treatment-resistant depression

2022

Journal Article

Antidepressants that increase mitochondrial energetics may elevate risk of treatment-emergent mania

Gardea-Resendez, Manuel, Coombes, Brandon J., Veldic, Marin, Tye, Susannah J., Romo-Nava, Francisco, Ozerdem, Aysegul, Prieto, Miguel L., Cuellar-Barboza, Alfredo, Nunez, Nicolas A., Singh, Balwinder, Pendegraft, Richard S., Miola, Alessandro, McElroy, Susan L., Biernacka, Joanna M., Morava, Eva, Kozicz, Tamas and Frye, Mark A. (2022). Antidepressants that increase mitochondrial energetics may elevate risk of treatment-emergent mania. Molecular Psychiatry, 28 (3), 1020-1026. doi: 10.1038/s41380-022-01888-x

Antidepressants that increase mitochondrial energetics may elevate risk of treatment-emergent mania

2022

Journal Article

Interleukin-8 and depressive responses to an inflammatory challenge: secondary analysis of a randomized controlled trial

Kruse, Jennifer L., Boyle, Chloe C., Olmstead, Richard, Breen, Elizabeth C., Tye, Susannah J., Eisenberger, Naomi I. and Irwin, Michael R. (2022). Interleukin-8 and depressive responses to an inflammatory challenge: secondary analysis of a randomized controlled trial. Scientific Reports, 12 (1) 12627, 1-9. doi: 10.1038/s41598-022-16364-3

Interleukin-8 and depressive responses to an inflammatory challenge: secondary analysis of a randomized controlled trial

2022

Journal Article

Deep brain stimulation for addictive disorders—where are we now?

Yuen, Jason, Kouzani, Abbas Z., Berk, Michael, Tye, Susannah J., Rusheen, Aaron E., Blaha, Charles D., Bennet, Kevin E., Lee, Kendall H., Shin, Hojin, Kim, Jee Hyun and Oh, Yoonbae (2022). Deep brain stimulation for addictive disorders—where are we now?. Neurotherapeutics, 19 (4), 1193-1215. doi: 10.1007/s13311-022-01229-4

Deep brain stimulation for addictive disorders—where are we now?

2022

Journal Article

Contributions of epigenetic inheritance to the predisposition of major psychiatric disorders: Theoretical framework, evidence, and implications

Varela, Roger B., Cararo, José Henrique, Tye, Susannah J., Carvalho, Andre F., Valvassori, Samira S., Fries, Gabriel R. and Quevedo, João (2022). Contributions of epigenetic inheritance to the predisposition of major psychiatric disorders: Theoretical framework, evidence, and implications. Neuroscience and Biobehavioral Reviews, 135 104579, 104579. doi: 10.1016/j.neubiorev.2022.104579

Contributions of epigenetic inheritance to the predisposition of major psychiatric disorders: Theoretical framework, evidence, and implications

2022

Journal Article

Cocaine increases stimulation-evoked serotonin efflux in the nucleus accumbens

Yuen, Jason, Goyal, Abhinav, Rusheen, Aaron E., Kouzani, Abbas Z., Berk, Michael, Kim, Jee Hyun, Tye, Susannah J., Blaha, Charles D., Bennet, Kevin E., Lee, Kendall H., Oh, Yoonbae and Shin, Hojin (2022). Cocaine increases stimulation-evoked serotonin efflux in the nucleus accumbens. Journal of Neurophysiology, 127 (3), 714-724. doi: 10.1152/jn.00420.2021

Cocaine increases stimulation-evoked serotonin efflux in the nucleus accumbens

Funding

Current funding

  • 2024 - 2026
    Precision Medicine Approaches for Depression and Anxiety
    The Nicol Foundation
    Open grant
  • 2023 - 2026
    Neural circuit control of effort under stress
    ARC Discovery Projects
    Open grant
  • 2023 - 2024
    Intelligent Closed Loop Neuromodulation
    Bionics Queensland Challenge
    Open grant
  • 2021 - 2027
    Biomarker Discovery for Treatment Resistant Mood Disorders
    The Nicol Foundation
    Open grant

Past funding

  • 2023
    Cell-specific control of striatal neurotransmission for mood regulation (project under NHRMC CREDIT Centre of Research Excellence administered by Deakin University)
    Deakin University
    Open grant
  • 2022
    Prefrontal Mechanisms Regulating Striatal Dopamine Release Essential for Persistent Effort
    UQ Foundation Research Excellence Awards
    Open grant
  • 2019 - 2023
    Circuit, cellular and synaptic mechanisms of nucleus accumbens deep brain stimulation
    NHMRC Project Grant
    Open grant
  • 2019
    Common Mechanisms of Anti-Suicidal Drug Action
    UQ Early Career Researcher
    Open grant

Supervision

Availability

Associate Professor Susannah Tye is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort

    Principal Advisor

    Other advisors: Dr Roger Bitencourt Varela

  • Master Philosophy

    Predictive Biobehavioural Markers of Deep Brain Stimulation Efficacy

    Principal Advisor

    Other advisors: Professor Pankaj Sah

  • Doctor Philosophy

    Neurofeedback an intervention for emotion regulation and attention in children and adolescents that have Down syndrome.

    Principal Advisor

    Other advisors: Professor Rhonda Faragher

  • Doctor Philosophy

    Development of precision medicine biomarkers for ketamine as a treatment for TRD and PTSD

    Principal Advisor

    Other advisors: Associate Professor Fatima Nasrallah

  • Doctor Philosophy

    Immunometabolic Mechanisms of Mood Regulation

    Principal Advisor

    Other advisors: Dr Roger Bitencourt Varela

  • Doctor Philosophy

    The development of precision medical care for the use of ketamine as a treatment for Australian Veterans with TRD and PTSD

    Associate Advisor

    Other advisors: Associate Professor Fatima Nasrallah

Completed supervision

Media

Enquiries

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