Overview
Availability
- Dr Christopher Howard is:
- Available for supervision
Qualifications
- Doctor of Philosophy, Queensland University of Technology
Research interests
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Protein engineering, Programmable Bionanomaterials, Molecular Discovery, Bio Nano Technologies
Works
Search Professor Christopher Howard’s works on UQ eSpace
2020
Journal Article
Targeting the undruggable: emerging technologies in antibody delivery against intracellular targets
Niamsuphap, Suchada, Fercher, Christian, Kumble, Sumukh, Huda, Pie, Mahler, Stephen M. and Howard, Christopher B. (2020). Targeting the undruggable: emerging technologies in antibody delivery against intracellular targets. Expert Opinion on Drug Delivery, 17 (9), 1189-1211. doi: 10.1080/17425247.2020.1781088
2020
Journal Article
Identification of novel glycosylation events on human serum-derived factor IX
Pegg, Cassandra L., Zacchi, Lucia F., Recinos, Dinora Roche, Howard, Christopher B. and Schulz, Benjamin L. (2020). Identification of novel glycosylation events on human serum-derived factor IX. Glycoconjugate Journal, 37 (4), 471-483. doi: 10.1007/s10719-020-09922-2
2020
Conference Publication
Canine PET/CT imaging with 64Cu-nanomedicines
Daniel, Sarah, Houston, Zachary, Fletcher, Nicholas, Bell, Craig, Atcheson, Nicole, Al-Najjar, Aiman, Howard, Christopher, Mahler, Stephen, Straw, Rod and Thurecht, Kristofer (2020). Canine PET/CT imaging with 64Cu-nanomedicines. SNMMI Annual Meeting, Online, 11-14 July, 2020. Reston, VA, United States: Society of Nuclear Medicine.
2020
Journal Article
Targeted camptothecin delivery via silicon nanoparticles reduces breast cancer metastasis
Landgraf, Marietta, Lahr, Christoph A., Kaur, Ishdeep, Shafiee, Abbas, Sanchez-Herrero, Alvaro, Janowicz, Phillip W., Ravichandran, Akhilandeshwari, Howard, Christopher B., Cifuentes-Rius, Anna, McGovern, Jacqui A., Voelcker, Nicolas H. and Hutmacher, Dietmar W. (2020). Targeted camptothecin delivery via silicon nanoparticles reduces breast cancer metastasis. Biomaterials, 240 119791, 119791. doi: 10.1016/j.biomaterials.2020.119791
2020
Journal Article
Glycoproteomic measurement of site-specific polysialylation
Pelingon, Ruby, Pegg, Cassandra L., Zacchi, Lucia F., Phung, Toan K., Howard, Christopher B., Xu, Ping, Hardy, Matthew P., Owczarek, Catherine M. and Schulz, Benjamin L. (2020). Glycoproteomic measurement of site-specific polysialylation. Analytical Biochemistry, 596 113625, 113625. doi: 10.1016/j.ab.2020.113625
2020
Journal Article
Understanding the uptake of nanomedicines at different stages of brain cancer using a modular nanocarrier platform and precision bispecific antibodies
Houston, Zachary H., Bunt, Jens, Chen, Kok-Siong, Puttick, Simon, Howard, Christopher B., Fletcher, Nicholas L., Fuchs, Adrian V., Cui, Jiwei, Ju, Yi, Cowin, Gary, Song, Xin, Boyd, Andrew W., Mahler, Stephen M., Richards, Linda J., Caruso, Frank and Thurecht, Kristofer J. (2020). Understanding the uptake of nanomedicines at different stages of brain cancer using a modular nanocarrier platform and precision bispecific antibodies. ACS Central Science, 6 (5) acscentsci.9b01299, 727-738. doi: 10.1021/acscentsci.9b01299
2020
Journal Article
S-trap eliminates cell culture media polymeric surfactants for effective proteomic analysis of mammalian cell bioreactor supernatants
Zacchi, Lucia F., Roche Recinos, Dinora, Otte, Ellen, Aitken, Campbell, Hunt, Tony, Sandford, Vanessa, Lee, Yih Yean, Schulz, Benjamin L. and Howard, Christopher B. (2020). S-trap eliminates cell culture media polymeric surfactants for effective proteomic analysis of mammalian cell bioreactor supernatants. Journal of Proteome Research, 19 (5), 2149-2158. doi: 10.1021/acs.jproteome.0c00106
2020
Journal Article
Investigation of the therapeutic potential of a synergistic delivery system through dual controlled release of camptothecin-doxorubicin
Zhao, Yongmei, Fletcher, Nicholas L., Gemmell, Anna, Houston, Zachary H., Howard, Christopher B., Blakey, Idriss, Liu, Tianqing and Thurecht, Kristofer J. (2020). Investigation of the therapeutic potential of a synergistic delivery system through dual controlled release of camptothecin-doxorubicin. Advanced Therapeutics, 3 (6) 1900202, 1900202. doi: 10.1002/adtp.201900202
2020
Journal Article
Targeted and modular architectural polymers employing bioorthogonal chemistry for quantitative therapeutic delivery
Ediriweera, Gayathri R., Simpson, Joshua D., Fuchs, Adrian V., Venkatachalam, Taracad K., Van De Walle, Matthias, Howard, Christopher B., Mahler, Stephen M., Blinco, James P., Fletcher, Nicholas L., Houston, Zachary H., Bell, Craig A. and Thurecht, Kristofer J. (2020). Targeted and modular architectural polymers employing bioorthogonal chemistry for quantitative therapeutic delivery. Chemical Science, 11 (12), 3268-3280. doi: 10.1039/d0sc00078g
2019
Journal Article
Single droplet detection of immune checkpoints on a multiplexed electrohydrodynamic biosensor
Wuethrich, Alain, Rajkumar, Aswin Raj, Shanmugasundaram, Karthik Balaji, Reza, Kamil K., Dey, Shuvashis, Howard, Christopher B., Sina, Abu Ali Ibn and Trau, Matt (2019). Single droplet detection of immune checkpoints on a multiplexed electrohydrodynamic biosensor. The Analyst, 144 (23), 6914-6921. doi: 10.1039/c9an01450k
2019
Journal Article
Retooling phage display with electrohydrodynamic nanomixing and nanopore sequencing
Raftery, Lyndon J., Howard, Christopher B., Grewal, Yadveer S., Vaidyanathan, Ramanathan, Jones, Martina L., Anderson, Will, Korbie, Darren, Duarte, Tania, Duc Cao, Minh, Nguyen, Son Hoang, Coin, Lachlan JM, Mahler, Stephen M and Trau, Matt (2019). Retooling phage display with electrohydrodynamic nanomixing and nanopore sequencing. Lab on a Chip, 19 (24), 4083-4092. doi: 10.1039/c9lc00978g
2019
Journal Article
Multifunctional lipid-coated calcium phosphate nanoplatforms for complete inhibition of large triple negative breast cancer via targeted combined therapy
Tang, Jie, Li, Bei, Howard, Christopher B., Mahler, Stephen M., Thurecht, Kristofer J., Wu, Yilun, Huang, Leaf and Xu, Zhi Ping (2019). Multifunctional lipid-coated calcium phosphate nanoplatforms for complete inhibition of large triple negative breast cancer via targeted combined therapy. Biomaterials, 216 119232, 119232. doi: 10.1016/j.biomaterials.2019.119232
2019
Journal Article
Polymer design and component selection contribute to uptake, distribution & trafficking behaviours of polyethylene glycol hyperbranched polymers in live MDA-MB-468 breast cancer cells
Simpson, Joshua D., Ediriweera, Gayathri R., Howard, Christopher B., Fletcher, Nicholas L., Bell, Craig A. and Thurecht, Kristofer J. (2019). Polymer design and component selection contribute to uptake, distribution & trafficking behaviours of polyethylene glycol hyperbranched polymers in live MDA-MB-468 breast cancer cells. Biomaterials Science, 7 (11), 4661-4674. doi: 10.1039/c9bm00957d
2019
Journal Article
Cellular targeting of bispecific antibody-functionalized poly(ethylene glycol) capsules: do shape and size matter?
Song, Danzi, Cui, Jiwei, Ju, Yi, Faria, Matthew, Sun, Huanli, Howard, Christopher B., Thurecht, Kristofer J. and Caruso, Frank (2019). Cellular targeting of bispecific antibody-functionalized poly(ethylene glycol) capsules: do shape and size matter?. ACS Applied Materials & Interfaces, 11 (32), 28720-28731. doi: 10.1021/acsami.9b10304
2019
Journal Article
Wavelength-dependent fluorescent immunosensors via incorporation of polarity indicators near the binding interface of antibody fragments
Islam, Jiaul, Riley, Blake T., Fercher, Christian, Jones, Martina L., Buckle, Ashley M., Howard, Christopher B., Cox, Rosalind P., Bell, Toby D. M., Mahler, Stephen and Corrie, Simon R. (2019). Wavelength-dependent fluorescent immunosensors via incorporation of polarity indicators near the binding interface of antibody fragments. Analytical Chemistry, 91 (12), 7631-7638. doi: 10.1021/acs.analchem.9b00445
2019
Journal Article
Modulating targeting of poly(ethylene glycol) particles to tumor cells using bispecific antibodies
Cui, Jiwei, Ju, Yi, Houston, Zachary H., Glass, Joshua J., Fletcher, Nicholas L., Alcantara, Sheilajen, Dai, Qiong, Howard, Christopher B., Mahler, Stephen M., Wheatley, Adam K., De Rose, Robert, Brannon, Paul T., Paterson, Brett M., Donnelly, Paul S., Thurecht, Kristofer J., Caruso, Frank and Kent, Stephen J. (2019). Modulating targeting of poly(ethylene glycol) particles to tumor cells using bispecific antibodies. Advanced Healthcare Materials, 8 (9) 1801607, e1801607. doi: 10.1002/adhm.201801607
2019
Journal Article
Canine CD117-Specific Antibodies with Diverse Binding Properties Isolated from a Phage Display Library Using Cell-Based Biopanning
Alfaleh, Mohamed, Arora, Neetika, Yeh, Michael, de Bakker, Christopher, Howard, Christopher, Macpherson, Philip, Allavena, Rachel, Chen, Xiaoli, Harkness, Linda, Mahler, Stephen and Jones, Martina (2019). Canine CD117-Specific Antibodies with Diverse Binding Properties Isolated from a Phage Display Library Using Cell-Based Biopanning. Antibodies, 8 (1) 15, 15. doi: 10.3390/antib8010015
2018
Journal Article
RNA interference to enhance radiation therapy: targeting the DNA damage response
Ratnayake, G., Bain, A. L., Fletcher, N., Howard, C. B., Khanna, K. K. and Thurecht, K. J. (2018). RNA interference to enhance radiation therapy: targeting the DNA damage response. Cancer Letters, 439, 14-23. doi: 10.1016/j.canlet.2018.09.011
2018
Journal Article
A SERS microfluidic platform for targeting multiple soluble immune checkpoints
Reza, K. Kamil, Sina, Abu Ali Ibn, Wuethrich, Alain, Grewal, Yadveer S., Howard, Christopher B., Korbie, Darren and Trau, Matt (2018). A SERS microfluidic platform for targeting multiple soluble immune checkpoints. Biosensors and Bioelectronics, 126, 178-186. doi: 10.1016/j.bios.2018.10.044
2018
Journal Article
Multiplexed SERS detection of soluble cancer protein biomarkers with gold-silver alloy nanoboxes and nanoyeast single-chain variable fragments
Li, Junrong, Wang, Jing, Grewal, Yadveer S, Howard, Christopher B, Raftery, Lyndon J, Mahler, Stephen, Wang, Yuling and Trau, Matt (2018). Multiplexed SERS detection of soluble cancer protein biomarkers with gold-silver alloy nanoboxes and nanoyeast single-chain variable fragments. Analytical Chemistry, 90 (17) acs.analchem.8b02216, 10377-10384. doi: 10.1021/acs.analchem.8b02216
Funding
Current funding
Supervision
Availability
- Dr Christopher Howard is:
- Available for supervision
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Available projects
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Molecular Discovery and bioengineering of innovative biologics to detect pandemic threat pathogens, new virus variants and emerging viruses
Explore the molecular discovery and bioengineering of innovative biologics for the detection of pandemic threat pathogens, such as Sars Cov2, SCV2 variants and influenza.
Supervision history
Current supervision
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Doctor Philosophy
Engineering synthetic regulatory circuits for precise metabolic control in Saccharomyces cerevisiae
Principal Advisor
Other advisors: Professor Gary Schenk
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Doctor Philosophy
Engineering synthetic regulatory circuits for precise metabolic control in Saccharomyces cerevisiae
Principal Advisor
Other advisors: Professor Gary Schenk
-
Doctor Philosophy
Development of next-generation molecular tools for diagnostics
Principal Advisor
Other advisors: Professor Matt Trau
-
Doctor Philosophy
Surface engineering of nanoyeast
Principal Advisor
Other advisors: Professor Matt Trau
-
Doctor Philosophy
Development of next-generation molecular tools for diagnostics
Principal Advisor
Other advisors: Professor Matt Trau
-
Doctor Philosophy
mRNA cancer therapies
Associate Advisor
Other advisors: Professor Timothy Mercer, Associate Professor Seth Cheetham
-
Doctor Philosophy
Towards n-plex quantification of molecular interactions for evolution-free biopanning
Associate Advisor
Other advisors: Professor Matt Trau
-
Doctor Philosophy
Investigating therapeutic potentials of brain-derived exosomes
Associate Advisor
Other advisors: Professor Matt Trau, Dr Richard Lobb
-
Doctor Philosophy
Towards n-plex quantification of molecular interactions for evolution-free biopanning
Associate Advisor
Other advisors: Professor Matt Trau
-
Doctor Philosophy
An integrated nano-bioengineered chip for enhanced molecular evolution
Associate Advisor
Other advisors: Professor Matt Trau
-
Doctor Philosophy
Integration of innovative diagnostic technologies for the detection of flaviviral infections
Associate Advisor
Other advisors: Associate Professor Jody Peters
-
Doctor Philosophy
Integration of innovative platform technologies for the diagnosis of flaviviral infections
Associate Advisor
Other advisors: Associate Professor Jody Peters
-
Doctor Philosophy
Engineering Novel Theranostics for High Grade Glioma Through Site-Specific EphA2 Antibody Modification
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler, Dr Martina Jones
-
Doctor Philosophy
Engineering Novel Theranostics for High Grade Glioma Through Site-Specific EphA2 Antibody Modification
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler, Dr Martina Jones
-
Doctor Philosophy
Towards n-plex quantification of molecular interactions for evolution-free biopanning
Associate Advisor
Other advisors: Professor Matt Trau
Completed supervision
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2024
Doctor Philosophy
Engineering synthetic regulatory circuits for precise metabolic control in Saccharomyces cerevisiae
Principal Advisor
Other advisors: Professor Gary Schenk
-
2023
Doctor Philosophy
Discovery and Development of a Novel Human Glypican-1 Monoclonal Antibody for Targeting Solid Cancers
Principal Advisor
Other advisors: Emeritus Professor Stephen Mahler, Dr Martina Jones
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2021
Doctor Philosophy
Evaluation of the impact of the upstream bioprocess parameters on the proteomic profile of recombinant factor IX
Principal Advisor
Other advisors: Professor Benjamin Schulz
-
2020
Doctor Philosophy
Development of novel bioconjugation strategies for creating cancer-targeting nanomaterials
Principal Advisor
Other advisors: Emeritus Professor Stephen Mahler, Dr Martina Jones
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2024
Doctor Philosophy
Development of Antibody Delivery Systems Against Intracellular Targets
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler
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2023
Doctor Philosophy
Novel antibody theranostics for oncology
Associate Advisor
Other advisors: Dr Pie Huda, Professor Kristofer Thurecht
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2023
Doctor Philosophy
Bioengineering yeast nanofragment affinity probes for dengue diagnostics
Associate Advisor
Other advisors: Dr Alain Wuethrich, Professor Matt Trau
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2022
Doctor Philosophy
Engineering and production of recombinant proteins with appropriate glycostructures for early in vivo studies
Associate Advisor
Other advisors: Dr Lucia Zacchi, Professor Benjamin Schulz
-
2019
Doctor Philosophy
Isolation and characterisation of antibodies against human and canine EphA2_ targets for comparative studies in brain cancer
Associate Advisor
Other advisors: Dr Martina Jones, Professor Andrew Whittaker, Emeritus Professor Stephen Mahler
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2019
Master Philosophy
Radiosensitization of Prostate Cancer by Nanoparticle Mediated RNA Interference
Associate Advisor
Other advisors: Honorary Professor Kum Kum Khanna, Dr Nick Fletcher, Professor Kristofer Thurecht
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2018
Doctor Philosophy
Isolation and development of antibodies for active targeting of nanocells for cancer therapy
Associate Advisor
Other advisors: Dr Martina Jones, Emeritus Professor Stephen Mahler
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2018
Doctor Philosophy
Engineering lipid-coated calcium phosphate nanoparticles with multiple ligands to amplify in vivo tumor target delivery
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler
-
2017
Master Philosophy
Development of anti-PEG bispecific antibodies for targeting PEGylated nanoparticles to tumour cells
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler
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2017
Doctor Philosophy
Development and Application of Novel Biosensor Technologies
Associate Advisor
Other advisors: Dr Martina Jones, Emeritus Professor Stephen Mahler
Media
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