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Professor Waldemar Vollmer
Professor

Waldemar Vollmer

Email: 
Phone: 
+61 7 334 62055

Overview

Background

Overview

Professor Waldemar Vollmer is a microbiologist working on the structure and biogenesis of the bacterial cell wall in various model bacteria and a range of pathogenic and environmental bacteria. He is particularly interested in how bacteria enlarge their cell wall when they grow and divide, and how antibiotics inhibit cell wall synthesis to kill bacteria. Antimicrobial resistance (AMR) is a global problem that is predicted to claim 10 million lives annually by the year 2050 if no new antibiotics are developed. Currently the pipeline of antibiotic development is almost empty and mostly limited to slightly modified versions to existing antibiotics. Professor Vollmer addresses the problem of AMR by generating tailored assays for the development of novel antibiotics that target AMR bacteria.

Collaborations: Professor Vollmer collaborates world-wide with more than 50 researchers at top national and international institutions on cell wall topics in over 30 different bacteria. These topics include: structure and composition of the cell wall and its role in maintaining cell morphology; molecular mechanisms of cell envelope biogenesis; role of new cell wall modifying enzymes in the interaction of pathogenic bacteria with components of the immune system; mechanisms of antibiotic resistance and targeting of cell wall biogenesis by new antibiotics.

Funding and Publications: Professor Vollmer has been awarded more than $15 million funding from research councils and charities in Germany, UK, Europe and USA. He has published more than 200 articles in international journals and has been recognised as a Highly Cited Researcher in Microbiology.

Honours and Awards: Professor Vollmer has been elected to Fellow of the American Academy of Microbiology (2014) and European Academy of Microbiology (2018). He received the annual Academic Distinction Awards from the Vice Chancellor of Newcastle University (2014), has been awarded a Distinguished Scientist Visiting Scholarships at Ben-Gurion University of the Negev (Israel, 2012) and a Visiting Professorship at the University of Cagliari (Italy, 2015), and won a Wellcome Trust Senior Investigator Award (2014). He has co-organised the 2018 Gordon Conference (GRC) "Bacterial Cell Surfaces" (Mt Snow, USA) and the 2016 EMBO Workshop "Bacterial Cell Division: Orchestrating the Ring Cycle" (Prague, Czech Republic).

Short Biography: Prof Waldemar Vollmer has studied chemistry at the University of Applied Sciences in Reutlingen (Germany) and University of Basel (Switzerland). In 1998 he obtained a PhD degree (Dr.rer.nat.) from the University of Tübingen (Germany) for his work on cell wall synthesis in the model bacterium Escherichia coli undertaken at the Max Planck Institute for Developmental Biology. During his postdoctoral studies at the Rockefeller University (New York, USA) he discovered novel cell wall enzymes that are crucial for the virulence of the pathogenic bacterium Streptococcus pneumoiae. In 2003 he was appointed Assistant Professor at the University of Tübingen and moved 2007 to the Centre for Bacterial Cell Biology at Newcastle University (UK), where he worked as Professor of Bacterial Biochemistry on various bacterial cell wall topics in a range of different bacteria. Since April 2023 he is Professorial Research Fellow and Group Leader at the Centre for Superbug Solutions, Institute for Molecular Bioscience (IMB) at the University of Queensland.

Availability

Professor Waldemar Vollmer is:
Available for supervision

Fields of research

Research impacts

Professor Vollmer's basic research on the bacterial cell envelope has led to key advances in our understanding of bacterial cell function and has discovered molecular mechanisms that can be exploited for antibiotic development.

Key research outputs: Prof Vollmer's group has discovered mechanisms of PG biosynthesis and its regulation, novel cell wall enzymes, and mechanisms of coordination between PG synthesis and outer membrane biogenesis. These discoveries provided the first molecular insights into how bacteria robustly maintain, enlarge and modify their cell envelope when they propagate in diverse environments and under stress conditions, and when exposed to antibiotics.

Key capabilities: Prof Vollmer's group is expert in the analysis of the composition of peptidoglycan, the key shape-maintaining and stress-bearing component of the bacterial cell envelope. They also discover new cell wall enzymes and study the activities and interactions of of key cell wall synthases and hydrolases (lysins or autolysins). They are also expert in determining the cleavage site of cell wall-degrading lysins and establishing biochemical assays for cell wall enzymes, for studying their inhibition by antibiotics. They combine their molecular biology work with studies on the physiology of bacterial cells impaired in cell wall biogenesis.

Works

Search Professor Waldemar Vollmer’s works on UQ eSpace

239 works between 1993 and 2024

61 - 80 of 239 works

2020

Journal Article

Peptidoglycan editing provides immunity to Acinetobacter baumannii during bacterial warfare

Le, Nguyen-Hung, Peters, Katharina, Espaillat, Akbar, Sheldon, Jessica R., Gray, Joe, Di Venanzio, Gisela, Lopez, Juvenal, Djahanschiri, Bardya, Mueller, Elizabeth A., Hennon, Seth W., Levin, Petra Anne, Ebersberger, Ingo, Skaar, Eric P., Cava, Felipe, Vollmer, Waldemar and Feldman, Mario F. (2020). Peptidoglycan editing provides immunity to Acinetobacter baumannii during bacterial warfare. Science Advances, 6 (30), 1-8. doi: 10.1126/sciadv.abb5614

Peptidoglycan editing provides immunity to Acinetobacter baumannii during bacterial warfare

2020

Journal Article

Structure of the peptidoglycan synthase activator LpoP in Pseudomonas aeruginosa

Caveney, Nathanael A., Egan, Alexander J. F., Ayala, Isabel, Laguri, Cedric, Robb, Craig S., Breukink, Eefjan, Vollmer, Waldemar, Strynadka, Natalie C. J. and Simorre, Jean-Pierre (2020). Structure of the peptidoglycan synthase activator LpoP in Pseudomonas aeruginosa. Structure, 28 (6), 643-650.e5. doi: 10.1016/j.str.2020.03.012

Structure of the peptidoglycan synthase activator LpoP in Pseudomonas aeruginosa

2020

Journal Article

Tol-Pal system and Rgs proteins interact to promote unipolar growth and cell division in Sinorhizobium meliloti

Krol, Elizaveta, Yau, Hamish C. L., Lechner, Marcus, Schaeper, Simon, Bange, Gert, Vollmer, Waldemar and Becker, Anke (2020). Tol-Pal system and Rgs proteins interact to promote unipolar growth and cell division in Sinorhizobium meliloti. mBio, 11 (3), 1-21. doi: 10.1128/mBio.00306-20

Tol-Pal system and Rgs proteins interact to promote unipolar growth and cell division in Sinorhizobium meliloti

2020

Journal Article

Diffusion and capture permits dynamic coupling between treadmilling FtsZ filaments and cell division proteins

Baranova, Natalia, Radler, Philipp, Hernandez-Rocamora, Victor M., Alfonso, Carlos, Lopez-Pelegrin, Mar, Rivas, German, Vollmer, Waldemar and Loose, Martin (2020). Diffusion and capture permits dynamic coupling between treadmilling FtsZ filaments and cell division proteins. Nature Microbiology, 5 (3), 407-417. doi: 10.1038/s41564-019-0657-5

Diffusion and capture permits dynamic coupling between treadmilling FtsZ filaments and cell division proteins

2020

Journal Article

Distinct cytoskeletal proteins define zones of enhanced cell wall synthesis in Helicobacter pylori

Taylor, Jennifer A., Bratton, Benjamin P., Sichel, Sophie R., Blair, Kris M., Jacobs, Holly M., DeMeester, Kristen E., Kuru, Erkin, Gray, Joe, Biboy, Jacob, VanNieuwenhze, Michael S., Vollmer, Waldemar, Grimes, Catherine L., Shaevitz, Joshua W. and Salama, Nina R. (2020). Distinct cytoskeletal proteins define zones of enhanced cell wall synthesis in Helicobacter pylori. eLife, 9, 1-38. doi: 10.7554/eLife.52482

Distinct cytoskeletal proteins define zones of enhanced cell wall synthesis in Helicobacter pylori

2019

Book Chapter

The cell wall of Streptococcus pneumoniae

Vollmer, Waldemar, Massidda, Orietta and Tomasz, Alexander (2019). The cell wall of Streptococcus pneumoniae. Gram-positive pathogens. (pp. 284-303) edited by Vincent A. Fischetti, Richard P. Novick, Joseph J. Ferretti, Daniel A. Portnoy, Miriam Braunstein and Julian I. Rood. Washington, DC United States: American Society for Microbiology. doi: 10.1128/9781683670131.ch18

The cell wall of Streptococcus pneumoniae

2019

Journal Article

Mechanisms of incorporation for D-amino acid probes that target peptidoglycan biosynthesis

Kuru, Erkin, Radkov, Atanas, Meng, Xin, Egan, Alexander, Alvarez, Laura, Dowson, Amanda, Booher, Garrett, Breukink, Eefjan, Roper, David I., Cava, Felipe, Vollmer, Waldemar, Brun, Yves and VanNieuwenhze, Michael S. (2019). Mechanisms of incorporation for D-amino acid probes that target peptidoglycan biosynthesis. ACS Chemical Biology, 14 (12), 2745-2756. doi: 10.1021/acschembio.9b00664

Mechanisms of incorporation for D-amino acid probes that target peptidoglycan biosynthesis

2019

Journal Article

The Pseudomonas aeruginosa T6SS delivers a periplasmic toxin that disrupts bacterial cell morphology

Wood, Thomas E., Howard, Sophie A., Forster, Andreas, Nolan, Laura M., Manoli, Eleni, Bullen, Nathan P., Yau, Hamish C. L., Hachani, Abderrahman, Hayward, Richard D., Whitney, John C., Vollmer, Waldemar, Freemont, Paul S. and Filloux, Alain (2019). The Pseudomonas aeruginosa T6SS delivers a periplasmic toxin that disrupts bacterial cell morphology. Cell Reports, 29 (1), 187-201.e7. doi: 10.1016/j.celrep.2019.08.094

The Pseudomonas aeruginosa T6SS delivers a periplasmic toxin that disrupts bacterial cell morphology

2019

Journal Article

D-amino acid derivatives as in situ probes for visualizing bacterial peptidoglycan biosynthesis

Hsu, Yen-Pang, Booher, Garrett, Egan, Alexander, Vollmer, Waldemar and VanNieuwenhze, Michael S. (2019). D-amino acid derivatives as in situ probes for visualizing bacterial peptidoglycan biosynthesis. Accounts of Chemical Research, 52 (9), 2713-2722. doi: 10.1021/acs.accounts.9b00311

D-amino acid derivatives as in situ probes for visualizing bacterial peptidoglycan biosynthesis

2019

Journal Article

Cell wall peptidoglycan in Mycobacterium tuberculosis: an Achilles' heel for the TB-causing pathogen

Maitra, Arundhati, Munshi, Tulika, Healy, Jess, Martin, Liam T., Vollmer, Waldemar, Keep, Nicholas H. and Bhakta, Sanjib (2019). Cell wall peptidoglycan in Mycobacterium tuberculosis: an Achilles' heel for the TB-causing pathogen. Fems Microbiology Reviews, 43 (5), 548-575. doi: 10.1093/femsre/fuz016

Cell wall peptidoglycan in Mycobacterium tuberculosis: an Achilles' heel for the TB-causing pathogen

2019

Journal Article

Does the nucleoid determine cell dimensions in Escherichia coli?

Zaritsky, Arieh, Vollmer, Waldemar, Mannik, Jaan and Liu, Chenli (2019). Does the nucleoid determine cell dimensions in Escherichia coli?. Frontiers in Microbiology, 10, 1-7. doi: 10.3389/fmicb.2019.01717

Does the nucleoid determine cell dimensions in Escherichia coli?

2019

Journal Article

Optimized protocol for the incorporation of FDAA (HADA labeling) for in situ labeling of peptidoglycan

Peters, Katharina, Pazos, Manuel, VanNieuwenhze, Michael S. and Vollmer, Waldemar (2019). Optimized protocol for the incorporation of FDAA (HADA labeling) for in situ labeling of peptidoglycan. Bio-protocol, 9 (15), 1-12. doi: 10.21769/BioProtoc.3316

Optimized protocol for the incorporation of FDAA (HADA labeling) for in situ labeling of peptidoglycan

2019

Journal Article

Borrelia burgdorferi peptidoglycan is a persistent antigen in patients with Lyme arthritis

Jutras, Brandon L., Lochhead, Robert B., Kloos, Zachary A., Biboy, Jacob, Strle, Klemen, Booth, Carmen J., Govers, Sander K., Gray, Joe, Schumann, Peter, Vollmer, Waldemar, Bockenstedt, Linda K., Steere, Allen C. and Jacobs-Wagner, Christine (2019). Borrelia burgdorferi peptidoglycan is a persistent antigen in patients with Lyme arthritis. Proceedings of the National Academy of Sciences of the United States of America, 116 (27), 13498-13507. doi: 10.1073/pnas.1904170116

Borrelia burgdorferi peptidoglycan is a persistent antigen in patients with Lyme arthritis

2019

Journal Article

The Campylobacter jejuni helical to coccoid transition involves changes to peptidoglycan and the ability to elicit an immune response

Frirdich, Emilisa, Biboy, Jacob, Pryjma, Mark, Lee, Jooeun, Huynh, Steven, Parker, Craig T., Girardin, Stephen E., Vollmer, Waldemar and Gaynor, Erin C. (2019). The Campylobacter jejuni helical to coccoid transition involves changes to peptidoglycan and the ability to elicit an immune response. Molecular Microbiology, 112 (1), 280-301. doi: 10.1111/mmi.14269

The Campylobacter jejuni helical to coccoid transition involves changes to peptidoglycan and the ability to elicit an immune response

2019

Journal Article

A genome-wide Helicobacter pylori morphology screen uncovers a membrane-spanning helical cell shape complex

Yang, Desiree C., Blair, Kris M., Taylor, Jennifer A., Petersen, Timothy W., Sessler, Tate, Tull, Christina M., Leverich, Christina K., Collar, Amanda L., Wyckoff, Timna J., Biboy, Jacob, Vollmer, Waldemar and Salama, Nina R. (2019). A genome-wide Helicobacter pylori morphology screen uncovers a membrane-spanning helical cell shape complex. Journal of Bacteriology, 201 (14), 1-16. doi: 10.1128/JB.00724-18

A genome-wide Helicobacter pylori morphology screen uncovers a membrane-spanning helical cell shape complex

2019

Journal Article

The cell wall of Streptococcus pneumoniae

Vollmer, Waldemar, Massidda, Orietta and Tomasz, Alexander (2019). The cell wall of Streptococcus pneumoniae. Microbiology Spectrum, 7 (3), 1-25. doi: 10.1128/microbiolspec.GPP3-0018-2018

The cell wall of Streptococcus pneumoniae

2019

Journal Article

Plasticity of Escherichia coli cell wall metabolism promotes fitness and antibiotic resistance across environmental conditions

Mueller, Elizabeth A., Egan, Alexander J. F., Breukink, Eefjan, Vollmer, Waldemar and Levin, Petra Anne (2019). Plasticity of Escherichia coli cell wall metabolism promotes fitness and antibiotic resistance across environmental conditions. eLife, 8, 1-24. doi: 10.7554/eLife.40754

Plasticity of Escherichia coli cell wall metabolism promotes fitness and antibiotic resistance across environmental conditions

2019

Journal Article

Studying intact bacterial peptidoglycan by proton-detected NMR spectroscopy at 100 kHz MAS frequency

Bougault, Catherine, Ayala, Isabel, Vollmer, Waldemar, Simorre, Jean-Pierre and Schanda, Paul (2019). Studying intact bacterial peptidoglycan by proton-detected NMR spectroscopy at 100 kHz MAS frequency. Journal of Structural Biology, 206 (1), 66-72. doi: 10.1016/j.jsb.2018.07.009

Studying intact bacterial peptidoglycan by proton-detected NMR spectroscopy at 100 kHz MAS frequency

2019

Journal Article

Coordination of capsule assembly and cell wall biosynthesis in Staphylococcus aureus

Rausch, Marvin, Deisinger, Julia P., Ulm, Hannah, Mueller, Anna, Li, Wenjin, Hardt, Patrick, Wang, Xiaogang, Li, Xue, Sylvester, Marc, Engeser, Marianne, Vollmer, Waldemar, Mueller, Christa E., Sahl, Hans Georg, Lee, Jean Claire and Schneider, Tanja (2019). Coordination of capsule assembly and cell wall biosynthesis in Staphylococcus aureus. Nature Communications, 10 (1) 1404, 1404. doi: 10.1038/s41467-019-09356-x

Coordination of capsule assembly and cell wall biosynthesis in Staphylococcus aureus

2019

Journal Article

A specialized MreB-dependent cell wall biosynthetic complex mediates the formation of stalk-specific peptidoglycan in Caulobacter crescentus

Billini, Maria, Biboy, Jacob, Kuehn, Juliane, Vollmer, Waldemar and Thanbichler, Martin (2019). A specialized MreB-dependent cell wall biosynthetic complex mediates the formation of stalk-specific peptidoglycan in Caulobacter crescentus. Plos Genetics, 15 (2) ARTN e1007897, 1-33. doi: 10.1371/journal.pgen.1007897

A specialized MreB-dependent cell wall biosynthetic complex mediates the formation of stalk-specific peptidoglycan in Caulobacter crescentus

Supervision

Availability

Professor Waldemar Vollmer is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Targeting bacterial cell envelope coordination for antibiotic drug discovery

    Principal Advisor

    Other advisors: Professor Brett Collins

  • Doctor Philosophy

    Novel assays for antibiotic discovery

    Principal Advisor

    Other advisors: Professor Rob Capon

  • Doctor Philosophy

    Dissecting the bacterial cell envelope for antibiotic drug discovery

    Principal Advisor

    Other advisors: Dr Nicholas Ariotti, Professor Rob Capon

Media

Enquiries

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