
Overview
Background
Dr. Susannah Tye joined the Queensland Brain Institute in 2017 and has established a research program within the Asia Pacific Centre for Neuromodulation (QLD, Australia). Before returning to Australia, Dr. Tye directed the Translational Neuroscience Laboratory at the Mayo Clinic (2012-2017). While there she led efforts to develop brain stimulation devices (for rodents and humans) that can quantify neural activity and neurotransmitter dynamics in the living brain. This body of work now forms the basis of the neuropsychiatric arm of the Mayo Clinic’s Deep Brain Stimulation Consortium. Her specific research expertise are in utilising voltammetric (electrochemical) recording techniques to monitor rapid, synaptic neurotransmission in the living brain.
Dr. Tye has over ten years of experience studying neuromodulation in preclinical rodent models and human patients. Her long-term goal is to bridge preclinical and clinical studies to maximise translational impact, specifically in terms of improving patient outcomes for those with severe refractory psychiatric illness. Towards this end, she maintains many international collaborations with both clinical and basic science researchers. Dr. Tye also has a longstanding interest in mentoring young scientists to help them expand their skills in preclinical and basic science research and achieve a successful research career.
Availability
- Associate Professor Susannah Tye is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Macquarie University
Research interests
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Deep Brain Stimulation
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Neuromodulation
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Depression
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Bipolar Disorder
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Stress Disorders
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Parkinson's Disease
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Biomarkers
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Refractory Psychiatric Illness
Research impacts
The Tye group develops and applies novel technologies to modulate neuronal function. This work helps inform our basic understanding of signalling in the brain in both health and disease, with specific implications for understanding and correcting abnormal neuronal activity and neurotransmitter dynamics in chronic, unremitting brain-based illness. Working with both local and international collaborations in across clinical, engineering, and basic science fields, we work towards the long-term goal of translating cutting-edge brain stimulation technologies to the clinic to optimise therapeutic outcomes.
Works
Search Professor Susannah Tye’s works on UQ eSpace
2012
Journal Article
Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson's disease: a review of the literature
Chopra, Amit, Tye, Susannah J., Lee, Kendall H., Sampson, Shirlene, Matsumoto, Joseph, Adams, Andrea, Klassen, Bryan, Stead, Matt, Fields, Julie A. and Frye, Mark A. (2012). Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson's disease: a review of the literature. Journal of Neuropsychiatry and Clinical Neurosciences, 24 (1), 102-110. doi: 10.1176/appi.neuropsych.10070109
2012
Conference Publication
Compact stacked planar inverted-F antenna for passive deep brain stimulation implants
Hosain, Md Kamal, Kouzani, Abbas Z., Tye, Susannah, Mortazavi, Daryoush and Kaynak, Akif (2012). Compact stacked planar inverted-F antenna for passive deep brain stimulation implants. 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Diego, CA USA, 28 August-1 September 2012. doi: 10.1109/EMBC.2012.6346065
2011
Conference Publication
A head mountable deep brain stimulation device for laboratory animals
Kouzani, Abbas Z., Tye, Susannah, Walder, Ken and Kong, Lingxue (2011). A head mountable deep brain stimulation device for laboratory animals. 2011 International Conference on Computer, Communication, Control and Automation, 3CA 2011, , , November 19, 2011-November 20, 2011. doi: 10.1007/978-3-642-25541-0_36
2011
Journal Article
Voltage-dependent mania after subthalamic nucleus deep brain stimulation in Parkinson's disease: a case report
Chopra, Amit, Tye, Susannah J., Lee, Kendall H., Matsumoto, Joseph, Klassen, Bryan, Adams, Andrea C., Stead, Matt, Sampson, Shirlene, Kall, Bruce A. and Frye, Mark A. (2011). Voltage-dependent mania after subthalamic nucleus deep brain stimulation in Parkinson's disease: a case report. Biological Psychiatry, 70 (2), e5-e7. doi: 10.1016/j.biopsych.2010.12.035
2010
Journal Article
Wireless Instantaneous Neurotransmitter Concentration System: Electrochemical monitoring of serotonin using fast-scan cyclic voltammetry - A proof-of-principle study. Laboratory investigation
Griessenauer, Christoph J., Chang, Su-Youne, Tye, Susannah J., Kimble, Christopher J., Bennet, Kevin E., Garris, Paul A. and Lee, Kendall H. (2010). Wireless Instantaneous Neurotransmitter Concentration System: Electrochemical monitoring of serotonin using fast-scan cyclic voltammetry - A proof-of-principle study. Laboratory investigation. Journal of Neurosurgery, 113 (3), 656-665. doi: 10.3171/2010.3.JNS091627
2010
Journal Article
Comonitoring of adenosine and dopamine using the wireless instantaneous neurotransmitter concentration system: Proof of principle: Laboratory investigation
Shon, Young-Min, Chang, Su-Youne, Tye, Susannah J., Kimble, Christopher J., Bennet, Kevin E., Blaha, Charles D. and Lee, Kendall H. (2010). Comonitoring of adenosine and dopamine using the wireless instantaneous neurotransmitter concentration system: Proof of principle: Laboratory investigation. Journal of Neurosurgery, 112 (3), 539-548. doi: 10.3171/2009.7.JNS09787
2009
Journal Article
Differential corticosteroid receptor regulation of mesoaccumbens dopamine efflux during the peak and nadir of the circadian rhythm: a molecular equilibrium in the midbrain?
Tye, Susannah J, Miller, Anthony D and Blaha, Charles D (2009). Differential corticosteroid receptor regulation of mesoaccumbens dopamine efflux during the peak and nadir of the circadian rhythm: a molecular equilibrium in the midbrain?. Synapse (New York, N.Y.), 63 (11), 982-90. doi: 10.1002/syn.20682
2009
Journal Article
Wireless Instantaneous Neurotransmitter Concentration System-based amperometric detection of dopamine, adenosine, and glutamate for intraoperative neurochemical monitoring: Laboratory investigation
Agnesi, Filippo, Tye, Susannah J., Bledsoe, Jonathan M., Griessenauer, Christoph J., Kimble, Christopher J., Sieck, Gary C., Bennet, Kevin E., Garris, Paul A., Blaha, Charles D. and Lee, Kendall H. (2009). Wireless Instantaneous Neurotransmitter Concentration System-based amperometric detection of dopamine, adenosine, and glutamate for intraoperative neurochemical monitoring: Laboratory investigation. Journal of Neurosurgery, 111 (4), 701-711. doi: 10.3171/2009.3.JNS0990
2009
Journal Article
A balancing act: D4 receptor activation and the neurobiological basis of emotional learning
Tye, Susannah J., Covey, Dan P. and Griessenauer, Christoph J. (2009). A balancing act: D4 receptor activation and the neurobiological basis of emotional learning. Journal of Neuroscience, 29 (35), 10785-10787. doi: 10.1523/JNEUROSCI.2822-09.2009
2009
Journal Article
Disrupting disordered neurocircuitry: Treating refractory psychiatric illness with neuromodulation
Tye, Susannah J., Frye, Mark A. and Lee, Kendall H. (2009). Disrupting disordered neurocircuitry: Treating refractory psychiatric illness with neuromodulation. Mayo Clinic Proceedings, 84 (6), 522-532. doi: 10.4065/84.6.522
2009
Conference Publication
Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) for intraoperative neurochemical monitoring
Kimble, Christopher J., Johnson, David M., Winter, Bruce A., Whitlock, Sidney V., Kressin, Kenneth R., Horne, April E., Robinson, Justin C., Bledsoe, Jonathan M., Tye, Susannah J., Chang, Su-Youne, Agnesi, Filippo, Griessenauer, Christoph J., Covey, Daniel, Shon, Young-Min, Bennet, Kevin E., Garris, Paul A. and Lee, Kendall H. (2009). Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) for intraoperative neurochemical monitoring. 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, United States, 2- 6 September, 2009. Piscataway, NJ, United States: IEEE Computer Society. doi: 10.1109/IEMBS.2009.5332773
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Susannah Tye is:
- Available for supervision
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Supervision history
Current supervision
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Master Philosophy
Predictive Biobehavioural Markers of Deep Brain Stimulation Efficacy
Principal Advisor
Other advisors: Professor Pankaj Sah
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Doctor Philosophy
Development of precision medicine biomarkers for ketamine as a treatment for TRD and PTSD
Principal Advisor
Other advisors: Associate Professor Fatima Nasrallah
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Doctor Philosophy
Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
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Doctor Philosophy
Immunometabolic Mechanisms of Mood Regulation
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
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Doctor Philosophy
Neurofeedback an intervention for emotion regulation and attention in children and adolescents that have Down syndrome.
Principal Advisor
Other advisors: Professor Rhonda Faragher
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Doctor Philosophy
Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
-
Master Philosophy
Predictive Biobehavioural Markers of Deep Brain Stimulation Efficacy
Principal Advisor
Other advisors: Professor Pankaj Sah
-
Doctor Philosophy
Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
-
Doctor Philosophy
Neurofeedback an intervention for emotion regulation and attention in children and adolescents that have Down syndrome.
Principal Advisor
Other advisors: Professor Rhonda Faragher
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Doctor Philosophy
Modelling neural circuit control of effort under stress
Associate Advisor
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Doctor Philosophy
The development of precision medical care for the use of ketamine as a treatment for Australian Veterans with TRD and PTSD
Associate Advisor
Other advisors: Associate Professor Fatima Nasrallah
Completed supervision
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2023
Doctor Philosophy
Biomarkers of Treatment-Resistant Depression and Predictors of Antidepressant Response
Principal Advisor
Other advisors: Professor Avril Robertson
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2023
Doctor Philosophy
Targeting NLRP3 and Dopamine Receptors for Treatment Resistant Depression
Associate Advisor
Other advisors: Professor Avril Robertson
Media
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