Overview
Background
Overview
Professor Waldemar Vollmer is a microbiologist working on the structure and biogenesis of the bacterial cell wall in various model bacteria and a range of pathogenic and environmental bacteria. He is particularly interested in how bacteria enlarge their cell wall when they grow and divide, and how antibiotics inhibit cell wall synthesis to kill bacteria. Antimicrobial resistance (AMR) is a global problem that is predicted to claim 10 million lives annually by the year 2050 if no new antibiotics are developed. Currently the pipeline of antibiotic development is almost empty and mostly limited to slightly modified versions to existing antibiotics. Professor Vollmer addresses the problem of AMR by generating tailored assays for the development of novel antibiotics that target AMR bacteria.
Collaborations: Professor Vollmer collaborates world-wide with more than 50 researchers at top national and international institutions on cell wall topics in over 30 different bacteria. These topics include: structure and composition of the cell wall and its role in maintaining cell morphology; molecular mechanisms of cell envelope biogenesis; role of new cell wall modifying enzymes in the interaction of pathogenic bacteria with components of the immune system; mechanisms of antibiotic resistance and targeting of cell wall biogenesis by new antibiotics.
Funding and Publications: Professor Vollmer has been awarded more than $15 million funding from research councils and charities in Germany, UK, Europe and USA. He has published more than 200 articles in international journals and has been recognised as a Highly Cited Researcher in Microbiology.
Honours and Awards: Professor Vollmer has been elected to Fellow of the American Academy of Microbiology (2014) and European Academy of Microbiology (2018). He received the annual Academic Distinction Awards from the Vice Chancellor of Newcastle University (2014), has been awarded a Distinguished Scientist Visiting Scholarships at Ben-Gurion University of the Negev (Israel, 2012) and a Visiting Professorship at the University of Cagliari (Italy, 2015), and won a Wellcome Trust Senior Investigator Award (2014). He has co-organised the 2018 Gordon Conference (GRC) "Bacterial Cell Surfaces" (Mt Snow, USA) and the 2016 EMBO Workshop "Bacterial Cell Division: Orchestrating the Ring Cycle" (Prague, Czech Republic).
Short Biography: Prof Waldemar Vollmer has studied chemistry at the University of Applied Sciences in Reutlingen (Germany) and University of Basel (Switzerland). In 1998 he obtained a PhD degree (Dr.rer.nat.) from the University of Tübingen (Germany) for his work on cell wall synthesis in the model bacterium Escherichia coli undertaken at the Max Planck Institute for Developmental Biology. During his postdoctoral studies at the Rockefeller University (New York, USA) he discovered novel cell wall enzymes that are crucial for the virulence of the pathogenic bacterium Streptococcus pneumoiae. In 2003 he was appointed Assistant Professor at the University of Tübingen and moved 2007 to the Centre for Bacterial Cell Biology at Newcastle University (UK), where he worked as Professor of Bacterial Biochemistry on various bacterial cell wall topics in a range of different bacteria. Since April 2023 he is Professorial Research Fellow and Group Leader at the Centre for Superbug Solutions, Institute for Molecular Bioscience (IMB) at the University of Queensland.
Availability
- Professor Waldemar Vollmer is:
- Available for supervision
Fields of research
Research impacts
Professor Vollmer's basic research on the bacterial cell envelope has led to key advances in our understanding of bacterial cell function and has discovered molecular mechanisms that can be exploited for antibiotic development.
Key research outputs: Prof Vollmer's group has discovered mechanisms of PG biosynthesis and its regulation, novel cell wall enzymes, and mechanisms of coordination between PG synthesis and outer membrane biogenesis. These discoveries provided the first molecular insights into how bacteria robustly maintain, enlarge and modify their cell envelope when they propagate in diverse environments and under stress conditions, and when exposed to antibiotics.
Key capabilities: Prof Vollmer's group is expert in the analysis of the composition of peptidoglycan, the key shape-maintaining and stress-bearing component of the bacterial cell envelope. They also discover new cell wall enzymes and study the activities and interactions of of key cell wall synthases and hydrolases (lysins or autolysins). They are also expert in determining the cleavage site of cell wall-degrading lysins and establishing biochemical assays for cell wall enzymes, for studying their inhibition by antibiotics. They combine their molecular biology work with studies on the physiology of bacterial cells impaired in cell wall biogenesis.
Works
Search Professor Waldemar Vollmer’s works on UQ eSpace
2020
Journal Article
Peptidoglycan editing provides immunity to Acinetobacter baumannii during bacterial warfare
Le, Nguyen-Hung, Peters, Katharina, Espaillat, Akbar, Sheldon, Jessica R., Gray, Joe, Di Venanzio, Gisela, Lopez, Juvenal, Djahanschiri, Bardya, Mueller, Elizabeth A., Hennon, Seth W., Levin, Petra Anne, Ebersberger, Ingo, Skaar, Eric P., Cava, Felipe, Vollmer, Waldemar and Feldman, Mario F. (2020). Peptidoglycan editing provides immunity to Acinetobacter baumannii during bacterial warfare. Science Advances, 6 (30), 1-8. doi: 10.1126/sciadv.abb5614
2020
Journal Article
Structure of the peptidoglycan synthase activator LpoP in Pseudomonas aeruginosa
Caveney, Nathanael A., Egan, Alexander J. F., Ayala, Isabel, Laguri, Cedric, Robb, Craig S., Breukink, Eefjan, Vollmer, Waldemar, Strynadka, Natalie C. J. and Simorre, Jean-Pierre (2020). Structure of the peptidoglycan synthase activator LpoP in Pseudomonas aeruginosa. Structure, 28 (6), 643-650.e5. doi: 10.1016/j.str.2020.03.012
2020
Journal Article
Tol-Pal system and Rgs proteins interact to promote unipolar growth and cell division in Sinorhizobium meliloti
Krol, Elizaveta, Yau, Hamish C. L., Lechner, Marcus, Schaeper, Simon, Bange, Gert, Vollmer, Waldemar and Becker, Anke (2020). Tol-Pal system and Rgs proteins interact to promote unipolar growth and cell division in Sinorhizobium meliloti. mBio, 11 (3), 1-21. doi: 10.1128/mBio.00306-20
2020
Journal Article
Diffusion and capture permits dynamic coupling between treadmilling FtsZ filaments and cell division proteins
Baranova, Natalia, Radler, Philipp, Hernandez-Rocamora, Victor M., Alfonso, Carlos, Lopez-Pelegrin, Mar, Rivas, German, Vollmer, Waldemar and Loose, Martin (2020). Diffusion and capture permits dynamic coupling between treadmilling FtsZ filaments and cell division proteins. Nature Microbiology, 5 (3), 407-417. doi: 10.1038/s41564-019-0657-5
2020
Journal Article
Distinct cytoskeletal proteins define zones of enhanced cell wall synthesis in Helicobacter pylori
Taylor, Jennifer A., Bratton, Benjamin P., Sichel, Sophie R., Blair, Kris M., Jacobs, Holly M., DeMeester, Kristen E., Kuru, Erkin, Gray, Joe, Biboy, Jacob, VanNieuwenhze, Michael S., Vollmer, Waldemar, Grimes, Catherine L., Shaevitz, Joshua W. and Salama, Nina R. (2020). Distinct cytoskeletal proteins define zones of enhanced cell wall synthesis in Helicobacter pylori. eLife, 9, 1-38. doi: 10.7554/eLife.52482
2019
Book Chapter
The cell wall of Streptococcus pneumoniae
Vollmer, Waldemar, Massidda, Orietta and Tomasz, Alexander (2019). The cell wall of Streptococcus pneumoniae. Gram-positive pathogens. (pp. 284-303) edited by Vincent A. Fischetti, Richard P. Novick, Joseph J. Ferretti, Daniel A. Portnoy, Miriam Braunstein and Julian I. Rood. Washington, DC United States: American Society for Microbiology. doi: 10.1128/9781683670131.ch18
2019
Journal Article
Mechanisms of incorporation for D-amino acid probes that target peptidoglycan biosynthesis
Kuru, Erkin, Radkov, Atanas, Meng, Xin, Egan, Alexander, Alvarez, Laura, Dowson, Amanda, Booher, Garrett, Breukink, Eefjan, Roper, David I., Cava, Felipe, Vollmer, Waldemar, Brun, Yves and VanNieuwenhze, Michael S. (2019). Mechanisms of incorporation for D-amino acid probes that target peptidoglycan biosynthesis. ACS Chemical Biology, 14 (12), 2745-2756. doi: 10.1021/acschembio.9b00664
2019
Journal Article
The Pseudomonas aeruginosa T6SS delivers a periplasmic toxin that disrupts bacterial cell morphology
Wood, Thomas E., Howard, Sophie A., Forster, Andreas, Nolan, Laura M., Manoli, Eleni, Bullen, Nathan P., Yau, Hamish C. L., Hachani, Abderrahman, Hayward, Richard D., Whitney, John C., Vollmer, Waldemar, Freemont, Paul S. and Filloux, Alain (2019). The Pseudomonas aeruginosa T6SS delivers a periplasmic toxin that disrupts bacterial cell morphology. Cell Reports, 29 (1), 187-201.e7. doi: 10.1016/j.celrep.2019.08.094
2019
Journal Article
D-amino acid derivatives as in situ probes for visualizing bacterial peptidoglycan biosynthesis
Hsu, Yen-Pang, Booher, Garrett, Egan, Alexander, Vollmer, Waldemar and VanNieuwenhze, Michael S. (2019). D-amino acid derivatives as in situ probes for visualizing bacterial peptidoglycan biosynthesis. Accounts of Chemical Research, 52 (9), 2713-2722. doi: 10.1021/acs.accounts.9b00311
2019
Journal Article
Cell wall peptidoglycan in Mycobacterium tuberculosis: an Achilles' heel for the TB-causing pathogen
Maitra, Arundhati, Munshi, Tulika, Healy, Jess, Martin, Liam T., Vollmer, Waldemar, Keep, Nicholas H. and Bhakta, Sanjib (2019). Cell wall peptidoglycan in Mycobacterium tuberculosis: an Achilles' heel for the TB-causing pathogen. Fems Microbiology Reviews, 43 (5), 548-575. doi: 10.1093/femsre/fuz016
2019
Journal Article
Does the nucleoid determine cell dimensions in Escherichia coli?
Zaritsky, Arieh, Vollmer, Waldemar, Mannik, Jaan and Liu, Chenli (2019). Does the nucleoid determine cell dimensions in Escherichia coli?. Frontiers in Microbiology, 10, 1-7. doi: 10.3389/fmicb.2019.01717
2019
Journal Article
Optimized protocol for the incorporation of FDAA (HADA labeling) for in situ labeling of peptidoglycan
Peters, Katharina, Pazos, Manuel, VanNieuwenhze, Michael S. and Vollmer, Waldemar (2019). Optimized protocol for the incorporation of FDAA (HADA labeling) for in situ labeling of peptidoglycan. Bio-protocol, 9 (15), 1-12. doi: 10.21769/BioProtoc.3316
2019
Journal Article
Borrelia burgdorferi peptidoglycan is a persistent antigen in patients with Lyme arthritis
Jutras, Brandon L., Lochhead, Robert B., Kloos, Zachary A., Biboy, Jacob, Strle, Klemen, Booth, Carmen J., Govers, Sander K., Gray, Joe, Schumann, Peter, Vollmer, Waldemar, Bockenstedt, Linda K., Steere, Allen C. and Jacobs-Wagner, Christine (2019). Borrelia burgdorferi peptidoglycan is a persistent antigen in patients with Lyme arthritis. Proceedings of the National Academy of Sciences of the United States of America, 116 (27), 13498-13507. doi: 10.1073/pnas.1904170116
2019
Journal Article
The Campylobacter jejuni helical to coccoid transition involves changes to peptidoglycan and the ability to elicit an immune response
Frirdich, Emilisa, Biboy, Jacob, Pryjma, Mark, Lee, Jooeun, Huynh, Steven, Parker, Craig T., Girardin, Stephen E., Vollmer, Waldemar and Gaynor, Erin C. (2019). The Campylobacter jejuni helical to coccoid transition involves changes to peptidoglycan and the ability to elicit an immune response. Molecular Microbiology, 112 (1), 280-301. doi: 10.1111/mmi.14269
2019
Journal Article
A genome-wide Helicobacter pylori morphology screen uncovers a membrane-spanning helical cell shape complex
Yang, Desiree C., Blair, Kris M., Taylor, Jennifer A., Petersen, Timothy W., Sessler, Tate, Tull, Christina M., Leverich, Christina K., Collar, Amanda L., Wyckoff, Timna J., Biboy, Jacob, Vollmer, Waldemar and Salama, Nina R. (2019). A genome-wide Helicobacter pylori morphology screen uncovers a membrane-spanning helical cell shape complex. Journal of Bacteriology, 201 (14), 1-16. doi: 10.1128/JB.00724-18
2019
Journal Article
The cell wall of Streptococcus pneumoniae
Vollmer, Waldemar, Massidda, Orietta and Tomasz, Alexander (2019). The cell wall of Streptococcus pneumoniae. Microbiology Spectrum, 7 (3), 1-25. doi: 10.1128/microbiolspec.GPP3-0018-2018
2019
Journal Article
Plasticity of Escherichia coli cell wall metabolism promotes fitness and antibiotic resistance across environmental conditions
Mueller, Elizabeth A., Egan, Alexander J. F., Breukink, Eefjan, Vollmer, Waldemar and Levin, Petra Anne (2019). Plasticity of Escherichia coli cell wall metabolism promotes fitness and antibiotic resistance across environmental conditions. eLife, 8, 1-24. doi: 10.7554/eLife.40754
2019
Journal Article
Studying intact bacterial peptidoglycan by proton-detected NMR spectroscopy at 100 kHz MAS frequency
Bougault, Catherine, Ayala, Isabel, Vollmer, Waldemar, Simorre, Jean-Pierre and Schanda, Paul (2019). Studying intact bacterial peptidoglycan by proton-detected NMR spectroscopy at 100 kHz MAS frequency. Journal of Structural Biology, 206 (1), 66-72. doi: 10.1016/j.jsb.2018.07.009
2019
Journal Article
Coordination of capsule assembly and cell wall biosynthesis in Staphylococcus aureus
Rausch, Marvin, Deisinger, Julia P., Ulm, Hannah, Mueller, Anna, Li, Wenjin, Hardt, Patrick, Wang, Xiaogang, Li, Xue, Sylvester, Marc, Engeser, Marianne, Vollmer, Waldemar, Mueller, Christa E., Sahl, Hans Georg, Lee, Jean Claire and Schneider, Tanja (2019). Coordination of capsule assembly and cell wall biosynthesis in Staphylococcus aureus. Nature Communications, 10 (1) 1404, 1404. doi: 10.1038/s41467-019-09356-x
2019
Journal Article
A specialized MreB-dependent cell wall biosynthetic complex mediates the formation of stalk-specific peptidoglycan in Caulobacter crescentus
Billini, Maria, Biboy, Jacob, Kuehn, Juliane, Vollmer, Waldemar and Thanbichler, Martin (2019). A specialized MreB-dependent cell wall biosynthetic complex mediates the formation of stalk-specific peptidoglycan in Caulobacter crescentus. Plos Genetics, 15 (2) ARTN e1007897, 1-33. doi: 10.1371/journal.pgen.1007897
Supervision
Availability
- Professor Waldemar Vollmer is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Targeting bacterial cell envelope coordination for antibiotic drug discovery
Principal Advisor
Other advisors: Professor Brett Collins
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Doctor Philosophy
Novel assays for antibiotic discovery
Principal Advisor
Other advisors: Professor Rob Capon
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Doctor Philosophy
Dissecting the bacterial cell envelope for antibiotic drug discovery
Principal Advisor
Other advisors: Dr Nicholas Ariotti, Professor Rob Capon
Media
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