Emeritus Professor Stephen Mahler
Emeritus Professor

Stephen Mahler

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Background

Professor Stephen Mahler is a Senior Group Leader at the Australian Institute for Bioengineering and Nanotechnology and Director of the Australian Research Council Training Centre for Biopharmaceutical Innovation (CBI), University of Queensland. Professor Mahler is a biotechnologist with a focus on R&D of recombinant-DNA derived protein biopharmaceuticals, drug delivery systems and nanomedicines. Professor Mahler has a record of translational research success and engages extensively with industry associated with the biomedical sciences both nationally and internationally.

Research within CBI covers three thematic research areas; discovery of new biopharmaceuticals, engineering cells for production of protein-based biopharmaceuticals and advanced manufacturing for industrial production. A current research interest is at the interface of the life sciences and materials science, using a synthetic biology approach for creating novel therapeutic entities as well as new systems for drug delivery.

Professor Mahler has a strong interest in education and training and was formerly Head of the Chemical and Biological Engineering Plan at the University of Queensland (2010-2016). Other educational initiatives include development of Masters Programs and a Continuing Professional Development program in the area of biopharmaceuticals. The CPD program is available to stakeholders in the industry, both in Australia and internationally.

Availability

Emeritus Professor Stephen Mahler is:
Available for supervision
Media expert

Fields of research

Biological Sciences Industrial biotechnology Medical biotechnology

Qualifications

  • Doctor of Philosophy, The University of Queensland

Research impacts

Professor Mahler has a strong engagement with industry both nationally and internationally, that through collaborative research has led to some significant translational outcomes including clinical trial of biopharmaceutical drug candidates through to approval. The Australian Research Council Training Centre for Biopharmaceutical Innovation is a consortium of partners including government, the University of Queensland and several industry partners, with a goal of contributing to the transformation of the biopharmaceutical industry. Through the Centre and the CPD Program in Biopharmaceuticals, Professor Mahler continues to work with stakeholders to ensure a vibrant future for the biopharmaceutical industry in Australia.

Search Professor Stephen Mahler’s works on UQ eSpace

137 works between 1984 and 2024
All (137) Journal Article (101) Book Chapter (13) Conference Publication (18) Other Outputs (5)

101 - 120 of 137 works

2008

Journal Article

Cytotoxic activity of CD48 monoclonal antibodies against human lymphoma cells

Wei, Jiewei, Chin, David Y. and Mahler, Stephen M. (2008). Cytotoxic activity of CD48 monoclonal antibodies against human lymphoma cells. Open Biotechnology Journal, 2 (1), 219-223. doi: 10.2174/1874070700802010219

Cytotoxic activity of CD48 monoclonal antibodies against human lymphoma cells

2007

Journal Article

Material surfaces affect the protein expression patterns of human macrophages: A proteomics approach

Mahler, Stephen Michael, Dinnes, Donna Lee M., Marçal, Helder, Santerre, J. Paul and Labow, Rosalind S. (2007). Material surfaces affect the protein expression patterns of human macrophages: A proteomics approach. Journal of Biomedical Materials Research Part A, 80A (4), 895-908. doi: 10.1002/jbm.a.30967

Material surfaces affect the protein expression patterns of human macrophages: A proteomics approach

2006

Journal Article

Fractionation of follicle stimulating hormone charge isoforms in their native form by preparative electrophoresis technology

Catzel, D., Chin, D. Y., Stanton, P. G., Gray, P. P. and Mahler, S. A. (2006). Fractionation of follicle stimulating hormone charge isoforms in their native form by preparative electrophoresis technology. Journal of Biotechnology, 122 (1), 73-85. doi: 10.1016/j.jbiotec.2005.08.026

Fractionation of follicle stimulating hormone charge isoforms in their native form by preparative electrophoresis technology

2006

Journal Article

Purification of monoclonal antibodies from cell culture supernatants by Gradiflow (TM) electrophoresis technology

Mahler, Stephen M., Leong, Sharon, Gilbert, Andrew, Yang, Fan, Gray, Peter, Van Dyk, Derek and Roeth, Philip (2006). Purification of monoclonal antibodies from cell culture supernatants by Gradiflow (TM) electrophoresis technology. Journal of Chemical Technology And Biotechnology, 81 (3), 445-453. doi: 10.1002/jctb.1426

Purification of monoclonal antibodies from cell culture supernatants by Gradiflow (TM) electrophoresis technology

2006

Conference Publication

A CMRF-56 blood dendritic cell preparation loaded with control and tumour-associated antigens, for the immune therapy of multiple myeloma: Transition to a phase I clinical trial

Vari, F., Rossetti, T., Prue, R., Mahler, S. and Hart, D.N. (2006). A CMRF-56 blood dendritic cell preparation loaded with control and tumour-associated antigens, for the immune therapy of multiple myeloma: Transition to a phase I clinical trial. x, x, x. United Kingdom: Informa Healthcare.

A CMRF-56 blood dendritic cell preparation loaded with control and tumour-associated antigens, for the immune therapy of multiple myeloma: Transition to a phase I clinical trial

2006

Conference Publication

Secretome analysis of olfactory ensheathing cells for use in tissue engineering and regenerative medicine applications

Marcal, H, Raftery, M, Sarris, M, Mcfarland, C, Milthorpe, BK, Bhasin, V, Mackay-Sim, A and Mahler, S (2006). Secretome analysis of olfactory ensheathing cells for use in tissue engineering and regenerative medicine applications. Unknown, unknown, Unknown. BETHESDA: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC.

Secretome analysis of olfactory ensheathing cells for use in tissue engineering and regenerative medicine applications

2005

Journal Article

Expression and characterisation of recombinant human CD48 and isolation of a human anti-CD48 monoclonal antibody by phage display

Wei, J. W., Chin, D. Y., Catzel, D., Pera, N. and Mahler, S. M. (2005). Expression and characterisation of recombinant human CD48 and isolation of a human anti-CD48 monoclonal antibody by phage display. Journal of Chemical Technology And Biotechnology, 80 (7), 782-795. doi: 10.1002/jctb.1238

Expression and characterisation of recombinant human CD48 and isolation of a human anti-CD48 monoclonal antibody by phage display

2003

Journal Article

Purification of Fab fragments from a monoclonal antibody papain digest by Gradiflow electrophoresis

Coleman, L. and Mahler, S. M. (2003). Purification of Fab fragments from a monoclonal antibody papain digest by Gradiflow electrophoresis. Protein Expression And Purification, 32 (2), 246-251. doi: 10.1016/j.pep.2003.07.005

Purification of Fab fragments from a monoclonal antibody papain digest by Gradiflow electrophoresis

2003

Journal Article

Increase in synthesis of human monoclonal antibodies by transfected Sp2/0 myeloma mouse cell line under conditions of microgravity

Foster, L. J. R., Catzel, D., Atwa, S., Zarka, M. and Mahler, S. M. (2003). Increase in synthesis of human monoclonal antibodies by transfected Sp2/0 myeloma mouse cell line under conditions of microgravity. Biotechnology Letters, 25 (15), 1271-1274. doi: 10.1023/A:1025003800414

Increase in synthesis of human monoclonal antibodies by transfected Sp2/0 myeloma mouse cell line under conditions of microgravity

2003

Other Outputs

Isolation method for recombinant glycoprotein biopharmaceuticals

Catzel, D., Gray, P. P. and Mahler, S. M. (2003). Isolation method for recombinant glycoprotein biopharmaceuticals. Australian Provisional Patent #61759780.

Isolation method for recombinant glycoprotein biopharmaceuticals

2003

Journal Article

The application of emerging technologies in genomics and proteomics to drug development

Mahler, S. M., Chin, D. Y. and Van Dyk, D. D. (2003). The application of emerging technologies in genomics and proteomics to drug development. Journal of Pharmacy Practice and Research, 33 (1), 7-11.

The application of emerging technologies in genomics and proteomics to drug development

2003

Journal Article

Purification of recombinant human growth hormone from CHO cell culture supernatant by Gradiflow preparative electrophoresis technology

Catzel, D., Lalevski, H., Marquis, C. P., Gray, P. P., Van Dyk, D. and Mahler, S. M. (2003). Purification of recombinant human growth hormone from CHO cell culture supernatant by Gradiflow preparative electrophoresis technology. Protein Expression And Purification, 32 (1), 126-134. doi: 10.1016/j.pep.2003.07.002

Purification of recombinant human growth hormone from CHO cell culture supernatant by Gradiflow preparative electrophoresis technology

2001

Other Outputs

Compositions for protein delivery via the pulmonary route

Mahler, S. M., Waters, M., Chan, H. K. and Goodall, S. (2001). Compositions for protein delivery via the pulmonary route.

Compositions for protein delivery via the pulmonary route

2001

Journal Article

Bleeding babies

Marquis, Christopher, Mahler, Stephen, Pearson, Helen and Barcho, Shane (2001, 04 01). Bleeding babies Australasian Science 37-39.

Bleeding babies

1999

Journal Article

The effectiveness of different rat IgG subclasses as IgE-blocking antibodies in the Rat Basophil Leukemia cell model

Philips, J. R., Brouwer, W., Mahler, S., Ruhno, J., Collins, A. M. and Edwards, M. (1999). The effectiveness of different rat IgG subclasses as IgE-blocking antibodies in the Rat Basophil Leukemia cell model. Immunology and Cell Biology, 77 (2), 121-126. doi: 10.1046/j.1440-1711.1999.00801.x

The effectiveness of different rat IgG subclasses as IgE-blocking antibodies in the Rat Basophil Leukemia cell model

1998

Journal Article

Comparison of the efficiency of Moloney Murine Leukaemia Virus (M-MuLV) reverse transcriptase, RNase H--M-MuLV reverse transcriptase and Avian Myeloblastoma Leukaemia Virus (AMV) reverse transcriptase for the amplification of human immunoglobulin genes

Wong, L, Pearson, H, Fletcher, A, Marquis, CP and Mahler, S (1998). Comparison of the efficiency of Moloney Murine Leukaemia Virus (M-MuLV) reverse transcriptase, RNase H--M-MuLV reverse transcriptase and Avian Myeloblastoma Leukaemia Virus (AMV) reverse transcriptase for the amplification of human immunoglobulin genes. Biotechnology Techniques, 12 (6), 485-489. doi: 10.1023/A:1008871608947

Comparison of the efficiency of Moloney Murine Leukaemia Virus (M-MuLV) reverse transcriptase, RNase H--M-MuLV reverse transcriptase and Avian Myeloblastoma Leukaemia Virus (AMV) reverse transcriptase for the amplification of human immunoglobulin genes

1997

Journal Article

MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily

Bootcov, MR, Bauskin, AR, Valenzuela, SM, Moore, AG, Bansal, M, He, XY, Zhang, HP, Donnellan, M, Mahler, S, Pryor, K, Walsh, BJ, Nicholson, RC, Fairlie, WD, Por, SB, Robbins, JM and Breit, SN (1997). MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. Proceedings of the National Academy of Sciences of the United States of America, 94 (21), 11514-11519. doi: 10.1073/pnas.94.21.11514

MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily

1997

Journal Article

Expression of a recombinant single chain Fv antibody fragment in mammalian cells

Chotigeat, Wilaiwan and Mahler, Stephen M. (1997). Expression of a recombinant single chain Fv antibody fragment in mammalian cells. Journal of the Science Society of Thailand, 23 (3), 159-170. doi: 10.2306/scienceasia1513-1874.1997.23.159

Expression of a recombinant single chain Fv antibody fragment in mammalian cells

1997

Journal Article

Cloning and expression of human V-genes derived from phage display libraries as fully assembled human anti-TNF alpha monoclonal antibodies

Mahler, SM, Marquis, CP, Brown, G, Roberts, A and Hoogenboom, HR (1997). Cloning and expression of human V-genes derived from phage display libraries as fully assembled human anti-TNF alpha monoclonal antibodies. Immunotechnology, 3 (1), 31-43. doi: 10.1016/S1380-2933(96)00058-9

Cloning and expression of human V-genes derived from phage display libraries as fully assembled human anti-TNF alpha monoclonal antibodies

1996

Journal Article

A Master's program in biopharmaceutical science

Neering, IR, Fryer, MW and Mahler, SM (1996). A Master's program in biopharmaceutical science. Australasian Biotechnology, 6 (5), 272-276.

A Master's program in biopharmaceutical science

Past funding

  • 2021 - 2023
    ACRF Facility for Targeted Radiometals in Cancer (AFTRiC)
    Australian Cancer Research Foundation
    Open grant
  • 2020 - 2021
    An integrated, multi-node bio-layer interferometry facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2019 - 2022
    Smart affinity membranes for manufacture of high value therapeutic proteins
    ARC Linkage Projects
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019
    Advanced Nanoparticle, Colloid and Microparticle Characterisation and Precision Engineering Nanosystems Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019
    Cyto-Mine to accelerate Cell Line Development for Vaccines and Biopharmaceuticals
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2021
    Nanomedicine strategies for early detection and treatment of brain metastases
    NHMRC Project Grant
    Open grant
  • 2018
    Continuous chromatography system for advanced bioprocessing
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    In vivo optical imaging into the next generation
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2017 - 2018
    Affinity Maturation of Anti-Lipopolysaccharide Antibody
    Innovation Connections
    Open grant
  • 2017 - 2018
    Provision of research services to Minomic International Ltd
    Minomic International Ltd
    Open grant
  • 2017 - 2023
    ARC Training Centre for Biopharmaceutical Innovation
    ARC Industrial Transformation Training Centres
    Open grant
  • 2016 - 2017
    EGFR targeted nanoparticle feasibility study
    Samyang Biopharmaceuticals Corporation
    Open grant
  • 2016 - 2019
    Next generation hybrid nanomaterials: bispecific antibody-targeted polymers
    ARC Linkage Projects
    Open grant
  • 2016 - 2017
    The biophysical characterisation of novel, recombinant bi-specific antibodies utilised in drug-delivery technology using Bio-layer Interferometry (Octet).
    Research Connections
    Open grant
  • 2016
    Exosome and Bio/Nanoparticle Characterisation Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016 - 2018
    Immuno-polymeric drugs for prostate cancer therapy
    NHMRC Project Grant
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2016
    Developing targeted EphA2 based imaging technology for glioblastoma
    Cure Brain Cancer Foundation
    Open grant
  • 2014 - 2023
    The National Biologics Facility - NCRIS 2013/2015/2016-17/2017-18/2018-19/2019-2023 (administered by Therapeutic Innovation Australia (TIA))
    Therapeutic Innovation Australia Limited
    Open grant
  • 2013 - 2015
    Safety assessment of anti-hendra virus antibody in humans
    Queensland Health
    Open grant
  • 2013
    QM6 Process Investigations
    UniQuest Pty Ltd
    Open grant
  • 2012 - 2015
    Single molecule spectroscopy-guided design of thermostable industrial enzymes
    ARC Linkage Projects
    Open grant
  • 2012 - 2015
    The first integrated multimodal assay for the ultrasensitive detection of dengue contamination of blood
    ARC Linkage Projects
    Open grant
  • 2012 - 2013
    Safety of Hendra virus anti-G glycoprotein monoclonal antibody in humans
    NHMRC Targeted Research
    Open grant
  • 2012 - 2015
    Targeting the delivery of cytotoxic agents to tumour cells using novel minicells as drug delivery vehicles and engineered, bispecific antibodies
    ARC Linkage Projects
    Open grant
  • 2011
    Mass spectrometer for biomolecule discovery, structural analysis and quantification.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2012
    Development of an integrated technology platform for neural cell surface marker discovery and characterisation
    UQ Collaboration and Industry Engagement Fund
    Open grant
  • 2010 - 2013
    Development of chaperonin 10-based second generation biopharmaceuticals for treatment of inflammatory diseases
    ARC Linkage Projects
    Open grant
  • 2010 - 2011
    High throughput isolation and expression of recombinant antibodies in mammalian cells
    UQ FirstLink Scheme
    Open grant
  • 2010
    Cost effective acquisition of an LC-MS/MS system to support CIPDD organics analysis and preclinical and clinical operations
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009
    Robotics Instrumentation for High Throughput Sample preparation for Increased Productivity of the CIPDD/TetraQ's HPLC-MS/MS Systems for Quantitative Analysis of Organics in a Quality Systems NATA-Acc
    UQ Faculty Co-Funding
    Open grant
  • 2009
    Stem cell-based interface tissue engineering
    ARC Discovery Projects
    Open grant

Availability

Emeritus Professor Stephen Mahler is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Stephen Mahler directly for media enquiries about:

  • Antibodies
  • Biologic medicines
  • Pharmaceuticals

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