Overview
Background
Dr. Susannah Tye joined the Queensland Brain Institute in 2017 and has established a research program within the Asia Pacific Centre for Neuromodulation (QLD, Australia). Before returning to Australia, Dr. Tye directed the Translational Neuroscience Laboratory at the Mayo Clinic (2012-2017). While there she led efforts to develop brain stimulation devices (for rodents and humans) that can quantify neural activity and neurotransmitter dynamics in the living brain. This body of work now forms the basis of the neuropsychiatric arm of the Mayo Clinic’s Deep Brain Stimulation Consortium. Her specific research expertise are in utilising voltammetric (electrochemical) recording techniques to monitor rapid, synaptic neurotransmission in the living brain.
Dr. Tye has over ten years of experience studying neuromodulation in preclinical rodent models and human patients. Her long-term goal is to bridge preclinical and clinical studies to maximise translational impact, specifically in terms of improving patient outcomes for those with severe refractory psychiatric illness. Towards this end, she maintains many international collaborations with both clinical and basic science researchers. Dr. Tye also has a longstanding interest in mentoring young scientists to help them expand their skills in preclinical and basic science research and achieve a successful research career.
Availability
- Associate Professor Susannah Tye is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Macquarie University
Research interests
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Deep Brain Stimulation
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Neuromodulation
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Depression
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Bipolar Disorder
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Stress Disorders
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Parkinson's Disease
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Biomarkers
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Refractory Psychiatric Illness
Research impacts
The Tye group develops and applies novel technologies to modulate neuronal function. This work helps inform our basic understanding of signalling in the brain in both health and disease, with specific implications for understanding and correcting abnormal neuronal activity and neurotransmitter dynamics in chronic, unremitting brain-based illness. Working with both local and international collaborations in across clinical, engineering, and basic science fields, we work towards the long-term goal of translating cutting-edge brain stimulation technologies to the clinic to optimise therapeutic outcomes.
Works
Search Professor Susannah Tye’s works on UQ eSpace
2024
Journal Article
The Wnt signaling pathway in major depressive disorder: A systematic review of human studies
Sanchez-Ruiz, Jorge A., Treviño-Alvarez, Andres M., Zambrano-Lucio, Miguel, Lozano Díaz, Sofía T., Wang, Ning, Biernacka, Joanna M., Tye, Susannah J. and Cuellar-Barboza, Alfredo B. (2024). The Wnt signaling pathway in major depressive disorder: A systematic review of human studies. Psychiatry Research, 339 115983, 115983. doi: 10.1016/j.psychres.2024.115983
2024
Journal Article
Anti‐manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine
Varela, Roger B., Boschen, Suelen L., Yates, Nathanael, Houghton, Tristan, Blaha, Charles D., Lee, Kendall H., Bennet, Kevin E., Kouzani, Abbas Z., Berk, Michael, Quevedo, João, Valvassori, Samira S. and Tye, Susannah J. (2024). Anti‐manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine. Bipolar Disorders, 26 (4), 376-387. doi: 10.1111/bdi.13423
2024
Journal Article
Clinical outcomes in the biomarkers of ketamine (Bio-K) study of open-label IV ketamine for refractory depression
Parikh, Sagar V., Vande Voort, Jennifer L., Yocum, Anastasia K., Achtyes, Eric, Goes, Fernando S., Nykamp, Louis, Singh, Balwinder, Lopez-Vives, Daniela, Sera, Cortney E., Maixner, Daniel, Tarnal, Vijay, Severe, Jennifer, Bartek, Steven, Tye, Susannah J., Rico, Jose, Stoppel, Cynthia J., Becerra, Alexis, Smart, LeAnn, Miller, Christina R., Frye, Mark A., Greden, John F. and Bobo, William V. (2024). Clinical outcomes in the biomarkers of ketamine (Bio-K) study of open-label IV ketamine for refractory depression. Journal of Affective Disorders, 348, 143-151. doi: 10.1016/j.jad.2023.12.033
2024
Journal Article
Pharmacogenomic overlap between antidepressant treatment response in major depression & antidepressant associated treatment emergent mania in bipolar disorder
Nuñez, Nicolas A., Coombes, Brandon J., Beaupre, Lindsay Melhuish, Ozerdem, Aysegul, Resendez, Manuel Gardea, Romo-Nava, Francisco, Bond, David J., Veldic, Marin, Singh, Balwinder, Moore, Katherine M., Betcher, Hannah K., Kung, Simon, Prieto, Miguel L., Fuentes, Manuel, Ercis, Mete, Miola, Alessandro, Sanchez Ruiz, Jorge A., Jenkins, Gregory, Batzler, Anthony, Leung, Jonathan G., Cuellar-Barboza, Alfredo, Tye, Susannah J., McElroy, Susan L., Biernacka, Joanna M. and Frye, Mark A. (2024). Pharmacogenomic overlap between antidepressant treatment response in major depression & antidepressant associated treatment emergent mania in bipolar disorder. Translational Psychiatry, 14 (1) 93, 93. doi: 10.1038/s41398-024-02798-y
2024
Journal Article
SmartStim: An Artificial Intelligence Enabled Deep Brain Stimulation Device
Corva, Dean M., Parke, Brenna, West, Alyssa, Doeven, Egan H., Adams, Scott D., Tye, Susannah J., Hashemi, Parastoo, Berk, Michael and Kouzani, Abbas Z. (2024). SmartStim: An Artificial Intelligence Enabled Deep Brain Stimulation Device. IEEE Transactions on Medical Robotics and Bionics, PP (99), 1-1. doi: 10.1109/tmrb.2024.3381341
2024
Journal Article
SmartFSCV: An artificial intelligence enabled miniaturised FSCV device targeting serotonin
Corva, Dean M., Doeven, Egan H., Parke, Brenna, Adams, Scott D., Tye, Susannah J., Hashemi, Parastoo, Berk, Michael and Kouzani, Abbas Z. (2024). SmartFSCV: An artificial intelligence enabled miniaturised FSCV device targeting serotonin. IEEE Open Journal of Engineering in Medicine and Biology, 5 (99), 75-85. doi: 10.1109/OJEMB.2024.3356177
2023
Conference Publication
Circuit-Based Manipulation of Striatal Dopamine: A State-Dependent and Mood Stabilizing Approach
Tye, Susannah (2023). Circuit-Based Manipulation of Striatal Dopamine: A State-Dependent and Mood Stabilizing Approach. 62nd Annual Meeting of the American-College-of-Neuropsychopharmacology (ACNP), Tampa Fl, Dec 03-06, 2023. LONDON: SPRINGERNATURE.
2023
Journal Article
Oxycodone-induced dopaminergic and respiratory effects are modulated by deep brain stimulation
Yuen, Jason, Goyal, Abhinav, Rusheen, Aaron E., Kouzani, Abbas Z., Berk, Michael, Kim, Jee Hyun, Tye, Susannah J., Abulseoud, Osama A., Oesterle, Tyler S., Blaha, Charles D., Bennet, Kevin E., Lee, Kendall H., Oh, Yoonbae and Shin, Hojin (2023). Oxycodone-induced dopaminergic and respiratory effects are modulated by deep brain stimulation. Frontiers in Pharmacology, 14 1199655. doi: 10.3389/fphar.2023.1199655
2023
Conference Publication
Ketamine Associated Change in Anhedonia and Suicidal Ideation are Associated With Peripheral Immune Cell mTOR Expression and Kynurenine Levels and Treatment Resistant Depression
Voort, Jennifer Vande, Singh, Balwinder, Riva-Posse, Patricio, Erhardt, Sophie, Schwieler, Lilly, Pazdernik, Vanessa, Frye, Mark and Tye, Susannah (2023). Ketamine Associated Change in Anhedonia and Suicidal Ideation are Associated With Peripheral Immune Cell mTOR Expression and Kynurenine Levels and Treatment Resistant Depression. NEW YORK: ELSEVIER SCIENCE INC.
2023
Conference Publication
Critical Role of Insulin as an Immunomodulatory Target in Treatment Resistant Depression
Tye, Susannah, Price, Joshua, Walker, Adam, Sutor, Shari, Erhardt, Sophie, Schwieler, Lilly, Cullen, Kathryn, Voort, Jennifer Vande, Frye, Mark, Bobo, William and Shiroma, Paulo (2023). Critical Role of Insulin as an Immunomodulatory Target in Treatment Resistant Depression. 78th Annual Meeting of the Society of Biological Psychiatry, San Diego, CA United States, 27-29 April 2023. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.biopsych.2023.02.076
2023
Conference Publication
Critical Role of Insulin as an Immunomodulatory Target in Treatment Resistant Depression
Tye, Susannah, Price, Joshua, Walker, Adam, Sutor, Shari, Erhardt, Sophie, Schwieler, Lilly, Cullen, Kathryn, Voort, Jennifer Vande, Frye, Mark, Bobo, William and Shiroma, Paulo (2023). Critical Role of Insulin as an Immunomodulatory Target in Treatment Resistant Depression. NEW YORK: ELSEVIER SCIENCE INC.
2023
Conference Publication
Ketamine Associated Change in Anhedonia and Suicidal Ideation are Associated With Peripheral Immune Cell mTOR Expression and Kynurenine Levels and Treatment Resistant Depression
Voort, Jennifer Vande, Singh, Balwinder, Riva-Posse, Patricio, Erhardt, Sophie, Schwieler, Lilly, Pazdernik, Vanessa, Frye, Mark and Tye, Susannah (2023). Ketamine Associated Change in Anhedonia and Suicidal Ideation are Associated With Peripheral Immune Cell mTOR Expression and Kynurenine Levels and Treatment Resistant Depression. 78th Annual Meeting of the Society of Biological Psychiatry, San Diego, CA United States, 27-29 April 2023. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.biopsych.2023.02.077
2023
Conference Publication
PRECISION PSYCHIATRY IN MILITARY MENTAL HEALTH CARE
Tye, S., Nasrallah, Fatima and Lim, Alex (2023). PRECISION PSYCHIATRY IN MILITARY MENTAL HEALTH CARE. LONDON: SAGE PUBLICATIONS LTD.
2023
Journal Article
High frequency deep brain stimulation can mitigate the acute effects of cocaine administration on tonic dopamine levels in the rat nucleus accumbens
Yuen, Jason, Goyal, Abhinav, Rusheen, Aaron E., Kouzani, Abbas Z., Berk, Michael, Kim, Jee Hyun, Tye, Susannah J., Blaha, Charles D., Bennet, Kevin E., Lee, Kendall H., Shin, Hojin and Oh, Yoonbae (2023). High frequency deep brain stimulation can mitigate the acute effects of cocaine administration on tonic dopamine levels in the rat nucleus accumbens. Frontiers in Neuroscience, 17 1061578, 1-12. doi: 10.3389/fnins.2023.1061578
2023
Journal Article
Ketamine-associated change in anhedonia and mTOR expression in treatment-resistant depression
Singh, Balwinder, Vande Voort, Jennifer L., Riva-Posse, Patricio, Pazdernik, Vanessa M., Frye, Mark A. and Tye, Susannah J. (2023). Ketamine-associated change in anhedonia and mTOR expression in treatment-resistant depression. Biological Psychiatry, 93 (12), e65-e68. doi: 10.1016/j.biopsych.2022.10.007
2022
Journal Article
Antidepressants that increase mitochondrial energetics may elevate risk of treatment-emergent mania
Gardea-Resendez, Manuel, Coombes, Brandon J., Veldic, Marin, Tye, Susannah J., Romo-Nava, Francisco, Ozerdem, Aysegul, Prieto, Miguel L., Cuellar-Barboza, Alfredo, Nunez, Nicolas A., Singh, Balwinder, Pendegraft, Richard S., Miola, Alessandro, McElroy, Susan L., Biernacka, Joanna M., Morava, Eva, Kozicz, Tamas and Frye, Mark A. (2022). Antidepressants that increase mitochondrial energetics may elevate risk of treatment-emergent mania. Molecular Psychiatry, 28 (3), 1020-1026. doi: 10.1038/s41380-022-01888-x
2022
Journal Article
Interleukin-8 and depressive responses to an inflammatory challenge: secondary analysis of a randomized controlled trial
Kruse, Jennifer L., Boyle, Chloe C., Olmstead, Richard, Breen, Elizabeth C., Tye, Susannah J., Eisenberger, Naomi I. and Irwin, Michael R. (2022). Interleukin-8 and depressive responses to an inflammatory challenge: secondary analysis of a randomized controlled trial. Scientific Reports, 12 (1) 12627, 1-9. doi: 10.1038/s41598-022-16364-3
2022
Journal Article
Deep brain stimulation for addictive disorders—where are we now?
Yuen, Jason, Kouzani, Abbas Z., Berk, Michael, Tye, Susannah J., Rusheen, Aaron E., Blaha, Charles D., Bennet, Kevin E., Lee, Kendall H., Shin, Hojin, Kim, Jee Hyun and Oh, Yoonbae (2022). Deep brain stimulation for addictive disorders—where are we now?. Neurotherapeutics, 19 (4), 1193-1215. doi: 10.1007/s13311-022-01229-4
2022
Journal Article
Contributions of epigenetic inheritance to the predisposition of major psychiatric disorders: Theoretical framework, evidence, and implications
Varela, Roger B., Cararo, José Henrique, Tye, Susannah J., Carvalho, Andre F., Valvassori, Samira S., Fries, Gabriel R. and Quevedo, João (2022). Contributions of epigenetic inheritance to the predisposition of major psychiatric disorders: Theoretical framework, evidence, and implications. Neuroscience and Biobehavioral Reviews, 135 104579, 104579. doi: 10.1016/j.neubiorev.2022.104579
2022
Journal Article
Cocaine increases stimulation-evoked serotonin efflux in the nucleus accumbens
Yuen, Jason, Goyal, Abhinav, Rusheen, Aaron E., Kouzani, Abbas Z., Berk, Michael, Kim, Jee Hyun, Tye, Susannah J., Blaha, Charles D., Bennet, Kevin E., Lee, Kendall H., Oh, Yoonbae and Shin, Hojin (2022). Cocaine increases stimulation-evoked serotonin efflux in the nucleus accumbens. Journal of Neurophysiology, 127 (3), 714-724. doi: 10.1152/jn.00420.2021
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Susannah Tye is:
- Available for supervision
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Supervision history
Current supervision
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Master Philosophy
Predictive Biobehavioural Markers of Deep Brain Stimulation Efficacy
Principal Advisor
Other advisors: Professor Pankaj Sah
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Doctor Philosophy
Development of precision medicine biomarkers for ketamine as a treatment for TRD and PTSD
Principal Advisor
Other advisors: Associate Professor Fatima Nasrallah
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Doctor Philosophy
Immunometabolic Mechanisms of Mood Regulation
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
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Doctor Philosophy
Neurofeedback an intervention for emotion regulation and attention in children and adolescents that have Down syndrome.
Principal Advisor
Other advisors: Professor Rhonda Faragher
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Doctor Philosophy
Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
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Master Philosophy
Predictive Biobehavioural Markers of Deep Brain Stimulation Efficacy
Principal Advisor
Other advisors: Professor Pankaj Sah
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Doctor Philosophy
Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
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Doctor Philosophy
Neurofeedback an intervention for emotion regulation and attention in children and adolescents that have Down syndrome.
Principal Advisor
Other advisors: Professor Rhonda Faragher
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Doctor Philosophy
The development of precision medical care for the use of ketamine as a treatment for Australian Veterans with TRD and PTSD
Associate Advisor
Other advisors: Associate Professor Fatima Nasrallah
Completed supervision
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2023
Doctor Philosophy
Biomarkers of Treatment-Resistant Depression and Predictors of Antidepressant Response
Principal Advisor
Other advisors: Professor Avril Robertson
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2023
Doctor Philosophy
Targeting NLRP3 and Dopamine Receptors for Treatment Resistant Depression
Associate Advisor
Other advisors: Professor Avril Robertson
Media
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