Overview
Background
Dr. Susannah Tye joined the Queensland Brain Institute in 2017 and has established a research program within the Asia Pacific Centre for Neuromodulation (QLD, Australia). Before returning to Australia, Dr. Tye directed the Translational Neuroscience Laboratory at the Mayo Clinic (2012-2017). While there she led efforts to develop brain stimulation devices (for rodents and humans) that can quantify neural activity and neurotransmitter dynamics in the living brain. This body of work now forms the basis of the neuropsychiatric arm of the Mayo Clinic’s Deep Brain Stimulation Consortium. Her specific research expertise are in utilising voltammetric (electrochemical) recording techniques to monitor rapid, synaptic neurotransmission in the living brain.
Dr. Tye has over ten years of experience studying neuromodulation in preclinical rodent models and human patients. Her long-term goal is to bridge preclinical and clinical studies to maximise translational impact, specifically in terms of improving patient outcomes for those with severe refractory psychiatric illness. Towards this end, she maintains many international collaborations with both clinical and basic science researchers. Dr. Tye also has a longstanding interest in mentoring young scientists to help them expand their skills in preclinical and basic science research and achieve a successful research career.
Availability
- Associate Professor Susannah Tye is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Macquarie University
Research interests
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Deep Brain Stimulation
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Neuromodulation
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Depression
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Bipolar Disorder
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Stress Disorders
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Parkinson's Disease
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Biomarkers
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Refractory Psychiatric Illness
Research impacts
The Tye group develops and applies novel technologies to modulate neuronal function. This work helps inform our basic understanding of signalling in the brain in both health and disease, with specific implications for understanding and correcting abnormal neuronal activity and neurotransmitter dynamics in chronic, unremitting brain-based illness. Working with both local and international collaborations in across clinical, engineering, and basic science fields, we work towards the long-term goal of translating cutting-edge brain stimulation technologies to the clinic to optimise therapeutic outcomes.
Works
Search Professor Susannah Tye’s works on UQ eSpace
2016
Journal Article
Antidepressant actions of lateral habenula deep brain stimulation differentially correlate with CaMKII/GSK3/AMPK signaling locally and in the infralimbic cortex
Kim, Yesul, Morath, Brooke, Hu, Chunling, Byrne, Linda K., Sutor, Shari L., Frye, Mark A. and Tye, Susannah J. (2016). Antidepressant actions of lateral habenula deep brain stimulation differentially correlate with CaMKII/GSK3/AMPK signaling locally and in the infralimbic cortex. Behavioural Brain Research, 306, 170-177. doi: 10.1016/j.bbr.2016.02.039
2016
Journal Article
Stimulation-induced transient nonmotor psychiatric symptoms following subthalamic deep brain stimulation in patients with Parkinson's disease: association with clinical outcomes and neuroanatomical correlates
Abulseoud, Osama A., Kasasbeh, Aimen, Min, Hoon-Ki, Fields, Julie A., Tye, Susannah J., Goerss, Stephan, Knight, Emily J., Sampson, Shirlene M., Klassen, Bryan T., Matsumoto, Joseph Y., Stoppel, Cynthia, Lee, Kendall H. and Frye, Mark A. (2016). Stimulation-induced transient nonmotor psychiatric symptoms following subthalamic deep brain stimulation in patients with Parkinson's disease: association with clinical outcomes and neuroanatomical correlates. Stereotactic and Functional Neurosurgery, 94 (2), 93-101. doi: 10.1159/000445076
2016
Conference Publication
Portable closed-loop optogenetic stimulation device
Edward, Epsy S., Kouzani, Abbas Z., Kale, Rajas P. and Tye, Susannah J. (2016). Portable closed-loop optogenetic stimulation device. 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016, Orlando, Florida, 16-20 August 2016 . Piscataway, NJ, United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/embc.2016.7591911
2016
Conference Publication
A miniature neural recording device
Edward, Epsy S., Kouzani, Abbas Z., Berk, Julian and Tye, Susannah J. (2016). A miniature neural recording device. IEEE International Conference on Industrial Technology, ICIT 2016, Taipei, Taiwan, 14-17 March 2016. Piscataway, NJ United States: IEEE. doi: 10.1109/icit.2016.7474892
2016
Conference Publication
A miniature closed-loop deep brain stimulation device
Parastarfeizabadi, Mahboubeh, Kouzani, Abbas Z., Gibson, Ian and Tye, Susannah J. (2016). A miniature closed-loop deep brain stimulation device. 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016, Orlando, Florida, 16-20 August 2016 . Piscataway, NJ, United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/embc.2016.7591064
2016
Conference Publication
Electrical resistance increases at the tissue-electrode interface as an early response to nucleus accumbens deep brain stimulation
Kale, Rajas P., Kouzani, Abbas Z., Berk, Julian, Walder, Ken, Berk, Michael and Tye, Susannah J. (2016). Electrical resistance increases at the tissue-electrode interface as an early response to nucleus accumbens deep brain stimulation. 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016, Orlando, FL, United States, 16-20 August 2016. Piscataway, NJ, United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/EMBC.2016.7591071
2016
Journal Article
Fabrication of biocompatible enclosures for an electronic implant using 3D printing
Adams, Scott, Kouzani, Abbas Z., Mohammed, Mazher, Usma, Clara and Tye, Susannah J. (2016). Fabrication of biocompatible enclosures for an electronic implant using 3D printing. International Journal of Rapid Manufacturing, 6 (1), 17-32. doi: 10.1504/ijrapidm.2016.078742
2015
Journal Article
Feasibility of investigating differential proteomic expression in depression: implications for biomarker development in mood disorders
Frye, M. A., Nassan, M., Jenkins, G. D., Kung, S., Veldic, M., Palmer, B. A., Feeder, S. E., Tye, S. J., Choi, D. S. and Biernacka, J. M. (2015). Feasibility of investigating differential proteomic expression in depression: implications for biomarker development in mood disorders. Translational Psychiatry, 5 (12) e689, e689-e689. doi: 10.1038/tp.2015.185
2015
Journal Article
Peripheral proinflammatory markers associated with ketamine response in a preclinical model of antidepressant-resistance
Walker, Adam J., Foley, Brittany M., Sutor, Shari L., McGillivray, Jane A., Frye, Mark A. and Tye, Susannah J. (2015). Peripheral proinflammatory markers associated with ketamine response in a preclinical model of antidepressant-resistance. Behavioural Brain Research, 293, 198-202. doi: 10.1016/j.bbr.2015.07.026
2015
Journal Article
Radio frequency energy harvesting from a feeding source in a passive deep brain stimulation device for murine preclinical research
Hosain, Md Kamal, Kouzani, Abbas Z., Tye, Susannah J., Samad, Mst Fateha, Kale, Rajas P., Bennet, Kevin E., Manciu, Felicia S. and Berk, Michael (2015). Radio frequency energy harvesting from a feeding source in a passive deep brain stimulation device for murine preclinical research. Medical Engineering and Physics, 37 (10), 1020-1026. doi: 10.1016/j.medengphy.2015.07.003
2015
Journal Article
Evolution of optogenetic microdevices
Kale, Rajas P., Kouzani, Abbas Z., Walder, Ken, Berk, Michael and Tye, Susannah J. (2015). Evolution of optogenetic microdevices. Neurophotonics, 2 (3) 031206, 031206. doi: 10.1117/1.NPh.2.3.031206
2015
Journal Article
Concomitant benzodiazepine use attenuates ketamine response: implications for large scale study design and clinical development
Frye, Mark A., Blier, Pierre and Tye, Susannah J. (2015). Concomitant benzodiazepine use attenuates ketamine response: implications for large scale study design and clinical development. Journal of Clinical Psychopharmacology, 35 (3), 334-6. doi: 10.1097/JCP.0000000000000316
2015
Journal Article
A miniature energy harvesting rectenna for operating a head-mountable deep brain stimulation device
Hosain, Md Kamal, Kouzani, Abbas Z., Samad, Mst Fateha and Tye, Susannah J. (2015). A miniature energy harvesting rectenna for operating a head-mountable deep brain stimulation device. IEEE Access, 3 7062898, 223-234. doi: 10.1109/ACCESS.2015.2414411
2015
Journal Article
RF rectifiers for EM power harvesting in a Deep Brain Stimulating device
Hosain, Md Kamal, Kouzani, Abbas Z., Tye, Susannah, Kaynak, Akif and Berk, Michael (2015). RF rectifiers for EM power harvesting in a Deep Brain Stimulating device. Australasian Physical and Engineering Sciences in Medicine, 38 (1), 157-72. doi: 10.1007/s13246-015-0328-7
2015
Journal Article
Towards a classification of biomarkers of neuropsychiatric disease: from encompass to compass
Davis, J., Maes, M., Andreazza, A., McGrath, J. J., Tye, S. J. and Berk, M. (2015). Towards a classification of biomarkers of neuropsychiatric disease: from encompass to compass. Molecular Psychiatry, 20 (2), 152-153. doi: 10.1038/mp.2014.139
2015
Journal Article
Preclinical perspectives on posttraumatic stress disorder criteria in DSM-5
Tye, Susannah, Van Voorhees, Elizabeth, Hu, Chunling and Lineberry, Timothy (2015). Preclinical perspectives on posttraumatic stress disorder criteria in DSM-5. Harvard Review of Psychiatry, 23 (1), 51-58. doi: 10.1097/HRP.0000000000000035
2015
Conference Publication
Statistical modelling of artificial neural network for sorting temporally synchronous spikes
Veerabhadrappa, Rakesh, Bhatti, Asim, Lim, Chee Peng, Nguyen, Thanh Thi, Tye, S. J., Monaghan, Paul and Nahavandi, Saeid (2015). Statistical modelling of artificial neural network for sorting temporally synchronous spikes. 22nd International Conference on Neural Information Processing, ICONIP 2015, Istanbul, Turkey, 9-12 November 2015. Heidelberg, 69121 Germany: Springer Verlag. doi: 10.1007/978-3-319-26555-1_30
2014
Journal Article
Current landscape, unmet needs, and future directions for treatment of bipolar depression
Frye, Mark A., Prieto, Miguel L., Bobo, William V., Kung, Simon, Veldic, Marin, Alarcon, Renato D., Moore, Katherine M., Choi, Doo-Sup, Biernacka, Joanna M. and Tye, Susannah J. (2014). Current landscape, unmet needs, and future directions for treatment of bipolar depression. Journal of Affective Disorders, 169 (S1), S17-S23. doi: 10.1016/S0165-0327(14)70005-9
2014
Journal Article
Determination of neurotransmitters and their metabolites using one- and two-dimensional liquid chromatography with acidic potassium permanganate chemiluminescence detection
Holland, Brendan J., Conlan, Xavier A., Stevenson, Paul G., Tye, Susannah, Reker, Ashlie, Barnett, Neil W., Adcock, Jacqui L. and Francis, Paul S. (2014). Determination of neurotransmitters and their metabolites using one- and two-dimensional liquid chromatography with acidic potassium permanganate chemiluminescence detection. Analytical and Bioanalytical Chemistry, 406 (23), 5669-5676. doi: 10.1007/s00216-013-7514-9
2014
Journal Article
Stress, Inflammation, and Cellular Vulnerability during Early Stages of Affective Disorders: Biomarker Strategies and Opportunities for Prevention and Intervention
Walker, Adam J., Kim, Yesul, Price, J. Blair, Kale, Rajas P., McGillivray, Jane A., Berk, Michael and Tye, Susannah J. (2014). Stress, Inflammation, and Cellular Vulnerability during Early Stages of Affective Disorders: Biomarker Strategies and Opportunities for Prevention and Intervention. Frontiers in Psychiatry, 5 (APR) Article 34, 34. doi: 10.3389/fpsyt.2014.00034
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Susannah Tye is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Neurofeedback an intervention for emotion regulation and attention in children and adolescents that have Down syndrome.
Principal Advisor
Other advisors: Professor Rhonda Faragher
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Master Philosophy
Predictive Biobehavioural Markers of Deep Brain Stimulation Efficacy
Principal Advisor
Other advisors: Professor Pankaj Sah
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Doctor Philosophy
Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
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Doctor Philosophy
Development of precision medicine biomarkers for ketamine as a treatment for TRD and PTSD
Principal Advisor
Other advisors: Professor Fatima Nasrallah
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Doctor Philosophy
The development of precision medical care for the use of ketamine as a treatment for Australian Veterans with TRD and PTSD
Associate Advisor
Other advisors: Professor Fatima Nasrallah
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Master Philosophy
Biopsychosocial Adaptations and Early OperationalOutcomes: Longitudinal Neurophysiological tracking of Police Recruits' transition to Operational Policing
Associate Advisor
Other advisors: Associate Professor Sarah Bennett
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Doctor Philosophy
Modelling neural circuit control of effort under stress
Associate Advisor
Completed supervision
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2026
Doctor Philosophy
Circadian mechanisms of mood regulation
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
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2023
Doctor Philosophy
Biomarkers of Treatment-Resistant Depression and Predictors of Antidepressant Response
Principal Advisor
Other advisors: Professor Avril Robertson
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2023
Doctor Philosophy
Targeting NLRP3 and Dopamine Receptors for Treatment Resistant Depression
Associate Advisor
Other advisors: Professor Avril Robertson
Media
Enquiries
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