Overview
Availability
- Dr Christopher Howard is:
- Available for supervision
Qualifications
- Doctor of Philosophy, Queensland University of Technology
Research interests
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Protein engineering, Programmable Bionanomaterials, Molecular Discovery, Bio Nano Technologies
Works
Search Professor Christopher Howard’s works on UQ eSpace
2024
Journal Article
Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma
Logan, Amy, Howard, Christopher B., Huda, Pie, Kimpton, Kathleen, Ma, Zerong, Thurecht, Kristofer J., McCarroll, Joshua A., Moles, Ernest and Kavallaris, Maria (2024). Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma. Journal of Controlled Release, 367, 806-820. doi: 10.1016/j.jconrel.2024.02.007
2023
Journal Article
Integration of yeast episomal/integrative plasmid causes genotypic and phenotypic diversity and improved sesquiterpene production in metabolically engineered Saccharomyces cerevisiae
Peng, Bingyin, Weintraub, Sarah J., Lu, Zeyu, Evans, Samuel, Shen, Qianyi, McDonnell, Liam, Plan, Manuel, Collier, Thomas, Cheah, Li Chen, Ji, Lei, Howard, Christopher B., Anderson, Will, Trau, Matt, Dumsday, Geoff, Bredeweg, Erin L., Young, Eric M., Speight, Robert and Vickers, Claudia E. (2023). Integration of yeast episomal/integrative plasmid causes genotypic and phenotypic diversity and improved sesquiterpene production in metabolically engineered Saccharomyces cerevisiae. ACS Synthetic Biology, 13 (1), 141-156. doi: 10.1021/acssynbio.3c00363
2023
Journal Article
An immunomodulating peptide with potential to suppress tumour growth and autoimmunity
Agrez, Michael, Chandler, Christopher, Thurecht, Kristofer J., Fletcher, Nicholas L., Liu, Feifei, Subramaniam, Gayathri, Howard, Christopher B., Blyth, Benjamin, Parker, Stephen, Turner, Darryl, Rzepecka, Justyna, Knox, Gavin, Nika, Anastasia, Hall, Andrew M., Gooding, Hayley and Gallagher, Laura (2023). An immunomodulating peptide with potential to suppress tumour growth and autoimmunity. Scientific Reports, 13 (1) 19741, 19741. doi: 10.1038/s41598-023-47229-y
2023
Journal Article
Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporation
Huda, Pie, Humphries, James, Fletcher, Nicholas L., Howard, Christopher B., Thurecht, Kristofer J. and Bell, Craig A. (2023). Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporation. Chemistry–Methods, 4 (2) e202300036. doi: 10.1002/cmtd.202300036
2023
Journal Article
Profiling proteomics responses to hexokinase-II depletion in terpene-producing Saccharomyces cerevisiae
Lu, Zeyu, Shen, Qianyi, Liu, Lian, Talbo, Gert, Speight, Robert, Trau, Matt, Dumsday, Geoff, Howard, Christopher B., Vickers, Claudia E. and Peng, Bingyin (2023). Profiling proteomics responses to hexokinase-II depletion in terpene-producing Saccharomyces cerevisiae. Engineering Microbiology, 3 (3) 100079, 100079. doi: 10.1016/j.engmic.2023.100079
2023
Journal Article
An immunomodulating peptide to counteract solar radiation-induced immunosuppression and DNA damage
Agrez, Michael, Rybchyn, Mark Stephen, De Silva, Warusavithana Gunawardena Manori, Mason, Rebecca Sara, Chandler, Christopher, Piva, Terrence J., Thurecht, Kristofer, Fletcher, Nicholas, Liu, Feifei, Subramaniam, Gayathri, Howard, Christopher B., Blyth, Benjamin, Parker, Stephen, Turner, Darryl, Rzepecka, Justyna, Knox, Gavin, Nika, Anastasia, Hall, Andrew, Gooding, Hayley and Gallagher, Laura (2023). An immunomodulating peptide to counteract solar radiation-induced immunosuppression and DNA damage. Scientific Reports, 13 (1) 11702, 1-19. doi: 10.1038/s41598-023-38890-4
2023
Conference Publication
Dox- loaded mpeg nanoparticles as a promising treatment in a humanized mouse model for breast cancer bone metastasis
Frankenbach, Tina, Landgraf, Marietta, Fletcher, Nicholas, Howard, Christopher, Ravichandran, Akhilandeshwari, Akhter, Dewan, Shafiee, Abbas, Holzapfel, Boris M., Thurecht, Kristofer, McGovern, Jacqui and Hutmacher, Dietmar W. (2023). Dox- loaded mpeg nanoparticles as a promising treatment in a humanized mouse model for breast cancer bone metastasis. Tissue Engineering and Regenerative Medicine International Society (TERMIS), Krakow, Poland, 28 June - 1 July 2022. New Rochelle, NY United States: Mary Ann Liebert.
2023
Journal Article
Pharmacokinetics and Biodistribution of Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in Glioblastoma
Ghosh, Saikat, Fletcher, Nicholas L., Huda, Pie, Houston, Zachary H., Howard, Christopher B., Lund, Maria E., Lu, Yanling, Campbell, Douglas H., Walsh, Bradley J. and Thurecht, Kristofer J. (2023). Pharmacokinetics and Biodistribution of Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in Glioblastoma. Molecular pharmaceutics, 20 (3), 1549-1563. doi: 10.1021/acs.molpharmaceut.2c00760
2022
Journal Article
Detection of Dengue Virus 2 with single infected mosquito resolution using yeast affinity bionanofragments and plasmonic SERS nanoboxes
Farokhinejad, Fahimeh, Li, Junrong, Hugo, Leon E., Howard, Christopher B., Wuethrich, Alain and Trau, Matt (2022). Detection of Dengue Virus 2 with single infected mosquito resolution using yeast affinity bionanofragments and plasmonic SERS nanoboxes. Analytical Chemistry, 94 (41), 14177-14184. doi: 10.1021/acs.analchem.2c02012
2022
Journal Article
PD-L1-targeted co-delivery of two chemotherapeutics for efficient suppression of skin cancer growth
Movahedi, Fatemeh, Liu, Jie, Sun, Bing, Cao, Pei, Sun, Luyao, Howard, Christopher, Gu, Wenyi and Xu, Zhi Ping (2022). PD-L1-targeted co-delivery of two chemotherapeutics for efficient suppression of skin cancer growth. Pharmaceutics, 14 (7) 1488, 1488. doi: 10.3390/pharmaceutics14071488
2022
Journal Article
A novel lipidic peptide with potential to promote balanced effector-regulatory T cell responses
Agrez, Michael, Rzepecka, Justyna, Turner, Darryl, Knox, Gavin, Chandler, Christopher, Howard, Christopher B., Fletcher, Nicholas, Thurecht, Kristofer, Parker, Stephen, Gooding, Hayley and Gallagher, Laura (2022). A novel lipidic peptide with potential to promote balanced effector-regulatory T cell responses. Scientific Reports, 12 (1) 11185, 11185. doi: 10.1038/s41598-022-15455-5
2022
Journal Article
Confined microemulsion sono-polymerization of poly(ethylene glycol) nanoparticles for targeted delivery
Gao, Zhiliang, Li, Xiaoyu, Zhao, Kaijie, Geng, Huimin, Zhang, Peiyu, Ju, Yi, Huda, Pie, Howard, Christopher B, Thurecht, Kristofer J, Ashokkumar, Muthupandian, Hao, Jingcheng and Cui, Jiwei (2022). Confined microemulsion sono-polymerization of poly(ethylene glycol) nanoparticles for targeted delivery. Chemical Communications, 58 (56), 7777-7780. doi: 10.1039/d2cc01874h
2022
Journal Article
An in vivo gene amplification system for high level expression in Saccharomyces cerevisiae
Peng, Bingyin, Esquirol, Lygie, Lu, Zeyu, Shen, Qianyi, Cheah, Li Chen, Howard, Christopher B., Scott, Colin, Trau, Matt, Dumsday, Geoff and Vickers, Claudia E. (2022). An in vivo gene amplification system for high level expression in Saccharomyces cerevisiae. Nature Communications, 13 (1) 2895, 2895. doi: 10.1038/s41467-022-30529-8
2022
Conference Publication
Immuno-PET agents for targeting glioblastoma
Ghosh, S., Huda, P., Fletcher, N., Howard, C., Lu, Y., Campbell, D., Walsh, B. and Thurecht, K. (2022). Immuno-PET agents for targeting glioblastoma. Australian and New Zealand Society of Nuclear Medicine (ANZSNM) 52nd ASM, Brisbane, QLD, Australia, 13–15 May 2022. Richmond, VIC, Australia: John Wiley & Sons.
2022
Journal Article
Antibody-based formats to target glioblastoma: overcoming barriers to protein drug delivery
Ghosh, Saikat, Huda, Pie, Fletcher, Nicholas L., Howard, Christopher B., Walsh, Bradley, Campbell, Douglas, Pinkham, Mark B. and Thurecht, Kristofer J. (2022). Antibody-based formats to target glioblastoma: overcoming barriers to protein drug delivery. Molecular Pharmaceutics, 19 (5), 1233-1247. doi: 10.1021/acs.molpharmaceut.1c00996
2022
Journal Article
Recent advances in the production of recombinant factor IX: bioprocessing and cell engineering
Beauglehole, Aiden C, Roche Recinos, Dinora, Pegg, Cassandra L, Lee, Yih Yean, Turnbull, Victor, Herrmann, Susann, Marcellin, Esteban, Howard, Christopher B and Schulz, Benjamin L (2022). Recent advances in the production of recombinant factor IX: bioprocessing and cell engineering. Critical Reviews in Biotechnology, 43 (3), 1-19. doi: 10.1080/07388551.2022.2036691
2022
Journal Article
Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruption
Janowicz, Phillip W., Houston, Zachary H., Bunt, Jens, Fletcher, Nicholas L., Bell, Craig A., Cowin, Gary, Howard, Christopher B., Taslima, Dewan, Westra van Holthe, Nicholas, Prior, Amber, Soh, Vanessa, Ghosh, Saikat, Humphries, James, Huda, Pie, Mahler, Stephen M., Richards, Linda J. and Thurecht, Kristofer J. (2022). Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruption. Biomaterials, 283 121416, 121416. doi: 10.1016/j.biomaterials.2022.121416
2022
Journal Article
Next-Generation Molecular Discovery: From Bottom-Up In Vivo and In Vitro Approaches to In Silico Top-Down Approaches for Therapeutics Neogenesis
Kenny, Sophie E., Antaw, Fiach, Locke, Warwick J., Howard, Christopher B., Korbie, Darren and Trau, Matt (2022). Next-Generation Molecular Discovery: From Bottom-Up In Vivo and In Vitro Approaches to In Silico Top-Down Approaches for Therapeutics Neogenesis. Life, 12 (3) 363, 1-24. doi: 10.3390/life12030363
2022
Journal Article
Engineering eukaryote-like regulatory circuits to expand artificial control mechanisms for metabolic engineering in Saccharomyces cerevisiae
Peng, Bingyin, Bandari, Naga Chandra, Lu, Zeyu, Howard, Christopher B., Scott, Colin, Trau, Matt, Dumsday, Geoff and Vickers, Claudia E. (2022). Engineering eukaryote-like regulatory circuits to expand artificial control mechanisms for metabolic engineering in Saccharomyces cerevisiae. Communications Biology, 5 (1) 135, 135. doi: 10.1038/s42003-022-03070-z
2021
Journal Article
Generation of nanoyeast single-chain variable fragments as high-avidity biomaterials for dengue virus detection
Farokhinejad, Fahimeh, Lane, Rebecca E., Lobb, Richard J., Edwardraja, Selvakumar, Wuethrich, Alain, Howard, Christopher B. and Trau, Matt (2021). Generation of nanoyeast single-chain variable fragments as high-avidity biomaterials for dengue virus detection. ACS Biomaterials Science and Engineering, 7 (12) acsbiomaterials.1c01001, 5850-5860. doi: 10.1021/acsbiomaterials.1c01001
Funding
Current funding
Supervision
Availability
- Dr Christopher Howard is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Available projects
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Molecular Discovery and bioengineering of innovative biologics to detect pandemic threat pathogens, new virus variants and emerging viruses
Explore the molecular discovery and bioengineering of innovative biologics for the detection of pandemic threat pathogens, such as Sars Cov2, SCV2 variants and influenza.
Supervision history
Current supervision
-
Doctor Philosophy
Molecular Discovery and bioengineering of innovative biologics to detect pandemic threat pathogens, new virus variants and emerging viruses
Principal Advisor
Other advisors: Professor David Owen, Dr Kym Lowry, Dr Pie Huda
-
Doctor Philosophy
Engineering Novel Theranostics for High Grade Glioma Through Site-Specific EphA2 Antibody Modification
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler, Dr Martina Jones
-
Doctor Philosophy
An integrated nano-bioengineered chip for enhanced molecular evolution
Associate Advisor
Other advisors: Professor Matt Trau, Dr Selvakumar Edwardraja, Dr Fiach Antaw
-
Doctor Philosophy
mRNA cancer therapies
Associate Advisor
Other advisors: Professor Timothy Mercer, Associate Professor Seth Cheetham
-
Doctor Philosophy
Investigating therapeutic potentials of brain-derived exosomes
Associate Advisor
Other advisors: Professor Matt Trau, Dr Richard Lobb
Completed supervision
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2025
Doctor Philosophy
Development of next-generation molecular tools for diagnostics
Principal Advisor
Other advisors: Professor Matt Trau, Dr Selvakumar Edwardraja
-
2024
Doctor Philosophy
Engineering synthetic regulatory circuits for precise metabolic control in Saccharomyces cerevisiae
Principal Advisor
Other advisors: Professor Gary Schenk
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2023
Doctor Philosophy
Discovery and Development of a Novel Human Glypican-1 Monoclonal Antibody for Targeting Solid Cancers
Principal Advisor
Other advisors: Emeritus Professor Stephen Mahler, Dr Martina Jones
-
2021
Doctor Philosophy
Evaluation of the impact of the upstream bioprocess parameters on the proteomic profile of recombinant factor IX
Principal Advisor
Other advisors: Professor Benjamin Schulz
-
2020
Doctor Philosophy
Development of novel bioconjugation strategies for creating cancer-targeting nanomaterials
Principal Advisor
Other advisors: Emeritus Professor Stephen Mahler, Dr Martina Jones
-
2025
Doctor Philosophy
Integration of innovative diagnostic technologies for the detection of flaviviral infections
Associate Advisor
Other advisors: Associate Professor Jody Peters
-
2025
Doctor Philosophy
Towards n-plex quantitation of molecular interactions for evolution-free biopanning
Associate Advisor
Other advisors: Professor Matt Trau
-
2024
Doctor Philosophy
Development of Antibody Delivery Systems Against Intracellular Targets
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler
-
2023
Doctor Philosophy
Novel antibody theranostics for oncology
Associate Advisor
Other advisors: Dr Pie Huda, Professor Kristofer Thurecht
-
2023
Doctor Philosophy
Bioengineering yeast nanofragment affinity probes for dengue diagnostics
Associate Advisor
Other advisors: Associate Professor Alain Wuethrich, Professor Matt Trau
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2022
Doctor Philosophy
Engineering and production of recombinant proteins with appropriate glycostructures for early in vivo studies
Associate Advisor
Other advisors: Dr Lucia Zacchi, Professor Benjamin Schulz
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2019
Master Philosophy
Radiosensitization of Prostate Cancer by Nanoparticle Mediated RNA Interference
Associate Advisor
Other advisors: Honorary Professor Kum Kum Khanna, Dr Nick Fletcher, Professor Kristofer Thurecht
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2019
Doctor Philosophy
Isolation and characterisation of antibodies against human and canine EphA2_ targets for comparative studies in brain cancer
Associate Advisor
Other advisors: Dr Martina Jones, Professor Andrew Whittaker, Emeritus Professor Stephen Mahler
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2018
Doctor Philosophy
Isolation and development of antibodies for active targeting of nanocells for cancer therapy
Associate Advisor
Other advisors: Dr Martina Jones, Emeritus Professor Stephen Mahler
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2018
Doctor Philosophy
Engineering lipid-coated calcium phosphate nanoparticles with multiple ligands to amplify in vivo tumor target delivery
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler
-
2017
Doctor Philosophy
Development and Application of Novel Biosensor Technologies
Associate Advisor
Other advisors: Dr Martina Jones, Emeritus Professor Stephen Mahler
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2017
Master Philosophy
Development of anti-PEG bispecific antibodies for targeting PEGylated nanoparticles to tumour cells
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler
Media
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