Overview
Background
Overview
Professor Waldemar Vollmer is a microbiologist working on the structure and biogenesis of the bacterial cell wall in various model bacteria and a range of pathogenic and environmental bacteria. He is particularly interested in how bacteria enlarge their cell wall when they grow and divide, and how antibiotics inhibit cell wall synthesis to kill bacteria. Antimicrobial resistance (AMR) is a global problem that is predicted to claim 10 million lives annually by the year 2050 if no new antibiotics are developed. Currently the pipeline of antibiotic development is almost empty and mostly limited to slightly modified versions to existing antibiotics. Professor Vollmer addresses the problem of AMR by generating tailored assays for the development of novel antibiotics that target AMR bacteria.
Collaborations: Professor Vollmer collaborates world-wide with more than 50 researchers at top national and international institutions on cell wall topics in over 30 different bacteria. These topics include: structure and composition of the cell wall and its role in maintaining cell morphology; molecular mechanisms of cell envelope biogenesis; role of new cell wall modifying enzymes in the interaction of pathogenic bacteria with components of the immune system; mechanisms of antibiotic resistance and targeting of cell wall biogenesis by new antibiotics.
Funding and Publications: Professor Vollmer has been awarded more than $15 million funding from research councils and charities in Germany, UK, Europe and USA. He has published more than 200 articles in international journals and has been recognised as a Highly Cited Researcher in Microbiology.
Honours and Awards: Professor Vollmer has been elected to Fellow of the American Academy of Microbiology (2014) and European Academy of Microbiology (2018). He received the annual Academic Distinction Awards from the Vice Chancellor of Newcastle University (2014), has been awarded a Distinguished Scientist Visiting Scholarships at Ben-Gurion University of the Negev (Israel, 2012) and a Visiting Professorship at the University of Cagliari (Italy, 2015), and won a Wellcome Trust Senior Investigator Award (2014). He has co-organised the 2018 Gordon Conference (GRC) "Bacterial Cell Surfaces" (Mt Snow, USA) and the 2016 EMBO Workshop "Bacterial Cell Division: Orchestrating the Ring Cycle" (Prague, Czech Republic).
Short Biography: Prof Waldemar Vollmer has studied chemistry at the University of Applied Sciences in Reutlingen (Germany) and University of Basel (Switzerland). In 1998 he obtained a PhD degree (Dr.rer.nat.) from the University of Tübingen (Germany) for his work on cell wall synthesis in the model bacterium Escherichia coli undertaken at the Max Planck Institute for Developmental Biology. During his postdoctoral studies at the Rockefeller University (New York, USA) he discovered novel cell wall enzymes that are crucial for the virulence of the pathogenic bacterium Streptococcus pneumoiae. In 2003 he was appointed Assistant Professor at the University of Tübingen and moved 2007 to the Centre for Bacterial Cell Biology at Newcastle University (UK), where he worked as Professor of Bacterial Biochemistry on various bacterial cell wall topics in a range of different bacteria. Since April 2023 he is Professorial Research Fellow and Group Leader at the Centre for Superbug Solutions, Institute for Molecular Bioscience (IMB) at the University of Queensland.
Availability
- Professor Waldemar Vollmer is:
- Available for supervision
Fields of research
Research impacts
Professor Vollmer's basic research on the bacterial cell envelope has led to key advances in our understanding of bacterial cell function and has discovered molecular mechanisms that can be exploited for antibiotic development.
Key research outputs: Prof Vollmer's group has discovered mechanisms of PG biosynthesis and its regulation, novel cell wall enzymes, and mechanisms of coordination between PG synthesis and outer membrane biogenesis. These discoveries provided the first molecular insights into how bacteria robustly maintain, enlarge and modify their cell envelope when they propagate in diverse environments and under stress conditions, and when exposed to antibiotics.
Key capabilities: Prof Vollmer's group is expert in the analysis of the composition of peptidoglycan, the key shape-maintaining and stress-bearing component of the bacterial cell envelope. They also discover new cell wall enzymes and study the activities and interactions of of key cell wall synthases and hydrolases (lysins or autolysins). They are also expert in determining the cleavage site of cell wall-degrading lysins and establishing biochemical assays for cell wall enzymes, for studying their inhibition by antibiotics. They combine their molecular biology work with studies on the physiology of bacterial cells impaired in cell wall biogenesis.
Works
Search Professor Waldemar Vollmer’s works on UQ eSpace
2017
Journal Article
Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae
Hess, Nathalie, Waldow, Franziska, Kohler, Thomas P., Rohde, Manfred, Kreikemeyer, Bernd, Gomez-Mejia, Alejandro, Hain, Torsten, Schwudke, Dominik, Vollmer, Waldemar, Hammerschmidt, Sven and Gisch, Nicolas (2017). Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae. Nature Communications, 8 (1) 2093, 2093. doi: 10.1038/s41467-017-01720-z
2017
Journal Article
Fluorescent D-amino-acids reveal bi-cellular cell wall modifications important for Bdellovibrio bacteriovorus predation
Kuru, Erkin, Lambert, Carey, Rittichier, Jonathan, Till, Rob, Ducret, Adrien, Derouaux, Adeline, Gray, Joe, Biboy, Jacob, Vollmer, Waldemar, VanNieuwenhze, Michael, Brun, Yves V. and Sockett, R. Elizabeth (2017). Fluorescent D-amino-acids reveal bi-cellular cell wall modifications important for Bdellovibrio bacteriovorus predation. Nature Microbiology, 2 (12), 1648-1657. doi: 10.1038/s41564-017-0029-y
2017
Journal Article
Traceless Cleavage of Protein-Biotin Conjugates under Biologically Compatible Conditions
Cowell, Joseph, Buck, Matthew, Essa, Ali H., Clarke, Rebecca, Vollmer, Waldemar, Vollmer, Daniela, Hilkens, Catharien M., Isaacs, John D., Hall, Michael J. and Gray, Joe (2017). Traceless Cleavage of Protein-Biotin Conjugates under Biologically Compatible Conditions. ChemBioChem, 18 (17), 1688-1691. doi: 10.1002/cbic.201700214
2017
Journal Article
AmiD Is a Novel Peptidoglycan Amidase in Wolbachia Endosymbionts of Drosophila melanogaster
Wilmes, Miriam, Meier, Kirstin, Schiefer, Andrea, Josten, Michaele, Otten, Christian F., Klockner, Anna, Henrichfreise, Beate, Vollmer, Waldemar, Hoerauf, Achim and Pfarr, Kenneth (2017). AmiD Is a Novel Peptidoglycan Amidase in Wolbachia Endosymbionts of Drosophila melanogaster. Frontiers in Cellular and Infection Microbiology, 7, 353. doi: 10.3389/fcimb.2017.00353
2017
Journal Article
A broadly distributed toxin family mediates contact-dependent antagonism between gram-positive bacteria
Whitney, John C., Peterson, S. Brook, Kim, Jungyun, Pazos, Manuel, Verster, Adrian J., Radey, Matthew C., Kulasekara, Hemantha D., Ching, Mary Q., Bullen, Nathan P., Bryant, Diane, Goo, Young Ah, Surette, Michael G., Borenstein, Elhanan, Vollmer, Waldemar and Mougous, Joseph D. (2017). A broadly distributed toxin family mediates contact-dependent antagonism between gram-positive bacteria. eLife, 6 e26938, 1-24. doi: 10.7554/eLife.26938
2017
Journal Article
New Aspects of the Interplay between Penicillin Binding Proteins, murM, and the Two-Component System CiaRH of Penicillin-Resistant Streptococcus pneumoniae Serotype 19A Isolates from Hungary
Schweizer, Inga, Blaettner, Sebastian, Maurer, Patrick, Peters, Katharina, Vollmer, Daniela, Vollmer, Waldemar, Hakenbeck, Regine and Denapaite, Dalia (2017). New Aspects of the Interplay between Penicillin Binding Proteins, murM, and the Two-Component System CiaRH of Penicillin-Resistant Streptococcus pneumoniae Serotype 19A Isolates from Hungary. Antimicrobial Agents and Chemotherapy, 61 (7) e00414-17, 1-19. doi: 10.1128/AAC.00414-17
2017
Journal Article
A mutant isoform of ObgE causes cell death by interfering with cell division
Dewachter, Liselot, Verstraeten, Natalie, Jennes, Michiel, Verbeelen, Tom, Biboy, Jacob, Monteyne, Daniel, Perez-Morga, David, Verstrepen, Kevin J., Vollmer, Waldemar, Fauvart, Maarten and Michiels, Jan (2017). A mutant isoform of ObgE causes cell death by interfering with cell division. Frontiers in Microbiology, 8 1193, 1-12. doi: 10.3389/fmicb.2017.01193
2017
Journal Article
Morphology heterogeneity within a Campylobacter jejuni helical population: the use of calcofluor white to generate rod-shaped C-jejuni 81-176 clones and the genetic determinants responsible for differences in morphology within 11168 strains
Frirdich, Emilisa, Biboy, Jacob, Huynh, Steven, Parker, Craig T., Vollmer, Waldemar and Gaynor, Erin C. (2017). Morphology heterogeneity within a Campylobacter jejuni helical population: the use of calcofluor white to generate rod-shaped C-jejuni 81-176 clones and the genetic determinants responsible for differences in morphology within 11168 strains. Molecular Microbiology, 104 (6), 948-971. doi: 10.1111/mmi.13672
2017
Journal Article
Robust peptidoglycan growth by dynamic and variable multi-protein complexes
Pazos, Manuel, Peters, Katharina and Vollmer, Waldemar (2017). Robust peptidoglycan growth by dynamic and variable multi-protein complexes. Current Opinion in Microbiology, 36, 55-61. doi: 10.1016/j.mib.2017.01.006
2017
Journal Article
Regulation of bacterial cell wall growth
Egan, Alexander J. F., Cleverley, Robert M., Peters, Katharina, Lewis, Richard J. and Vollmer, Waldemar (2017). Regulation of bacterial cell wall growth. The FEBS Journal, 284 (6), 851-867. doi: 10.1111/febs.13959
2017
Journal Article
Interplay between Penicillin-binding proteins and SEDS proteins promotes bacterial cell wall synthesis
Leclercq, Sophie, Derouaux, Adeline, Olatunji, Samir, Fraipont, Claudine, Egan, Alexander J. F., Vollmer, Waldemar, Breukink, Eefjan and Terrak, Mohammed (2017). Interplay between Penicillin-binding proteins and SEDS proteins promotes bacterial cell wall synthesis. Scientific Reports, 7 43306, 1-13. doi: 10.1038/srep43306
2016
Journal Article
Site-Specific Immobilization of the Peptidoglycan Synthase PBP1B on a Surface Plasmon Resonance Chip Surface
van't Veer, Inge L., Leloup, Nadia O. L., Egan, Alexander J. F., Janssen, Bert J. C., Martin, Nathaniel I., Vollmer, Waldemar and Breukink, Eefjan (2016). Site-Specific Immobilization of the Peptidoglycan Synthase PBP1B on a Surface Plasmon Resonance Chip Surface. ChemBioChem, 17 (23), 2250-2256. doi: 10.1002/cbic.201600461
2016
Journal Article
Accumulation of peptidoglycan O-acetylation leads to altered cell wall biochemistry and negatively impacts pathogenesis factors of Campylobacter jejuni
Ha, Reuben, Frirdich, Emilisa, Sychantha, David, Biboy, Jacob, Taveirne, Michael E., Johnson, Jeremiah G., DiRita, Victor J., Vollmer, Waldemar, Clarke, Anthony J. and Gaynor, Erin C. (2016). Accumulation of peptidoglycan O-acetylation leads to altered cell wall biochemistry and negatively impacts pathogenesis factors of Campylobacter jejuni. Journal of Biological Chemistry, 291 (43), 22686-22702. doi: 10.1074/jbc.M116.746404
2016
Journal Article
A penicillin-binding protein inhibits selection of colistin-resistant, lipooligosaccharide-deficient Acinetobacter baumannii
Boll, Joseph M., Crofts, Alexander A., Peters, Katharina, Cattoir, Vincent, Vollmer, Waldemar, Davies, Bryan W. and Trent, M. Stephen (2016). A penicillin-binding protein inhibits selection of colistin-resistant, lipooligosaccharide-deficient Acinetobacter baumannii. Proceedings of the National Academy of Sciences of the United States of America, 113 (41), E6228-E6237. doi: 10.1073/pnas.1611594113
2016
Journal Article
Subunit Arrangement in GpsB, a Regulator of Cell Wall Biosynthesis
Cleverley, Robert M., Rismondo, Jeanine, Lockhart-Cairns, Michael P., Van Bentum, Paulien T., Egan, Alexander J. F., Vollmer, Waldemar, Halbedel, Sven, Baldock, Clair, Breukink, Eefjan and Lewis, Richard J. (2016). Subunit Arrangement in GpsB, a Regulator of Cell Wall Biosynthesis. Microbial Drug Resistance, 22 (6), 446-460. doi: 10.1089/mdr.2016.0050
2016
Journal Article
Lyme disease and relapsing fever Borrelia elongate through zones of peptidoglycan synthesis that mark division sites of daughter cells
Jutras, Brandon Lyon, Scott, Molly, Parry, Bradley, Biboy, Jacob, Gray, Joe, Vollmer, Waldemar and Jacobs-Wagner, Christine (2016). Lyme disease and relapsing fever Borrelia elongate through zones of peptidoglycan synthesis that mark division sites of daughter cells. Proceedings of the National Academy of Sciences, 113 (33), 9162-9170. doi: 10.1073/pnas.1610805113
2016
Journal Article
Interrupting peptidoglycan deacetylation during Bdellovibrio predator-prey interaction prevents ultimate destruction of prey wall, liberating bacterial-ghosts
Lambert, Carey, Lerner, Thomas R., Bui, Nhat Khai, Somers, Hannah, Aizawa, Shin-Ichi, Liddell, Susan, Clark, Ana, Vollmer, Waldemar, Lovering, Andrew L. and Sockett, R. Elizabeth (2016). Interrupting peptidoglycan deacetylation during Bdellovibrio predator-prey interaction prevents ultimate destruction of prey wall, liberating bacterial-ghosts. Scientific Reports, 6 26010, 1-19. doi: 10.1038/srep26010
2016
Journal Article
The Redundancy of Peptidoglycan Carboxypeptidases Ensures Robust Cell Shape Maintenance in Escherichia coli
Peters, Katharina, Kannan, Suresh, Rao, Vincenzo A., Biboy, Jacob, Vollmer, Daniela, Erickson, Stephen W., Lewis, Richard J., Young, Kevin D. and Vollmer, Waldemar (2016). The Redundancy of Peptidoglycan Carboxypeptidases Ensures Robust Cell Shape Maintenance in Escherichia coli. mBio. doi: 10.1128/mBio.00819-16
2016
Book Chapter
Continuous Fluorescence Assay for Peptidoglycan Glycosyltransferases
Egan, Alexander J. F. and Vollmer, Waldemar (2016). Continuous Fluorescence Assay for Peptidoglycan Glycosyltransferases. Bacterial Cell Wall Homeostasis: Methods and Protocols. (pp. 171-184) edited by Hong, HJ. New York, NY United States: Humana Press. doi: 10.1007/978-1-4939-3676-2_13
2015
Journal Article
Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus
Lambert, Carey, Cadby, Ian T., Till, Rob, Bui, Nhat Khai, Lerner, Thomas R., Hughes, William S., Lee, David J., Alderwick, Luke J., Vollmer, Waldemar, Sockett, R. Elizabeth and Lovering, Andrew L. (2015). Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus. Nature Communications, 6, 1-9. doi: 10.1038/ncomms9884
Funding
Current funding
Supervision
Availability
- Professor Waldemar Vollmer is:
- Available for supervision
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Available projects
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Novel antibacterials from nature targeting the bacterial cell envelope
The project uses methods in molecular microbiology and natural product chemistry to discover new antibiotics from natural sources that kill bacteria by targeting their cell wall.
Supervision history
Current supervision
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Doctor Philosophy
Novel assays for antibiotic discovery
Principal Advisor
Other advisors: Professor Rob Capon
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Doctor Philosophy
Targeting bacterial cell envelope coordination for antibiotic drug discovery
Principal Advisor
Other advisors: Professor Brett Collins
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Doctor Philosophy
Dissecting the bacterial cell envelope for antibiotic drug discovery
Principal Advisor
Other advisors: Dr Nicholas Ariotti, Professor Rob Capon
Media
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