
Overview
Background
Dr. Susannah Tye joined the Queensland Brain Institute in 2017 and has established a research program within the Asia Pacific Centre for Neuromodulation (QLD, Australia). Before returning to Australia, Dr. Tye directed the Translational Neuroscience Laboratory at the Mayo Clinic (2012-2017). While there she led efforts to develop brain stimulation devices (for rodents and humans) that can quantify neural activity and neurotransmitter dynamics in the living brain. This body of work now forms the basis of the neuropsychiatric arm of the Mayo Clinic’s Deep Brain Stimulation Consortium. Her specific research expertise are in utilising voltammetric (electrochemical) recording techniques to monitor rapid, synaptic neurotransmission in the living brain.
Dr. Tye has over ten years of experience studying neuromodulation in preclinical rodent models and human patients. Her long-term goal is to bridge preclinical and clinical studies to maximise translational impact, specifically in terms of improving patient outcomes for those with severe refractory psychiatric illness. Towards this end, she maintains many international collaborations with both clinical and basic science researchers. Dr. Tye also has a longstanding interest in mentoring young scientists to help them expand their skills in preclinical and basic science research and achieve a successful research career.
Availability
- Associate Professor Susannah Tye is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Macquarie University
Research interests
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Deep Brain Stimulation
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Neuromodulation
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Depression
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Bipolar Disorder
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Stress Disorders
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Parkinson's Disease
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Biomarkers
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Refractory Psychiatric Illness
Research impacts
The Tye group develops and applies novel technologies to modulate neuronal function. This work helps inform our basic understanding of signalling in the brain in both health and disease, with specific implications for understanding and correcting abnormal neuronal activity and neurotransmitter dynamics in chronic, unremitting brain-based illness. Working with both local and international collaborations in across clinical, engineering, and basic science fields, we work towards the long-term goal of translating cutting-edge brain stimulation technologies to the clinic to optimise therapeutic outcomes.
Works
Search Professor Susannah Tye’s works on UQ eSpace
2022
Journal Article
Contributions of epigenetic inheritance to the predisposition of major psychiatric disorders: Theoretical framework, evidence, and implications
Varela, Roger B., Cararo, José Henrique, Tye, Susannah J., Carvalho, Andre F., Valvassori, Samira S., Fries, Gabriel R. and Quevedo, João (2022). Contributions of epigenetic inheritance to the predisposition of major psychiatric disorders: Theoretical framework, evidence, and implications. Neuroscience and Biobehavioral Reviews, 135 104579, 104579. doi: 10.1016/j.neubiorev.2022.104579
2022
Journal Article
Cocaine increases stimulation-evoked serotonin efflux in the nucleus accumbens
Yuen, Jason, Goyal, Abhinav, Rusheen, Aaron E., Kouzani, Abbas Z., Berk, Michael, Kim, Jee Hyun, Tye, Susannah J., Blaha, Charles D., Bennet, Kevin E., Lee, Kendall H., Oh, Yoonbae and Shin, Hojin (2022). Cocaine increases stimulation-evoked serotonin efflux in the nucleus accumbens. Journal of Neurophysiology, 127 (3), 714-724. doi: 10.1152/jn.00420.2021
2022
Journal Article
Dynamic insulin-stimulated mTOR/GSK3 signaling in peripheral immune cells: preliminary evidence for an association with lithium response in bipolar disorder
Tye, Susannah J., Borreggine, Kristin, Price, J. Blair, Sutor, Shari L., Cuéllar-Barboza, Alfredo B., McElroy, Susan L., Biernacka, Joanna M. and Frye, Mark A. (2022). Dynamic insulin-stimulated mTOR/GSK3 signaling in peripheral immune cells: preliminary evidence for an association with lithium response in bipolar disorder. Bipolar Disorders, 24 (1) bdi.13081, 1-9. doi: 10.1111/bdi.13081
2022
Book Chapter
Modeling treatment-resistant depression in the preclinical setting
Tye, Susannah, Yates, Clarissa G. and Postorivo, Danielle (2022). Modeling treatment-resistant depression in the preclinical setting. Managing treatment-resistant depression: road to novel therapeutics. (pp. 61-80) edited by Joao Quevedo, Patricio Riva-Posse and William V. Bobo. Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-12-824067-0.00005-0
2021
Journal Article
Lithium augmentation of ketamine increases insulin signaling and antidepressant-like active stress coping in a rodent model of treatment-resistant depression
Price, J. Blair, Yates, Clarissa G., Morath, Brooke A., Van De Wakker, Sam K., Yates, Nathanael J., Butters, Kim, Frye, Mark A., McGee, Sean L. and Tye, Susannah J. (2021). Lithium augmentation of ketamine increases insulin signaling and antidepressant-like active stress coping in a rodent model of treatment-resistant depression. Translational Psychiatry, 11 (1) 598, 598. doi: 10.1038/s41398-021-01716-w
2021
Journal Article
Modulating neuroplasticity: lessons learned from antidepressants and emerging novel therapeutics
Yates, Clarissa, Kruse, Jennifer L., Price, J. Blair, Robertson, Avril A. B. and Tye, Susannah J. (2021). Modulating neuroplasticity: lessons learned from antidepressants and emerging novel therapeutics. Current Treatment Options in Psychiatry, 8 (4), 229-257. doi: 10.1007/s40501-021-00249-9
2021
Journal Article
Interleukin-8 and lower severity of depression in females, but not males, with treatment-resistant depression
Kruse, Jennifer L., Olmstead, Richard, Hellemann, Gerhard, Breen, Elizabeth C., Tye, Susannah J., Brooks, John O., Wade, Benjamin, Congdon, Eliza, Espinoza, Randall, Narr, Katherine L. and Irwin, Michael R. (2021). Interleukin-8 and lower severity of depression in females, but not males, with treatment-resistant depression. Journal of Psychiatric Research, 140, 350-356. doi: 10.1016/j.jpsychires.2021.06.009
2021
Journal Article
Mood regulatory actions of active and sham nucleus accumbens deep brain stimulation in antidepressant resistant rats
Kale, Rajas P., Nguyen, Thanh Thanh L., Price, J. Blair, Yates, Nathanael J., Walder, Ken, Berk, Michael, Sillitoe, Roy V., Kouzani, Abbas Z. and Tye, Susannah J. (2021). Mood regulatory actions of active and sham nucleus accumbens deep brain stimulation in antidepressant resistant rats. Frontiers in Human Neuroscience, 15 644921, 644921. doi: 10.3389/fnhum.2021.644921
2021
Journal Article
Cocaine-induced changes in tonic dopamine concentrations measured using multiple-cyclic square wave voltammetry in vivo
Yuen, Jason, Goyal, Abhinav, Rusheen, Aaron E., Kouzani, Abbas Z., Berk, Michael, Kim, Jee Hyun, Tye, Susannah J., Blaha, Charles D., Bennet, Kevin E., Jang, Dong-Pyo, Lee, Kendall H., Shin, Hojin and Oh, Yoonbae (2021). Cocaine-induced changes in tonic dopamine concentrations measured using multiple-cyclic square wave voltammetry in vivo. Frontiers in Pharmacology, 12 705254, 705254. doi: 10.3389/fphar.2021.705254
2021
Journal Article
Inflammatory mechanisms in Parkinson’s disease: from pathogenesis to targeted therapies
Lee, Stellina Y. H., Yates, Nathanael J. and Tye, Susannah J. (2021). Inflammatory mechanisms in Parkinson’s disease: from pathogenesis to targeted therapies. The Neuroscientist, 28 (5) 1073858421992265, 1073858421992265-506. doi: 10.1177/1073858421992265
2021
Journal Article
Novel antidepressant approaches for refractory depression
Postorivo, Danielle and Tye, Susannah J. (2021). Novel antidepressant approaches for refractory depression. Current Treatment Options in Psychiatry, 8 (3), 141-157. doi: 10.1007/s40501-021-00246-y
2020
Journal Article
Neurocognitive performance of repeated versus single intravenous subanesthetic ketamine in treatment resistant depression
Shiroma, Paulo R., Thuras, Paul, Wels, Joseph, Albott, C. Sophia, Erbes, Christopher, Tye, Susannah and Lim, Kelvin O. (2020). Neurocognitive performance of repeated versus single intravenous subanesthetic ketamine in treatment resistant depression. Journal of Affective Disorders, 277, 470-477. doi: 10.1016/j.jad.2020.08.058
2020
Journal Article
Role of epigenetic regulatory enzymes in animal models of mania induced by amphetamine and paradoxical sleep deprivation
Varela, Roger B., Resende, Wilson R., Dal-Pont, Gustavo C., Gava, Fernanda F., Nadas, Gabriella B., Tye, Susannah J., Andersen, Monica L., Quevedo, João and Valvassori, Samira S (2020). Role of epigenetic regulatory enzymes in animal models of mania induced by amphetamine and paradoxical sleep deprivation. European Journal of Neuroscience, 53 (2) ejn.14922, 649-662. doi: 10.1111/ejn.14922
2020
Journal Article
A randomized, double-blind, active placebo-controlled study of efficacy, safety, and durability of repeated vs single subanesthetic ketamine for treatment-resistant depression
Shiroma, Paulo R., Thuras, Paul, Wels, Joseph, Albott, C Sophia, Erbes, Christopher, Tye, Susannah and Lim, Kelvin O. (2020). A randomized, double-blind, active placebo-controlled study of efficacy, safety, and durability of repeated vs single subanesthetic ketamine for treatment-resistant depression. Translational Psychiatry, 10 (1) 206, 206. doi: 10.1038/s41398-020-00897-0
2020
Journal Article
HDAC inhibitors reverse mania-like behavior and modulate epigenetic regulatory enzymes in an animal model of mania induced by Ouabain
Varela, Roger B., Resende, Wilson R., Dal-Pont, Gustavo C., Gava, Fernanda F., Tye, Susannah J., Quevedo, João and Valvassori, Samira S. (2020). HDAC inhibitors reverse mania-like behavior and modulate epigenetic regulatory enzymes in an animal model of mania induced by Ouabain. Pharmacology Biochemistry and Behavior, 193 172917, 172917. doi: 10.1016/j.pbb.2020.172917
2020
Journal Article
Feasibility study of Stress Management and Resiliency Training (SMART) in patients with major depressive disorder
Seshadri, Ashok, Clark, Matthew M., Kung, Simon, Fuller-Tyszkiewicz, Matthew, Sood, Amit, Dammen, Kristina C., Rico, Jose A., Tye, Susannah J., McGillivray, Jane and Frye, Mark A. (2020). Feasibility study of Stress Management and Resiliency Training (SMART) in patients with major depressive disorder. Primary Care Companion to CNS Disorders, 22 (3) 19m02556. doi: 10.4088/PCC.19m02556
2020
Journal Article
Brain entropy and neurotrophic molecular markers accompanying clinical improvement after ketamine: preliminary evidence in adolescents with treatment-resistant depression
Roy, Abhrajeet V., Thai, Michelle, Klimes-Dougan, Bonnie, Westlund Schreiner, Mindy, Mueller, Bryon A., Albott, Christina Sophia, Lim, Kelvin O., Fiecas, Mark, Tye, Susannah J. and Cullen, Kathryn R. (2020). Brain entropy and neurotrophic molecular markers accompanying clinical improvement after ketamine: preliminary evidence in adolescents with treatment-resistant depression. Journal of Psychopharmacology, 35 (2), 026988112092820-177. doi: 10.1177/0269881120928203
2020
Journal Article
TinyFSCV: FSCV for the masses
Adams, Scott D., Doeven, Egan H., Tye, Susannah J., Bennet, Kevin E., Berk, Michael and Kouzani, Abbas Z. (2020). TinyFSCV: FSCV for the masses. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 28 (1) 8917694, 133-142. doi: 10.1109/TNSRE.2019.2956479
2019
Journal Article
Insulin-stimulated mTOR activation in peripheral blood mononuclear cells associated with early treatment response to lithium augmentation in rodent model of antidepressant-resistance
Walker, Adam J., Price, J. Blair, Borreggine, Kristin, Sutor, Shari L., Gogos, Andrea, McGillivray, Jane A., Frye, Mark A. and Tye, Susannah J. (2019). Insulin-stimulated mTOR activation in peripheral blood mononuclear cells associated with early treatment response to lithium augmentation in rodent model of antidepressant-resistance. Translational Psychiatry, 9 (1) 113, 113. doi: 10.1038/s41398-019-0434-5
2019
Journal Article
Development of a miniature device for emerging deep brain stimulation paradigms
Adams, Scott D., Bennet, Kevin E., Tye, Susannah J., Berk, Michael and Kouzani, Abbas Z. (2019). Development of a miniature device for emerging deep brain stimulation paradigms. PLoS ONE, 14 (2) e0212554, e0212554. doi: 10.1371/journal.pone.0212554
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Susannah Tye is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
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Master Philosophy
Predictive Biobehavioural Markers of Deep Brain Stimulation Efficacy
Principal Advisor
Other advisors: Professor Pankaj Sah
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Doctor Philosophy
Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
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Doctor Philosophy
Neurofeedback an intervention for emotion regulation and attention in children and adolescents that have Down syndrome.
Principal Advisor
Other advisors: Professor Rhonda Faragher
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Master Philosophy
Predictive Biobehavioural Markers of Deep Brain Stimulation Efficacy
Principal Advisor
Other advisors: Professor Pankaj Sah
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Doctor Philosophy
Development of precision medicine biomarkers for ketamine as a treatment for TRD and PTSD
Principal Advisor
Other advisors: Associate Professor Fatima Nasrallah
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Doctor Philosophy
Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
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Doctor Philosophy
Immunometabolic Mechanisms of Mood Regulation
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
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Doctor Philosophy
Neurofeedback an intervention for emotion regulation and attention in children and adolescents that have Down syndrome.
Principal Advisor
Other advisors: Professor Rhonda Faragher
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Doctor Philosophy
Modelling neural circuit control of effort under stress
Associate Advisor
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Doctor Philosophy
The development of precision medical care for the use of ketamine as a treatment for Australian Veterans with TRD and PTSD
Associate Advisor
Other advisors: Associate Professor Fatima Nasrallah
Completed supervision
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2023
Doctor Philosophy
Biomarkers of Treatment-Resistant Depression and Predictors of Antidepressant Response
Principal Advisor
Other advisors: Professor Avril Robertson
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2023
Doctor Philosophy
Targeting NLRP3 and Dopamine Receptors for Treatment Resistant Depression
Associate Advisor
Other advisors: Professor Avril Robertson
Media
Enquiries
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