
Overview
Background
Dr. Susannah Tye joined the Queensland Brain Institute in 2017 and has established a research program within the Asia Pacific Centre for Neuromodulation (QLD, Australia). Before returning to Australia, Dr. Tye directed the Translational Neuroscience Laboratory at the Mayo Clinic (2012-2017). While there she led efforts to develop brain stimulation devices (for rodents and humans) that can quantify neural activity and neurotransmitter dynamics in the living brain. This body of work now forms the basis of the neuropsychiatric arm of the Mayo Clinic’s Deep Brain Stimulation Consortium. Her specific research expertise are in utilising voltammetric (electrochemical) recording techniques to monitor rapid, synaptic neurotransmission in the living brain.
Dr. Tye has over ten years of experience studying neuromodulation in preclinical rodent models and human patients. Her long-term goal is to bridge preclinical and clinical studies to maximise translational impact, specifically in terms of improving patient outcomes for those with severe refractory psychiatric illness. Towards this end, she maintains many international collaborations with both clinical and basic science researchers. Dr. Tye also has a longstanding interest in mentoring young scientists to help them expand their skills in preclinical and basic science research and achieve a successful research career.
Availability
- Associate Professor Susannah Tye is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Macquarie University
Research interests
-
Deep Brain Stimulation
-
Neuromodulation
-
Depression
-
Bipolar Disorder
-
Stress Disorders
-
Parkinson's Disease
-
Biomarkers
-
Refractory Psychiatric Illness
Research impacts
The Tye group develops and applies novel technologies to modulate neuronal function. This work helps inform our basic understanding of signalling in the brain in both health and disease, with specific implications for understanding and correcting abnormal neuronal activity and neurotransmitter dynamics in chronic, unremitting brain-based illness. Working with both local and international collaborations in across clinical, engineering, and basic science fields, we work towards the long-term goal of translating cutting-edge brain stimulation technologies to the clinic to optimise therapeutic outcomes.
Works
Search Professor Susannah Tye’s works on UQ eSpace
2015
Journal Article
Evolution of optogenetic microdevices
Kale, Rajas P., Kouzani, Abbas Z., Walder, Ken, Berk, Michael and Tye, Susannah J. (2015). Evolution of optogenetic microdevices. Neurophotonics, 2 (3) 031206, 031206. doi: 10.1117/1.NPh.2.3.031206
2015
Journal Article
Concomitant benzodiazepine use attenuates ketamine response: implications for large scale study design and clinical development
Frye, Mark A., Blier, Pierre and Tye, Susannah J. (2015). Concomitant benzodiazepine use attenuates ketamine response: implications for large scale study design and clinical development. Journal of Clinical Psychopharmacology, 35 (3), 334-6. doi: 10.1097/JCP.0000000000000316
2015
Journal Article
A miniature energy harvesting rectenna for operating a head-mountable deep brain stimulation device
Hosain, Md Kamal, Kouzani, Abbas Z., Samad, Mst Fateha and Tye, Susannah J. (2015). A miniature energy harvesting rectenna for operating a head-mountable deep brain stimulation device. IEEE Access, 3 7062898, 223-234. doi: 10.1109/ACCESS.2015.2414411
2015
Journal Article
RF rectifiers for EM power harvesting in a Deep Brain Stimulating device
Hosain, Md Kamal, Kouzani, Abbas Z., Tye, Susannah, Kaynak, Akif and Berk, Michael (2015). RF rectifiers for EM power harvesting in a Deep Brain Stimulating device. Australasian Physical and Engineering Sciences in Medicine, 38 (1), 157-72. doi: 10.1007/s13246-015-0328-7
2015
Journal Article
Towards a classification of biomarkers of neuropsychiatric disease: from encompass to compass
Davis, J., Maes, M., Andreazza, A., McGrath, J. J., Tye, S. J. and Berk, M. (2015). Towards a classification of biomarkers of neuropsychiatric disease: from encompass to compass. Molecular Psychiatry, 20 (2), 152-153. doi: 10.1038/mp.2014.139
2015
Conference Publication
Statistical modelling of artificial neural network for sorting temporally synchronous spikes
Veerabhadrappa, Rakesh, Bhatti, Asim, Lim, Chee Peng, Nguyen, Thanh Thi, Tye, S. J., Monaghan, Paul and Nahavandi, Saeid (2015). Statistical modelling of artificial neural network for sorting temporally synchronous spikes. 22nd International Conference on Neural Information Processing, ICONIP 2015, Istanbul, Turkey, 9-12 November 2015. Heidelberg, 69121 Germany: Springer Verlag. doi: 10.1007/978-3-319-26555-1_30
2015
Journal Article
Preclinical perspectives on posttraumatic stress disorder criteria in DSM-5
Tye, Susannah, Van Voorhees, Elizabeth, Hu, Chunling and Lineberry, Timothy (2015). Preclinical perspectives on posttraumatic stress disorder criteria in DSM-5. Harvard Review of Psychiatry, 23 (1), 51-58. doi: 10.1097/HRP.0000000000000035
2014
Journal Article
Current landscape, unmet needs, and future directions for treatment of bipolar depression
Frye, Mark A., Prieto, Miguel L., Bobo, William V., Kung, Simon, Veldic, Marin, Alarcon, Renato D., Moore, Katherine M., Choi, Doo-Sup, Biernacka, Joanna M. and Tye, Susannah J. (2014). Current landscape, unmet needs, and future directions for treatment of bipolar depression. Journal of Affective Disorders, 169 (S1), S17-S23. doi: 10.1016/S0165-0327(14)70005-9
2014
Journal Article
Determination of neurotransmitters and their metabolites using one- and two-dimensional liquid chromatography with acidic potassium permanganate chemiluminescence detection
Holland, Brendan J., Conlan, Xavier A., Stevenson, Paul G., Tye, Susannah, Reker, Ashlie, Barnett, Neil W., Adcock, Jacqui L. and Francis, Paul S. (2014). Determination of neurotransmitters and their metabolites using one- and two-dimensional liquid chromatography with acidic potassium permanganate chemiluminescence detection. Analytical and Bioanalytical Chemistry, 406 (23), 5669-5676. doi: 10.1007/s00216-013-7514-9
2014
Journal Article
Stress, Inflammation, and Cellular Vulnerability during Early Stages of Affective Disorders: Biomarker Strategies and Opportunities for Prevention and Intervention
Walker, Adam J., Kim, Yesul, Price, J. Blair, Kale, Rajas P., McGillivray, Jane A., Berk, Michael and Tye, Susannah J. (2014). Stress, Inflammation, and Cellular Vulnerability during Early Stages of Affective Disorders: Biomarker Strategies and Opportunities for Prevention and Intervention. Frontiers in Psychiatry, 5 (APR) Article 34, 34. doi: 10.3389/fpsyt.2014.00034
2014
Journal Article
Development of a compact rectenna for wireless powering of a head-mountable deep brain stimulation device
Hosain, M. D. Kamal, Kouzani, Abbas Z., Tye, Susannah J., Abulseoud, Osama A., Amiet, Andrew, Galehdar, Amir, Kaynak, Akif and Berk, Michael (2014). Development of a compact rectenna for wireless powering of a head-mountable deep brain stimulation device. IEEE Journal of Translational Engineering in Health and Medicine, 2 1500113, 1500113-13. doi: 10.1109/JTEHM.2014.2313856
2014
Journal Article
Informing Brain Health Behaviour Choices: The Efficacy of a High-School Brain Awareness Pilot Study
Broadbent, J., Sitka, N., Macfarlane, S. , McGillivray, J. and Tye, S. (2014). Informing Brain Health Behaviour Choices: The Efficacy of a High-School Brain Awareness Pilot Study. British Journal of Education, Society & Behavioural Science, 4 (6), 755-767. doi: 10.9734/bjesbs/2014/6694
2014
Journal Article
Closed loop deep brain stimulation: an evolving technology
Hosain, Md Kamal, Kouzani, Abbas and Tye, Susannah (2014). Closed loop deep brain stimulation: an evolving technology. Australasian Physical and Engineering Sciences in Medicine, 37 (4), 619-634. doi: 10.1007/s13246-014-0297-2
2013
Journal Article
Ventral tegmental ionotropic glutamate receptor stimulation of nucleus accumbens tonic dopamine efflux blunts hindbrain-evoked phasic neurotransmission: implications for dopamine dysregulation disorders
Tye, S. J., Miller, A. D. and Blaha, C. D. (2013). Ventral tegmental ionotropic glutamate receptor stimulation of nucleus accumbens tonic dopamine efflux blunts hindbrain-evoked phasic neurotransmission: implications for dopamine dysregulation disorders. Neuroscience, 252, 337-345. doi: 10.1016/j.neuroscience.2013.08.010
2013
Journal Article
A low power micro deep brain stimulation device for murine preclinical research
Kouzani, Abbas Z, Abulseoud, Osama A, Tye, Susannah J, Hosain, M D Kamal and Berk, Michael (2013). A low power micro deep brain stimulation device for murine preclinical research. IEEE Journal of Translational Engineering in Health and Medicine, 2, 1500109-1500109. doi: 10.1109/JTEHM.2013.2264093
2013
Journal Article
Chronic adrenocorticotrophic hormone treatment alters tricyclic antidepressant efficacy and prefrontal monoamine tissue levels
Walker, Adam J., Burnett, Sandy A., Hasebe, Kyoko, McGillivray, Jane A., Gray, Laura J., McGee, Sean L., Walder, Ken, Berk, Michael and Tye, Susannah J. (2013). Chronic adrenocorticotrophic hormone treatment alters tricyclic antidepressant efficacy and prefrontal monoamine tissue levels. Behavioural Brain Research, 242 (1), 76-83. doi: 10.1016/j.bbr.2012.12.033
2013
Conference Publication
Design and analysis of an antenna for wireless energy harvesting in a head-mountable DBS device
Hosain, Md Kamal, Kouzani, Abbas Z., Tye, Susannah J., Abulseoud, Osama A. and Berk, Michael (2013). Design and analysis of an antenna for wireless energy harvesting in a head-mountable DBS device. 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013, Osaka, Japan, 3-7 July 2013. Piscataway, NJ, United States: IEEE. doi: 10.1109/EMBC.2013.6610191
2012
Journal Article
Deep brain stimulation for treatment-resistant depression: efficacy, safety and mechanisms of action
Anderson, Rodney J., Frye, Mark A., Abulseoud, Osama A., Lee, Kendall H., McGillivray, Jane A., Berk, Michael and Tye, Susannah J. (2012). Deep brain stimulation for treatment-resistant depression: efficacy, safety and mechanisms of action. Neuroscience and Biobehavioral Reviews, 36 (8), 1920-1933. doi: 10.1016/j.neubiorev.2012.06.001
2012
Journal Article
Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson's disease: a review of the literature
Chopra, Amit, Tye, Susannah J., Lee, Kendall H., Sampson, Shirlene, Matsumoto, Joseph, Adams, Andrea, Klassen, Bryan, Stead, Matt, Fields, Julie A. and Frye, Mark A. (2012). Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson's disease: a review of the literature. Journal of Neuropsychiatry and Clinical Neurosciences, 24 (1), 102-110. doi: 10.1176/appi.neuropsych.10070109
2012
Conference Publication
Compact stacked planar inverted-F antenna for passive deep brain stimulation implants
Hosain, Md Kamal, Kouzani, Abbas Z., Tye, Susannah, Mortazavi, Daryoush and Kaynak, Akif (2012). Compact stacked planar inverted-F antenna for passive deep brain stimulation implants. 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Diego, CA USA, 28 August-1 September 2012. doi: 10.1109/EMBC.2012.6346065
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Susannah Tye is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
-
Master Philosophy
Predictive Biobehavioural Markers of Deep Brain Stimulation Efficacy
Principal Advisor
Other advisors: Professor Pankaj Sah
-
Doctor Philosophy
Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
-
Doctor Philosophy
Neurofeedback an intervention for emotion regulation and attention in children and adolescents that have Down syndrome.
Principal Advisor
Other advisors: Professor Rhonda Faragher
-
Master Philosophy
Predictive Biobehavioural Markers of Deep Brain Stimulation Efficacy
Principal Advisor
Other advisors: Professor Pankaj Sah
-
Doctor Philosophy
Development of precision medicine biomarkers for ketamine as a treatment for TRD and PTSD
Principal Advisor
Other advisors: Associate Professor Fatima Nasrallah
-
Doctor Philosophy
Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
-
Doctor Philosophy
Immunometabolic Mechanisms of Mood Regulation
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
-
Doctor Philosophy
Neurofeedback an intervention for emotion regulation and attention in children and adolescents that have Down syndrome.
Principal Advisor
Other advisors: Professor Rhonda Faragher
-
Doctor Philosophy
Modelling neural circuit control of effort under stress
Associate Advisor
-
Doctor Philosophy
The development of precision medical care for the use of ketamine as a treatment for Australian Veterans with TRD and PTSD
Associate Advisor
Other advisors: Associate Professor Fatima Nasrallah
Completed supervision
-
2023
Doctor Philosophy
Biomarkers of Treatment-Resistant Depression and Predictors of Antidepressant Response
Principal Advisor
Other advisors: Professor Avril Robertson
-
2023
Doctor Philosophy
Targeting NLRP3 and Dopamine Receptors for Treatment Resistant Depression
Associate Advisor
Other advisors: Professor Avril Robertson
Media
Enquiries
For media enquiries about Associate Professor Susannah Tye's areas of expertise, story ideas and help finding experts, contact our Media team: