Overview
Background
Dr. Susannah Tye joined the Queensland Brain Institute in 2017 and has established a research program within the Asia Pacific Centre for Neuromodulation (QLD, Australia). Before returning to Australia, Dr. Tye directed the Translational Neuroscience Laboratory at the Mayo Clinic (2012-2017). While there she led efforts to develop brain stimulation devices (for rodents and humans) that can quantify neural activity and neurotransmitter dynamics in the living brain. This body of work now forms the basis of the neuropsychiatric arm of the Mayo Clinic’s Deep Brain Stimulation Consortium. Her specific research expertise are in utilising voltammetric (electrochemical) recording techniques to monitor rapid, synaptic neurotransmission in the living brain.
Dr. Tye has over ten years of experience studying neuromodulation in preclinical rodent models and human patients. Her long-term goal is to bridge preclinical and clinical studies to maximise translational impact, specifically in terms of improving patient outcomes for those with severe refractory psychiatric illness. Towards this end, she maintains many international collaborations with both clinical and basic science researchers. Dr. Tye also has a longstanding interest in mentoring young scientists to help them expand their skills in preclinical and basic science research and achieve a successful research career.
Availability
- Associate Professor Susannah Tye is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Macquarie University
Research interests
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Deep Brain Stimulation
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Neuromodulation
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Depression
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Bipolar Disorder
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Stress Disorders
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Parkinson's Disease
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Biomarkers
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Refractory Psychiatric Illness
Research impacts
The Tye group develops and applies novel technologies to modulate neuronal function. This work helps inform our basic understanding of signalling in the brain in both health and disease, with specific implications for understanding and correcting abnormal neuronal activity and neurotransmitter dynamics in chronic, unremitting brain-based illness. Working with both local and international collaborations in across clinical, engineering, and basic science fields, we work towards the long-term goal of translating cutting-edge brain stimulation technologies to the clinic to optimise therapeutic outcomes.
Works
Search Professor Susannah Tye’s works on UQ eSpace
2020
Journal Article
Neurocognitive performance of repeated versus single intravenous subanesthetic ketamine in treatment resistant depression
Shiroma, Paulo R., Thuras, Paul, Wels, Joseph, Albott, C. Sophia, Erbes, Christopher, Tye, Susannah and Lim, Kelvin O. (2020). Neurocognitive performance of repeated versus single intravenous subanesthetic ketamine in treatment resistant depression. Journal of Affective Disorders, 277, 470-477. doi: 10.1016/j.jad.2020.08.058
2020
Journal Article
Role of epigenetic regulatory enzymes in animal models of mania induced by amphetamine and paradoxical sleep deprivation
Varela, Roger B., Resende, Wilson R., Dal-Pont, Gustavo C., Gava, Fernanda F., Nadas, Gabriella B., Tye, Susannah J., Andersen, Monica L., Quevedo, João and Valvassori, Samira S (2020). Role of epigenetic regulatory enzymes in animal models of mania induced by amphetamine and paradoxical sleep deprivation. European Journal of Neuroscience, 53 (2) ejn.14922, 649-662. doi: 10.1111/ejn.14922
2020
Journal Article
A randomized, double-blind, active placebo-controlled study of efficacy, safety, and durability of repeated vs single subanesthetic ketamine for treatment-resistant depression
Shiroma, Paulo R., Thuras, Paul, Wels, Joseph, Albott, C Sophia, Erbes, Christopher, Tye, Susannah and Lim, Kelvin O. (2020). A randomized, double-blind, active placebo-controlled study of efficacy, safety, and durability of repeated vs single subanesthetic ketamine for treatment-resistant depression. Translational Psychiatry, 10 (1) 206, 206. doi: 10.1038/s41398-020-00897-0
2020
Journal Article
HDAC inhibitors reverse mania-like behavior and modulate epigenetic regulatory enzymes in an animal model of mania induced by Ouabain
Varela, Roger B., Resende, Wilson R., Dal-Pont, Gustavo C., Gava, Fernanda F., Tye, Susannah J., Quevedo, João and Valvassori, Samira S. (2020). HDAC inhibitors reverse mania-like behavior and modulate epigenetic regulatory enzymes in an animal model of mania induced by Ouabain. Pharmacology Biochemistry and Behavior, 193 172917, 172917. doi: 10.1016/j.pbb.2020.172917
2020
Journal Article
Feasibility study of Stress Management and Resiliency Training (SMART) in patients with major depressive disorder
Seshadri, Ashok, Clark, Matthew M., Kung, Simon, Fuller-Tyszkiewicz, Matthew, Sood, Amit, Dammen, Kristina C., Rico, Jose A., Tye, Susannah J., McGillivray, Jane and Frye, Mark A. (2020). Feasibility study of Stress Management and Resiliency Training (SMART) in patients with major depressive disorder. Primary Care Companion to CNS Disorders, 22 (3) 19m02556. doi: 10.4088/PCC.19m02556
2020
Other Outputs
Time course effects of ketamine on treatment-resistant depression (ACTH) in rats
Tye, Susannah (2020). Time course effects of ketamine on treatment-resistant depression (ACTH) in rats. The University of Queensland. (Dataset) doi: 10.48610/55ad988
2020
Journal Article
Brain entropy and neurotrophic molecular markers accompanying clinical improvement after ketamine: preliminary evidence in adolescents with treatment-resistant depression
Roy, Abhrajeet V., Thai, Michelle, Klimes-Dougan, Bonnie, Westlund Schreiner, Mindy, Mueller, Bryon A., Albott, Christina Sophia, Lim, Kelvin O., Fiecas, Mark, Tye, Susannah J. and Cullen, Kathryn R. (2020). Brain entropy and neurotrophic molecular markers accompanying clinical improvement after ketamine: preliminary evidence in adolescents with treatment-resistant depression. Journal of Psychopharmacology, 35 (2), 026988112092820-177. doi: 10.1177/0269881120928203
2020
Journal Article
TinyFSCV: FSCV for the masses
Adams, Scott D., Doeven, Egan H., Tye, Susannah J., Bennet, Kevin E., Berk, Michael and Kouzani, Abbas Z. (2020). TinyFSCV: FSCV for the masses. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 28 (1) 8917694, 133-142. doi: 10.1109/TNSRE.2019.2956479
2019
Journal Article
Insulin-stimulated mTOR activation in peripheral blood mononuclear cells associated with early treatment response to lithium augmentation in rodent model of antidepressant-resistance
Walker, Adam J., Price, J. Blair, Borreggine, Kristin, Sutor, Shari L., Gogos, Andrea, McGillivray, Jane A., Frye, Mark A. and Tye, Susannah J. (2019). Insulin-stimulated mTOR activation in peripheral blood mononuclear cells associated with early treatment response to lithium augmentation in rodent model of antidepressant-resistance. Translational Psychiatry, 9 (1) 113, 113. doi: 10.1038/s41398-019-0434-5
2019
Journal Article
Development of a miniature device for emerging deep brain stimulation paradigms
Adams, Scott D., Bennet, Kevin E., Tye, Susannah J., Berk, Michael and Kouzani, Abbas Z. (2019). Development of a miniature device for emerging deep brain stimulation paradigms. PLoS ONE, 14 (2) e0212554, e0212554. doi: 10.1371/journal.pone.0212554
2019
Journal Article
The role of neurotrophic factors in manic-, anxious- and depressive-like behaviors induced by amphetamine sensitization: implications to the animal model of bipolar disorder
Valvassori, Samira S., Mariot, Edemilson, Varela, Roger B., Bavaresco, Daniela V., Dal-Pont, Gustavo C., Ferreira, Camila L., Andersen, Monica L., Tye, Susannah J. and Quevedo, João (2019). The role of neurotrophic factors in manic-, anxious- and depressive-like behaviors induced by amphetamine sensitization: implications to the animal model of bipolar disorder. Journal of Affective Disorders, 245, 1106-1113. doi: 10.1016/j.jad.2018.10.370
2019
Book Chapter
Mitochondrial function and inflammation pathways in the neuroprogression of mental disorders
Andreazza, Ana C., Kale, Rajas P., Duong, Angela, Molina, Fabio and Tye, Susannah J. (2019). Mitochondrial function and inflammation pathways in the neuroprogression of mental disorders. Neuroprogression in psychiatry. (pp. 35-62) Oxford, United Kingdom: Oxford University Press. doi: 10.1093/med/9780198787143.003.0004
2019
Journal Article
Erratum: Intravenous ketamine for adolescents with treatment-resistant depression: An Open-Label Study, by Cullen KR, Amatya P, Roback MG, Albott CS, Westlund Schreiner M, Ren Y, Eberly LE, Carstedt P, Samikoglu A, Gunlicks-Stoessel M, Reigstad K, Horek N, Tye S, Lim KO, Klimes-Dougan B. (J Child Adolesc Psychopharmacol (2018) 28:7 (437-444) DOI: 10.1089/cap.2018.0030)
Cullen, K. R., Amatya, P., Roback, M. G., Albott, C. S., Westlund Schreiner, M., Ren, Y., Eberly, L. E., Carstedt, P., Samikoglu, A., Gunlicks-Stoessel, M., Reigstad, K., Horek, N., Tye, S., Lim, K. O. and Klimes-Dougan, B. (2019). Erratum: Intravenous ketamine for adolescents with treatment-resistant depression: An Open-Label Study, by Cullen KR, Amatya P, Roback MG, Albott CS, Westlund Schreiner M, Ren Y, Eberly LE, Carstedt P, Samikoglu A, Gunlicks-Stoessel M, Reigstad K, Horek N, Tye S, Lim KO, Klimes-Dougan B. (J Child Adolesc Psychopharmacol (2018) 28:7 (437-444) DOI: 10.1089/cap.2018.0030). Journal of Child and Adolescent Psychopharmacology, 29 (1), 77-77. doi: 10.1089/cap.2018.0030.correx
2019
Conference Publication
Molecular, cellular, and bioenergetic actions of ketamine and lithium combinatorial treatment in antidepressant resistant rats
Blair, Joshua, Morath, Brooke, Butters, Kim, Frye, Mark, McGee, Sean and Tye, Susannah (2019). Molecular, cellular, and bioenergetic actions of ketamine and lithium combinatorial treatment in antidepressant resistant rats. 58th Annual Meeting of the American College of Neuropsychopharmacology , Orlando, Florida, 8-11 December 2019 . London, United Kingdom: Nature Publishing Group.
2019
Other Outputs
Manipulating ghrelin tone for stress resilience
Tye, Susannah (2019). Manipulating ghrelin tone for stress resilience. The University of Queensland. (Dataset) doi: 10.48610/7a58088
2019
Conference Publication
Antidepressant and antimanic effects of deep brain stimulation of the ventral tegmental area
Varella, R. B., Boschen, S. L., Blaha, C. D., Chye, N., Ghandi, K., Valvassori, S. S. and Tye, S. J. (2019). Antidepressant and antimanic effects of deep brain stimulation of the ventral tegmental area. 21st Annual ISBD Conference on Global Advances in Bipolar Disorder and Depression, Sydney Australia, Mar 20-23, 2019. HOBOKEN: WILEY. doi: 10.1111/bdi.12745
2018
Journal Article
Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders
Ahmed, T. Ahmed, Frye, Mark A., Rush, A. John, Biernacka, Joanna M., Craighead, W. Edward, McDonald, William M., Bobo, William V., Riva-Posse, Patricio, Tye, Susannah J., Mayberg, Helen S., Hall-Flavin, Daniel K., Skime, Michelle K., Jenkins, Greg D., Wang, Liewei, Krishnan, Ranga Rama, Weinshilboum, Richard M., Kaddurah-Daouk, Rima and Dunlop, Boadie W. (2018). Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders. Journal of Affective Disorders, 238, 1-7. doi: 10.1016/j.jad.2018.05.005
2018
Journal Article
Intravenous ketamine for adolescents with treatment-resistant depression: an open-label study
Cullen, Kathryn R., Amatya, Palistha, Roback, Mark G., Albott, Christina Sophia, Westlund Schreiner, Melinda, Ren, Yanan, Eberly, Lynn E., Carstedt, Patricia, Samikoglu, Ali, Gunlicks-Stoessel, Meredith, Reigstad, Kristina, Horek, Nathan, Tye, Susannah, Lim, Kelvin O. and Klimes-Dougan, Bonnie (2018). Intravenous ketamine for adolescents with treatment-resistant depression: an open-label study. Journal of Child and Adolescent Psychopharmacology, 28 (7), 437-444. doi: 10.1089/cap.2018.0030
2018
Journal Article
A review of brain insulin signaling in mood disorders: from biomarker to clinical target
Nguyen, Thanh Thanh L., Chan, Lily C., Borreginne, Kristin, Kale, Rajas P., Hu, Chunling and Tye, Susannah J. (2018). A review of brain insulin signaling in mood disorders: from biomarker to clinical target. Neuroscience & Biobehavioral Reviews, 92, 7-15. doi: 10.1016/j.neubiorev.2018.05.014
2018
Journal Article
Corrigendum to “Continuation phase intravenous ketamine in adults with treatment-resistant depression” [J. Affect. Disord. 206 (2016) 300–304]
Vande Voort, Jennifer L., Morgan, Robert J., Kung, Simon, Rasmussen, Keith G., Rico, Jose, Palmer, Brian A., Schak, Kathryn M., Tye, Susannah J., Ritter, Matthew J., Frye, Mark A. and Bobo, William V. (2018). Corrigendum to “Continuation phase intravenous ketamine in adults with treatment-resistant depression” [J. Affect. Disord. 206 (2016) 300–304]. Journal of Affective Disorders, 236, 313-313. doi: 10.1016/j.jad.2017.09.024
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Susannah Tye is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Neurofeedback an intervention for emotion regulation and attention in children and adolescents that have Down syndrome.
Principal Advisor
Other advisors: Professor Rhonda Faragher
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Master Philosophy
Predictive Biobehavioural Markers of Deep Brain Stimulation Efficacy
Principal Advisor
Other advisors: Professor Pankaj Sah
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Doctor Philosophy
Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
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Doctor Philosophy
Development of precision medicine biomarkers for ketamine as a treatment for TRD and PTSD
Principal Advisor
Other advisors: Professor Fatima Nasrallah
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Doctor Philosophy
The development of precision medical care for the use of ketamine as a treatment for Australian Veterans with TRD and PTSD
Associate Advisor
Other advisors: Professor Fatima Nasrallah
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Master Philosophy
Biopsychosocial Adaptations and Early OperationalOutcomes: Longitudinal Neurophysiological tracking of Police Recruits' transition to Operational Policing
Associate Advisor
Other advisors: Associate Professor Sarah Bennett
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Doctor Philosophy
Modelling neural circuit control of effort under stress
Associate Advisor
Completed supervision
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2026
Doctor Philosophy
Circadian mechanisms of mood regulation
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
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2023
Doctor Philosophy
Biomarkers of Treatment-Resistant Depression and Predictors of Antidepressant Response
Principal Advisor
Other advisors: Professor Avril Robertson
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2023
Doctor Philosophy
Targeting NLRP3 and Dopamine Receptors for Treatment Resistant Depression
Associate Advisor
Other advisors: Professor Avril Robertson
Media
Enquiries
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