Emeritus Professor Stephen Mahler
Emeritus Professor

Stephen Mahler

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Background

Professor Stephen Mahler is a Senior Group Leader at the Australian Institute for Bioengineering and Nanotechnology and Director of the Australian Research Council Training Centre for Biopharmaceutical Innovation (CBI), University of Queensland. Professor Mahler is a biotechnologist with a focus on R&D of recombinant-DNA derived protein biopharmaceuticals, drug delivery systems and nanomedicines. Professor Mahler has a record of translational research success and engages extensively with industry associated with the biomedical sciences both nationally and internationally.

Research within CBI covers three thematic research areas; discovery of new biopharmaceuticals, engineering cells for production of protein-based biopharmaceuticals and advanced manufacturing for industrial production. A current research interest is at the interface of the life sciences and materials science, using a synthetic biology approach for creating novel therapeutic entities as well as new systems for drug delivery.

Professor Mahler has a strong interest in education and training and was formerly Head of the Chemical and Biological Engineering Plan at the University of Queensland (2010-2016). Other educational initiatives include development of Masters Programs and a Continuing Professional Development program in the area of biopharmaceuticals. The CPD program is available to stakeholders in the industry, both in Australia and internationally.

Availability

Emeritus Professor Stephen Mahler is:
Available for supervision
Media expert

Fields of research

Biological Sciences Industrial biotechnology Medical biotechnology

Qualifications

  • Doctor of Philosophy, The University of Queensland

Research impacts

Professor Mahler has a strong engagement with industry both nationally and internationally, that through collaborative research has led to some significant translational outcomes including clinical trial of biopharmaceutical drug candidates through to approval. The Australian Research Council Training Centre for Biopharmaceutical Innovation is a consortium of partners including government, the University of Queensland and several industry partners, with a goal of contributing to the transformation of the biopharmaceutical industry. Through the Centre and the CPD Program in Biopharmaceuticals, Professor Mahler continues to work with stakeholders to ensure a vibrant future for the biopharmaceutical industry in Australia.

Search Professor Stephen Mahler’s works on UQ eSpace

137 works between 1984 and 2024
All (137) Journal Article (101) Book Chapter (13) Conference Publication (18) Other Outputs (5)

121 - 137 of 137 works

1996

Other Outputs

Process for production of glycoproteins

Mahler, S. M., Gebert, C., Chotigeat, W. and Gray, P. P. (1996). Process for production of glycoproteins.

Process for production of glycoproteins

1996

Other Outputs

A system for expression of recombinant proteins

Rajkovic, I., Chin, C. K. and Mahler, S. M. (1996). A system for expression of recombinant proteins. PM4219.

A system for expression of recombinant proteins

1996

Journal Article

Biological activity and metabolic clearance of recombinant human follicle stimulating hormone produced in Sp2/0 myeloma cells

Chin, C. K., Schofield, P. R., Robertson, D. M., Gray, P. P., Chotigeat, W. and Mahler, S. M. (1996). Biological activity and metabolic clearance of recombinant human follicle stimulating hormone produced in Sp2/0 myeloma cells. Cytotechnology, 21 (2), 171-182. doi: 10.1007/BF02215667

Biological activity and metabolic clearance of recombinant human follicle stimulating hormone produced in Sp2/0 myeloma cells

1995

Book Chapter

Downstream processing of monoclonal antibodies produced by cell culture techniques

Mahler, S. M. (1995). Downstream processing of monoclonal antibodies produced by cell culture techniques. Fundamental and applied aspects of animal cell culture. (pp. 197-232) edited by J. P. Barford, C. Harbour, C. P. Marquis, R. Malik, S. Mahler and P. J. Phillips. Singapore: Singapore University Press.

Downstream processing of monoclonal antibodies produced by cell culture techniques

1994

Journal Article

Guiding the Selection of Human-Antibodies From Phage Display Repertoires to a Single Epitope of An Antigen

Jespers, LS, Roberts, A, Mahler, SM, Winter, G and Hoogenboom, HR (1994). Guiding the Selection of Human-Antibodies From Phage Display Repertoires to a Single Epitope of An Antigen. Bio-Technology, 12 (9), 899-903. doi: 10.1038/nbt0994-899

Guiding the Selection of Human-Antibodies From Phage Display Repertoires to a Single Epitope of An Antigen

1994

Journal Article

Role of environmental conditions on the expression levels, glycoform pattern and levels of sialyltransferase enzymes for hFSH produced by recombinant CHO cells

Chotigeat, W., Watanapokasin, Y., Mahler, S. M. and Gray, P. P. (1994). Role of environmental conditions on the expression levels, glycoform pattern and levels of sialyltransferase enzymes for hFSH produced by recombinant CHO cells. Cytotechnology, 15 (1-3), 217-221. doi: 10.1007/BF00762396

Role of environmental conditions on the expression levels, glycoform pattern and levels of sialyltransferase enzymes for hFSH produced by recombinant CHO cells

1994

Conference Publication

Human-Antibodies Derived From Rodent Antibodies Via Epitope Imprinted Selection (eis)

Hoogenboom, HR, Jespers, L, Mahler, S, Roberts, AJ, Chiswell, DJ and Winter, G (1994). Human-Antibodies Derived From Rodent Antibodies Via Epitope Imprinted Selection (eis). NEW YORK: WILEY-LISS.

Human-Antibodies Derived From Rodent Antibodies Via Epitope Imprinted Selection (eis)

1994

Conference Publication

Role of Environmental-Conditions On the Expression Levels, Glycoform Pattern and Levels of Sialyltransferase for Hfsh Produced by Recombinant Cho Cells

Chotigeat, W, Watanapokasin, Y, Mahler, S and Gray, PP (1994). Role of Environmental-Conditions On the Expression Levels, Glycoform Pattern and Levels of Sialyltransferase for Hfsh Produced by Recombinant Cho Cells. Cell Culture Engineering IV Conference, San Diego Ca, Mar 07-12, 1994. DORDRECHT: SPRINGER. doi: 10.1007/BF00762396

Role of Environmental-Conditions On the Expression Levels, Glycoform Pattern and Levels of Sialyltransferase for Hfsh Produced by Recombinant Cho Cells

1993

Journal Article

Isoelectric Charge of Recombinant Human Follicle-Stimulating-Hormone Isoforms Determines Receptor Affinity and Invitro Bioactivity

Cerpapoljak, A, Bishop, LA, Hort, YJ, Chin, Ckh, Dekroon, R, Mahler, SM, Smith, GM, Stuart, MC and Schofield, PR (1993). Isoelectric Charge of Recombinant Human Follicle-Stimulating-Hormone Isoforms Determines Receptor Affinity and Invitro Bioactivity. Endocrinology, 132 (1), 351-356. doi: 10.1210/en.132.1.351

Isoelectric Charge of Recombinant Human Follicle-Stimulating-Hormone Isoforms Determines Receptor Affinity and Invitro Bioactivity

1990

Journal Article

Mammalian cell culture at the University of New South Wales

Gray, P. P., Marsden, W. L., Crowley, J., Gebert, C., Jirasripongpun, K., Lovrecz, G., Mitchell, C. and Mahler, S. M. (1990). Mammalian cell culture at the University of New South Wales. Australian Journal of Biotechnology, 4 (2), 121-134.

Mammalian cell culture at the University of New South Wales

1990

Book Chapter

Protein engineering and diagnostic techniques

Mahler, Stephen M. (1990). Protein engineering and diagnostic techniques. Directions in Modern Biotechnology. (pp. 51-71) edited by Pauline M. Doran. Melbourne, VIC, Australia: Hawker Brownlow Education.

Protein engineering and diagnostic techniques

1989

Journal Article

Downstream processing of monoclonal antibodies

Gunnersen, J. M., Fowles, L. F., Snelgar, J. M., Mitchell, C. A., Patava, J. V., Osborne, K. J. and Mahler, S. M. (1989). Downstream processing of monoclonal antibodies. Australian Journal of Biotechnology, 3 (1), 69-71.

Downstream processing of monoclonal antibodies

1988

Journal Article

Desensitization of Adenylate-Cyclase and Cyclic-Amp Flux During the Early Stages of Liver-Regeneration

Mahler, SM and Wilce, PA (1988). Desensitization of Adenylate-Cyclase and Cyclic-Amp Flux During the Early Stages of Liver-Regeneration. Journal of Cellular Physiology, 136 (1), 88-94. doi: 10.1002/jcp.1041360111

Desensitization of Adenylate-Cyclase and Cyclic-Amp Flux During the Early Stages of Liver-Regeneration

1988

Journal Article

Studies On Regenerating Liver and Hepatoma Plasma-Membranes .2. Membrane Fluidity and Enzyme-Activity

Mahler, SM, Wilce, PA and Shanley, BC (1988). Studies On Regenerating Liver and Hepatoma Plasma-Membranes .2. Membrane Fluidity and Enzyme-Activity. International Journal of Biochemistry, 20 (6), 613-619. doi: 10.1016/0020-711X(88)90101-2

Studies On Regenerating Liver and Hepatoma Plasma-Membranes .2. Membrane Fluidity and Enzyme-Activity

1988

Journal Article

Studies On Regenerating Liver and Hepatoma Plasma-Membranes .1. Lipid and Protein-Composition

Mahler, SM, Wilce, PA and Shanley, BC (1988). Studies On Regenerating Liver and Hepatoma Plasma-Membranes .1. Lipid and Protein-Composition. International Journal of Biochemistry, 20 (6), 605-&. doi: 10.1016/0020-711X(88)90100-0

Studies On Regenerating Liver and Hepatoma Plasma-Membranes .1. Lipid and Protein-Composition

1986

Conference Publication

Comparative-Studies On Plasma-Membrane Isolated From Liver, Hepatoma and Regenerating Liver

Mahler, S, Wilce, PA and Shanley, BC (1986). Comparative-Studies On Plasma-Membrane Isolated From Liver, Hepatoma and Regenerating Liver. BALGOWLAH: ADIS PRESS AUSTRALASIA P/L.

Comparative-Studies On Plasma-Membrane Isolated From Liver, Hepatoma and Regenerating Liver

1984

Conference Publication

Membrane Fluidity in Rat Hepatoma Plasma-Membranes

Mahler, S, Shanley, BC and Wilce, PA (1984). Membrane Fluidity in Rat Hepatoma Plasma-Membranes. CLAYTON: PROC AUST BIOCHEMICAL SOC.

Membrane Fluidity in Rat Hepatoma Plasma-Membranes

Past funding

  • 2021 - 2023
    ACRF Facility for Targeted Radiometals in Cancer (AFTRiC)
    Australian Cancer Research Foundation
    Open grant
  • 2020 - 2021
    An integrated, multi-node bio-layer interferometry facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2019 - 2022
    Smart affinity membranes for manufacture of high value therapeutic proteins
    ARC Linkage Projects
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019
    Advanced Nanoparticle, Colloid and Microparticle Characterisation and Precision Engineering Nanosystems Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019
    Cyto-Mine to accelerate Cell Line Development for Vaccines and Biopharmaceuticals
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2021
    Nanomedicine strategies for early detection and treatment of brain metastases
    NHMRC Project Grant
    Open grant
  • 2018
    Continuous chromatography system for advanced bioprocessing
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    In vivo optical imaging into the next generation
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2017 - 2018
    Affinity Maturation of Anti-Lipopolysaccharide Antibody
    Innovation Connections
    Open grant
  • 2017 - 2018
    Provision of research services to Minomic International Ltd
    Minomic International Ltd
    Open grant
  • 2017 - 2023
    ARC Training Centre for Biopharmaceutical Innovation
    ARC Industrial Transformation Training Centres
    Open grant
  • 2016 - 2017
    EGFR targeted nanoparticle feasibility study
    Samyang Biopharmaceuticals Corporation
    Open grant
  • 2016 - 2019
    Next generation hybrid nanomaterials: bispecific antibody-targeted polymers
    ARC Linkage Projects
    Open grant
  • 2016 - 2017
    The biophysical characterisation of novel, recombinant bi-specific antibodies utilised in drug-delivery technology using Bio-layer Interferometry (Octet).
    Research Connections
    Open grant
  • 2016
    Exosome and Bio/Nanoparticle Characterisation Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016 - 2018
    Immuno-polymeric drugs for prostate cancer therapy
    NHMRC Project Grant
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2016
    Developing targeted EphA2 based imaging technology for glioblastoma
    Cure Brain Cancer Foundation
    Open grant
  • 2014 - 2023
    The National Biologics Facility - NCRIS 2013/2015/2016-17/2017-18/2018-19/2019-2023 (administered by Therapeutic Innovation Australia (TIA))
    Therapeutic Innovation Australia Limited
    Open grant
  • 2013 - 2015
    Safety assessment of anti-hendra virus antibody in humans
    Queensland Health
    Open grant
  • 2013
    QM6 Process Investigations
    UniQuest Pty Ltd
    Open grant
  • 2012 - 2015
    Single molecule spectroscopy-guided design of thermostable industrial enzymes
    ARC Linkage Projects
    Open grant
  • 2012 - 2015
    The first integrated multimodal assay for the ultrasensitive detection of dengue contamination of blood
    ARC Linkage Projects
    Open grant
  • 2012 - 2013
    Safety of Hendra virus anti-G glycoprotein monoclonal antibody in humans
    NHMRC Targeted Research
    Open grant
  • 2012 - 2015
    Targeting the delivery of cytotoxic agents to tumour cells using novel minicells as drug delivery vehicles and engineered, bispecific antibodies
    ARC Linkage Projects
    Open grant
  • 2011
    Mass spectrometer for biomolecule discovery, structural analysis and quantification.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2012
    Development of an integrated technology platform for neural cell surface marker discovery and characterisation
    UQ Collaboration and Industry Engagement Fund
    Open grant
  • 2010 - 2013
    Development of chaperonin 10-based second generation biopharmaceuticals for treatment of inflammatory diseases
    ARC Linkage Projects
    Open grant
  • 2010 - 2011
    High throughput isolation and expression of recombinant antibodies in mammalian cells
    UQ FirstLink Scheme
    Open grant
  • 2010
    Cost effective acquisition of an LC-MS/MS system to support CIPDD organics analysis and preclinical and clinical operations
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009
    Robotics Instrumentation for High Throughput Sample preparation for Increased Productivity of the CIPDD/TetraQ's HPLC-MS/MS Systems for Quantitative Analysis of Organics in a Quality Systems NATA-Acc
    UQ Faculty Co-Funding
    Open grant
  • 2009
    Stem cell-based interface tissue engineering
    ARC Discovery Projects
    Open grant

Availability

Emeritus Professor Stephen Mahler is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Stephen Mahler directly for media enquiries about:

  • Antibodies
  • Biologic medicines
  • Pharmaceuticals

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