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Associate Professor Susannah Tye
Associate Professor

Susannah Tye

Email: 
Phone: 
+61 7 344 32493

Overview

Background

Dr. Susannah Tye joined the Queensland Brain Institute in 2017 and has established a research program within the Asia Pacific Centre for Neuromodulation (QLD, Australia). Before returning to Australia, Dr. Tye directed the Translational Neuroscience Laboratory at the Mayo Clinic (2012-2017). While there she led efforts to develop brain stimulation devices (for rodents and humans) that can quantify neural activity and neurotransmitter dynamics in the living brain. This body of work now forms the basis of the neuropsychiatric arm of the Mayo Clinic’s Deep Brain Stimulation Consortium. Her specific research expertise are in utilising voltammetric (electrochemical) recording techniques to monitor rapid, synaptic neurotransmission in the living brain.

Dr. Tye has over ten years of experience studying neuromodulation in preclinical rodent models and human patients. Her long-term goal is to bridge preclinical and clinical studies to maximise translational impact, specifically in terms of improving patient outcomes for those with severe refractory psychiatric illness. Towards this end, she maintains many international collaborations with both clinical and basic science researchers. Dr. Tye also has a longstanding interest in mentoring young scientists to help them expand their skills in preclinical and basic science research and achieve a successful research career.

Availability

Associate Professor Susannah Tye is:
Available for supervision

Qualifications

  • Doctor of Philosophy, Macquarie University

Research interests

  • Deep Brain Stimulation

  • Neuromodulation

  • Depression

  • Bipolar Disorder

  • Stress Disorders

  • Parkinson's Disease

  • Biomarkers

  • Refractory Psychiatric Illness

Research impacts

The Tye group develops and applies novel technologies to modulate neuronal function. This work helps inform our basic understanding of signalling in the brain in both health and disease, with specific implications for understanding and correcting abnormal neuronal activity and neurotransmitter dynamics in chronic, unremitting brain-based illness. Working with both local and international collaborations in across clinical, engineering, and basic science fields, we work towards the long-term goal of translating cutting-edge brain stimulation technologies to the clinic to optimise therapeutic outcomes.

Works

Search Professor Susannah Tye’s works on UQ eSpace

130 works between 2009 and 2026

1 - 20 of 130 works

2026

Journal Article

Deep brain stimulation of the nucleus accumbens modulates effort-based decision-making and phasic dopamine release in male Wistar rats

McCullough, Sebastian, Varela, Roger B., Houghton, Tristan, Cruickshank, Heather and Tye, Susannah J. (2026). Deep brain stimulation of the nucleus accumbens modulates effort-based decision-making and phasic dopamine release in male Wistar rats. Journal of Neurochemistry, 170 (6) e70485. doi: 10.1111/jnc.70485

Deep brain stimulation of the nucleus accumbens modulates effort-based decision-making and phasic dopamine release in male Wistar rats

2026

Conference Publication

Leveraging expert and lived experience of mental ill health perspectives to traverse the research translational gap

Milton, Laura, McDonnell, Conor, Thivisol, Ulysse, Foldi, Claire, Kesby, James, Tye, Susannah, Cruickshank, Heather, Hedberg, Anette, Boyce, Niall, Hill, Rachel and Sundram, Suresh (2026). 589. Leveraging Expert and Lived Experience of Mental Ill Health Perspectives to Traverse the Research Translational Gap. Biological Psychiatry, 99 (10), S352. doi: 10.1016/j.biopsych.2026.03.823

Leveraging expert and lived experience of mental ill health perspectives to traverse the research translational gap

2026

Journal Article

220. An Online Library of Animal Models: Finding the Best Models and Assays for Depression, Anxiety, and Psychosis

Donnell, Conor Mc, Milton, Laura, Thivisol, Ulysse, Foldi, Claire, Kesby, James, Tye, Susannah, Boyce, Niall, Hill, Rachel and Sundram, Suresh (2026). 220. An Online Library of Animal Models: Finding the Best Models and Assays for Depression, Anxiety, and Psychosis. Biological Psychiatry, 99 (10), S193. doi: 10.1016/j.biopsych.2026.03.454

220. An Online Library of Animal Models: Finding the Best Models and Assays for Depression, Anxiety, and Psychosis

2026

Journal Article

198. Plasma Lactate as a Metabolic Predictor of Ketamine Response in Treatment-Resistant Depression

Scaini, Giselli, Pinheiro Gusmao, Camilla Teixeira, Carbajal Tamez, Marcela C., Cordeiro, Rafaela C., de Quevedo, Joao, Tye, Susannah, Elmallakh, Rifaat, Parikh, Sagar, Bobo, William, Goes, Fernando S., Vande Voort, Jennifer L., Nykamp, Louis, Balwinder, Singh, Nelson, Erik, Thase, Michael, Frye, Mark, Greden, John and Achtyes, Eric (2026). 198. Plasma Lactate as a Metabolic Predictor of Ketamine Response in Treatment-Resistant Depression. Biological Psychiatry, 99 (10), S183-S184. doi: 10.1016/j.biopsych.2026.03.432

198. Plasma Lactate as a Metabolic Predictor of Ketamine Response in Treatment-Resistant Depression

2026

Journal Article

Melatonin in bipolar disorder

Macpherson, Heather K., Varela, Roger B., Truong, Trang T. T., Walder, Ken, Berk, Michael and Tye, Susannah J. (2026). Melatonin in bipolar disorder. Journal of Affective Disorders, 398 120871, 1-24. doi: 10.1016/j.jad.2025.120871

Melatonin in bipolar disorder

2026

Journal Article

ATP bioenergetics and fatigue in young adults with and without major depression

Cullen, Kathryn R., Tye, Susannah J., Klimes-Dougan, Bonnie, Wiesner, Hannes M., Varela, Roger B., Morath, Brooke, Zhang, Lin, Chen, Wei and Zhu, Xiao-Hong (2026). ATP bioenergetics and fatigue in young adults with and without major depression. Translational Psychiatry, 16 (1) 158. doi: 10.1038/s41398-026-03904-y

ATP bioenergetics and fatigue in young adults with and without major depression

2026

Journal Article

Of mice, molecules and mental health: establishment of the consortium for preclinical psychiatric research to find solutions to the translational gap

Consortium for Preclinical Psychiatric Research, Hill, Rachel A., Bastawy, Eslam M., Berk, Michael, Brown, Robyn M., Burne, Thomas H., Chesworth, Rose, Clark, Scott R., Clemens, Kelly J., Cui, Xiaoying, Dunn, Ariel L., Eratne, Dhamidhu, Foldi, Claire J., Gatt, Justine M., Gubert, Carolina, Gurvich, Caroline, Hannan, Anthony J., Harms, Lauren, Hill-Yardin, Elisa L., Jaehne, Emily J., Jawahar, Magdalene C., Jones, Nigel C., Kang, Matthew JY, Karl, Tim, Kesby, James P., Kim, Jee Hyun, Lawrence, Andrew J., Cruickshank, Heather, Manning, Elizabeth E. ... Sundram, Suresh (2026). Of mice, molecules and mental health: establishment of the consortium for preclinical psychiatric research to find solutions to the translational gap. Molecular Psychiatry, 31 (2), 1167-1170. doi: 10.1038/s41380-025-03361-x

Of mice, molecules and mental health: establishment of the consortium for preclinical psychiatric research to find solutions to the translational gap

2026

Conference Publication

Unlocking clinical mechanisms through animal models: a Wellcome Initiative

Tye, Susannah, Mayberg, Helen, Sundram, Suresh, Hill, Rachel, Erhardt, Sophie, Ahmari, Susanne and Young, Jared (2026). Unlocking clinical mechanisms through animal models: a Wellcome Initiative. 64th Annual Meeting of the American-College-of-Neuropsychopharmacology (ACNP), Nassau, Bahamas, 12-15 January 2026. London, United Kingdom: Nature Publishing Group. doi: 10.1038/s41386-025-02278-x

Unlocking clinical mechanisms through animal models: a Wellcome Initiative

2025

Journal Article

Novel psychedelic interventions for post-traumatic stress disorder and their promise for precision medicine

Dodds, Charles, Dawson, Rachelle, Lim, Alexander, Tye, Susannah and Nasrallah, Fatima (2025). Novel psychedelic interventions for post-traumatic stress disorder and their promise for precision medicine. Therapeutic Advances in Psychopharmacology, 15 20451253251396255, 1-25. doi: 10.1177/20451253251396255

Novel psychedelic interventions for post-traumatic stress disorder and their promise for precision medicine

2025

Journal Article

Fueling the future: brain bioenergetics as a driver of neurodevelopment and mental health trajectories

Tye, Susannah J. and Cullen, Kathryn R. (2025). Fueling the future: brain bioenergetics as a driver of neurodevelopment and mental health trajectories. Neuropsychopharmacology, 51 (1), 334-336. doi: 10.1038/s41386-025-02230-z

Fueling the future: brain bioenergetics as a driver of neurodevelopment and mental health trajectories

2025

Other Outputs

Unpredictable circadian rhythm disruption in Wistar rats: biological and behavioural changes reflecting bipolar disorder pathophysiology

MacPherson, Heather, Varela, Roger B., McCullough, Sebastian C., Houghton, Tristan, Chawla, Isha, Wang, Ning, Daygon, Venea Dara, Cui, Xiaoying and Tye, Susannah J. (2025). Unpredictable circadian rhythm disruption in Wistar rats: biological and behavioural changes reflecting bipolar disorder pathophysiology. doi: 10.1101/2025.09.06.674601

Unpredictable circadian rhythm disruption in Wistar rats: biological and behavioural changes reflecting bipolar disorder pathophysiology

2025

Other Outputs

Melatonin mitigates oxidative stress and metabolic dysfunction induced by interleukin-6 and dopamine in SH-SY5Y cells

MacPherson, Heather, Varela, Roger B., Daygon, Venea Dara, Kesby, James P., Cui, Xiaoying and Tye, Susannah J. (2025). Melatonin mitigates oxidative stress and metabolic dysfunction induced by interleukin-6 and dopamine in SH-SY5Y cells. doi: 10.1101/2025.09.03.673920

Melatonin mitigates oxidative stress and metabolic dysfunction induced by interleukin-6 and dopamine in SH-SY5Y cells

2025

Other Outputs

Investigating the role of melatonin in bipolar disorder using transcriptomics

MacPherson, Heather, Truong, Trang T. T., Berk, Michael, Walder, Ken and Tye, Susannah J. (2025). Investigating the role of melatonin in bipolar disorder using transcriptomics. doi: 10.1101/2025.09.03.673928

Investigating the role of melatonin in bipolar disorder using transcriptomics

2025

Conference Publication

Bioenergetic Dysregulation in Peripheral Immune Cells: Links to Anhedonia and Fatigue in Depressed Young Adults

Varela, Roger, Cullen, Kathryn, Morath, Brooke and Tye, Susannah (2025). Bioenergetic Dysregulation in Peripheral Immune Cells: Links to Anhedonia and Fatigue in Depressed Young Adults. The 27th Annual Conference of the International Society for Bipolar Disorders, Chiba, Japan, 17 – 19 September 2025. Hoboken, NJ, United States: Wiley-Blackwell Publishing.

Bioenergetic Dysregulation in Peripheral Immune Cells: Links to Anhedonia and Fatigue in Depressed Young Adults

2025

Conference Publication

Melatonin Mitigates IL-6-Induced Hyperdopaminergia, Oxidative Stress, and Metabolic Dysfunction: Implications for Dopaminergic Dysregulation in Bipolar Disorder

Macpherson, Heather, Varela, Roger, Daygon, Venea, Kesby, James, Cui, Xiaoying and Tye, Susannah (2025). Melatonin Mitigates IL-6-Induced Hyperdopaminergia, Oxidative Stress, and Metabolic Dysfunction: Implications for Dopaminergic Dysregulation in Bipolar Disorder. The 27th Annual Conference of the International Society for Bipolar Disorders, Chiba, Japan, 17 – 19 September 2025. Hoboken, NJ, United States: Wiley-Blackwell Publishing.

Melatonin Mitigates IL-6-Induced Hyperdopaminergia, Oxidative Stress, and Metabolic Dysfunction: Implications for Dopaminergic Dysregulation in Bipolar Disorder

2025

Conference Publication

Immunometabolic dysfunction and dopaminergic impairment in an animal model of treatment-resistant anhedonia: implications for bipolar disorder

Varela, Roger, Macpherson, Heather, Houghton, Tristan, Yates, Clarissa, Yates, Nathanael, Daygon, Dara and Tye, Susannah (2025). Immunometabolic dysfunction and dopaminergic impairment in an animal model of treatment-resistant anhedonia: implications for bipolar disorder. The 27th Annual Conference of the International Society for Bipolar Disorders, Chiba, Japan, 17 – 19 September 2025. Hoboken, NJ, United States: Wiley-Blackwell Publishing.

Immunometabolic dysfunction and dopaminergic impairment in an animal model of treatment-resistant anhedonia: implications for bipolar disorder

2025

Conference Publication

Unpredictable Circadian Disturbance Induces Bipolar-Like Behavioural and Immunometabolic Dysregulation in Rats

Macpherson, Heather, Varela, Roger, McCullough, Sebastian, Houghton, Tristan, Chawla, Isha, Wang, Ning, Daygon, Venea, Cui, Xiaoying and Tye, Susannah (2025). Unpredictable Circadian Disturbance Induces Bipolar-Like Behavioural and Immunometabolic Dysregulation in Rats. 27th Annual Conference of the International Society for Bipolar Disorders, Chiba, Japan, 17-19 September 2025. Hoboken, NJ, United States: Wiley-Blackwell.

Unpredictable Circadian Disturbance Induces Bipolar-Like Behavioural and Immunometabolic Dysregulation in Rats

2025

Conference Publication

Exploring the Role of Antidepressants on Mitochondrial Energetics and Risk of Antidepressant Induced Mania

Resendez, Manuel Gardea, Coombes, Brandon, Veldic, Marin, Tye, Susannah, Romo-Nava, Francisco, Ozerdem, Aysegul, Prieto, Miguel, Cuellar-Barboza, Alfredo, Nunez, Nicolas, Miola, Alessandro, McElroy, Susan, Biernacka, Joanna, Morava, Eva, Kozicz, Tamas and Frye, Mark (2025). Exploring the Role of Antidepressants on Mitochondrial Energetics and Risk of Antidepressant Induced Mania. The 27th Annual Conference of the International Society for Bipolar Disorders, Chiba, Japa, 17 – 19 September 2025. Hoboken, NJ, United States: Wiley-Blackwell Publishing.

Exploring the Role of Antidepressants on Mitochondrial Energetics and Risk of Antidepressant Induced Mania

2025

Journal Article

Inflammation and metabolic dysfunction underly anhedonia-like behavior in antidepressant resistant male rats

Varela, Roger B., Macpherson, Heather, Walker, Adam J., Houghton, Tristan, Yates, Clarissa, Yates, Nathanael J., Daygon, Dara and Tye, Susannah J. (2025). Inflammation and metabolic dysfunction underly anhedonia-like behavior in antidepressant resistant male rats. Brain, Behavior, and Immunity, 127, 170-182. doi: 10.1016/j.bbi.2025.03.001

Inflammation and metabolic dysfunction underly anhedonia-like behavior in antidepressant resistant male rats

2024

Conference Publication

Inflammation in combination with metabolic deficits underly Anhedonia-like behavior in treatment resistant male rats

Varela, Roger, Macpherson, Heather, Houghton, Tristan, Yates, Clarissa, Yates, Nathanael, Daygon, Dara and Tye, Susannah (2024). Inflammation in combination with metabolic deficits underly Anhedonia-like behavior in treatment resistant male rats. ACNP 63rd Annual Meeting: Poster Abstracts P609-P914, Phoenix, AZ United States, 8-11 December 2024. London, United Kingdom: Nature Publishing Group.

Inflammation in combination with metabolic deficits underly Anhedonia-like behavior in treatment resistant male rats

Funding

Current funding

  • 2026 - 2029
    An intelligent deep brain stimulation approach for treating human movement disorders
    NHMRC IDEAS Grants
    Open grant
  • 2025 - 2027
    Preclinical Evaluation of a Novel Analgesic to Improve Pain Relief for People with a Current or Past Opioid Use Disorder
    NHMRC MRFF Alcohol and Other Drugs
    Open grant
  • 2024 - 2026
    Precision Medicine Approaches for Depression and Anxiety
    The Nicol Foundation
    Open grant
  • 2023 - 2026
    Neural circuit control of effort under stress
    ARC Discovery Projects
    Open grant
  • 2021 - 2027
    Biomarker Discovery for Treatment Resistant Mood Disorders
    The Nicol Foundation
    Open grant

Past funding

  • 2023 - 2024
    Intelligent Closed Loop Neuromodulation
    Bionics Queensland Challenge
    Open grant
  • 2023
    Cell-specific control of striatal neurotransmission for mood regulation (project under NHRMC CREDIT Centre of Research Excellence administered by Deakin University)
    Deakin University
    Open grant
  • 2022
    Prefrontal Mechanisms Regulating Striatal Dopamine Release Essential for Persistent Effort
    UQ Foundation Research Excellence Awards
    Open grant
  • 2019 - 2023
    Circuit, cellular and synaptic mechanisms of nucleus accumbens deep brain stimulation
    NHMRC Project Grant
    Open grant
  • 2019
    Common Mechanisms of Anti-Suicidal Drug Action
    UQ Early Career Researcher
    Open grant

Supervision

Availability

Associate Professor Susannah Tye is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort

    Principal Advisor

    Other advisors: Dr Roger Bitencourt Varela

  • Doctor Philosophy

    Neurofeedback an intervention for emotion regulation and attention in children and adolescents that have Down syndrome.

    Principal Advisor

    Other advisors: Professor Rhonda Faragher

  • Doctor Philosophy

    Real-World Implementation of Personalised Ketamine Therapy for Treatment-Resistant Depression: Advancing Health System Integration and Rural Access

    Principal Advisor

  • Doctor Philosophy

    Development of precision medicine biomarkers for ketamine as a treatment for TRD and PTSD

    Principal Advisor

    Other advisors: Professor Fatima Nasrallah

  • Doctor Philosophy

    The development of precision medical care for the use of ketamine as a treatment for Australian Veterans with TRD and PTSD

    Associate Advisor

    Other advisors: Professor Fatima Nasrallah

  • Master Philosophy

    Biopsychosocial Adaptations and Early OperationalOutcomes: Longitudinal Neurophysiological tracking of Police Recruits' transition to Operational Policing

    Associate Advisor

    Other advisors: Associate Professor Sarah Bennett

  • Doctor Philosophy

    Modelling neural circuit control of effort under stress

    Associate Advisor

Completed supervision

Media

Enquiries

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