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Associate Professor Susannah Tye
Associate Professor

Susannah Tye

Email: 
Phone: 
+61 7 344 32493

Overview

Background

Dr. Susannah Tye joined the Queensland Brain Institute in 2017 and has established a research program within the Asia Pacific Centre for Neuromodulation (QLD, Australia). Before returning to Australia, Dr. Tye directed the Translational Neuroscience Laboratory at the Mayo Clinic (2012-2017). While there she led efforts to develop brain stimulation devices (for rodents and humans) that can quantify neural activity and neurotransmitter dynamics in the living brain. This body of work now forms the basis of the neuropsychiatric arm of the Mayo Clinic’s Deep Brain Stimulation Consortium. Her specific research expertise are in utilising voltammetric (electrochemical) recording techniques to monitor rapid, synaptic neurotransmission in the living brain.

Dr. Tye has over ten years of experience studying neuromodulation in preclinical rodent models and human patients. Her long-term goal is to bridge preclinical and clinical studies to maximise translational impact, specifically in terms of improving patient outcomes for those with severe refractory psychiatric illness. Towards this end, she maintains many international collaborations with both clinical and basic science researchers. Dr. Tye also has a longstanding interest in mentoring young scientists to help them expand their skills in preclinical and basic science research and achieve a successful research career.

Availability

Associate Professor Susannah Tye is:
Available for supervision

Qualifications

  • Doctor of Philosophy, Macquarie University

Research interests

  • Deep Brain Stimulation

  • Neuromodulation

  • Depression

  • Bipolar Disorder

  • Stress Disorders

  • Parkinson's Disease

  • Biomarkers

  • Refractory Psychiatric Illness

Research impacts

The Tye group develops and applies novel technologies to modulate neuronal function. This work helps inform our basic understanding of signalling in the brain in both health and disease, with specific implications for understanding and correcting abnormal neuronal activity and neurotransmitter dynamics in chronic, unremitting brain-based illness. Working with both local and international collaborations in across clinical, engineering, and basic science fields, we work towards the long-term goal of translating cutting-edge brain stimulation technologies to the clinic to optimise therapeutic outcomes.

Works

Search Professor Susannah Tye’s works on UQ eSpace

111 works between 2009 and 2025

101 - 111 of 111 works

2012

Journal Article

Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson's disease: a review of the literature

Chopra, Amit, Tye, Susannah J., Lee, Kendall H., Sampson, Shirlene, Matsumoto, Joseph, Adams, Andrea, Klassen, Bryan, Stead, Matt, Fields, Julie A. and Frye, Mark A. (2012). Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson's disease: a review of the literature. Journal of Neuropsychiatry and Clinical Neurosciences, 24 (1), 102-110. doi: 10.1176/appi.neuropsych.10070109

Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson's disease: a review of the literature

2012

Conference Publication

Compact stacked planar inverted-F antenna for passive deep brain stimulation implants

Hosain, Md Kamal, Kouzani, Abbas Z., Tye, Susannah, Mortazavi, Daryoush and Kaynak, Akif (2012). Compact stacked planar inverted-F antenna for passive deep brain stimulation implants. 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Diego, CA USA, 28 August-1 September 2012. doi: 10.1109/EMBC.2012.6346065

Compact stacked planar inverted-F antenna for passive deep brain stimulation implants

2011

Conference Publication

A head mountable deep brain stimulation device for laboratory animals

Kouzani, Abbas Z., Tye, Susannah, Walder, Ken and Kong, Lingxue (2011). A head mountable deep brain stimulation device for laboratory animals. 2011 International Conference on Computer, Communication, Control and Automation, 3CA 2011, , , November 19, 2011-November 20, 2011. doi: 10.1007/978-3-642-25541-0_36

A head mountable deep brain stimulation device for laboratory animals

2011

Journal Article

Voltage-dependent mania after subthalamic nucleus deep brain stimulation in Parkinson's disease: a case report

Chopra, Amit, Tye, Susannah J., Lee, Kendall H., Matsumoto, Joseph, Klassen, Bryan, Adams, Andrea C., Stead, Matt, Sampson, Shirlene, Kall, Bruce A. and Frye, Mark A. (2011). Voltage-dependent mania after subthalamic nucleus deep brain stimulation in Parkinson's disease: a case report. Biological Psychiatry, 70 (2), e5-e7. doi: 10.1016/j.biopsych.2010.12.035

Voltage-dependent mania after subthalamic nucleus deep brain stimulation in Parkinson's disease: a case report

2010

Journal Article

Wireless Instantaneous Neurotransmitter Concentration System: Electrochemical monitoring of serotonin using fast-scan cyclic voltammetry - A proof-of-principle study. Laboratory investigation

Griessenauer, Christoph J., Chang, Su-Youne, Tye, Susannah J., Kimble, Christopher J., Bennet, Kevin E., Garris, Paul A. and Lee, Kendall H. (2010). Wireless Instantaneous Neurotransmitter Concentration System: Electrochemical monitoring of serotonin using fast-scan cyclic voltammetry - A proof-of-principle study. Laboratory investigation. Journal of Neurosurgery, 113 (3), 656-665. doi: 10.3171/2010.3.JNS091627

Wireless Instantaneous Neurotransmitter Concentration System: Electrochemical monitoring of serotonin using fast-scan cyclic voltammetry - A proof-of-principle study. Laboratory investigation

2010

Journal Article

Comonitoring of adenosine and dopamine using the wireless instantaneous neurotransmitter concentration system: Proof of principle: Laboratory investigation

Shon, Young-Min, Chang, Su-Youne, Tye, Susannah J., Kimble, Christopher J., Bennet, Kevin E., Blaha, Charles D. and Lee, Kendall H. (2010). Comonitoring of adenosine and dopamine using the wireless instantaneous neurotransmitter concentration system: Proof of principle: Laboratory investigation. Journal of Neurosurgery, 112 (3), 539-548. doi: 10.3171/2009.7.JNS09787

Comonitoring of adenosine and dopamine using the wireless instantaneous neurotransmitter concentration system: Proof of principle: Laboratory investigation

2009

Journal Article

Differential corticosteroid receptor regulation of mesoaccumbens dopamine efflux during the peak and nadir of the circadian rhythm: a molecular equilibrium in the midbrain?

Tye, Susannah J, Miller, Anthony D and Blaha, Charles D (2009). Differential corticosteroid receptor regulation of mesoaccumbens dopamine efflux during the peak and nadir of the circadian rhythm: a molecular equilibrium in the midbrain?. Synapse (New York, N.Y.), 63 (11), 982-90. doi: 10.1002/syn.20682

Differential corticosteroid receptor regulation of mesoaccumbens dopamine efflux during the peak and nadir of the circadian rhythm: a molecular equilibrium in the midbrain?

2009

Journal Article

Wireless Instantaneous Neurotransmitter Concentration System-based amperometric detection of dopamine, adenosine, and glutamate for intraoperative neurochemical monitoring: Laboratory investigation

Agnesi, Filippo, Tye, Susannah J., Bledsoe, Jonathan M., Griessenauer, Christoph J., Kimble, Christopher J., Sieck, Gary C., Bennet, Kevin E., Garris, Paul A., Blaha, Charles D. and Lee, Kendall H. (2009). Wireless Instantaneous Neurotransmitter Concentration System-based amperometric detection of dopamine, adenosine, and glutamate for intraoperative neurochemical monitoring: Laboratory investigation. Journal of Neurosurgery, 111 (4), 701-711. doi: 10.3171/2009.3.JNS0990

Wireless Instantaneous Neurotransmitter Concentration System-based amperometric detection of dopamine, adenosine, and glutamate for intraoperative neurochemical monitoring: Laboratory investigation

2009

Journal Article

A balancing act: D4 receptor activation and the neurobiological basis of emotional learning

Tye, Susannah J., Covey, Dan P. and Griessenauer, Christoph J. (2009). A balancing act: D4 receptor activation and the neurobiological basis of emotional learning. Journal of Neuroscience, 29 (35), 10785-10787. doi: 10.1523/JNEUROSCI.2822-09.2009

A balancing act: D4 receptor activation and the neurobiological basis of emotional learning

2009

Journal Article

Disrupting disordered neurocircuitry: Treating refractory psychiatric illness with neuromodulation

Tye, Susannah J., Frye, Mark A. and Lee, Kendall H. (2009). Disrupting disordered neurocircuitry: Treating refractory psychiatric illness with neuromodulation. Mayo Clinic Proceedings, 84 (6), 522-532. doi: 10.4065/84.6.522

Disrupting disordered neurocircuitry: Treating refractory psychiatric illness with neuromodulation

2009

Conference Publication

Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) for intraoperative neurochemical monitoring

Kimble, Christopher J., Johnson, David M., Winter, Bruce A., Whitlock, Sidney V., Kressin, Kenneth R., Horne, April E., Robinson, Justin C., Bledsoe, Jonathan M., Tye, Susannah J., Chang, Su-Youne, Agnesi, Filippo, Griessenauer, Christoph J., Covey, Daniel, Shon, Young-Min, Bennet, Kevin E., Garris, Paul A. and Lee, Kendall H. (2009). Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) for intraoperative neurochemical monitoring. 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, United States, 2- 6 September, 2009. Piscataway, NJ, United States: IEEE Computer Society. doi: 10.1109/IEMBS.2009.5332773

Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) for intraoperative neurochemical monitoring

Funding

Current funding

  • 2024 - 2026
    Precision Medicine Approaches for Depression and Anxiety
    The Nicol Foundation
    Open grant
  • 2023 - 2026
    Neural circuit control of effort under stress
    ARC Discovery Projects
    Open grant
  • 2021 - 2027
    Biomarker Discovery for Treatment Resistant Mood Disorders
    The Nicol Foundation
    Open grant

Past funding

  • 2023 - 2024
    Intelligent Closed Loop Neuromodulation
    Bionics Queensland Challenge
    Open grant
  • 2023
    Cell-specific control of striatal neurotransmission for mood regulation (project under NHRMC CREDIT Centre of Research Excellence administered by Deakin University)
    Deakin University
    Open grant
  • 2022
    Prefrontal Mechanisms Regulating Striatal Dopamine Release Essential for Persistent Effort
    UQ Foundation Research Excellence Awards
    Open grant
  • 2019 - 2023
    Circuit, cellular and synaptic mechanisms of nucleus accumbens deep brain stimulation
    NHMRC Project Grant
    Open grant
  • 2019
    Common Mechanisms of Anti-Suicidal Drug Action
    UQ Early Career Researcher
    Open grant

Supervision

Availability

Associate Professor Susannah Tye is:
Available for supervision

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Supervision history

Current supervision

  • Master Philosophy

    Predictive Biobehavioural Markers of Deep Brain Stimulation Efficacy

    Principal Advisor

    Other advisors: Professor Pankaj Sah

  • Doctor Philosophy

    Development of precision medicine biomarkers for ketamine as a treatment for TRD and PTSD

    Principal Advisor

    Other advisors: Associate Professor Fatima Nasrallah

  • Doctor Philosophy

    Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort

    Principal Advisor

    Other advisors: Dr Roger Bitencourt Varela

  • Doctor Philosophy

    Immunometabolic Mechanisms of Mood Regulation

    Principal Advisor

    Other advisors: Dr Roger Bitencourt Varela

  • Doctor Philosophy

    Neurofeedback an intervention for emotion regulation and attention in children and adolescents that have Down syndrome.

    Principal Advisor

    Other advisors: Professor Rhonda Faragher

  • Doctor Philosophy

    Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort

    Principal Advisor

    Other advisors: Dr Roger Bitencourt Varela

  • Master Philosophy

    Predictive Biobehavioural Markers of Deep Brain Stimulation Efficacy

    Principal Advisor

    Other advisors: Professor Pankaj Sah

  • Doctor Philosophy

    Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort

    Principal Advisor

    Other advisors: Dr Roger Bitencourt Varela

  • Doctor Philosophy

    Neurofeedback an intervention for emotion regulation and attention in children and adolescents that have Down syndrome.

    Principal Advisor

    Other advisors: Professor Rhonda Faragher

  • Doctor Philosophy

    Modelling neural circuit control of effort under stress

    Associate Advisor

  • Doctor Philosophy

    The development of precision medical care for the use of ketamine as a treatment for Australian Veterans with TRD and PTSD

    Associate Advisor

    Other advisors: Associate Professor Fatima Nasrallah

Completed supervision

Media

Enquiries

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