Overview
Availability
- Dr Christopher Howard is:
- Available for supervision
Qualifications
- Doctor of Philosophy, Queensland University of Technology
Research interests
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Protein engineering, Programmable Bionanomaterials, Molecular Discovery, Bio Nano Technologies
Works
Search Professor Christopher Howard’s works on UQ eSpace
2021
Journal Article
Amplification-free SARS-CoV-2 detection using nanoyeast-scFv and ultrasensitive plasmonic nanobox-integrated nanomixing microassay
Li, Junrong, Wuethrich, Alain, Edwardraja, Selvakumar, Lobb, Richard J., Puttick, Simon, Rose, Stephen, Howard, Christopher B. and Trau, Matt (2021). Amplification-free SARS-CoV-2 detection using nanoyeast-scFv and ultrasensitive plasmonic nanobox-integrated nanomixing microassay. Analytical Chemistry, 93 (29) acs.analchem.1c01657, 10251-10260. doi: 10.1021/acs.analchem.1c01657
2021
Journal Article
Coagulation factor IX analysis in bioreactor cell culture supernatant predicts quality of the purified product
Zacchi, Lucia F., Roche-Recinos, Dinora, Pegg, Cassandra L., Phung, Toan K., Napoli, Mark, Aitken, Campbell, Sandford, Vanessa, Mahler, Stephen M., Lee, Yih Yean, Schulz, Benjamin L. and Howard, Christopher B. (2021). Coagulation factor IX analysis in bioreactor cell culture supernatant predicts quality of the purified product. Communications Biology, 4 (1) 390, 390. doi: 10.1038/s42003-021-01903-x
2021
Journal Article
Incorporation of unnatural amino acid into antibody fragment for creating a stable antibody-drug conjugate
Wardiana, Andri, Jones, Martina L., Mahler, Stephen M. and Howard, Christopher B. (2021). Incorporation of unnatural amino acid into antibody fragment for creating a stable antibody-drug conjugate. Indonesian Journal of Pharmacy, 32 (1), 96-105. doi: 10.22146/ijp.1101
2021
Journal Article
Perfusion culture of Chinese Hamster Ovary cells for bioprocessing applications
MacDonald, Michael A., Nöbel, Matthias, Roche Recinos, Dinora, Martínez, Verónica S., Schulz, Benjamin L., Howard, Christopher B., Baker, Kym, Shave, Evan, Lee, Yih Yean, Marcellin, Esteban, Mahler, Stephen, Nielsen, Lars Keld and Munro, Trent (2021). Perfusion culture of Chinese Hamster Ovary cells for bioprocessing applications. Critical Reviews in Biotechnology, 42 (7), 1-17. doi: 10.1080/07388551.2021.1998821
2020
Journal Article
A bispecific T cell engager targeting Glypican-1 redirects T cell cytolytic activity to kill prostate cancer cells
Lund, Maria E., Howard, Christopher B., Thurecht, Kristofer J., Campbell, Douglas H., Mahler, Stephen M. and Walsh, Bradley J. (2020). A bispecific T cell engager targeting Glypican-1 redirects T cell cytolytic activity to kill prostate cancer cells. BMC Cancer, 20 (1) 1214, 1214. doi: 10.1186/s12885-020-07562-1
2020
Journal Article
Effect of chain‐end chemistries on the efficiency of coupling antibodies to polymers using unnatural amino acids
Sivaram, Amal J., Wardiana, Andri, Preethi, S. S. Hema, Fuchs, Adrian V., Howard, Christopher B., Fletcher, Nicholas L., Bell, Craig A. and Thurecht, Kristofer J. (2020). Effect of chain‐end chemistries on the efficiency of coupling antibodies to polymers using unnatural amino acids. Macromolecular Rapid Communications, 41 (21) 2000294, e2000294. doi: 10.1002/marc.202000294
2020
Journal Article
Controlling the biological fate of micellar nanoparticles: balancing stealth and targeting
Sivaram, Amal J., Wardiana, Andri, Alcantara, Sheilajen, Sonderegger, Stefan E., Fletcher, Nicholas L., Houston, Zachary H., Howard, Christopher B., Mahler, Stephen M., Alexander, Cameron, Kent, Stephen J., Bell, Craig A. and Thurecht, Kristofer J. (2020). Controlling the biological fate of micellar nanoparticles: balancing stealth and targeting. ACS Nano, 14 (10) acsnano.0c06033, 13739-13753. doi: 10.1021/acsnano.0c06033
2020
Journal Article
Targeting the undruggable: emerging technologies in antibody delivery against intracellular targets
Niamsuphap, Suchada, Fercher, Christian, Kumble, Sumukh, Huda, Pie, Mahler, Stephen M. and Howard, Christopher B. (2020). Targeting the undruggable: emerging technologies in antibody delivery against intracellular targets. Expert Opinion on Drug Delivery, 17 (9), 1189-1211. doi: 10.1080/17425247.2020.1781088
2020
Journal Article
Identification of novel glycosylation events on human serum-derived factor IX
Pegg, Cassandra L., Zacchi, Lucia F., Recinos, Dinora Roche, Howard, Christopher B. and Schulz, Benjamin L. (2020). Identification of novel glycosylation events on human serum-derived factor IX. Glycoconjugate Journal, 37 (4), 471-483. doi: 10.1007/s10719-020-09922-2
2020
Conference Publication
Canine PET/CT imaging with 64Cu-nanomedicines
Daniel, Sarah, Houston, Zachary, Fletcher, Nicholas, Bell, Craig, Atcheson, Nicole, Al-Najjar, Aiman, Howard, Christopher, Mahler, Stephen, Straw, Rod and Thurecht, Kristofer (2020). Canine PET/CT imaging with 64Cu-nanomedicines. SNMMI Annual Meeting, Online, 11-14 July, 2020. Reston, VA, United States: Society of Nuclear Medicine.
2020
Journal Article
Targeted camptothecin delivery via silicon nanoparticles reduces breast cancer metastasis
Landgraf, Marietta, Lahr, Christoph A., Kaur, Ishdeep, Shafiee, Abbas, Sanchez-Herrero, Alvaro, Janowicz, Phillip W., Ravichandran, Akhilandeshwari, Howard, Christopher B., Cifuentes-Rius, Anna, McGovern, Jacqui A., Voelcker, Nicolas H. and Hutmacher, Dietmar W. (2020). Targeted camptothecin delivery via silicon nanoparticles reduces breast cancer metastasis. Biomaterials, 240 119791, 119791. doi: 10.1016/j.biomaterials.2020.119791
2020
Journal Article
Glycoproteomic measurement of site-specific polysialylation
Pelingon, Ruby, Pegg, Cassandra L., Zacchi, Lucia F., Phung, Toan K., Howard, Christopher B., Xu, Ping, Hardy, Matthew P., Owczarek, Catherine M. and Schulz, Benjamin L. (2020). Glycoproteomic measurement of site-specific polysialylation. Analytical Biochemistry, 596 113625, 113625. doi: 10.1016/j.ab.2020.113625
2020
Journal Article
Understanding the uptake of nanomedicines at different stages of brain cancer using a modular nanocarrier platform and precision bispecific antibodies
Houston, Zachary H., Bunt, Jens, Chen, Kok-Siong, Puttick, Simon, Howard, Christopher B., Fletcher, Nicholas L., Fuchs, Adrian V., Cui, Jiwei, Ju, Yi, Cowin, Gary, Song, Xin, Boyd, Andrew W., Mahler, Stephen M., Richards, Linda J., Caruso, Frank and Thurecht, Kristofer J. (2020). Understanding the uptake of nanomedicines at different stages of brain cancer using a modular nanocarrier platform and precision bispecific antibodies. ACS Central Science, 6 (5) acscentsci.9b01299, 727-738. doi: 10.1021/acscentsci.9b01299
2020
Journal Article
S-trap eliminates cell culture media polymeric surfactants for effective proteomic analysis of mammalian cell bioreactor supernatants
Zacchi, Lucia F., Roche Recinos, Dinora, Otte, Ellen, Aitken, Campbell, Hunt, Tony, Sandford, Vanessa, Lee, Yih Yean, Schulz, Benjamin L. and Howard, Christopher B. (2020). S-trap eliminates cell culture media polymeric surfactants for effective proteomic analysis of mammalian cell bioreactor supernatants. Journal of Proteome Research, 19 (5), 2149-2158. doi: 10.1021/acs.jproteome.0c00106
2020
Journal Article
Investigation of the therapeutic potential of a synergistic delivery system through dual controlled release of camptothecin-doxorubicin
Zhao, Yongmei, Fletcher, Nicholas L., Gemmell, Anna, Houston, Zachary H., Howard, Christopher B., Blakey, Idriss, Liu, Tianqing and Thurecht, Kristofer J. (2020). Investigation of the therapeutic potential of a synergistic delivery system through dual controlled release of camptothecin-doxorubicin. Advanced Therapeutics, 3 (6) 1900202, 1900202. doi: 10.1002/adtp.201900202
2020
Journal Article
Targeted and modular architectural polymers employing bioorthogonal chemistry for quantitative therapeutic delivery
Ediriweera, Gayathri R., Simpson, Joshua D., Fuchs, Adrian V., Venkatachalam, Taracad K., Van De Walle, Matthias, Howard, Christopher B., Mahler, Stephen M., Blinco, James P., Fletcher, Nicholas L., Houston, Zachary H., Bell, Craig A. and Thurecht, Kristofer J. (2020). Targeted and modular architectural polymers employing bioorthogonal chemistry for quantitative therapeutic delivery. Chemical Science, 11 (12), 3268-3280. doi: 10.1039/d0sc00078g
2019
Journal Article
Single droplet detection of immune checkpoints on a multiplexed electrohydrodynamic biosensor
Wuethrich, Alain, Rajkumar, Aswin Raj, Shanmugasundaram, Karthik Balaji, Reza, Kamil K., Dey, Shuvashis, Howard, Christopher B., Sina, Abu Ali Ibn and Trau, Matt (2019). Single droplet detection of immune checkpoints on a multiplexed electrohydrodynamic biosensor. The Analyst, 144 (23), 6914-6921. doi: 10.1039/c9an01450k
2019
Journal Article
Retooling phage display with electrohydrodynamic nanomixing and nanopore sequencing
Raftery, Lyndon J., Howard, Christopher B., Grewal, Yadveer S., Vaidyanathan, Ramanathan, Jones, Martina L., Anderson, Will, Korbie, Darren, Duarte, Tania, Duc Cao, Minh, Nguyen, Son Hoang, Coin, Lachlan JM, Mahler, Stephen M and Trau, Matt (2019). Retooling phage display with electrohydrodynamic nanomixing and nanopore sequencing. Lab on a Chip, 19 (24), 4083-4092. doi: 10.1039/c9lc00978g
2019
Journal Article
Multifunctional lipid-coated calcium phosphate nanoplatforms for complete inhibition of large triple negative breast cancer via targeted combined therapy
Tang, Jie, Li, Bei, Howard, Christopher B., Mahler, Stephen M., Thurecht, Kristofer J., Wu, Yilun, Huang, Leaf and Xu, Zhi Ping (2019). Multifunctional lipid-coated calcium phosphate nanoplatforms for complete inhibition of large triple negative breast cancer via targeted combined therapy. Biomaterials, 216 119232, 119232. doi: 10.1016/j.biomaterials.2019.119232
2019
Journal Article
Polymer design and component selection contribute to uptake, distribution & trafficking behaviours of polyethylene glycol hyperbranched polymers in live MDA-MB-468 breast cancer cells
Simpson, Joshua D., Ediriweera, Gayathri R., Howard, Christopher B., Fletcher, Nicholas L., Bell, Craig A. and Thurecht, Kristofer J. (2019). Polymer design and component selection contribute to uptake, distribution & trafficking behaviours of polyethylene glycol hyperbranched polymers in live MDA-MB-468 breast cancer cells. Biomaterials Science, 7 (11), 4661-4674. doi: 10.1039/c9bm00957d
Funding
Current funding
Supervision
Availability
- Dr Christopher Howard is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Available projects
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Molecular Discovery and bioengineering of innovative biologics to detect pandemic threat pathogens, new virus variants and emerging viruses
Explore the molecular discovery and bioengineering of innovative biologics for the detection of pandemic threat pathogens, such as Sars Cov2, SCV2 variants and influenza.
Supervision history
Current supervision
-
Doctor Philosophy
Molecular Discovery and bioengineering of innovative biologics to detect pandemic threat pathogens, new virus variants and emerging viruses
Principal Advisor
Other advisors: Professor David Owen, Dr Kym Lowry, Dr Pie Huda
-
Doctor Philosophy
Engineering Novel Theranostics for High Grade Glioma Through Site-Specific EphA2 Antibody Modification
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler, Dr Martina Jones
-
Doctor Philosophy
An integrated nano-bioengineered chip for enhanced molecular evolution
Associate Advisor
Other advisors: Professor Matt Trau, Dr Selvakumar Edwardraja, Dr Fiach Antaw
-
Doctor Philosophy
mRNA cancer therapies
Associate Advisor
Other advisors: Professor Timothy Mercer, Associate Professor Seth Cheetham
-
Doctor Philosophy
Investigating therapeutic potentials of brain-derived exosomes
Associate Advisor
Other advisors: Professor Matt Trau, Dr Richard Lobb
Completed supervision
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2025
Doctor Philosophy
Development of next-generation molecular tools for diagnostics
Principal Advisor
Other advisors: Professor Matt Trau, Dr Selvakumar Edwardraja
-
2024
Doctor Philosophy
Engineering synthetic regulatory circuits for precise metabolic control in Saccharomyces cerevisiae
Principal Advisor
Other advisors: Professor Gary Schenk
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2023
Doctor Philosophy
Discovery and Development of a Novel Human Glypican-1 Monoclonal Antibody for Targeting Solid Cancers
Principal Advisor
Other advisors: Emeritus Professor Stephen Mahler, Dr Martina Jones
-
2021
Doctor Philosophy
Evaluation of the impact of the upstream bioprocess parameters on the proteomic profile of recombinant factor IX
Principal Advisor
Other advisors: Professor Benjamin Schulz
-
2020
Doctor Philosophy
Development of novel bioconjugation strategies for creating cancer-targeting nanomaterials
Principal Advisor
Other advisors: Emeritus Professor Stephen Mahler, Dr Martina Jones
-
2025
Doctor Philosophy
Integration of innovative diagnostic technologies for the detection of flaviviral infections
Associate Advisor
Other advisors: Associate Professor Jody Peters
-
2025
Doctor Philosophy
Towards n-plex quantitation of molecular interactions for evolution-free biopanning
Associate Advisor
Other advisors: Professor Matt Trau
-
2024
Doctor Philosophy
Development of Antibody Delivery Systems Against Intracellular Targets
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler
-
2023
Doctor Philosophy
Novel antibody theranostics for oncology
Associate Advisor
Other advisors: Dr Pie Huda, Professor Kristofer Thurecht
-
2023
Doctor Philosophy
Bioengineering yeast nanofragment affinity probes for dengue diagnostics
Associate Advisor
Other advisors: Associate Professor Alain Wuethrich, Professor Matt Trau
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2022
Doctor Philosophy
Engineering and production of recombinant proteins with appropriate glycostructures for early in vivo studies
Associate Advisor
Other advisors: Dr Lucia Zacchi, Professor Benjamin Schulz
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2019
Master Philosophy
Radiosensitization of Prostate Cancer by Nanoparticle Mediated RNA Interference
Associate Advisor
Other advisors: Honorary Professor Kum Kum Khanna, Dr Nick Fletcher, Professor Kristofer Thurecht
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2019
Doctor Philosophy
Isolation and characterisation of antibodies against human and canine EphA2_ targets for comparative studies in brain cancer
Associate Advisor
Other advisors: Dr Martina Jones, Professor Andrew Whittaker, Emeritus Professor Stephen Mahler
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2018
Doctor Philosophy
Isolation and development of antibodies for active targeting of nanocells for cancer therapy
Associate Advisor
Other advisors: Dr Martina Jones, Emeritus Professor Stephen Mahler
-
2018
Doctor Philosophy
Engineering lipid-coated calcium phosphate nanoparticles with multiple ligands to amplify in vivo tumor target delivery
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler
-
2017
Doctor Philosophy
Development and Application of Novel Biosensor Technologies
Associate Advisor
Other advisors: Dr Martina Jones, Emeritus Professor Stephen Mahler
-
2017
Master Philosophy
Development of anti-PEG bispecific antibodies for targeting PEGylated nanoparticles to tumour cells
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler
Media
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