
Overview
Background
Dr. Susannah Tye joined the Queensland Brain Institute in 2017 and has established a research program within the Asia Pacific Centre for Neuromodulation (QLD, Australia). Before returning to Australia, Dr. Tye directed the Translational Neuroscience Laboratory at the Mayo Clinic (2012-2017). While there she led efforts to develop brain stimulation devices (for rodents and humans) that can quantify neural activity and neurotransmitter dynamics in the living brain. This body of work now forms the basis of the neuropsychiatric arm of the Mayo Clinic’s Deep Brain Stimulation Consortium. Her specific research expertise are in utilising voltammetric (electrochemical) recording techniques to monitor rapid, synaptic neurotransmission in the living brain.
Dr. Tye has over ten years of experience studying neuromodulation in preclinical rodent models and human patients. Her long-term goal is to bridge preclinical and clinical studies to maximise translational impact, specifically in terms of improving patient outcomes for those with severe refractory psychiatric illness. Towards this end, she maintains many international collaborations with both clinical and basic science researchers. Dr. Tye also has a longstanding interest in mentoring young scientists to help them expand their skills in preclinical and basic science research and achieve a successful research career.
Availability
- Associate Professor Susannah Tye is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Macquarie University
Research interests
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Deep Brain Stimulation
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Neuromodulation
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Depression
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Bipolar Disorder
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Stress Disorders
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Parkinson's Disease
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Biomarkers
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Refractory Psychiatric Illness
Research impacts
The Tye group develops and applies novel technologies to modulate neuronal function. This work helps inform our basic understanding of signalling in the brain in both health and disease, with specific implications for understanding and correcting abnormal neuronal activity and neurotransmitter dynamics in chronic, unremitting brain-based illness. Working with both local and international collaborations in across clinical, engineering, and basic science fields, we work towards the long-term goal of translating cutting-edge brain stimulation technologies to the clinic to optimise therapeutic outcomes.
Works
Search Professor Susannah Tye’s works on UQ eSpace
2019
Journal Article
The role of neurotrophic factors in manic-, anxious- and depressive-like behaviors induced by amphetamine sensitization: implications to the animal model of bipolar disorder
Valvassori, Samira S., Mariot, Edemilson, Varela, Roger B., Bavaresco, Daniela V., Dal-Pont, Gustavo C., Ferreira, Camila L., Andersen, Monica L., Tye, Susannah J. and Quevedo, João (2019). The role of neurotrophic factors in manic-, anxious- and depressive-like behaviors induced by amphetamine sensitization: implications to the animal model of bipolar disorder. Journal of Affective Disorders, 245, 1106-1113. doi: 10.1016/j.jad.2018.10.370
2019
Book Chapter
Mitochondrial function and inflammation pathways in the neuroprogression of mental disorders
Andreazza, Ana C., Kale, Rajas P., Duong, Angela, Molina, Fabio and Tye, Susannah J. (2019). Mitochondrial function and inflammation pathways in the neuroprogression of mental disorders. Neuroprogression in psychiatry. (pp. 35-62) Oxford, United Kingdom: Oxford University Press. doi: 10.1093/med/9780198787143.003.0004
2019
Journal Article
Erratum: Intravenous ketamine for adolescents with treatment-resistant depression: An Open-Label Study, by Cullen KR, Amatya P, Roback MG, Albott CS, Westlund Schreiner M, Ren Y, Eberly LE, Carstedt P, Samikoglu A, Gunlicks-Stoessel M, Reigstad K, Horek N, Tye S, Lim KO, Klimes-Dougan B. (J Child Adolesc Psychopharmacol (2018) 28:7 (437-444) DOI: 10.1089/cap.2018.0030)
Cullen, K. R., Amatya, P., Roback, M. G., Albott, C. S., Westlund Schreiner, M., Ren, Y., Eberly, L. E., Carstedt, P., Samikoglu, A., Gunlicks-Stoessel, M., Reigstad, K., Horek, N., Tye, S., Lim, K. O. and Klimes-Dougan, B. (2019). Erratum: Intravenous ketamine for adolescents with treatment-resistant depression: An Open-Label Study, by Cullen KR, Amatya P, Roback MG, Albott CS, Westlund Schreiner M, Ren Y, Eberly LE, Carstedt P, Samikoglu A, Gunlicks-Stoessel M, Reigstad K, Horek N, Tye S, Lim KO, Klimes-Dougan B. (J Child Adolesc Psychopharmacol (2018) 28:7 (437-444) DOI: 10.1089/cap.2018.0030). Journal of Child and Adolescent Psychopharmacology, 29 (1), 77-77. doi: 10.1089/cap.2018.0030.correx
2019
Conference Publication
Molecular, cellular, and bioenergetic actions of ketamine and lithium combinatorial treatment in antidepressant resistant rats
Blair, Joshua, Morath, Brooke, Butters, Kim, Frye, Mark, McGee, Sean and Tye, Susannah (2019). Molecular, cellular, and bioenergetic actions of ketamine and lithium combinatorial treatment in antidepressant resistant rats. 58th Annual Meeting of the American College of Neuropsychopharmacology , Orlando, Florida, 8-11 December 2019 . London, United Kingdom: Nature Publishing Group.
2019
Other Outputs
Manipulating ghrelin tone for stress resilience
Tye, Susannah (2019). Manipulating ghrelin tone for stress resilience. The University of Queensland. (Dataset) doi: 10.48610/7a58088
2019
Conference Publication
Antidepressant and antimanic effects of deep brain stimulation of the ventral tegmental area
Varella, R. B., Boschen, S. L., Blaha, C. D., Chye, N., Ghandi, K., Valvassori, S. S. and Tye, S. J. (2019). Antidepressant and antimanic effects of deep brain stimulation of the ventral tegmental area. 21st Annual ISBD Conference on Global Advances in Bipolar Disorder and Depression, Sydney Australia, Mar 20-23, 2019. HOBOKEN: WILEY. doi: 10.1111/bdi.12745
2018
Journal Article
Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders
Ahmed, T. Ahmed, Frye, Mark A., Rush, A. John, Biernacka, Joanna M., Craighead, W. Edward, McDonald, William M., Bobo, William V., Riva-Posse, Patricio, Tye, Susannah J., Mayberg, Helen S., Hall-Flavin, Daniel K., Skime, Michelle K., Jenkins, Greg D., Wang, Liewei, Krishnan, Ranga Rama, Weinshilboum, Richard M., Kaddurah-Daouk, Rima and Dunlop, Boadie W. (2018). Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders. Journal of Affective Disorders, 238, 1-7. doi: 10.1016/j.jad.2018.05.005
2018
Journal Article
A review of brain insulin signaling in mood disorders: from biomarker to clinical target
Nguyen, Thanh Thanh L., Chan, Lily C., Borreginne, Kristin, Kale, Rajas P., Hu, Chunling and Tye, Susannah J. (2018). A review of brain insulin signaling in mood disorders: from biomarker to clinical target. Neuroscience & Biobehavioral Reviews, 92, 7-15. doi: 10.1016/j.neubiorev.2018.05.014
2018
Journal Article
Intravenous ketamine for adolescents with treatment-resistant depression: an open-label study
Cullen, Kathryn R., Amatya, Palistha, Roback, Mark G., Albott, Christina Sophia, Westlund Schreiner, Melinda, Ren, Yanan, Eberly, Lynn E., Carstedt, Patricia, Samikoglu, Ali, Gunlicks-Stoessel, Meredith, Reigstad, Kristina, Horek, Nathan, Tye, Susannah, Lim, Kelvin O. and Klimes-Dougan, Bonnie (2018). Intravenous ketamine for adolescents with treatment-resistant depression: an open-label study. Journal of Child and Adolescent Psychopharmacology, 28 (7), 437-444. doi: 10.1089/cap.2018.0030
2018
Journal Article
Corrigendum to “Continuation phase intravenous ketamine in adults with treatment-resistant depression” [J. Affect. Disord. 206 (2016) 300–304]
Vande Voort, Jennifer L., Morgan, Robert J., Kung, Simon, Rasmussen, Keith G., Rico, Jose, Palmer, Brian A., Schak, Kathryn M., Tye, Susannah J., Ritter, Matthew J., Frye, Mark A. and Bobo, William V. (2018). Corrigendum to “Continuation phase intravenous ketamine in adults with treatment-resistant depression” [J. Affect. Disord. 206 (2016) 300–304]. Journal of Affective Disorders, 236, 313-313. doi: 10.1016/j.jad.2017.09.024
2018
Journal Article
Bioenergetics and synaptic plasticity as potential targets for individualizing treatment for depression
Price, J. Blair, Bronars, Carrie, Erhardt, Sophie, Cullen, Kathyrn R., Schwieler, Lilly, Berk, Michael, Walder, Ken, McGee, Sean L., Frye, Mark A. and Tye, Susannah J. (2018). Bioenergetics and synaptic plasticity as potential targets for individualizing treatment for depression. Neuroscience and Biobehavioral Reviews, 90, 212-220. doi: 10.1016/j.neubiorev.2018.04.002
2018
Journal Article
Adolescent mental health education InSciEd Out: a case study of an alternative middle school population
Yang, Joanna, Lopez Cervera, Roberto, Tye, Susannah J., Ekker, Stephen C. and Pierret, Chris (2018). Adolescent mental health education InSciEd Out: a case study of an alternative middle school population. Journal of Translational Medicine, 16 (1) 84, 84. doi: 10.1186/s12967-018-1459-x
2018
Journal Article
An investigation into closed-loop treatment of neurological disorders based on sensing mitochondrial dysfunction
Adams, Scott D., Kouzani, Abbas Z., Tye, Susannah J., Bennet, Kevin E. and Berk, Michael (2018). An investigation into closed-loop treatment of neurological disorders based on sensing mitochondrial dysfunction. Journal of NeuroEngineering and Rehabilitation, 15 (1) 8, 8. doi: 10.1186/s12984-018-0349-z
2018
Journal Article
Towards miniaturized closed-loop optogenetic stimulation devices
Edward, Epsy S, Kouzani, Abbas Z. and Tye, Susannah J (2018). Towards miniaturized closed-loop optogenetic stimulation devices. Journal of Neural Engineering, 15 (2) 021002, 021002. doi: 10.1088/1741-2552/aa7d62
2018
Journal Article
The role of hypernitrosylation in the pathogenesis and pathophysiology of neuroprogressive diseases
Morris, Gerwyn, Walder, Ken, Carvalho, André F., Tye, Susannah J., Lucas, Kurt, Berk, Michael and Maes, Michael (2018). The role of hypernitrosylation in the pathogenesis and pathophysiology of neuroprogressive diseases. Neuroscience and Biobehavioral Reviews, 84, 453-469. doi: 10.1016/j.neubiorev.2017.07.017
2018
Journal Article
Favorable impact on stress-related behaviors by modulating plasma Butyrylcholinesterase
Brimijoin, Stephen and Tye, Susannah (2018). Favorable impact on stress-related behaviors by modulating plasma Butyrylcholinesterase. Cellular and Molecular Neurobiology, 38 (1), 7-12. doi: 10.1007/s10571-017-0523-z
2017
Journal Article
Validation of a portable low-power deep brain stimulation device through anxiolytic effects in a laboratory rat model
Kouzani, Abbas Z., Kale, Rajas P., Zarate-Garza, Pablo Patricio, Berk, Michael, Walder, Ken and Tye, Susannah J. (2017). Validation of a portable low-power deep brain stimulation device through anxiolytic effects in a laboratory rat model. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 25 (9) 7744659, 1365-1374. doi: 10.1109/TNSRE.2016.2628760
2017
Journal Article
Hierarchical estimation of neural activity through explicit identification of temporally synchronous spikes
Veerabhadrappa, R., Bhatti, A., Berk, Michael, Tye, S. J. and Nahavandi, S. (2017). Hierarchical estimation of neural activity through explicit identification of temporally synchronous spikes. Neurocomputing, 249, 299-313. doi: 10.1016/j.neucom.2016.09.135
2017
Journal Article
Fostering resilience among mothers under stress: "Authentic Connections Groups" for medical professionals
Luthar, Suniya S., Curlee, Alexandria, Tye, Susannah J., Engelman, Judith C. and Stonnington, Cynthia M. (2017). Fostering resilience among mothers under stress: "Authentic Connections Groups" for medical professionals. Women's Health Issues, 27 (3), 382-390. doi: 10.1016/j.whi.2017.02.007
2017
Journal Article
A model of the mitochondrial basis of bipolar disorder
Morris, Gerwyn, Walder, Ken, McGee, Sean L., Dean, Olivia M., Tye, Susannah J., Maes, Michael and Berk, Michael (2017). A model of the mitochondrial basis of bipolar disorder. Neuroscience and Biobehavioral Reviews, 74, 1-20. doi: 10.1016/j.neubiorev.2017.01.014
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Susannah Tye is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
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Master Philosophy
Predictive Biobehavioural Markers of Deep Brain Stimulation Efficacy
Principal Advisor
Other advisors: Professor Pankaj Sah
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Doctor Philosophy
Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
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Doctor Philosophy
Neurofeedback an intervention for emotion regulation and attention in children and adolescents that have Down syndrome.
Principal Advisor
Other advisors: Professor Rhonda Faragher
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Master Philosophy
Predictive Biobehavioural Markers of Deep Brain Stimulation Efficacy
Principal Advisor
Other advisors: Professor Pankaj Sah
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Doctor Philosophy
Development of precision medicine biomarkers for ketamine as a treatment for TRD and PTSD
Principal Advisor
Other advisors: Associate Professor Fatima Nasrallah
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Doctor Philosophy
Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
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Doctor Philosophy
Immunometabolic Mechanisms of Mood Regulation
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
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Doctor Philosophy
Neurofeedback an intervention for emotion regulation and attention in children and adolescents that have Down syndrome.
Principal Advisor
Other advisors: Professor Rhonda Faragher
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Doctor Philosophy
Modelling neural circuit control of effort under stress
Associate Advisor
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Doctor Philosophy
The development of precision medical care for the use of ketamine as a treatment for Australian Veterans with TRD and PTSD
Associate Advisor
Other advisors: Associate Professor Fatima Nasrallah
Completed supervision
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2023
Doctor Philosophy
Biomarkers of Treatment-Resistant Depression and Predictors of Antidepressant Response
Principal Advisor
Other advisors: Professor Avril Robertson
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2023
Doctor Philosophy
Targeting NLRP3 and Dopamine Receptors for Treatment Resistant Depression
Associate Advisor
Other advisors: Professor Avril Robertson
Media
Enquiries
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