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Associate Professor Susannah Tye
Associate Professor

Susannah Tye

Email: 
Phone: 
+61 7 344 32493

Overview

Background

Dr. Susannah Tye joined the Queensland Brain Institute in 2017 and has established a research program within the Asia Pacific Centre for Neuromodulation (QLD, Australia). Before returning to Australia, Dr. Tye directed the Translational Neuroscience Laboratory at the Mayo Clinic (2012-2017). While there she led efforts to develop brain stimulation devices (for rodents and humans) that can quantify neural activity and neurotransmitter dynamics in the living brain. This body of work now forms the basis of the neuropsychiatric arm of the Mayo Clinic’s Deep Brain Stimulation Consortium. Her specific research expertise are in utilising voltammetric (electrochemical) recording techniques to monitor rapid, synaptic neurotransmission in the living brain.

Dr. Tye has over ten years of experience studying neuromodulation in preclinical rodent models and human patients. Her long-term goal is to bridge preclinical and clinical studies to maximise translational impact, specifically in terms of improving patient outcomes for those with severe refractory psychiatric illness. Towards this end, she maintains many international collaborations with both clinical and basic science researchers. Dr. Tye also has a longstanding interest in mentoring young scientists to help them expand their skills in preclinical and basic science research and achieve a successful research career.

Availability

Associate Professor Susannah Tye is:
Available for supervision

Qualifications

  • Doctor of Philosophy, Macquarie University

Research interests

  • Deep Brain Stimulation

  • Neuromodulation

  • Depression

  • Bipolar Disorder

  • Stress Disorders

  • Parkinson's Disease

  • Biomarkers

  • Refractory Psychiatric Illness

Research impacts

The Tye group develops and applies novel technologies to modulate neuronal function. This work helps inform our basic understanding of signalling in the brain in both health and disease, with specific implications for understanding and correcting abnormal neuronal activity and neurotransmitter dynamics in chronic, unremitting brain-based illness. Working with both local and international collaborations in across clinical, engineering, and basic science fields, we work towards the long-term goal of translating cutting-edge brain stimulation technologies to the clinic to optimise therapeutic outcomes.

Works

Search Professor Susannah Tye’s works on UQ eSpace

111 works between 2009 and 2025

81 - 100 of 111 works

2015

Journal Article

Evolution of optogenetic microdevices

Kale, Rajas P., Kouzani, Abbas Z., Walder, Ken, Berk, Michael and Tye, Susannah J. (2015). Evolution of optogenetic microdevices. Neurophotonics, 2 (3) 031206, 031206. doi: 10.1117/1.NPh.2.3.031206

Evolution of optogenetic microdevices

2015

Journal Article

Concomitant benzodiazepine use attenuates ketamine response: implications for large scale study design and clinical development

Frye, Mark A., Blier, Pierre and Tye, Susannah J. (2015). Concomitant benzodiazepine use attenuates ketamine response: implications for large scale study design and clinical development. Journal of Clinical Psychopharmacology, 35 (3), 334-6. doi: 10.1097/JCP.0000000000000316

Concomitant benzodiazepine use attenuates ketamine response: implications for large scale study design and clinical development

2015

Journal Article

A miniature energy harvesting rectenna for operating a head-mountable deep brain stimulation device

Hosain, Md Kamal, Kouzani, Abbas Z., Samad, Mst Fateha and Tye, Susannah J. (2015). A miniature energy harvesting rectenna for operating a head-mountable deep brain stimulation device. IEEE Access, 3 7062898, 223-234. doi: 10.1109/ACCESS.2015.2414411

A miniature energy harvesting rectenna for operating a head-mountable deep brain stimulation device

2015

Journal Article

RF rectifiers for EM power harvesting in a Deep Brain Stimulating device

Hosain, Md Kamal, Kouzani, Abbas Z., Tye, Susannah, Kaynak, Akif and Berk, Michael (2015). RF rectifiers for EM power harvesting in a Deep Brain Stimulating device. Australasian Physical and Engineering Sciences in Medicine, 38 (1), 157-72. doi: 10.1007/s13246-015-0328-7

RF rectifiers for EM power harvesting in a Deep Brain Stimulating device

2015

Journal Article

Towards a classification of biomarkers of neuropsychiatric disease: from encompass to compass

Davis, J., Maes, M., Andreazza, A., McGrath, J. J., Tye, S. J. and Berk, M. (2015). Towards a classification of biomarkers of neuropsychiatric disease: from encompass to compass. Molecular Psychiatry, 20 (2), 152-153. doi: 10.1038/mp.2014.139

Towards a classification of biomarkers of neuropsychiatric disease: from encompass to compass

2015

Conference Publication

Statistical modelling of artificial neural network for sorting temporally synchronous spikes

Veerabhadrappa, Rakesh, Bhatti, Asim, Lim, Chee Peng, Nguyen, Thanh Thi, Tye, S. J., Monaghan, Paul and Nahavandi, Saeid (2015). Statistical modelling of artificial neural network for sorting temporally synchronous spikes. 22nd International Conference on Neural Information Processing, ICONIP 2015, Istanbul, Turkey, 9-12 November 2015. Heidelberg, 69121 Germany: Springer Verlag. doi: 10.1007/978-3-319-26555-1_30

Statistical modelling of artificial neural network for sorting temporally synchronous spikes

2015

Journal Article

Preclinical perspectives on posttraumatic stress disorder criteria in DSM-5

Tye, Susannah, Van Voorhees, Elizabeth, Hu, Chunling and Lineberry, Timothy (2015). Preclinical perspectives on posttraumatic stress disorder criteria in DSM-5. Harvard Review of Psychiatry, 23 (1), 51-58. doi: 10.1097/HRP.0000000000000035

Preclinical perspectives on posttraumatic stress disorder criteria in DSM-5

2014

Journal Article

Current landscape, unmet needs, and future directions for treatment of bipolar depression

Frye, Mark A., Prieto, Miguel L., Bobo, William V., Kung, Simon, Veldic, Marin, Alarcon, Renato D., Moore, Katherine M., Choi, Doo-Sup, Biernacka, Joanna M. and Tye, Susannah J. (2014). Current landscape, unmet needs, and future directions for treatment of bipolar depression. Journal of Affective Disorders, 169 (S1), S17-S23. doi: 10.1016/S0165-0327(14)70005-9

Current landscape, unmet needs, and future directions for treatment of bipolar depression

2014

Journal Article

Determination of neurotransmitters and their metabolites using one- and two-dimensional liquid chromatography with acidic potassium permanganate chemiluminescence detection

Holland, Brendan J., Conlan, Xavier A., Stevenson, Paul G., Tye, Susannah, Reker, Ashlie, Barnett, Neil W., Adcock, Jacqui L. and Francis, Paul S. (2014). Determination of neurotransmitters and their metabolites using one- and two-dimensional liquid chromatography with acidic potassium permanganate chemiluminescence detection. Analytical and Bioanalytical Chemistry, 406 (23), 5669-5676. doi: 10.1007/s00216-013-7514-9

Determination of neurotransmitters and their metabolites using one- and two-dimensional liquid chromatography with acidic potassium permanganate chemiluminescence detection

2014

Journal Article

Stress, Inflammation, and Cellular Vulnerability during Early Stages of Affective Disorders: Biomarker Strategies and Opportunities for Prevention and Intervention

Walker, Adam J., Kim, Yesul, Price, J. Blair, Kale, Rajas P., McGillivray, Jane A., Berk, Michael and Tye, Susannah J. (2014). Stress, Inflammation, and Cellular Vulnerability during Early Stages of Affective Disorders: Biomarker Strategies and Opportunities for Prevention and Intervention. Frontiers in Psychiatry, 5 (APR) Article 34, 34. doi: 10.3389/fpsyt.2014.00034

Stress, Inflammation, and Cellular Vulnerability during Early Stages of Affective Disorders: Biomarker Strategies and Opportunities for Prevention and Intervention

2014

Journal Article

Development of a compact rectenna for wireless powering of a head-mountable deep brain stimulation device

Hosain, M. D. Kamal, Kouzani, Abbas Z., Tye, Susannah J., Abulseoud, Osama A., Amiet, Andrew, Galehdar, Amir, Kaynak, Akif and Berk, Michael (2014). Development of a compact rectenna for wireless powering of a head-mountable deep brain stimulation device. IEEE Journal of Translational Engineering in Health and Medicine, 2 1500113, 1500113-13. doi: 10.1109/JTEHM.2014.2313856

Development of a compact rectenna for wireless powering of a head-mountable deep brain stimulation device

2014

Journal Article

Informing Brain Health Behaviour Choices: The Efficacy of a High-School Brain Awareness Pilot Study

Broadbent, J., Sitka, N., Macfarlane, S. , McGillivray, J. and Tye, S. (2014). Informing Brain Health Behaviour Choices: The Efficacy of a High-School Brain Awareness Pilot Study. British Journal of Education, Society & Behavioural Science, 4 (6), 755-767. doi: 10.9734/bjesbs/2014/6694

Informing Brain Health Behaviour Choices: The Efficacy of a High-School Brain Awareness Pilot Study

2014

Journal Article

Closed loop deep brain stimulation: an evolving technology

Hosain, Md Kamal, Kouzani, Abbas and Tye, Susannah (2014). Closed loop deep brain stimulation: an evolving technology. Australasian Physical and Engineering Sciences in Medicine, 37 (4), 619-634. doi: 10.1007/s13246-014-0297-2

Closed loop deep brain stimulation: an evolving technology

2013

Journal Article

Ventral tegmental ionotropic glutamate receptor stimulation of nucleus accumbens tonic dopamine efflux blunts hindbrain-evoked phasic neurotransmission: implications for dopamine dysregulation disorders

Tye, S. J., Miller, A. D. and Blaha, C. D. (2013). Ventral tegmental ionotropic glutamate receptor stimulation of nucleus accumbens tonic dopamine efflux blunts hindbrain-evoked phasic neurotransmission: implications for dopamine dysregulation disorders. Neuroscience, 252, 337-345. doi: 10.1016/j.neuroscience.2013.08.010

Ventral tegmental ionotropic glutamate receptor stimulation of nucleus accumbens tonic dopamine efflux blunts hindbrain-evoked phasic neurotransmission: implications for dopamine dysregulation disorders

2013

Journal Article

A low power micro deep brain stimulation device for murine preclinical research

Kouzani, Abbas Z, Abulseoud, Osama A, Tye, Susannah J, Hosain, M D Kamal and Berk, Michael (2013). A low power micro deep brain stimulation device for murine preclinical research. IEEE Journal of Translational Engineering in Health and Medicine, 2, 1500109-1500109. doi: 10.1109/JTEHM.2013.2264093

A low power micro deep brain stimulation device for murine preclinical research

2013

Journal Article

Chronic adrenocorticotrophic hormone treatment alters tricyclic antidepressant efficacy and prefrontal monoamine tissue levels

Walker, Adam J., Burnett, Sandy A., Hasebe, Kyoko, McGillivray, Jane A., Gray, Laura J., McGee, Sean L., Walder, Ken, Berk, Michael and Tye, Susannah J. (2013). Chronic adrenocorticotrophic hormone treatment alters tricyclic antidepressant efficacy and prefrontal monoamine tissue levels. Behavioural Brain Research, 242 (1), 76-83. doi: 10.1016/j.bbr.2012.12.033

Chronic adrenocorticotrophic hormone treatment alters tricyclic antidepressant efficacy and prefrontal monoamine tissue levels

2013

Conference Publication

Design and analysis of an antenna for wireless energy harvesting in a head-mountable DBS device

Hosain, Md Kamal, Kouzani, Abbas Z., Tye, Susannah J., Abulseoud, Osama A. and Berk, Michael (2013). Design and analysis of an antenna for wireless energy harvesting in a head-mountable DBS device. 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013, Osaka, Japan, 3-7 July 2013. Piscataway, NJ, United States: IEEE. doi: 10.1109/EMBC.2013.6610191

Design and analysis of an antenna for wireless energy harvesting in a head-mountable DBS device

2012

Journal Article

Deep brain stimulation for treatment-resistant depression: efficacy, safety and mechanisms of action

Anderson, Rodney J., Frye, Mark A., Abulseoud, Osama A., Lee, Kendall H., McGillivray, Jane A., Berk, Michael and Tye, Susannah J. (2012). Deep brain stimulation for treatment-resistant depression: efficacy, safety and mechanisms of action. Neuroscience and Biobehavioral Reviews, 36 (8), 1920-1933. doi: 10.1016/j.neubiorev.2012.06.001

Deep brain stimulation for treatment-resistant depression: efficacy, safety and mechanisms of action

2012

Journal Article

Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson's disease: a review of the literature

Chopra, Amit, Tye, Susannah J., Lee, Kendall H., Sampson, Shirlene, Matsumoto, Joseph, Adams, Andrea, Klassen, Bryan, Stead, Matt, Fields, Julie A. and Frye, Mark A. (2012). Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson's disease: a review of the literature. Journal of Neuropsychiatry and Clinical Neurosciences, 24 (1), 102-110. doi: 10.1176/appi.neuropsych.10070109

Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson's disease: a review of the literature

2012

Conference Publication

Compact stacked planar inverted-F antenna for passive deep brain stimulation implants

Hosain, Md Kamal, Kouzani, Abbas Z., Tye, Susannah, Mortazavi, Daryoush and Kaynak, Akif (2012). Compact stacked planar inverted-F antenna for passive deep brain stimulation implants. 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Diego, CA USA, 28 August-1 September 2012. doi: 10.1109/EMBC.2012.6346065

Compact stacked planar inverted-F antenna for passive deep brain stimulation implants

Funding

Current funding

  • 2024 - 2026
    Precision Medicine Approaches for Depression and Anxiety
    The Nicol Foundation
    Open grant
  • 2023 - 2026
    Neural circuit control of effort under stress
    ARC Discovery Projects
    Open grant
  • 2021 - 2027
    Biomarker Discovery for Treatment Resistant Mood Disorders
    The Nicol Foundation
    Open grant

Past funding

  • 2023 - 2024
    Intelligent Closed Loop Neuromodulation
    Bionics Queensland Challenge
    Open grant
  • 2023
    Cell-specific control of striatal neurotransmission for mood regulation (project under NHRMC CREDIT Centre of Research Excellence administered by Deakin University)
    Deakin University
    Open grant
  • 2022
    Prefrontal Mechanisms Regulating Striatal Dopamine Release Essential for Persistent Effort
    UQ Foundation Research Excellence Awards
    Open grant
  • 2019 - 2023
    Circuit, cellular and synaptic mechanisms of nucleus accumbens deep brain stimulation
    NHMRC Project Grant
    Open grant
  • 2019
    Common Mechanisms of Anti-Suicidal Drug Action
    UQ Early Career Researcher
    Open grant

Supervision

Availability

Associate Professor Susannah Tye is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort

    Principal Advisor

    Other advisors: Dr Roger Bitencourt Varela

  • Master Philosophy

    Predictive Biobehavioural Markers of Deep Brain Stimulation Efficacy

    Principal Advisor

    Other advisors: Professor Pankaj Sah

  • Doctor Philosophy

    Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort

    Principal Advisor

    Other advisors: Dr Roger Bitencourt Varela

  • Doctor Philosophy

    Neurofeedback an intervention for emotion regulation and attention in children and adolescents that have Down syndrome.

    Principal Advisor

    Other advisors: Professor Rhonda Faragher

  • Master Philosophy

    Predictive Biobehavioural Markers of Deep Brain Stimulation Efficacy

    Principal Advisor

    Other advisors: Professor Pankaj Sah

  • Doctor Philosophy

    Development of precision medicine biomarkers for ketamine as a treatment for TRD and PTSD

    Principal Advisor

    Other advisors: Associate Professor Fatima Nasrallah

  • Doctor Philosophy

    Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort

    Principal Advisor

    Other advisors: Dr Roger Bitencourt Varela

  • Doctor Philosophy

    Immunometabolic Mechanisms of Mood Regulation

    Principal Advisor

    Other advisors: Dr Roger Bitencourt Varela

  • Doctor Philosophy

    Neurofeedback an intervention for emotion regulation and attention in children and adolescents that have Down syndrome.

    Principal Advisor

    Other advisors: Professor Rhonda Faragher

  • Doctor Philosophy

    Modelling neural circuit control of effort under stress

    Associate Advisor

  • Doctor Philosophy

    The development of precision medical care for the use of ketamine as a treatment for Australian Veterans with TRD and PTSD

    Associate Advisor

    Other advisors: Associate Professor Fatima Nasrallah

Completed supervision

Media

Enquiries

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