Skip to menu Skip to content Skip to footer
Associate Professor Susannah Tye
Associate Professor

Susannah Tye

Email: 
Phone: 
+61 7 344 32493

Overview

Background

Dr. Susannah Tye joined the Queensland Brain Institute in 2017 and has established a research program within the Asia Pacific Centre for Neuromodulation (QLD, Australia). Before returning to Australia, Dr. Tye directed the Translational Neuroscience Laboratory at the Mayo Clinic (2012-2017). While there she led efforts to develop brain stimulation devices (for rodents and humans) that can quantify neural activity and neurotransmitter dynamics in the living brain. This body of work now forms the basis of the neuropsychiatric arm of the Mayo Clinic’s Deep Brain Stimulation Consortium. Her specific research expertise are in utilising voltammetric (electrochemical) recording techniques to monitor rapid, synaptic neurotransmission in the living brain.

Dr. Tye has over ten years of experience studying neuromodulation in preclinical rodent models and human patients. Her long-term goal is to bridge preclinical and clinical studies to maximise translational impact, specifically in terms of improving patient outcomes for those with severe refractory psychiatric illness. Towards this end, she maintains many international collaborations with both clinical and basic science researchers. Dr. Tye also has a longstanding interest in mentoring young scientists to help them expand their skills in preclinical and basic science research and achieve a successful research career.

Availability

Associate Professor Susannah Tye is:
Available for supervision

Qualifications

  • Doctor of Philosophy, Macquarie University

Research interests

  • Deep Brain Stimulation

  • Neuromodulation

  • Depression

  • Bipolar Disorder

  • Stress Disorders

  • Parkinson's Disease

  • Biomarkers

  • Refractory Psychiatric Illness

Research impacts

The Tye group develops and applies novel technologies to modulate neuronal function. This work helps inform our basic understanding of signalling in the brain in both health and disease, with specific implications for understanding and correcting abnormal neuronal activity and neurotransmitter dynamics in chronic, unremitting brain-based illness. Working with both local and international collaborations in across clinical, engineering, and basic science fields, we work towards the long-term goal of translating cutting-edge brain stimulation technologies to the clinic to optimise therapeutic outcomes.

Works

Search Professor Susannah Tye’s works on UQ eSpace

111 works between 2009 and 2025

21 - 40 of 111 works

2022

Journal Article

Contributions of epigenetic inheritance to the predisposition of major psychiatric disorders: Theoretical framework, evidence, and implications

Varela, Roger B., Cararo, José Henrique, Tye, Susannah J., Carvalho, Andre F., Valvassori, Samira S., Fries, Gabriel R. and Quevedo, João (2022). Contributions of epigenetic inheritance to the predisposition of major psychiatric disorders: Theoretical framework, evidence, and implications. Neuroscience and Biobehavioral Reviews, 135 104579, 104579. doi: 10.1016/j.neubiorev.2022.104579

Contributions of epigenetic inheritance to the predisposition of major psychiatric disorders: Theoretical framework, evidence, and implications

2022

Journal Article

Cocaine increases stimulation-evoked serotonin efflux in the nucleus accumbens

Yuen, Jason, Goyal, Abhinav, Rusheen, Aaron E., Kouzani, Abbas Z., Berk, Michael, Kim, Jee Hyun, Tye, Susannah J., Blaha, Charles D., Bennet, Kevin E., Lee, Kendall H., Oh, Yoonbae and Shin, Hojin (2022). Cocaine increases stimulation-evoked serotonin efflux in the nucleus accumbens. Journal of Neurophysiology, 127 (3), 714-724. doi: 10.1152/jn.00420.2021

Cocaine increases stimulation-evoked serotonin efflux in the nucleus accumbens

2022

Journal Article

Dynamic insulin-stimulated mTOR/GSK3 signaling in peripheral immune cells: preliminary evidence for an association with lithium response in bipolar disorder

Tye, Susannah J., Borreggine, Kristin, Price, J. Blair, Sutor, Shari L., Cuéllar-Barboza, Alfredo B., McElroy, Susan L., Biernacka, Joanna M. and Frye, Mark A. (2022). Dynamic insulin-stimulated mTOR/GSK3 signaling in peripheral immune cells: preliminary evidence for an association with lithium response in bipolar disorder. Bipolar Disorders, 24 (1) bdi.13081, 1-9. doi: 10.1111/bdi.13081

Dynamic insulin-stimulated mTOR/GSK3 signaling in peripheral immune cells: preliminary evidence for an association with lithium response in bipolar disorder

2022

Book Chapter

Modeling treatment-resistant depression in the preclinical setting

Tye, Susannah, Yates, Clarissa G. and Postorivo, Danielle (2022). Modeling treatment-resistant depression in the preclinical setting. Managing treatment-resistant depression: road to novel therapeutics. (pp. 61-80) edited by Joao Quevedo, Patricio Riva-Posse and William V. Bobo. Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-12-824067-0.00005-0

Modeling treatment-resistant depression in the preclinical setting

2021

Journal Article

Lithium augmentation of ketamine increases insulin signaling and antidepressant-like active stress coping in a rodent model of treatment-resistant depression

Price, J. Blair, Yates, Clarissa G., Morath, Brooke A., Van De Wakker, Sam K., Yates, Nathanael J., Butters, Kim, Frye, Mark A., McGee, Sean L. and Tye, Susannah J. (2021). Lithium augmentation of ketamine increases insulin signaling and antidepressant-like active stress coping in a rodent model of treatment-resistant depression. Translational Psychiatry, 11 (1) 598, 598. doi: 10.1038/s41398-021-01716-w

Lithium augmentation of ketamine increases insulin signaling and antidepressant-like active stress coping in a rodent model of treatment-resistant depression

2021

Journal Article

Modulating neuroplasticity: lessons learned from antidepressants and emerging novel therapeutics

Yates, Clarissa, Kruse, Jennifer L., Price, J. Blair, Robertson, Avril A. B. and Tye, Susannah J. (2021). Modulating neuroplasticity: lessons learned from antidepressants and emerging novel therapeutics. Current Treatment Options in Psychiatry, 8 (4), 229-257. doi: 10.1007/s40501-021-00249-9

Modulating neuroplasticity: lessons learned from antidepressants and emerging novel therapeutics

2021

Journal Article

Interleukin-8 and lower severity of depression in females, but not males, with treatment-resistant depression

Kruse, Jennifer L., Olmstead, Richard, Hellemann, Gerhard, Breen, Elizabeth C., Tye, Susannah J., Brooks, John O., Wade, Benjamin, Congdon, Eliza, Espinoza, Randall, Narr, Katherine L. and Irwin, Michael R. (2021). Interleukin-8 and lower severity of depression in females, but not males, with treatment-resistant depression. Journal of Psychiatric Research, 140, 350-356. doi: 10.1016/j.jpsychires.2021.06.009

Interleukin-8 and lower severity of depression in females, but not males, with treatment-resistant depression

2021

Journal Article

Mood regulatory actions of active and sham nucleus accumbens deep brain stimulation in antidepressant resistant rats

Kale, Rajas P., Nguyen, Thanh Thanh L., Price, J. Blair, Yates, Nathanael J., Walder, Ken, Berk, Michael, Sillitoe, Roy V., Kouzani, Abbas Z. and Tye, Susannah J. (2021). Mood regulatory actions of active and sham nucleus accumbens deep brain stimulation in antidepressant resistant rats. Frontiers in Human Neuroscience, 15 644921, 644921. doi: 10.3389/fnhum.2021.644921

Mood regulatory actions of active and sham nucleus accumbens deep brain stimulation in antidepressant resistant rats

2021

Journal Article

Cocaine-induced changes in tonic dopamine concentrations measured using multiple-cyclic square wave voltammetry in vivo

Yuen, Jason, Goyal, Abhinav, Rusheen, Aaron E., Kouzani, Abbas Z., Berk, Michael, Kim, Jee Hyun, Tye, Susannah J., Blaha, Charles D., Bennet, Kevin E., Jang, Dong-Pyo, Lee, Kendall H., Shin, Hojin and Oh, Yoonbae (2021). Cocaine-induced changes in tonic dopamine concentrations measured using multiple-cyclic square wave voltammetry in vivo. Frontiers in Pharmacology, 12 705254, 705254. doi: 10.3389/fphar.2021.705254

Cocaine-induced changes in tonic dopamine concentrations measured using multiple-cyclic square wave voltammetry in vivo

2021

Journal Article

Inflammatory mechanisms in Parkinson’s disease: from pathogenesis to targeted therapies

Lee, Stellina Y. H., Yates, Nathanael J. and Tye, Susannah J. (2021). Inflammatory mechanisms in Parkinson’s disease: from pathogenesis to targeted therapies. The Neuroscientist, 28 (5) 1073858421992265, 1073858421992265-506. doi: 10.1177/1073858421992265

Inflammatory mechanisms in Parkinson’s disease: from pathogenesis to targeted therapies

2021

Journal Article

Novel antidepressant approaches for refractory depression

Postorivo, Danielle and Tye, Susannah J. (2021). Novel antidepressant approaches for refractory depression. Current Treatment Options in Psychiatry, 8 (3), 141-157. doi: 10.1007/s40501-021-00246-y

Novel antidepressant approaches for refractory depression

2020

Journal Article

Neurocognitive performance of repeated versus single intravenous subanesthetic ketamine in treatment resistant depression

Shiroma, Paulo R., Thuras, Paul, Wels, Joseph, Albott, C. Sophia, Erbes, Christopher, Tye, Susannah and Lim, Kelvin O. (2020). Neurocognitive performance of repeated versus single intravenous subanesthetic ketamine in treatment resistant depression. Journal of Affective Disorders, 277, 470-477. doi: 10.1016/j.jad.2020.08.058

Neurocognitive performance of repeated versus single intravenous subanesthetic ketamine in treatment resistant depression

2020

Journal Article

Role of epigenetic regulatory enzymes in animal models of mania induced by amphetamine and paradoxical sleep deprivation

Varela, Roger B., Resende, Wilson R., Dal-Pont, Gustavo C., Gava, Fernanda F., Nadas, Gabriella B., Tye, Susannah J., Andersen, Monica L., Quevedo, João and Valvassori, Samira S (2020). Role of epigenetic regulatory enzymes in animal models of mania induced by amphetamine and paradoxical sleep deprivation. European Journal of Neuroscience, 53 (2) ejn.14922, 649-662. doi: 10.1111/ejn.14922

Role of epigenetic regulatory enzymes in animal models of mania induced by amphetamine and paradoxical sleep deprivation

2020

Journal Article

A randomized, double-blind, active placebo-controlled study of efficacy, safety, and durability of repeated vs single subanesthetic ketamine for treatment-resistant depression

Shiroma, Paulo R., Thuras, Paul, Wels, Joseph, Albott, C Sophia, Erbes, Christopher, Tye, Susannah and Lim, Kelvin O. (2020). A randomized, double-blind, active placebo-controlled study of efficacy, safety, and durability of repeated vs single subanesthetic ketamine for treatment-resistant depression. Translational Psychiatry, 10 (1) 206, 206. doi: 10.1038/s41398-020-00897-0

A randomized, double-blind, active placebo-controlled study of efficacy, safety, and durability of repeated vs single subanesthetic ketamine for treatment-resistant depression

2020

Journal Article

HDAC inhibitors reverse mania-like behavior and modulate epigenetic regulatory enzymes in an animal model of mania induced by Ouabain

Varela, Roger B., Resende, Wilson R., Dal-Pont, Gustavo C., Gava, Fernanda F., Tye, Susannah J., Quevedo, João and Valvassori, Samira S. (2020). HDAC inhibitors reverse mania-like behavior and modulate epigenetic regulatory enzymes in an animal model of mania induced by Ouabain. Pharmacology Biochemistry and Behavior, 193 172917, 172917. doi: 10.1016/j.pbb.2020.172917

HDAC inhibitors reverse mania-like behavior and modulate epigenetic regulatory enzymes in an animal model of mania induced by Ouabain

2020

Journal Article

Feasibility study of Stress Management and Resiliency Training (SMART) in patients with major depressive disorder

Seshadri, Ashok, Clark, Matthew M., Kung, Simon, Fuller-Tyszkiewicz, Matthew, Sood, Amit, Dammen, Kristina C., Rico, Jose A., Tye, Susannah J., McGillivray, Jane and Frye, Mark A. (2020). Feasibility study of Stress Management and Resiliency Training (SMART) in patients with major depressive disorder. Primary Care Companion to CNS Disorders, 22 (3) 19m02556. doi: 10.4088/PCC.19m02556

Feasibility study of Stress Management and Resiliency Training (SMART) in patients with major depressive disorder

2020

Journal Article

Brain entropy and neurotrophic molecular markers accompanying clinical improvement after ketamine: preliminary evidence in adolescents with treatment-resistant depression

Roy, Abhrajeet V., Thai, Michelle, Klimes-Dougan, Bonnie, Westlund Schreiner, Mindy, Mueller, Bryon A., Albott, Christina Sophia, Lim, Kelvin O., Fiecas, Mark, Tye, Susannah J. and Cullen, Kathryn R. (2020). Brain entropy and neurotrophic molecular markers accompanying clinical improvement after ketamine: preliminary evidence in adolescents with treatment-resistant depression. Journal of Psychopharmacology, 35 (2), 026988112092820-177. doi: 10.1177/0269881120928203

Brain entropy and neurotrophic molecular markers accompanying clinical improvement after ketamine: preliminary evidence in adolescents with treatment-resistant depression

2020

Journal Article

TinyFSCV: FSCV for the masses

Adams, Scott D., Doeven, Egan H., Tye, Susannah J., Bennet, Kevin E., Berk, Michael and Kouzani, Abbas Z. (2020). TinyFSCV: FSCV for the masses. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 28 (1) 8917694, 133-142. doi: 10.1109/TNSRE.2019.2956479

TinyFSCV: FSCV for the masses

2019

Journal Article

Insulin-stimulated mTOR activation in peripheral blood mononuclear cells associated with early treatment response to lithium augmentation in rodent model of antidepressant-resistance

Walker, Adam J., Price, J. Blair, Borreggine, Kristin, Sutor, Shari L., Gogos, Andrea, McGillivray, Jane A., Frye, Mark A. and Tye, Susannah J. (2019). Insulin-stimulated mTOR activation in peripheral blood mononuclear cells associated with early treatment response to lithium augmentation in rodent model of antidepressant-resistance. Translational Psychiatry, 9 (1) 113, 113. doi: 10.1038/s41398-019-0434-5

Insulin-stimulated mTOR activation in peripheral blood mononuclear cells associated with early treatment response to lithium augmentation in rodent model of antidepressant-resistance

2019

Journal Article

Development of a miniature device for emerging deep brain stimulation paradigms

Adams, Scott D., Bennet, Kevin E., Tye, Susannah J., Berk, Michael and Kouzani, Abbas Z. (2019). Development of a miniature device for emerging deep brain stimulation paradigms. PLoS ONE, 14 (2) e0212554, e0212554. doi: 10.1371/journal.pone.0212554

Development of a miniature device for emerging deep brain stimulation paradigms

Funding

Current funding

  • 2024 - 2026
    Precision Medicine Approaches for Depression and Anxiety
    The Nicol Foundation
    Open grant
  • 2023 - 2026
    Neural circuit control of effort under stress
    ARC Discovery Projects
    Open grant
  • 2021 - 2027
    Biomarker Discovery for Treatment Resistant Mood Disorders
    The Nicol Foundation
    Open grant

Past funding

  • 2023 - 2024
    Intelligent Closed Loop Neuromodulation
    Bionics Queensland Challenge
    Open grant
  • 2023
    Cell-specific control of striatal neurotransmission for mood regulation (project under NHRMC CREDIT Centre of Research Excellence administered by Deakin University)
    Deakin University
    Open grant
  • 2022
    Prefrontal Mechanisms Regulating Striatal Dopamine Release Essential for Persistent Effort
    UQ Foundation Research Excellence Awards
    Open grant
  • 2019 - 2023
    Circuit, cellular and synaptic mechanisms of nucleus accumbens deep brain stimulation
    NHMRC Project Grant
    Open grant
  • 2019
    Common Mechanisms of Anti-Suicidal Drug Action
    UQ Early Career Researcher
    Open grant

Supervision

Availability

Associate Professor Susannah Tye is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort

    Principal Advisor

    Other advisors: Dr Roger Bitencourt Varela

  • Master Philosophy

    Predictive Biobehavioural Markers of Deep Brain Stimulation Efficacy

    Principal Advisor

    Other advisors: Professor Pankaj Sah

  • Doctor Philosophy

    Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort

    Principal Advisor

    Other advisors: Dr Roger Bitencourt Varela

  • Doctor Philosophy

    Neurofeedback an intervention for emotion regulation and attention in children and adolescents that have Down syndrome.

    Principal Advisor

    Other advisors: Professor Rhonda Faragher

  • Master Philosophy

    Predictive Biobehavioural Markers of Deep Brain Stimulation Efficacy

    Principal Advisor

    Other advisors: Professor Pankaj Sah

  • Doctor Philosophy

    Development of precision medicine biomarkers for ketamine as a treatment for TRD and PTSD

    Principal Advisor

    Other advisors: Associate Professor Fatima Nasrallah

  • Doctor Philosophy

    Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort

    Principal Advisor

    Other advisors: Dr Roger Bitencourt Varela

  • Doctor Philosophy

    Immunometabolic Mechanisms of Mood Regulation

    Principal Advisor

    Other advisors: Dr Roger Bitencourt Varela

  • Doctor Philosophy

    Neurofeedback an intervention for emotion regulation and attention in children and adolescents that have Down syndrome.

    Principal Advisor

    Other advisors: Professor Rhonda Faragher

  • Doctor Philosophy

    Modelling neural circuit control of effort under stress

    Associate Advisor

  • Doctor Philosophy

    The development of precision medical care for the use of ketamine as a treatment for Australian Veterans with TRD and PTSD

    Associate Advisor

    Other advisors: Associate Professor Fatima Nasrallah

Completed supervision

Media

Enquiries

For media enquiries about Associate Professor Susannah Tye's areas of expertise, story ideas and help finding experts, contact our Media team:

communications@uq.edu.au