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Associate Professor Susannah Tye
Associate Professor

Susannah Tye

Email: 
Phone: 
+61 7 344 32493

Overview

Background

Dr. Susannah Tye joined the Queensland Brain Institute in 2017 and has established a research program within the Asia Pacific Centre for Neuromodulation (QLD, Australia). Before returning to Australia, Dr. Tye directed the Translational Neuroscience Laboratory at the Mayo Clinic (2012-2017). While there she led efforts to develop brain stimulation devices (for rodents and humans) that can quantify neural activity and neurotransmitter dynamics in the living brain. This body of work now forms the basis of the neuropsychiatric arm of the Mayo Clinic’s Deep Brain Stimulation Consortium. Her specific research expertise are in utilising voltammetric (electrochemical) recording techniques to monitor rapid, synaptic neurotransmission in the living brain.

Dr. Tye has over ten years of experience studying neuromodulation in preclinical rodent models and human patients. Her long-term goal is to bridge preclinical and clinical studies to maximise translational impact, specifically in terms of improving patient outcomes for those with severe refractory psychiatric illness. Towards this end, she maintains many international collaborations with both clinical and basic science researchers. Dr. Tye also has a longstanding interest in mentoring young scientists to help them expand their skills in preclinical and basic science research and achieve a successful research career.

Availability

Associate Professor Susannah Tye is:
Available for supervision

Qualifications

  • Doctor of Philosophy, Macquarie University

Research interests

  • Deep Brain Stimulation

  • Neuromodulation

  • Depression

  • Bipolar Disorder

  • Stress Disorders

  • Parkinson's Disease

  • Biomarkers

  • Refractory Psychiatric Illness

Research impacts

The Tye group develops and applies novel technologies to modulate neuronal function. This work helps inform our basic understanding of signalling in the brain in both health and disease, with specific implications for understanding and correcting abnormal neuronal activity and neurotransmitter dynamics in chronic, unremitting brain-based illness. Working with both local and international collaborations in across clinical, engineering, and basic science fields, we work towards the long-term goal of translating cutting-edge brain stimulation technologies to the clinic to optimise therapeutic outcomes.

Works

Search Professor Susannah Tye’s works on UQ eSpace

111 works between 2009 and 2025

41 - 60 of 111 works

2019

Journal Article

The role of neurotrophic factors in manic-, anxious- and depressive-like behaviors induced by amphetamine sensitization: implications to the animal model of bipolar disorder

Valvassori, Samira S., Mariot, Edemilson, Varela, Roger B., Bavaresco, Daniela V., Dal-Pont, Gustavo C., Ferreira, Camila L., Andersen, Monica L., Tye, Susannah J. and Quevedo, João (2019). The role of neurotrophic factors in manic-, anxious- and depressive-like behaviors induced by amphetamine sensitization: implications to the animal model of bipolar disorder. Journal of Affective Disorders, 245, 1106-1113. doi: 10.1016/j.jad.2018.10.370

The role of neurotrophic factors in manic-, anxious- and depressive-like behaviors induced by amphetamine sensitization: implications to the animal model of bipolar disorder

2019

Book Chapter

Mitochondrial function and inflammation pathways in the neuroprogression of mental disorders

Andreazza, Ana C., Kale, Rajas P., Duong, Angela, Molina, Fabio and Tye, Susannah J. (2019). Mitochondrial function and inflammation pathways in the neuroprogression of mental disorders. Neuroprogression in psychiatry. (pp. 35-62) Oxford, United Kingdom: Oxford University Press. doi: 10.1093/med/9780198787143.003.0004

Mitochondrial function and inflammation pathways in the neuroprogression of mental disorders

2019

Journal Article

Erratum: Intravenous ketamine for adolescents with treatment-resistant depression: An Open-Label Study, by Cullen KR, Amatya P, Roback MG, Albott CS, Westlund Schreiner M, Ren Y, Eberly LE, Carstedt P, Samikoglu A, Gunlicks-Stoessel M, Reigstad K, Horek N, Tye S, Lim KO, Klimes-Dougan B. (J Child Adolesc Psychopharmacol (2018) 28:7 (437-444) DOI: 10.1089/cap.2018.0030)

Cullen, K. R., Amatya, P., Roback, M. G., Albott, C. S., Westlund Schreiner, M., Ren, Y., Eberly, L. E., Carstedt, P., Samikoglu, A., Gunlicks-Stoessel, M., Reigstad, K., Horek, N., Tye, S., Lim, K. O. and Klimes-Dougan, B. (2019). Erratum: Intravenous ketamine for adolescents with treatment-resistant depression: An Open-Label Study, by Cullen KR, Amatya P, Roback MG, Albott CS, Westlund Schreiner M, Ren Y, Eberly LE, Carstedt P, Samikoglu A, Gunlicks-Stoessel M, Reigstad K, Horek N, Tye S, Lim KO, Klimes-Dougan B. (J Child Adolesc Psychopharmacol (2018) 28:7 (437-444) DOI: 10.1089/cap.2018.0030). Journal of Child and Adolescent Psychopharmacology, 29 (1), 77-77. doi: 10.1089/cap.2018.0030.correx

Erratum: Intravenous ketamine for adolescents with treatment-resistant depression: An Open-Label Study, by Cullen KR, Amatya P, Roback MG, Albott CS, Westlund Schreiner M, Ren Y, Eberly LE, Carstedt P, Samikoglu A, Gunlicks-Stoessel M, Reigstad K, Horek N, Tye S, Lim KO, Klimes-Dougan B. (J Child Adolesc Psychopharmacol (2018) 28:7 (437-444) DOI: 10.1089/cap.2018.0030)

2019

Conference Publication

Molecular, cellular, and bioenergetic actions of ketamine and lithium combinatorial treatment in antidepressant resistant rats

Blair, Joshua, Morath, Brooke, Butters, Kim, Frye, Mark, McGee, Sean and Tye, Susannah (2019). Molecular, cellular, and bioenergetic actions of ketamine and lithium combinatorial treatment in antidepressant resistant rats. 58th Annual Meeting of the American College of Neuropsychopharmacology , Orlando, Florida, 8-11 December 2019 . London, United Kingdom: Nature Publishing Group.

Molecular, cellular, and bioenergetic actions of ketamine and lithium combinatorial treatment in antidepressant resistant rats

2019

Other Outputs

Manipulating ghrelin tone for stress resilience

Tye, Susannah (2019). Manipulating ghrelin tone for stress resilience. The University of Queensland. (Dataset) doi: 10.48610/7a58088

Manipulating ghrelin tone for stress resilience

2019

Conference Publication

Antidepressant and antimanic effects of deep brain stimulation of the ventral tegmental area

Varella, R. B., Boschen, S. L., Blaha, C. D., Chye, N., Ghandi, K., Valvassori, S. S. and Tye, S. J. (2019). Antidepressant and antimanic effects of deep brain stimulation of the ventral tegmental area. 21st Annual ISBD Conference on Global Advances in Bipolar Disorder and Depression, Sydney Australia, Mar 20-23, 2019. HOBOKEN: WILEY. doi: 10.1111/bdi.12745

Antidepressant and antimanic effects of deep brain stimulation of the ventral tegmental area

2018

Journal Article

Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders

Ahmed, T. Ahmed, Frye, Mark A., Rush, A. John, Biernacka, Joanna M., Craighead, W. Edward, McDonald, William M., Bobo, William V., Riva-Posse, Patricio, Tye, Susannah J., Mayberg, Helen S., Hall-Flavin, Daniel K., Skime, Michelle K., Jenkins, Greg D., Wang, Liewei, Krishnan, Ranga Rama, Weinshilboum, Richard M., Kaddurah-Daouk, Rima and Dunlop, Boadie W. (2018). Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders. Journal of Affective Disorders, 238, 1-7. doi: 10.1016/j.jad.2018.05.005

Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders

2018

Journal Article

A review of brain insulin signaling in mood disorders: from biomarker to clinical target

Nguyen, Thanh Thanh L., Chan, Lily C., Borreginne, Kristin, Kale, Rajas P., Hu, Chunling and Tye, Susannah J. (2018). A review of brain insulin signaling in mood disorders: from biomarker to clinical target. Neuroscience & Biobehavioral Reviews, 92, 7-15. doi: 10.1016/j.neubiorev.2018.05.014

A review of brain insulin signaling in mood disorders: from biomarker to clinical target

2018

Journal Article

Intravenous ketamine for adolescents with treatment-resistant depression: an open-label study

Cullen, Kathryn R., Amatya, Palistha, Roback, Mark G., Albott, Christina Sophia, Westlund Schreiner, Melinda, Ren, Yanan, Eberly, Lynn E., Carstedt, Patricia, Samikoglu, Ali, Gunlicks-Stoessel, Meredith, Reigstad, Kristina, Horek, Nathan, Tye, Susannah, Lim, Kelvin O. and Klimes-Dougan, Bonnie (2018). Intravenous ketamine for adolescents with treatment-resistant depression: an open-label study. Journal of Child and Adolescent Psychopharmacology, 28 (7), 437-444. doi: 10.1089/cap.2018.0030

Intravenous ketamine for adolescents with treatment-resistant depression: an open-label study

2018

Journal Article

Corrigendum to “Continuation phase intravenous ketamine in adults with treatment-resistant depression” [J. Affect. Disord. 206 (2016) 300–304]

Vande Voort, Jennifer L., Morgan, Robert J., Kung, Simon, Rasmussen, Keith G., Rico, Jose, Palmer, Brian A., Schak, Kathryn M., Tye, Susannah J., Ritter, Matthew J., Frye, Mark A. and Bobo, William V. (2018). Corrigendum to “Continuation phase intravenous ketamine in adults with treatment-resistant depression” [J. Affect. Disord. 206 (2016) 300–304]. Journal of Affective Disorders, 236, 313-313. doi: 10.1016/j.jad.2017.09.024

Corrigendum to “Continuation phase intravenous ketamine in adults with treatment-resistant depression” [J. Affect. Disord. 206 (2016) 300–304]

2018

Journal Article

Bioenergetics and synaptic plasticity as potential targets for individualizing treatment for depression

Price, J. Blair, Bronars, Carrie, Erhardt, Sophie, Cullen, Kathyrn R., Schwieler, Lilly, Berk, Michael, Walder, Ken, McGee, Sean L., Frye, Mark A. and Tye, Susannah J. (2018). Bioenergetics and synaptic plasticity as potential targets for individualizing treatment for depression. Neuroscience and Biobehavioral Reviews, 90, 212-220. doi: 10.1016/j.neubiorev.2018.04.002

Bioenergetics and synaptic plasticity as potential targets for individualizing treatment for depression

2018

Journal Article

Adolescent mental health education InSciEd Out: a case study of an alternative middle school population

Yang, Joanna, Lopez Cervera, Roberto, Tye, Susannah J., Ekker, Stephen C. and Pierret, Chris (2018). Adolescent mental health education InSciEd Out: a case study of an alternative middle school population. Journal of Translational Medicine, 16 (1) 84, 84. doi: 10.1186/s12967-018-1459-x

Adolescent mental health education InSciEd Out: a case study of an alternative middle school population

2018

Journal Article

An investigation into closed-loop treatment of neurological disorders based on sensing mitochondrial dysfunction

Adams, Scott D., Kouzani, Abbas Z., Tye, Susannah J., Bennet, Kevin E. and Berk, Michael (2018). An investigation into closed-loop treatment of neurological disorders based on sensing mitochondrial dysfunction. Journal of NeuroEngineering and Rehabilitation, 15 (1) 8, 8. doi: 10.1186/s12984-018-0349-z

An investigation into closed-loop treatment of neurological disorders based on sensing mitochondrial dysfunction

2018

Journal Article

Towards miniaturized closed-loop optogenetic stimulation devices

Edward, Epsy S, Kouzani, Abbas Z. and Tye, Susannah J (2018). Towards miniaturized closed-loop optogenetic stimulation devices. Journal of Neural Engineering, 15 (2) 021002, 021002. doi: 10.1088/1741-2552/aa7d62

Towards miniaturized closed-loop optogenetic stimulation devices

2018

Journal Article

The role of hypernitrosylation in the pathogenesis and pathophysiology of neuroprogressive diseases

Morris, Gerwyn, Walder, Ken, Carvalho, André F., Tye, Susannah J., Lucas, Kurt, Berk, Michael and Maes, Michael (2018). The role of hypernitrosylation in the pathogenesis and pathophysiology of neuroprogressive diseases. Neuroscience and Biobehavioral Reviews, 84, 453-469. doi: 10.1016/j.neubiorev.2017.07.017

The role of hypernitrosylation in the pathogenesis and pathophysiology of neuroprogressive diseases

2018

Journal Article

Favorable impact on stress-related behaviors by modulating plasma Butyrylcholinesterase

Brimijoin, Stephen and Tye, Susannah (2018). Favorable impact on stress-related behaviors by modulating plasma Butyrylcholinesterase. Cellular and Molecular Neurobiology, 38 (1), 7-12. doi: 10.1007/s10571-017-0523-z

Favorable impact on stress-related behaviors by modulating plasma Butyrylcholinesterase

2017

Journal Article

Validation of a portable low-power deep brain stimulation device through anxiolytic effects in a laboratory rat model

Kouzani, Abbas Z., Kale, Rajas P., Zarate-Garza, Pablo Patricio, Berk, Michael, Walder, Ken and Tye, Susannah J. (2017). Validation of a portable low-power deep brain stimulation device through anxiolytic effects in a laboratory rat model. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 25 (9) 7744659, 1365-1374. doi: 10.1109/TNSRE.2016.2628760

Validation of a portable low-power deep brain stimulation device through anxiolytic effects in a laboratory rat model

2017

Journal Article

Hierarchical estimation of neural activity through explicit identification of temporally synchronous spikes

Veerabhadrappa, R., Bhatti, A., Berk, Michael, Tye, S. J. and Nahavandi, S. (2017). Hierarchical estimation of neural activity through explicit identification of temporally synchronous spikes. Neurocomputing, 249, 299-313. doi: 10.1016/j.neucom.2016.09.135

Hierarchical estimation of neural activity through explicit identification of temporally synchronous spikes

2017

Journal Article

Fostering resilience among mothers under stress: "Authentic Connections Groups" for medical professionals

Luthar, Suniya S., Curlee, Alexandria, Tye, Susannah J., Engelman, Judith C. and Stonnington, Cynthia M. (2017). Fostering resilience among mothers under stress: "Authentic Connections Groups" for medical professionals. Women's Health Issues, 27 (3), 382-390. doi: 10.1016/j.whi.2017.02.007

Fostering resilience among mothers under stress: "Authentic Connections Groups" for medical professionals

2017

Journal Article

A model of the mitochondrial basis of bipolar disorder

Morris, Gerwyn, Walder, Ken, McGee, Sean L., Dean, Olivia M., Tye, Susannah J., Maes, Michael and Berk, Michael (2017). A model of the mitochondrial basis of bipolar disorder. Neuroscience and Biobehavioral Reviews, 74, 1-20. doi: 10.1016/j.neubiorev.2017.01.014

A model of the mitochondrial basis of bipolar disorder

Funding

Current funding

  • 2024 - 2026
    Precision Medicine Approaches for Depression and Anxiety
    The Nicol Foundation
    Open grant
  • 2023 - 2026
    Neural circuit control of effort under stress
    ARC Discovery Projects
    Open grant
  • 2021 - 2027
    Biomarker Discovery for Treatment Resistant Mood Disorders
    The Nicol Foundation
    Open grant

Past funding

  • 2023 - 2024
    Intelligent Closed Loop Neuromodulation
    Bionics Queensland Challenge
    Open grant
  • 2023
    Cell-specific control of striatal neurotransmission for mood regulation (project under NHRMC CREDIT Centre of Research Excellence administered by Deakin University)
    Deakin University
    Open grant
  • 2022
    Prefrontal Mechanisms Regulating Striatal Dopamine Release Essential for Persistent Effort
    UQ Foundation Research Excellence Awards
    Open grant
  • 2019 - 2023
    Circuit, cellular and synaptic mechanisms of nucleus accumbens deep brain stimulation
    NHMRC Project Grant
    Open grant
  • 2019
    Common Mechanisms of Anti-Suicidal Drug Action
    UQ Early Career Researcher
    Open grant

Supervision

Availability

Associate Professor Susannah Tye is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort

    Principal Advisor

    Other advisors: Dr Roger Bitencourt Varela

  • Master Philosophy

    Predictive Biobehavioural Markers of Deep Brain Stimulation Efficacy

    Principal Advisor

    Other advisors: Professor Pankaj Sah

  • Doctor Philosophy

    Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort

    Principal Advisor

    Other advisors: Dr Roger Bitencourt Varela

  • Doctor Philosophy

    Neurofeedback an intervention for emotion regulation and attention in children and adolescents that have Down syndrome.

    Principal Advisor

    Other advisors: Professor Rhonda Faragher

  • Master Philosophy

    Predictive Biobehavioural Markers of Deep Brain Stimulation Efficacy

    Principal Advisor

    Other advisors: Professor Pankaj Sah

  • Doctor Philosophy

    Development of precision medicine biomarkers for ketamine as a treatment for TRD and PTSD

    Principal Advisor

    Other advisors: Associate Professor Fatima Nasrallah

  • Doctor Philosophy

    Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort

    Principal Advisor

    Other advisors: Dr Roger Bitencourt Varela

  • Doctor Philosophy

    Immunometabolic Mechanisms of Mood Regulation

    Principal Advisor

    Other advisors: Dr Roger Bitencourt Varela

  • Doctor Philosophy

    Neurofeedback an intervention for emotion regulation and attention in children and adolescents that have Down syndrome.

    Principal Advisor

    Other advisors: Professor Rhonda Faragher

  • Doctor Philosophy

    Modelling neural circuit control of effort under stress

    Associate Advisor

  • Doctor Philosophy

    The development of precision medical care for the use of ketamine as a treatment for Australian Veterans with TRD and PTSD

    Associate Advisor

    Other advisors: Associate Professor Fatima Nasrallah

Completed supervision

Media

Enquiries

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