Overview
Background
Dr. Susannah Tye joined the Queensland Brain Institute in 2017 and has established a research program within the Asia Pacific Centre for Neuromodulation (QLD, Australia). Before returning to Australia, Dr. Tye directed the Translational Neuroscience Laboratory at the Mayo Clinic (2012-2017). While there she led efforts to develop brain stimulation devices (for rodents and humans) that can quantify neural activity and neurotransmitter dynamics in the living brain. This body of work now forms the basis of the neuropsychiatric arm of the Mayo Clinic’s Deep Brain Stimulation Consortium. Her specific research expertise are in utilising voltammetric (electrochemical) recording techniques to monitor rapid, synaptic neurotransmission in the living brain.
Dr. Tye has over ten years of experience studying neuromodulation in preclinical rodent models and human patients. Her long-term goal is to bridge preclinical and clinical studies to maximise translational impact, specifically in terms of improving patient outcomes for those with severe refractory psychiatric illness. Towards this end, she maintains many international collaborations with both clinical and basic science researchers. Dr. Tye also has a longstanding interest in mentoring young scientists to help them expand their skills in preclinical and basic science research and achieve a successful research career.
Availability
- Associate Professor Susannah Tye is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Macquarie University
Research interests
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Deep Brain Stimulation
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Neuromodulation
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Depression
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Bipolar Disorder
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Stress Disorders
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Parkinson's Disease
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Biomarkers
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Refractory Psychiatric Illness
Research impacts
The Tye group develops and applies novel technologies to modulate neuronal function. This work helps inform our basic understanding of signalling in the brain in both health and disease, with specific implications for understanding and correcting abnormal neuronal activity and neurotransmitter dynamics in chronic, unremitting brain-based illness. Working with both local and international collaborations in across clinical, engineering, and basic science fields, we work towards the long-term goal of translating cutting-edge brain stimulation technologies to the clinic to optimise therapeutic outcomes.
Works
Search Professor Susannah Tye’s works on UQ eSpace
2017
Journal Article
How well do we understand the long-term health implications of childhood bullying?
Zarate-Garza, Pablo Patricio, Biggs, Bridget K, Croarkin, Paul, Morath, Brooke, Leffler, Jarrod, Cuellar-Barboza, Alfredo and Tye, Susannah J (2017). How well do we understand the long-term health implications of childhood bullying?. Harvard Review of Psychiatry, 25 (2), 89-95. doi: 10.1097/HRP.0000000000000137
2017
Conference Publication
501. Epigenetic modifications of stress-relevant genes as peripheral biomarkers of treatment-resistant depression
Pfeiffer, John, Bustamante, Angela, Price, Joshua, Tye, Susannah and Uddin, Monica (2017). 501. Epigenetic modifications of stress-relevant genes as peripheral biomarkers of treatment-resistant depression. 72nd Annual Scientific Convention and Meeting, San Diego, CA, United States, 15 May 2017. NEW YORK: Elsevier BV. doi: 10.1016/j.biopsych.2017.02.1109
2017
Conference Publication
Towards in-vivo ATP sensing
Adams, Scott, Kouzani, Abbas Z., Bennet, Kevin and Tye, Susannah J. (2017). Towards in-vivo ATP sensing. 2016 IEEE Region 10 Conference (TENCON), Singapore, 22-25 November 2016. Piscataway, NJ United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/TENCON.2016.7848474
2017
Journal Article
Supervised, vigorous intensity exercise intervention for depressed female smokers: a pilot study
Patten, Christi A., Bronars, Carrie A., Vickers Douglas, Kristin S., Ussher, Michael H., Levine, James A., Tye, Susannah J., Hughes, Christine A., Brockman, Tabetha A., Decker, Paul A., DeJesus, Ramona S., Williams, Mark D., Olson, Thomas P., Clark, Matthew M. and Dieterich, Angela M. (2017). Supervised, vigorous intensity exercise intervention for depressed female smokers: a pilot study. Nicotine & Tobacco Research, 19 (1), 77-86. doi: 10.1093/ntr/ntw208
2017
Book Chapter
Deep brain stimulation for treatment-resistant depression
Kim, Yesul, Wininger, Katheryn M. and Tye, Susannah J. (2017). Deep brain stimulation for treatment-resistant depression. Deep brain stimulation: indications and applications. (pp. 197-214) edited by Kendall H. Lee, Penelope S. Duffy and Allan J. Bieber. Singapore: Pan Stanford Publishing. doi: 10.1201/9781315364759-18
2016
Journal Article
Continuation phase intravenous ketamine in adults with treatment-resistant depression
Vande Voort, Jennifer L., Morgan, Robert J., Kung, Simon, Rasmussen, Keith G., Rico, Jose, Palmer, Brian A., Schak, Kathryn M., Tye, Susannah J., Ritter, Matthew J., Frye, Mark A. and Bobo, William V. (2016). Continuation phase intravenous ketamine in adults with treatment-resistant depression. Journal of Affective Disorders, 206, 300-304. doi: 10.1016/j.jad.2016.09.008
2016
Journal Article
Hyperthermia for major depressive disorder?
Berk, Michael, Tye, Susannah, Walder, Ken and McGee, Sean (2016). Hyperthermia for major depressive disorder?. JAMA Psychiatry, 73 (10), 1095-1096. doi: 10.1001/jamapsychiatry.2016.1532
2016
Journal Article
Ketamine for treatment-resistant unipolar and bipolar major depression: critical review and implications for clinical practice
Bobo, William V., Voort, Jennifer L. Vande, Croarkin, Paul E., Leung, Jonathan G., Tye, Susannah J. and Frye, Mark A. (2016). Ketamine for treatment-resistant unipolar and bipolar major depression: critical review and implications for clinical practice. Depression and Anxiety, 33 (8), 698-710. doi: 10.1002/da.22505
2016
Journal Article
Unified selective sorting approach to analyse multi-electrode extracellular data
Veerabhadrappa, R., Lim, C. P., Nguyen, T. T., Berk, M., Tye, S. J., Monaghan, P., Nahavandi, S. and Bhatti, A. (2016). Unified selective sorting approach to analyse multi-electrode extracellular data. Scientific Reports, 6 (1) 28533. doi: 10.1038/srep28533
2016
Journal Article
Nucleus accumbens deep-brain stimulation efficacy in ACTH-pretreated rats: alterations in mitochondrial function relate to antidepressant-like effects
Kim, Y., McGee, S., Czeczor, J. K., Walker, A. J., Kale, R. P., Kouzani, A. Z., Walder, K., Berk, M. and Tye, S. J. (2016). Nucleus accumbens deep-brain stimulation efficacy in ACTH-pretreated rats: alterations in mitochondrial function relate to antidepressant-like effects. Translational Psychiatry, 6 (6) e842, e842-e842. doi: 10.1038/tp.2016.84
2016
Journal Article
Antidepressant actions of lateral habenula deep brain stimulation differentially correlate with CaMKII/GSK3/AMPK signaling locally and in the infralimbic cortex
Kim, Yesul, Morath, Brooke, Hu, Chunling, Byrne, Linda K., Sutor, Shari L., Frye, Mark A. and Tye, Susannah J. (2016). Antidepressant actions of lateral habenula deep brain stimulation differentially correlate with CaMKII/GSK3/AMPK signaling locally and in the infralimbic cortex. Behavioural Brain Research, 306, 170-177. doi: 10.1016/j.bbr.2016.02.039
2016
Journal Article
Stimulation-induced transient nonmotor psychiatric symptoms following subthalamic deep brain stimulation in patients with Parkinson's disease: association with clinical outcomes and neuroanatomical correlates
Abulseoud, Osama A., Kasasbeh, Aimen, Min, Hoon-Ki, Fields, Julie A., Tye, Susannah J., Goerss, Stephan, Knight, Emily J., Sampson, Shirlene M., Klassen, Bryan T., Matsumoto, Joseph Y., Stoppel, Cynthia, Lee, Kendall H. and Frye, Mark A. (2016). Stimulation-induced transient nonmotor psychiatric symptoms following subthalamic deep brain stimulation in patients with Parkinson's disease: association with clinical outcomes and neuroanatomical correlates. Stereotactic and Functional Neurosurgery, 94 (2), 93-101. doi: 10.1159/000445076
2016
Conference Publication
A miniature closed-loop deep brain stimulation device
Parastarfeizabadi, Mahboubeh, Kouzani, Abbas Z., Gibson, Ian and Tye, Susannah J. (2016). A miniature closed-loop deep brain stimulation device. 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016, Orlando, Florida, 16-20 August 2016 . Piscataway, NJ, United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/embc.2016.7591064
2016
Conference Publication
Electrical resistance increases at the tissue-electrode interface as an early response to nucleus accumbens deep brain stimulation
Kale, Rajas P., Kouzani, Abbas Z., Berk, Julian, Walder, Ken, Berk, Michael and Tye, Susannah J. (2016). Electrical resistance increases at the tissue-electrode interface as an early response to nucleus accumbens deep brain stimulation. 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016, Orlando, FL, United States, 16-20 August 2016. Piscataway, NJ, United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/EMBC.2016.7591071
2016
Journal Article
Fabrication of biocompatible enclosures for an electronic implant using 3D printing
Adams, Scott, Kouzani, Abbas Z., Mohammed, Mazher, Usma, Clara and Tye, Susannah J. (2016). Fabrication of biocompatible enclosures for an electronic implant using 3D printing. International Journal of Rapid Manufacturing, 6 (1), 17-32. doi: 10.1504/ijrapidm.2016.078742
2016
Conference Publication
Portable closed-loop optogenetic stimulation device
Edward, Epsy S., Kouzani, Abbas Z., Kale, Rajas P. and Tye, Susannah J. (2016). Portable closed-loop optogenetic stimulation device. 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016, Orlando, Florida, 16-20 August 2016 . Piscataway, NJ, United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/embc.2016.7591911
2016
Conference Publication
A miniature neural recording device
Edward, Epsy S., Kouzani, Abbas Z., Berk, Julian and Tye, Susannah J. (2016). A miniature neural recording device. IEEE International Conference on Industrial Technology, ICIT 2016, Taipei, Taiwan, 14-17 March 2016. Piscataway, NJ United States: IEEE. doi: 10.1109/icit.2016.7474892
2015
Journal Article
Feasibility of investigating differential proteomic expression in depression: implications for biomarker development in mood disorders
Frye, M. A., Nassan, M., Jenkins, G. D., Kung, S., Veldic, M., Palmer, B. A., Feeder, S. E., Tye, S. J., Choi, D. S. and Biernacka, J. M. (2015). Feasibility of investigating differential proteomic expression in depression: implications for biomarker development in mood disorders. Translational Psychiatry, 5 (12) e689, e689-e689. doi: 10.1038/tp.2015.185
2015
Journal Article
Peripheral proinflammatory markers associated with ketamine response in a preclinical model of antidepressant-resistance
Walker, Adam J., Foley, Brittany M., Sutor, Shari L., McGillivray, Jane A., Frye, Mark A. and Tye, Susannah J. (2015). Peripheral proinflammatory markers associated with ketamine response in a preclinical model of antidepressant-resistance. Behavioural Brain Research, 293, 198-202. doi: 10.1016/j.bbr.2015.07.026
2015
Journal Article
Radio frequency energy harvesting from a feeding source in a passive deep brain stimulation device for murine preclinical research
Hosain, Md Kamal, Kouzani, Abbas Z., Tye, Susannah J., Samad, Mst Fateha, Kale, Rajas P., Bennet, Kevin E., Manciu, Felicia S. and Berk, Michael (2015). Radio frequency energy harvesting from a feeding source in a passive deep brain stimulation device for murine preclinical research. Medical Engineering and Physics, 37 (10), 1020-1026. doi: 10.1016/j.medengphy.2015.07.003
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Susannah Tye is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
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Master Philosophy
Predictive Biobehavioural Markers of Deep Brain Stimulation Efficacy
Principal Advisor
Other advisors: Professor Pankaj Sah
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Doctor Philosophy
Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
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Doctor Philosophy
Neurofeedback an intervention for emotion regulation and attention in children and adolescents that have Down syndrome.
Principal Advisor
Other advisors: Professor Rhonda Faragher
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Master Philosophy
Predictive Biobehavioural Markers of Deep Brain Stimulation Efficacy
Principal Advisor
Other advisors: Professor Pankaj Sah
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Doctor Philosophy
Development of precision medicine biomarkers for ketamine as a treatment for TRD and PTSD
Principal Advisor
Other advisors: Associate Professor Fatima Nasrallah
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Doctor Philosophy
Prefrontal Mechanisms Regulating Striatal Dopamine During Persistent Effort
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
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Doctor Philosophy
Immunometabolic Mechanisms of Mood Regulation
Principal Advisor
Other advisors: Dr Roger Bitencourt Varela
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Doctor Philosophy
Neurofeedback an intervention for emotion regulation and attention in children and adolescents that have Down syndrome.
Principal Advisor
Other advisors: Professor Rhonda Faragher
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Doctor Philosophy
Modelling neural circuit control of effort under stress
Associate Advisor
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Doctor Philosophy
The development of precision medical care for the use of ketamine as a treatment for Australian Veterans with TRD and PTSD
Associate Advisor
Other advisors: Associate Professor Fatima Nasrallah
Completed supervision
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2023
Doctor Philosophy
Biomarkers of Treatment-Resistant Depression and Predictors of Antidepressant Response
Principal Advisor
Other advisors: Professor Avril Robertson
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2023
Doctor Philosophy
Targeting NLRP3 and Dopamine Receptors for Treatment Resistant Depression
Associate Advisor
Other advisors: Professor Avril Robertson
Media
Enquiries
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