Emeritus Professor Stephen Mahler
Emeritus Professor

Stephen Mahler

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Background

Professor Stephen Mahler is a Senior Group Leader at the Australian Institute for Bioengineering and Nanotechnology and Director of the Australian Research Council Training Centre for Biopharmaceutical Innovation (CBI), University of Queensland. Professor Mahler is a biotechnologist with a focus on R&D of recombinant-DNA derived protein biopharmaceuticals, drug delivery systems and nanomedicines. Professor Mahler has a record of translational research success and engages extensively with industry associated with the biomedical sciences both nationally and internationally.

Research within CBI covers three thematic research areas; discovery of new biopharmaceuticals, engineering cells for production of protein-based biopharmaceuticals and advanced manufacturing for industrial production. A current research interest is at the interface of the life sciences and materials science, using a synthetic biology approach for creating novel therapeutic entities as well as new systems for drug delivery.

Professor Mahler has a strong interest in education and training and was formerly Head of the Chemical and Biological Engineering Plan at the University of Queensland (2010-2016). Other educational initiatives include development of Masters Programs and a Continuing Professional Development program in the area of biopharmaceuticals. The CPD program is available to stakeholders in the industry, both in Australia and internationally.

Availability

Emeritus Professor Stephen Mahler is:
Available for supervision
Media expert

Fields of research

Biological Sciences Industrial biotechnology Medical biotechnology

Qualifications

  • Doctor of Philosophy, The University of Queensland

Research impacts

Professor Mahler has a strong engagement with industry both nationally and internationally, that through collaborative research has led to some significant translational outcomes including clinical trial of biopharmaceutical drug candidates through to approval. The Australian Research Council Training Centre for Biopharmaceutical Innovation is a consortium of partners including government, the University of Queensland and several industry partners, with a goal of contributing to the transformation of the biopharmaceutical industry. Through the Centre and the CPD Program in Biopharmaceuticals, Professor Mahler continues to work with stakeholders to ensure a vibrant future for the biopharmaceutical industry in Australia.

Search Professor Stephen Mahler’s works on UQ eSpace

137 works between 1984 and 2024
All (137) Journal Article (101) Book Chapter (13) Conference Publication (18) Other Outputs (5)

81 - 100 of 137 works

2014

Journal Article

Comparison and evaluation of immobilization methods for preparing bacterial probes using acidophilic bioleaching bacteria Acidithiobacillus thiooxidans for AFM studies

Diao, Mengxue, Taran, Elena, Mahler, Stephen M. and Nguyen, Anh V. (2014). Comparison and evaluation of immobilization methods for preparing bacterial probes using acidophilic bioleaching bacteria Acidithiobacillus thiooxidans for AFM studies. Journal of Microbiological Methods, 102, 12-14. doi: 10.1016/j.mimet.2014.04.004

Comparison and evaluation of immobilization methods for preparing bacterial probes using acidophilic bioleaching bacteria Acidithiobacillus thiooxidans for AFM studies

2014

Conference Publication

The Monoclonal Antibody 3C12C, Targeting CD83 Is a T Cell Sparing, Potential New Immunosuppressive Agent

Hart, D, Verma, N., Seldon, T, Sheng, Y., Pryor, R., Palkova, A., Findova, M., Jones, M., Munro, T., Mahler, S., Braet, K., Barnard, R., Marks, J., Coley, A., Fan, F., Zhou, Y., Vu, P, Lo, K., Shahin, K., Elgundi, Z., Silveira, P., Fromm, P., Clark, G., Larsen, S., Bradstock, K. and Munster, D. (2014). The Monoclonal Antibody 3C12C, Targeting CD83 Is a T Cell Sparing, Potential New Immunosuppressive Agent. 2014 World Transplant Congress, San Francicso Ca, 26 - 31 July 2014. Malden, MA United States: Wiley-Blackwell Publishing, Inc.. doi: 10.1111/ajt.12888

The Monoclonal Antibody 3C12C, Targeting CD83 Is a T Cell Sparing, Potential New Immunosuppressive Agent

2013

Other Outputs

Anti-CD83 antibodies and use thereof

Seldon, T. A., Munster, D. J., Hart, D. N., Jones, M. L., Munro, T. P., Mahler, S. M., Zhou, Y. and Marks, D. (2013). Anti-CD83 antibodies and use thereof.

Anti-CD83 antibodies and use thereof

2012

Journal Article

Evolution of Proteomic Methods for Analysis of Complex Biological Samples - Implications for Personalized Medicine

Nouwens, Amanda and Mahler, Stephen (2012). Evolution of Proteomic Methods for Analysis of Complex Biological Samples - Implications for Personalized Medicine. Integrative Proteomics, 29-44.

Evolution of Proteomic Methods for Analysis of Complex Biological Samples - Implications for Personalized Medicine

2012

Book Chapter

Evolution of proteomic methods for analysis of complex biological samples - implications for personalized medicine.

Nouwens, Amanda and Mahler, Stephen (2012). Evolution of proteomic methods for analysis of complex biological samples - implications for personalized medicine.. Integrative Proteomics. (pp. 29-43) edited by Hon-Chiu Eastwood Leung, Tsz-Kwong Man and Ricardo J. Flores. Croatia: InTech. doi: 10.5772/29613

Evolution of proteomic methods for analysis of complex biological samples - implications for personalized medicine.

2011

Journal Article

Bridging the gap: Facilities and technologies for development of early stage therapeutic mAb candidates

Munro, Trent P., Mahler, Stephen M., Huang, Edwin P., Chin, David Y. and Gray, Peter P. (2011). Bridging the gap: Facilities and technologies for development of early stage therapeutic mAb candidates. mAbs, 3 (5), 440-452. doi: 10.4161/mabs.3.5.16968

Bridging the gap: Facilities and technologies for development of early stage therapeutic mAb candidates

2011

Journal Article

Clonal selection of high producing, stably transfected HEK293 cell lines utilizing modified, high-throughput FACS screening

Song, Michael, Raphaelli, Kristin, Jones, Martina L., Aliabadi-Zadeh, Khosrow, Leung, Kar Man, Crowley, David, Hughes, Benjamin, Mahler, Stephen, Gray, Peter P., Huang, Edwin P. and Chin, David Y. (2011). Clonal selection of high producing, stably transfected HEK293 cell lines utilizing modified, high-throughput FACS screening. Journal of Chemical Technology and Biotechnology, 86 (7), 935-941. doi: 10.1002/jctb.2618

Clonal selection of high producing, stably transfected HEK293 cell lines utilizing modified, high-throughput FACS screening

2011

Journal Article

Analytical strategies for assessing comparability of biosimilars

Falconer, Robert J., Jackson-Matthews, Dianne and Mahler, Stephen M. (2011). Analytical strategies for assessing comparability of biosimilars. Journal of Chemical Technology and Biotechnology, 86 (7), 915-922. doi: 10.1002/jctb.2629

Analytical strategies for assessing comparability of biosimilars

2011

Journal Article

Biologics and biosimilars: emerging technologies driving global opportunity

Mahler, Stephen and Gray, Peter (2011). Biologics and biosimilars: emerging technologies driving global opportunity. Journal of Chemical Technology & Biotechnology, 86 (7), 893-894. doi: 10.1002/jctb.2684

Biologics and biosimilars: emerging technologies driving global opportunity

2011

Book Chapter

C15 disease-modifying antirheumatic drugs

Pile, Kevin D., Graham, Garry G., Mahler, Stephen M. and Day, Richard O. (2011). C15 disease-modifying antirheumatic drugs. Principles of immunopharmacology. (pp. 585-619) edited by Frans P. Nijkamp and Michael J. Parnham. Basel, Switzerland: Springer. doi: 10.1007/978-3-0346-0136-8_30

C15 disease-modifying antirheumatic drugs

2010

Journal Article

Disease-specific, neurosphere-derived cells as models for brain disorders

Matigian, N, Abrahamsen, G, Sutharsan, R, Cook, AL, Vitale, AM, Nouwens, A, Bellette, B, An, JY, Anderson, M, Beckhouse, AG, Bennebroek, M, Cecil, R, Chalk, AM, Cochrane, J, Fan, YJ, Feron, F, McCurdy, R, McGrath, JJ, Murrell, W, Perry, C, Raju, J, Ravishankar, S, Silburn, PA, Sutherland, GT, Mahler, S, Mellick, GD, Wood, SA, Sue, CM, Wells, CA and Mackay-Sim, A (2010). Disease-specific, neurosphere-derived cells as models for brain disorders. Disease Models and Mechanisms, 3 (11-12), 785-798. doi: 10.1242/dmm.005447

Disease-specific, neurosphere-derived cells as models for brain disorders

2010

Journal Article

A method for rapid, ligation-independent reformatting of recombinant monoclonal antibodies

Jones, Martina L., Seldon, Therese, Smede, Matthew, Linville, Ashleigh, Chin, David Y., Barnard, Ross, Mahler, Stephen M., Munster, David, Hart, Derek, Gray, Peter P. and Munro, Trent P. (2010). A method for rapid, ligation-independent reformatting of recombinant monoclonal antibodies. Journal of Immunological Methods, 354 (1-2), 85-90. doi: 10.1016/j.jim.2010.02.001

A method for rapid, ligation-independent reformatting of recombinant monoclonal antibodies

2009

Journal Article

Evidence of heterogeneity in the antibody response against the platelet antigen 3a; recognition of an 11-mer peptide carrying the HPA-3a polymorphic determinant

de Leon, EJ, Yuan, FF, Pearson, H, Marquis, CP and Mahler, SM (2009). Evidence of heterogeneity in the antibody response against the platelet antigen 3a; recognition of an 11-mer peptide carrying the HPA-3a polymorphic determinant. VOX SANGUINIS, 96 (3), 252-255. doi: 10.1111/j.1423-0410.2008.01146.x

Evidence of heterogeneity in the antibody response against the platelet antigen 3a; recognition of an 11-mer peptide carrying the HPA-3a polymorphic determinant

2009

Journal Article

A sensitive and specific ELISA detects methionine sulfoxide-containing apolipoprotein A-I in HDL

Wang, XS, Shao, BH, Oda, MN, Heinecke, JW, Mahler, S and Stocker, R (2009). A sensitive and specific ELISA detects methionine sulfoxide-containing apolipoprotein A-I in HDL. JOURNAL OF LIPID RESEARCH, 50 (3), 586-594. doi: 10.1194/jlr.D800042-JLR200

A sensitive and specific ELISA detects methionine sulfoxide-containing apolipoprotein A-I in HDL

2009

Conference Publication

Developing a Therapeutic Anti - Dendritic Cell Antibody to Prevent Graft Versus Host Disease

Hart, D, Seldon, T, Jones, M, Sheng, Y, Palkova, A, Cullup, H, Munro, T, Sinfield, L, Rice, AM, Wilson, J, Gray, P, Barnard, R, Mahler, S and Munster, D (2009). Developing a Therapeutic Anti - Dendritic Cell Antibody to Prevent Graft Versus Host Disease. 51st Annual Meeting of the American Society of Hematology, New Orleans LA, 5-8 December 2009. Washington, D.C.: American Society of Hematology.

Developing a Therapeutic Anti - Dendritic Cell Antibody to Prevent Graft Versus Host Disease

2008

Journal Article

BioPEGylation of Polyhydroxyalkanoates: Influence on Properties and Satellite-Stem Cell Cycle

Marcal, Helder, Wanandy, Nico S., Sanguanchaipaiwong, Vorapat, Woolnough, Catherine E., Lauto, Antonio, Mahler, Stephen M. and Foster, L. John R. (2008). BioPEGylation of Polyhydroxyalkanoates: Influence on Properties and Satellite-Stem Cell Cycle. Biomacromolecules, 9 (10), 2719-2726. doi: 10.1021/bm800418e

BioPEGylation of Polyhydroxyalkanoates: Influence on Properties and Satellite-Stem Cell Cycle

2008

Journal Article

In Focus: Stem cell and tissue engineering applications in regenerative medicine

Mahler, Stephen (2008). In Focus: Stem cell and tissue engineering applications in regenerative medicine. Journal of Chemical Technology and Biotechnology, 83 (4), 395-396. doi: 10.1002/jctb.1933

In Focus: Stem cell and tissue engineering applications in regenerative medicine

2008

Journal Article

The macrophage-biomaterial interface: a proteomic analysis of the conditioned medium environment

Dinnes, Donna Lee M., Marcal, Helder, Raftery, Mark J., Labow, Rosalind S. and Mahler, Stephen M. (2008). The macrophage-biomaterial interface: a proteomic analysis of the conditioned medium environment. Journal of Chemical Technology And Biotechnology, 83 (4), 482-495. doi: 10.1002/jctb.1854

The macrophage-biomaterial interface: a proteomic analysis of the conditioned medium environment

2008

Journal Article

Expression proteomics of olfactory ensheathing cells

Marcal, Helder, Sarris, Maria, Raftery, Mark J., Bhasin, Vishal, McFarland, Clive and Mahler, Stephen M. (2008). Expression proteomics of olfactory ensheathing cells. Journal of Chemical Technology And Biotechnology, 83 (4), 473-481. doi: 10.1002/jctb.1900

Expression proteomics of olfactory ensheathing cells

2008

Journal Article

Practical blood dendritic cell vaccination for immunotherapy of multiple myeloma

Vari F, Munster D.J., Hsu J.L., Rossetti T.R., Stephen Mahler, Gray, Peter P., Turtle C.J., Prue R.L. and Hart D.N. (2008). Practical blood dendritic cell vaccination for immunotherapy of multiple myeloma. British Journal Of Haematology, 143 (3), 374-377. doi: 10.1111/j.1365-2141.2008.07346.x

Practical blood dendritic cell vaccination for immunotherapy of multiple myeloma

Past funding

  • 2021 - 2023
    ACRF Facility for Targeted Radiometals in Cancer (AFTRiC)
    Australian Cancer Research Foundation
    Open grant
  • 2020 - 2021
    An integrated, multi-node bio-layer interferometry facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2019 - 2022
    Smart affinity membranes for manufacture of high value therapeutic proteins
    ARC Linkage Projects
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019
    Advanced Nanoparticle, Colloid and Microparticle Characterisation and Precision Engineering Nanosystems Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019
    Cyto-Mine to accelerate Cell Line Development for Vaccines and Biopharmaceuticals
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2021
    Nanomedicine strategies for early detection and treatment of brain metastases
    NHMRC Project Grant
    Open grant
  • 2018
    Continuous chromatography system for advanced bioprocessing
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    In vivo optical imaging into the next generation
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2017 - 2018
    Affinity Maturation of Anti-Lipopolysaccharide Antibody
    Innovation Connections
    Open grant
  • 2017 - 2018
    Provision of research services to Minomic International Ltd
    Minomic International Ltd
    Open grant
  • 2017 - 2023
    ARC Training Centre for Biopharmaceutical Innovation
    ARC Industrial Transformation Training Centres
    Open grant
  • 2016 - 2017
    EGFR targeted nanoparticle feasibility study
    Samyang Biopharmaceuticals Corporation
    Open grant
  • 2016 - 2019
    Next generation hybrid nanomaterials: bispecific antibody-targeted polymers
    ARC Linkage Projects
    Open grant
  • 2016 - 2017
    The biophysical characterisation of novel, recombinant bi-specific antibodies utilised in drug-delivery technology using Bio-layer Interferometry (Octet).
    Research Connections
    Open grant
  • 2016
    Exosome and Bio/Nanoparticle Characterisation Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016 - 2018
    Immuno-polymeric drugs for prostate cancer therapy
    NHMRC Project Grant
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2016
    Developing targeted EphA2 based imaging technology for glioblastoma
    Cure Brain Cancer Foundation
    Open grant
  • 2014 - 2023
    The National Biologics Facility - NCRIS 2013/2015/2016-17/2017-18/2018-19/2019-2023 (administered by Therapeutic Innovation Australia (TIA))
    Therapeutic Innovation Australia Limited
    Open grant
  • 2013 - 2015
    Safety assessment of anti-hendra virus antibody in humans
    Queensland Health
    Open grant
  • 2013
    QM6 Process Investigations
    UniQuest Pty Ltd
    Open grant
  • 2012 - 2015
    Single molecule spectroscopy-guided design of thermostable industrial enzymes
    ARC Linkage Projects
    Open grant
  • 2012 - 2015
    The first integrated multimodal assay for the ultrasensitive detection of dengue contamination of blood
    ARC Linkage Projects
    Open grant
  • 2012 - 2013
    Safety of Hendra virus anti-G glycoprotein monoclonal antibody in humans
    NHMRC Targeted Research
    Open grant
  • 2012 - 2015
    Targeting the delivery of cytotoxic agents to tumour cells using novel minicells as drug delivery vehicles and engineered, bispecific antibodies
    ARC Linkage Projects
    Open grant
  • 2011
    Mass spectrometer for biomolecule discovery, structural analysis and quantification.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2012
    Development of an integrated technology platform for neural cell surface marker discovery and characterisation
    UQ Collaboration and Industry Engagement Fund
    Open grant
  • 2010 - 2013
    Development of chaperonin 10-based second generation biopharmaceuticals for treatment of inflammatory diseases
    ARC Linkage Projects
    Open grant
  • 2010 - 2011
    High throughput isolation and expression of recombinant antibodies in mammalian cells
    UQ FirstLink Scheme
    Open grant
  • 2010
    Cost effective acquisition of an LC-MS/MS system to support CIPDD organics analysis and preclinical and clinical operations
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009
    Robotics Instrumentation for High Throughput Sample preparation for Increased Productivity of the CIPDD/TetraQ's HPLC-MS/MS Systems for Quantitative Analysis of Organics in a Quality Systems NATA-Acc
    UQ Faculty Co-Funding
    Open grant
  • 2009
    Stem cell-based interface tissue engineering
    ARC Discovery Projects
    Open grant

Availability

Emeritus Professor Stephen Mahler is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Enquiries

Contact Emeritus Professor Stephen Mahler directly for media enquiries about:

  • Antibodies
  • Biologic medicines
  • Pharmaceuticals

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