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Professor Waldemar Vollmer
Professor

Waldemar Vollmer

Email: 
Phone: 
+61 7 334 62055

Overview

Background

Overview

Professor Waldemar Vollmer is a microbiologist working on the structure and biogenesis of the bacterial cell wall in various model bacteria and a range of pathogenic and environmental bacteria. He is particularly interested in how bacteria enlarge their cell wall when they grow and divide, and how antibiotics inhibit cell wall synthesis to kill bacteria. Antimicrobial resistance (AMR) is a global problem that is predicted to claim 10 million lives annually by the year 2050 if no new antibiotics are developed. Currently the pipeline of antibiotic development is almost empty and mostly limited to slightly modified versions to existing antibiotics. Professor Vollmer addresses the problem of AMR by generating tailored assays for the development of novel antibiotics that target AMR bacteria.

Collaborations: Professor Vollmer collaborates world-wide with more than 50 researchers at top national and international institutions on cell wall topics in over 30 different bacteria. These topics include: structure and composition of the cell wall and its role in maintaining cell morphology; molecular mechanisms of cell envelope biogenesis; role of new cell wall modifying enzymes in the interaction of pathogenic bacteria with components of the immune system; mechanisms of antibiotic resistance and targeting of cell wall biogenesis by new antibiotics.

Funding and Publications: Professor Vollmer has been awarded more than $15 million funding from research councils and charities in Germany, UK, Europe and USA. He has published more than 200 articles in international journals and has been recognised as a Highly Cited Researcher in Microbiology.

Honours and Awards: Professor Vollmer has been elected to Fellow of the American Academy of Microbiology (2014) and European Academy of Microbiology (2018). He received the annual Academic Distinction Awards from the Vice Chancellor of Newcastle University (2014), has been awarded a Distinguished Scientist Visiting Scholarships at Ben-Gurion University of the Negev (Israel, 2012) and a Visiting Professorship at the University of Cagliari (Italy, 2015), and won a Wellcome Trust Senior Investigator Award (2014). He has co-organised the 2018 Gordon Conference (GRC) "Bacterial Cell Surfaces" (Mt Snow, USA) and the 2016 EMBO Workshop "Bacterial Cell Division: Orchestrating the Ring Cycle" (Prague, Czech Republic).

Short Biography: Prof Waldemar Vollmer has studied chemistry at the University of Applied Sciences in Reutlingen (Germany) and University of Basel (Switzerland). In 1998 he obtained a PhD degree (Dr.rer.nat.) from the University of Tübingen (Germany) for his work on cell wall synthesis in the model bacterium Escherichia coli undertaken at the Max Planck Institute for Developmental Biology. During his postdoctoral studies at the Rockefeller University (New York, USA) he discovered novel cell wall enzymes that are crucial for the virulence of the pathogenic bacterium Streptococcus pneumoiae. In 2003 he was appointed Assistant Professor at the University of Tübingen and moved 2007 to the Centre for Bacterial Cell Biology at Newcastle University (UK), where he worked as Professor of Bacterial Biochemistry on various bacterial cell wall topics in a range of different bacteria. Since April 2023 he is Professorial Research Fellow and Group Leader at the Centre for Superbug Solutions, Institute for Molecular Bioscience (IMB) at the University of Queensland.

Availability

Professor Waldemar Vollmer is:
Available for supervision

Fields of research

Research impacts

Professor Vollmer's basic research on the bacterial cell envelope has led to key advances in our understanding of bacterial cell function and has discovered molecular mechanisms that can be exploited for antibiotic development.

Key research outputs: Prof Vollmer's group has discovered mechanisms of PG biosynthesis and its regulation, novel cell wall enzymes, and mechanisms of coordination between PG synthesis and outer membrane biogenesis. These discoveries provided the first molecular insights into how bacteria robustly maintain, enlarge and modify their cell envelope when they propagate in diverse environments and under stress conditions, and when exposed to antibiotics.

Key capabilities: Prof Vollmer's group is expert in the analysis of the composition of peptidoglycan, the key shape-maintaining and stress-bearing component of the bacterial cell envelope. They also discover new cell wall enzymes and study the activities and interactions of of key cell wall synthases and hydrolases (lysins or autolysins). They are also expert in determining the cleavage site of cell wall-degrading lysins and establishing biochemical assays for cell wall enzymes, for studying their inhibition by antibiotics. They combine their molecular biology work with studies on the physiology of bacterial cells impaired in cell wall biogenesis.

Works

Search Professor Waldemar Vollmer’s works on UQ eSpace

241 works between 1993 and 2024

141 - 160 of 241 works

2015

Journal Article

Discrete and overlapping functions of peptidoglycan synthases in growth, cell division and virulence of Listeria monocytogenes

Rismondo, Jeanine, Moeller, Lars, Aldridge, Christine, Gray, Joe, Vollmer, Waldemar and Halbedel, Sven (2015). Discrete and overlapping functions of peptidoglycan synthases in growth, cell division and virulence of Listeria monocytogenes. Molecular Microbiology, 95 (2), 332-351. doi: 10.1111/mmi.12873

Discrete and overlapping functions of peptidoglycan synthases in growth, cell division and virulence of Listeria monocytogenes

2015

Book Chapter

Peptidoglycan

Vollmer, Waldemar (2015). Peptidoglycan. Molecular medical microbiology. (pp. 105-124) edited by Yi-Wei Tang, Dongyou Liu, Max Sussman, Ian Poxton and Joseph Schwartzman. Cambridge, MA United States: Academic Press. doi: 10.1016/B978-0-12-397169-2.00006-8

Peptidoglycan

2014

Journal Article

The host metabolite D-serine contributes to bacterial niche specificity through gene selection.

Connolly, James P., Goldstone, Robert J., Burgess, Karl, Cogdell, Richard J., Beatson, Scott A., Vollmer, Waldemar, Smith, David G. E. and Roe, Andrew J. (2014). The host metabolite D-serine contributes to bacterial niche specificity through gene selection.. The ISME Journal, 9 (4), 1039-1051. doi: 10.1038/ismej.2014.242

The host metabolite D-serine contributes to bacterial niche specificity through gene selection.

2014

Journal Article

Structure and function of a spectrin-like regulator of bacterial cytokinesis

Cleverley, Robert M., Barrett, Jeffrey R., Baslé, Arnaud, Bui, Nhat Khai, Hewitt, Lorraine, Solovyova, Alexandra, Xu, Zhi-Qiang, Daniel, Richard A., Dixon, Nicholas E., Harry, Elizabeth J., Oakley, Aaron J., Vollmer, Waldemar and Lewis, Richard J. (2014). Structure and function of a spectrin-like regulator of bacterial cytokinesis. Nature Communications, 5 (1) 5421. doi: 10.1038/ncomms6421

Structure and function of a spectrin-like regulator of bacterial cytokinesis

2014

Journal Article

TLR-Mediated Inflammatory Responses to Streptococcus pneumoniae Are Highly Dependent on Surface Expression of Bacterial Lipoproteins

Tomlinson, Gillian, Chimalapati, Suneeta, Pollard, Tracey, Lapp, Thabo, Cohen, Jonathan, Camberlein, Emilie, Stafford, Sian, Periselneris, Jimstan, Aldridge, Christine, Vollmer, Waldemar, Picard, Capucine, Casanova, Jean-Laurent, Noursadeghi, Mahdad and Brown, Jeremy (2014). TLR-Mediated Inflammatory Responses to Streptococcus pneumoniae Are Highly Dependent on Surface Expression of Bacterial Lipoproteins. Journal of Immunology, 193 (7), 3736-3745. doi: 10.4049/jimmunol.1401413

TLR-Mediated Inflammatory Responses to Streptococcus pneumoniae Are Highly Dependent on Surface Expression of Bacterial Lipoproteins

2014

Journal Article

Elongated structure of the outer-membrane activator of peptidoglycan synthesis LpoA: implications for PBP1A stimulation

Jean, Nicolas L., Bougault, Catherine M., Lodge, Adam, Derouaux, Adeline, Callens, Gilles, Egan, Alexander J.F., Ayala, Isabel, Lewis, Richard J., Vollmer, Waldemar and Simorre, Jean-Pierre (2014). Elongated structure of the outer-membrane activator of peptidoglycan synthesis LpoA: implications for PBP1A stimulation. Structure, 22 (7), 1047-1054. doi: 10.1016/j.str.2014.04.017

Elongated structure of the outer-membrane activator of peptidoglycan synthesis LpoA: implications for PBP1A stimulation

2014

Journal Article

Structure of the LdcB LD-carboxypeptidase reveals the molecular basis of peptidoglycan recognition

Hoyland, Christopher N., Aldridge, Christine, Cleverley, Robert M., Duchêne, Marie-Clémence, Minasov, George, Onopriyenko, Olena, Sidiq, Karzan, Stogios, Peter J., Anderson, Wayne F., Daniel, Richard A., Savchenko, Alexei, Vollmer, Waldemar and Lewis, Richard J. (2014). Structure of the LdcB LD-carboxypeptidase reveals the molecular basis of peptidoglycan recognition. Structure, 22 (7), 949-960. doi: 10.1016/j.str.2014.04.015

Structure of the LdcB LD-carboxypeptidase reveals the molecular basis of peptidoglycan recognition

2014

Journal Article

AmiA is a penicillin target enzyme with dual activity in the intracellular pathogen Chlamydia pneumoniae

Kloeckner, Anna, Otten, Christian, Derouaux, Adeline, Vollmer, Waldemar, Buehl, Henrike, De Benedetti, Stefania, Muench, Daniela, Josten, Michaele, Moelleken, Katja, Sahl, Hans-Georg and Henrichfreise, Beate (2014). AmiA is a penicillin target enzyme with dual activity in the intracellular pathogen Chlamydia pneumoniae. Nature Communications, 5, 1-10. doi: 10.1038/ncomms5201

AmiA is a penicillin target enzyme with dual activity in the intracellular pathogen Chlamydia pneumoniae

2014

Journal Article

Peptidoglycan ld-carboxypeptidase Pgp2 influences Campylobacter jejuni helical cell shape and pathogenic properties and provides the substrate for the DL-carboxypeptidase Pgp1

Frirdich, Emilisa, Vermeulen, Jenny, Biboy, Jacob, Soares, Fraser, Taveirne, Michael E., Johnson, Jeremiah G., DiRita, Victor J., Girardin, Stephen E., Vollmer, Waldemar and Gaynor, Erin C. (2014). Peptidoglycan ld-carboxypeptidase Pgp2 influences Campylobacter jejuni helical cell shape and pathogenic properties and provides the substrate for the DL-carboxypeptidase Pgp1. Journal of Biological Chemistry, 289 (12), 8007-8018. doi: 10.1074/jbc.M113.491829

Peptidoglycan ld-carboxypeptidase Pgp2 influences Campylobacter jejuni helical cell shape and pathogenic properties and provides the substrate for the DL-carboxypeptidase Pgp1

2014

Journal Article

Different walls for rods and balls: the diversity of peptidoglycan

Turner, Robert D., Vollmer, Waldemar and Foster, Simon J. (2014). Different walls for rods and balls: the diversity of peptidoglycan. Molecular Microbiology, 91 (5), 862-874. doi: 10.1111/mmi.12513

Different walls for rods and balls: the diversity of peptidoglycan

2014

Book Chapter

Bacterial cell wall growth, shape and division

Derouaux, Adeline, Terrak, Mohammed, den Blaauwen, Tanneke and Vollmer, Waldemar (2014). Bacterial cell wall growth, shape and division. Bacterial membranes: structural and molecular biology. (pp. 3-54) edited by Han Remaut and Rémi Fronzes. Poole, United Kingdom: Caister Academic Press.

Bacterial cell wall growth, shape and division

2013

Journal Article

Structural basis for type VI secreted peptidoglycan DL-endopeptidase function, specificity and neutralization in Serratia marcescens

Srikannathasan, Velupillai, English, Grant, Bui, Nhat Khai, Trunk, Katharina, O'Rourke, Patrick E. F., Rao, Vincenzo A., Vollmer, Waldemar, Coulthurst, Sarah J. and Hunter, William N. (2013). Structural basis for type VI secreted peptidoglycan DL-endopeptidase function, specificity and neutralization in Serratia marcescens. Acta Crystallographica. Section D: Structural Biology, 69 (Pt 12), 2468-2482. doi: 10.1107/S0907444913022725

Structural basis for type VI secreted peptidoglycan DL-endopeptidase function, specificity and neutralization in Serratia marcescens

2013

Journal Article

Discovery of chlamydial peptidoglycan reveals bacteria with murein sacculi but without FtsZ

Pilhofer, Martin, Aistleitner, Karin, Biboy, Jacob, Gray, Joe, Kuru, Erkin, Hall, Edward, Brun, Yves V., VanNieuwenhze, Michael S., Vollmer, Waldemar, Horn, Matthias and Jensen, Grant J. (2013). Discovery of chlamydial peptidoglycan reveals bacteria with murein sacculi but without FtsZ. Nature Communications, 4 2856, 1-7. doi: 10.1038/ncomms3856

Discovery of chlamydial peptidoglycan reveals bacteria with murein sacculi but without FtsZ

2013

Journal Article

Mechanisms of bacterial morphogenesis and their subversion by phages

Bernhardt, Thomas G. and Vollmer, Waldemar (2013). Mechanisms of bacterial morphogenesis and their subversion by phages. Current Opinion in Microbiology, 16 (6), 728-730. doi: 10.1016/j.mib.2013.10.004

Mechanisms of bacterial morphogenesis and their subversion by phages

2013

Journal Article

From models to pathogens: how much have we learned about Streptococcus pneumoniae cell division?

Massidda, Orietta, Novakova, Linda and Vollmer, Waldemar (2013). From models to pathogens: how much have we learned about Streptococcus pneumoniae cell division?. Environmental Microbiology, 15 (12), 3133-3157. doi: 10.1111/1462-2920.12189

From models to pathogens: how much have we learned about Streptococcus pneumoniae cell division?

2013

Journal Article

Flow cytometry-based enrichment for cell shape mutants identifies multiple genes that influence Helicobacter pylori morphology

Sycuro, Laura K., Rule, Chelsea S., Petersen, Timothy W., Wyckoff, Timna J., Sessler, Tate, Nagarkar, Dilip B., Khalid, Fakhra, Pincus, Zachary, Biboy, Jacoby, Vollmer, Waldemar and Salama, Nina R. (2013). Flow cytometry-based enrichment for cell shape mutants identifies multiple genes that influence Helicobacter pylori morphology. Molecular Microbiology, 90 (4), 869-883. doi: 10.1111/mmi.12405

Flow cytometry-based enrichment for cell shape mutants identifies multiple genes that influence Helicobacter pylori morphology

2013

Journal Article

Identification, Structure, and Function of a Novel Type VI Secretion Peptidoglycan Glycoside Hydrolase Effector-Immunity Pair

Whitney, John C., Chou, Seemay, Russell, Alistair B., Biboy, Jacob, Gardiner, Taylor E., Ferrin, Michael A., Brittnacher, Mitchell, Vollmer, Waldemar and Mougous, Joseph D. (2013). Identification, Structure, and Function of a Novel Type VI Secretion Peptidoglycan Glycoside Hydrolase Effector-Immunity Pair. Journal of Biological Chemistry, 288 (37), 26616-26624. doi: 10.1074/jbc.M113.488320

Identification, Structure, and Function of a Novel Type VI Secretion Peptidoglycan Glycoside Hydrolase Effector-Immunity Pair

2013

Journal Article

Colocalization and interaction between elongasome and divisome during a preparative cell division phase in Escherichia coli

van der Ploeg, Rene, Verheul, Jolanda, Vischer, Norbert O. E., Alexeeva, Svetlana, Hoogendoorn, Eelco, Postma, Marten, Banzhaf, Manuel, Vollmer, Waldemar and den Blaauwen, Tanneke (2013). Colocalization and interaction between elongasome and divisome during a preparative cell division phase in Escherichia coli. Molecular Microbiology, 87 (5), 1074-1087. doi: 10.1111/mmi.12150

Colocalization and interaction between elongasome and divisome during a preparative cell division phase in Escherichia coli

2013

Journal Article

Growth medium-dependent glycine incorporation into the peptidoglycan of Caulobacter crescentus

Takacs, Constantin N., Hocking, Jason, Cabeen, Matthew T., Bui, Nhat Khai, Poggio, Sebastian, Vollmer, Waldemar and Jacobs-Wagner, Christine (2013). Growth medium-dependent glycine incorporation into the peptidoglycan of Caulobacter crescentus. Plos One, 8 (2) e57579, e57579. doi: 10.1371/journal.pone.0057579

Growth medium-dependent glycine incorporation into the peptidoglycan of Caulobacter crescentus

2013

Journal Article

Glutamate 83 and arginine 85 of helix H3 bend are key residues for FtsZ polymerization, GTPase activity and cellular viability of Escherichia coli: lateral mutations affect FtsZ polymerization and E. coli viability

Shin, Jae Yen, Vollmer, Waldemar, Lagos, Rosalba and Monasterio, Octavio (2013). Glutamate 83 and arginine 85 of helix H3 bend are key residues for FtsZ polymerization, GTPase activity and cellular viability of Escherichia coli: lateral mutations affect FtsZ polymerization and E. coli viability. BMC Microbiology, 13 26, 26. doi: 10.1186/1471-2180-13-26

Glutamate 83 and arginine 85 of helix H3 bend are key residues for FtsZ polymerization, GTPase activity and cellular viability of Escherichia coli: lateral mutations affect FtsZ polymerization and E. coli viability

Funding

Current funding

  • 2025 - 2028
    Novel antibacterials from nature targeting the bacterial cell envelope
    NHMRC IDEAS Grants
    Open grant

Supervision

Availability

Professor Waldemar Vollmer is:
Available for supervision

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Available projects

Supervision history

Current supervision

  • Doctor Philosophy

    Targeting bacterial cell envelope coordination for antibiotic drug discovery

    Principal Advisor

    Other advisors: Professor Brett Collins

  • Doctor Philosophy

    Novel assays for antibiotic discovery

    Principal Advisor

    Other advisors: Professor Rob Capon

  • Doctor Philosophy

    Dissecting the bacterial cell envelope for antibiotic drug discovery

    Principal Advisor

    Other advisors: Dr Nicholas Ariotti, Professor Rob Capon

Media

Enquiries

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