|
2024 Journal Article Insights into the structure of NLR family member X1: Paving the way for innovative drug discoveryJewell, Shannon, Nguyen, Thanh Binh, Ascher, David B. and Robertson, Avril A.B. (2024). Insights into the structure of NLR family member X1: Paving the way for innovative drug discovery. Computational and Structural Biotechnology Journal, 23, 3506-3513. doi: 10.1016/j.csbj.2024.09.013 |
|
2024 Journal Article Author Correction: Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degenerationWooff, Yvette, Fernando, Nilisha, Wong, Josephine H. C., Dietrich, Catherine, Aggio-Bruce, Riemke, Chu-Tan, Joshua A., Robertson, Avril A. B., Doyle, Sarah L., Man, Si Ming and Natoli, Riccardo (2024). Author Correction: Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration. Scientific Reports, 14 (1) 21585, 21585. doi: 10.1038/s41598-024-71519-8 |
|
2024 Journal Article Are manufacturing patents to blame for biosimilar market launch delays?Williamson, Rhys, Munro, Trent, Ascher, David, Robertson, Avril and Pregelj, Lisette (2024). Are manufacturing patents to blame for biosimilar market launch delays?. Value in Health, 27 (3), 287-293. doi: 10.1016/j.jval.2023.12.005 |
|
2024 Journal Article o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2Rahaman, Md. Habibur, Thygesen, Sara J., Maxwell, Michael J., Kim, Hyoyoung, Mudai, Prerna, Nanson, Jeffrey D., Jia, Xinying, Vajjhala, Parimala R., Hedger, Andrew, Vetter, Irina, Haselhorst, Thomas, Robertson, Avril A. B., Dymock, Brian, Ve, Thomas, Mobli, Mehdi, Stacey, Katryn J. and Kobe, Bostjan (2024). o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2. Journal of Enzyme Inhibition and Medicinal Chemistry, 39 (1) 2313055. doi: 10.1080/14756366.2024.2313055 |
|
2024 Journal Article MCC950 reduces autophagy and improves cognitive function by inhibiting NLRP3-dependent neuroinflammation in a rat model of Alzheimer's diseaseNaeem, Abdul, Prakash, Ravi, Kumari, Neha, Ali Khan, Mohsin, Quaiyoom Khan, Abdul, Uddin, Shahab, Verma, Sandeep, Robertson, Avril A.B., Boltze, Johannes and Shadab Raza, Syed (2024). MCC950 reduces autophagy and improves cognitive function by inhibiting NLRP3-dependent neuroinflammation in a rat model of Alzheimer's disease. Brain, Behavior, and Immunity, 116, 70-84. doi: 10.1016/j.bbi.2023.11.031 |
|
2024 Journal Article Therapeutic Potential of MCC950 in Restoring Autophagy and Cognitive Function in STZ-Induced Rat Model of Alzheimer's DiseaseNaeem, Abdul, Waseem, Arshi, Khan, Mohsin Ali, Robertson, Avril AB. and Raza, Syed Shadab (2024). Therapeutic Potential of MCC950 in Restoring Autophagy and Cognitive Function in STZ-Induced Rat Model of Alzheimer's Disease. Molecular Neurobiology. doi: 10.1007/s12035-024-04662-y |
|
2024 Journal Article The design, synthesis, and biological evaluation of 5,6,7,8-tetrahydropteridines as anti-inflammatory compoundsChen, Rachel M., Emming, Stefan, Cinnamon, Roseanna, Cameron, Jacob P., Schroder, Kate, Kobe, Bostjan and Robertson, Avril A. B. (2024). The design, synthesis, and biological evaluation of 5,6,7,8-tetrahydropteridines as anti-inflammatory compounds. Organic & Biomolecular Chemistry, 23 (1), 174-182. doi: 10.1039/d4ob01453g |
|
2023 Journal Article Characterization and inhibition of inflammasome responses in severe and non-severe asthmaHorvat, Jay C., Kim, Richard Y., Weaver, Natasha, Augood, Christopher, Brown, Alexandra C., Donovan, Chantal, Dupre, Pierrick, Gunawardhana, Lakshitha, Mayall, Jemma R., Hansbro, Nicole G., Robertson, Avril A. B., O’Neill, Luke A. J., Cooper, Matthew A., Holliday, Elizabeth G., Hansbro, Philip M. and Gibson, Peter G. (2023). Characterization and inhibition of inflammasome responses in severe and non-severe asthma. Respiratory Research, 24 (1) 303, 1-14. doi: 10.1186/s12931-023-02603-2 |
|
2023 Journal Article Correction: Pharmacological targeting of the transcription factor SOX18 delays breast cancer in miceOverman, Jeroen, Fontaine, Frank, Moustaqil, Mehdi, Mittal, Deepak, Sierecki, Emma, Sacilotto, Natalia, Zuegg, Johannes, Robertson, Avril AB, Holmes, Kelly, Salim, Angela A, Mamidyala, Sreeman, Butler, Mark S, Robinson, Ashley S, Lesieur, Emmanuelle, Johnston, Wayne, Alexandrov, Kirill, Black, Brian L, Hogan, Benjamin M, De Val, Sarah, Capon, Robert J, Carroll, Jason S, Bailey, Timothy L, Koopman, Peter, Jauch, Ralf, Cooper, Matthew A, Gambin, Yann and Francois, Mathias (2023). Correction: Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. eLife, 12 e90408. doi: 10.7554/elife.90408 |
|
Featured 2023 Journal Article Response to comment on “Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice”Albornoz, Eduardo A., Gordon, Richard, Kumar, Vinod, Robertson, Avril A. B., Schroder, Kate and Woodruff, Trent M. (2023). Response to comment on “Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice”. Science Translational Medicine, 15 (696) adh0604, 1-4. doi: 10.1126/scitranslmed.adh0604 |
|
2023 Journal Article NLRP3 inflammasome-targeting nanomicelles for preventing ischemia–reperfusion-induced inflammatory injuryPrakash, Ravi, Vyawahare, Akshay, Sakla, Rahul, Kumari, Neha, Kumar, Ajay, Ansari, Md. Meraj, Kanika,, Jori, Chandrashekhar, Waseem, Arshi, Siddiqui, Abu Junaid, Khan, Mohsin Ali, Robertson, Avril A.B., Khan, Rehan and Raza, Syed Shadab (2023). NLRP3 inflammasome-targeting nanomicelles for preventing ischemia–reperfusion-induced inflammatory injury. ACS Nano, 17 (9), 8680-8693. doi: 10.1021/acsnano.3c01760 |
|
2023 Journal Article Clostridium perfringens virulence factors are nonredundant activators of the NLRP3 inflammasomeMathur, Anukriti, Kay, Callum, Xue, Yansong, Pandey, Abhimanu, Lee, Jiwon, Jing, Weidong, Enosi Tuipulotu, Daniel, Lo Pilato, Jordan, Feng, Shouya, Ngo, Chinh, Zhao, Anyang, Shen, Cheng, Rug, Melanie, Miosge, Lisa A, Atmosukarto, Ines I, Price, Jason D, Ali, Sidra A, Gardiner, Elizabeth E, Robertson, Avril AB, Awad, Milena M, Lyras, Dena, Kaakoush, Nadeem O and Man, Si Ming (2023). Clostridium perfringens virulence factors are nonredundant activators of the NLRP3 inflammasome. EMBO Reports, 24 (6) e54600, e54600. doi: 10.15252/embr.202254600 |
|
2023 Journal Article MCC950 regulates stem cells destiny through modulating SIRT3-NLRP3 inflammasome dynamics during oxygen glucose deprivationPrakash, Ravi, Kumari, Neha, Siddiqui, Abu Junaid, Khan, Abdul Quaiyoom, Khan, Mohsin Ali, Khan, Rehan, Haque, Rizwanul, Robertson, Avril A. B., Boltze, Johannes and Raza, Syed Shadab (2023). MCC950 regulates stem cells destiny through modulating SIRT3-NLRP3 inflammasome dynamics during oxygen glucose deprivation. Stem Cell Reviews and Reports, 19 (5), 1415-1426. doi: 10.1007/s12015-023-10520-6 |
|
2023 Journal Article Immunity against Moraxella catarrhalis requires guanylate‐binding proteins and caspase‐11‐ NLRP3 inflammasomesEnosi Tuipulotu, Daniel, Feng, Shouya, Pandey, Abhimanu, Zhao, Anyang, Ngo, Chinh, Mathur, Anukriti, Lee, Jiwon, Shen, Cheng, Fox, Daniel, Xue, Yansong, Kay, Callum, Kirkby, Max, Lo Pilato, Jordan, Kaakoush, Nadeem O, Webb, Daryl, Rug, Melanie, Robertson, Avril AB, Tessema, Melkamu B, Pang, Stanley, Degrandi, Daniel, Pfeffer, Klaus, Augustyniak, Daria, Blumenthal, Antje, Miosge, Lisa A, Brüstle, Anne, Yamamoto, Masahiro, Reading, Patrick C, Burgio, Gaetan and Man, Si Ming (2023). Immunity against Moraxella catarrhalis requires guanylate‐binding proteins and caspase‐11‐ NLRP3 inflammasomes. The EMBO Journal, 42 (6) e112558, e112558. doi: 10.15252/embj.2022112558 |
|
2022 Journal Article Increased core body temperature exacerbates defective protein prenylation in mouse models of mevalonate kinase deficiencyMunoz, Marcia A., Skinner, Oliver P., Masle-Farquhar, Etienne, Jurczyluk, Julie, Xiao, Ya, Fletcher, Emma K., Kristianto, Esther, Hodson, Mark P., O’Donoghue, Seán I., Kaur, Sandeep, Brink, Robert, Zahra, David G., Deenick, Elissa K., Perry, Kristen A., Robertson, Avril A.B., Mehr, Sam, Hissaria, Pravin, Mulders-Manders, Catharina M., Simon, Anna and Rogers, Michael J. (2022). Increased core body temperature exacerbates defective protein prenylation in mouse models of mevalonate kinase deficiency. Journal of Clinical Investigation, 132 (19) e160929, 1-16. doi: 10.1172/jci160929 |
|
2022 Journal Article AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformansWizrah, Maha S. I., Chua, Sheena M. H., Luo, Zhenyao, Manik, Mohammad K., Pan, Mengqi, Whyte, Jessica M. L., Robertson, Avril A. B., Kappler, Ulrike, Kobe, Bostjan and Fraser, James A. (2022). AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans. Journal of Biological Chemistry, 298 (10) 102453, 102453. doi: 10.1016/j.jbc.2022.102453 |
|
2022 Journal Article Clostridium septicum α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteinsJing, Weidong, Pilato, Jordan Lo, Kay, Callum, Feng, Shouya, Tuipulotu, Daniel Enosi, Mathur, Anukriti, Shen, Cheng, Ngo, Chinh, Zhao, Anyang, Miosge, Lisa A., Ali, Sidra A., Gardiner, Elizabeth E., Awad, Milena M., Lyras, Dena, Robertson, Avril A. B., Kaakoush, Nadeem O. and Man, Si Ming (2022). Clostridium septicum α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins. Science Immunology, 7 (71) eabm1803, 1-17. doi: 10.1126/sciimmunol.abm1803 |
|
2022 Journal Article Prevention of the foreign body response to implantable medical devices by inflammasome inhibitionBarone, Damiano G., Carnicer-Lombarte, Alejandro, Tourlomousis, Panagiotis, Hamilton, Russell S., Prater, Malwina, Rutz, Alexandra L., Dimov, Ivan B., Malliaras, George G., Lacour, Stephanie P., Robertson, Avril A. B., Franze, Kristian, Fawcett, James W. and Bryant, Clare E. (2022). Prevention of the foreign body response to implantable medical devices by inflammasome inhibition. Proceedings of the National Academy of Sciences, 119 (12) e2115857119, e2115857119. doi: 10.1073/pnas.2115857119 |
|
2022 Journal Article Interleukin-1β suppression dampens inflammatory leukocyte production and uptake in atherosclerosisHettwer, Jan, Hinterdobler, Julia, Miritsch, Benedikt, Deutsch, Marcus-André, Li, Xinghai, Mauersberger, Carina, Moggio, Aldo, Braster, Quinte, Gram, Hermann, Robertson, Avril A. B., Cooper, Matthew A., Groß, Olaf, Krane, Markus, Weber, Christian, Koenig, Wolfgang, Soehnlein, Oliver, Adamstein, Nicholas H., Ridker, Paul, Schunkert, Heribert, Libby, Peter, Kessler, Thorsten and Sager, Hendrik B. (2022). Interleukin-1β suppression dampens inflammatory leukocyte production and uptake in atherosclerosis. Cardiovascular Research, 118 (13) cvab337, 2778-2791. doi: 10.1093/cvr/cvab337 |
|
2022 Journal Article Aim2 suppresses cigarette smoke-induced neutrophil recruitment, neutrophil caspase-1 activation and anti-Ly6G-mediated neutrophil depletionDonovan, Chantal, Kim, Richard Y, Galvao, Izabela, Jarnicki, Andrew G, Brown, Alexandra C, Jones-Freeman, Bernadette, Gomez, Henry M, Wadhwa, Ridhima, Hortle, Elinor, Jayaraman, Ranjith, Khan, Haroon, Pickles, Sophie, Sahu, Priyanka, Chimankar, Vrushali, Tu, Xiaofan, Ali, Md Khadem, Mayall, Jemma R, Nguyen, Duc H, Budden, Kurtis F, Kumar, Vinod, Schroder, Kate, Robertson, Avril AB, Cooper, Matthew A, Wark, Peter AB, Oliver, Brian G, Horvat, Jay C and Hansbro, Philip M (2022). Aim2 suppresses cigarette smoke-induced neutrophil recruitment, neutrophil caspase-1 activation and anti-Ly6G-mediated neutrophil depletion. Immunology and Cell Biology, 100 (4), 235-249. doi: 10.1111/imcb.12537 |
